Gregory Alexander Jicha MD

Hospital/Neurohospitalist

Professor in the Department of Neurology and Sanders-Brown Center on Aging at the University of Kentucky Director of the Telemedicine Cognitive Clinic at UK

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740 Rose St# J401Lexington, KY 40536
Phone+1 859-323-5661
Fax+1 859-257-4999

Summary

Dr. Gregory Jicha is a neurologist in Lexington, KY and is affiliated with multiple hospitals in the area, including UK HealthCare Good Samaritan Hospital and University of Kentucky Albert B. Chandler Hospital. He received his medical degree and doctorate in philosophy from Albert Einstein College of Medicine and has been in practice 17 years. He specializes in behavioral neurology and stroke with a focus on the diagnosis and treatment of Alzheimer's and related dementias.

Education & Training

Mayo Clinic College of Medicine and ScienceFellowship, Behavioral neurology, 2004 - 2005
Mayo Clinic College of Medicine and Science (Rochester)Residency, Neurology, 2001 - 2005
Mayo Clinic College of Medicine and Science (Rochester)Internship, Internal Medicine, 2000 - 2001
Albert Einstein College of MedicineClass of 2000

Certifications & Licensure

KY State Medical License 2005 - 2026
MN State Medical License 2001 - 2005
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

America's Most Honored Doctors American Registry, 2020
Regional Top Doctor Castle Connolly, 2014-2020
Best Doctors in America Best Doctors, 2007-2020
Presidential Award for Lifetime Achievement Greater Cincinnati and Northern Kentucky Alzheimer’s Association, 2019
Alpha Omega Alpha (AOA) National Medical Honor Society, 2000
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Clinical Trials

Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study Start of enrollment: 2012 Apr 01
Completed
Early Phase 1
Safety and Tolerability of Antioxidant (AT-001)for Reducing Brain Oxidative Stress Start of enrollment: 2012 Mar 01
Completed
Phase 1
The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF) Start of enrollment: 2014 Jan 08
COMPLETED
PHASE2, PHASE3
Early Detection and Prevention of Mild Cognitive Impairment Due to Cerebrovascular Disease Start of enrollment: 2013 May 01
Completed
Not Applicable
Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss Start of enrollment: 2014 Feb 28
Completed
Phase 3
Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease Start of enrollment: 2014 May 01
Completed
Early Phase 1
A Pilot Study to Reduce Inappropriate Anticholinergic Prescribing in the Elderly Start of enrollment: 2014 Sep 01
Completed
Not Applicable
Brain Exercises for Synaptic Plasticity Start of enrollment: 2016 Jul 15
Completed
Not Applicable
AT-001 for Long-term Preservation of Brain Health in Aging Start of enrollment: 2016 May 01
Completed
Not Applicable
Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging Start of enrollment: 2021 Dec 01
ACTIVE_NOT_RECRUITING
PHASE2
Environmental Design for Behavioral Regulation in People With Dementia Start of enrollment: 2021 Jan 25
Completed
Not Applicable
Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type Start of enrollment: 2022 Nov 01
RECRUITING
PHASE3
Roles: Contact, Principal Investigator
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium Start of enrollment: 2021 Sep 29
ACTIVE_NOT_RECRUITING
Roles: Contact
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Publications & Presentations

PubMed

Advancing clinical trial readiness in white matter disease and related dementias: key steps for future research progress.
Pradoldej Sompol, Gregory A Jicha, Jason D Hinman, Adam M Brickman, Steven M Greenberg
Geroscience. 2025-07-21
Creating harmony at home via environmental cueing: A feasibility trial of a non-pharmacological intervention for rural caregivers of persons with dementia.
Elizabeth K Rhodus, Richard Kryscio, Gregory Jicha, Carolyn Baum, Laura Henley
Alzheimer's & Dementia. 2025-07-01
Estimation of events in cohort studies based on probability of cognitive impairment.
Jiyeon Park, Erin L Abner, Pei Wang, Changrui Liu, Gregory Jicha
Journal of Alzheimer's Disease. 2025-06-26

Journal Articles

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults
Matthew D Cykowski, Gregory A Jicha, JAMA Neurology
Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults
Matthew D Cykowski, Gregory A Jicha, JAMA Neurology

Authored Content

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older AdultsJune 2020

Press Mentions

UK HealthCare, Community Leaders Celebrate Opening of New Sanders-Brown ClinicJuly 26th, 2022
New MRI Technique Can Detect Early Dysfunction of the Blood-Brain Barrier with Small Vessel DiseaseMay 5th, 2021
Aging Experts from Across U.S. To Speak at Optimal Aging Conference in Louisville in AprilMarch 16th, 2021
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Grant Support

The University of Kentucky MarkVCID Biomarker Validation Cohort: Development of a Toolbox to Advance VCID Interventional StudiesUNIVERSITY OF KENTUCKY2021–2026
The University of Kentucky MarkVCID Biomarker Validation Cohort: Development of a Toolbox to Advance VCID Interventional StudiesUNIVERSITY OF KENTUCKY2021–2026
Safety and modulation of ABCC9 pathways by nicorandil for the treatment of hippocampal sclerosis of aging (SMArTâHS)UNIVERSITY OF KENTUCKY2019–2025
Effects Of DHANational Center For Research Resources2007
Anti-Oxidant Treatment In ADNational Center For Research Resources2007