GregoryAlexanderJichaMD

Hospital/Neurohospitalist

Professor in the Department of Neurology and Sanders-Brown Center on Aging at the University of Kentucky Director of the Telemedicine Cognitive Clinic at UK

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Office
740 Rose St
# J
Lexington, KY 40536
Phone+1 859-323-5661
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Summary

Dr. Gregory Jicha is a neurologist in Lexington, KY and is affiliated with multiple hospitals in the area, including UK HealthCare Good Samaritan Hospital and University of Kentucky Albert B. Chandler Hospital. He received his medical degree and doctorate in philosophy from Albert Einstein College of Medicine and has been in practice 17 years. He specializes in behavioral neurology and stroke with a focus on the diagnosis and treatment of Alzheimer's and related dementias.

Education & Training

Mayo Clinic College of Medicine and ScienceFellowship, Behavioral neurology, 2004 - 2005
Mayo Clinic College of Medicine and Science (Rochester)Residency, Neurology, 2001 - 2005
Mayo Clinic College of Medicine and Science (Rochester)Internship, Internal Medicine, 2000 - 2001
Albert Einstein College of MedicineClass of 2000

Certifications & Licensure

KY State Medical License 2005 - 2025
MN State Medical License 2001 - 2005
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

America's Most Honored Doctors American Registry, 2020
Regional Top Doctor Castle Connolly, 2014-2020
Best Doctors in America Best Doctors, 2007-2020
Presidential Award for Lifetime Achievement Greater Cincinnati and Northern Kentucky Alzheimer’s Association, 2019
Alpha Omega Alpha (AOA) National Medical Honor Society, 2000
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Clinical Trials

Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study Start of enrollment: 2012 Apr 01
Completed
Early Phase 1
Safety and Tolerability of Antioxidant (AT-001)for Reducing Brain Oxidative Stress Start of enrollment: 2012 Mar 01
Completed
Phase 1
The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF) Start of enrollment: 2014 Jan 08
Completed
Phase 2, Phase 3
Early Detection and Prevention of Mild Cognitive Impairment Due to Cerebrovascular Disease Start of enrollment: 2013 May 01
Completed
Not Applicable
Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss Start of enrollment: 2014 Feb 28
Completed
Phase 3
Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease Start of enrollment: 2014 May 01
Completed
Early Phase 1
A Pilot Study to Reduce Inappropriate Anticholinergic Prescribing in the Elderly Start of enrollment: 2014 Sep 01
Completed
Not Applicable
Brain Exercises for Synaptic Plasticity Start of enrollment: 2016 Jul 15
Completed
Not Applicable
AT-001 for Long-term Preservation of Brain Health in Aging Start of enrollment: 2016 May 01
Completed
Not Applicable
Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging Start of enrollment: 2021 Dec 01
Recruiting
Phase 2
Environmental Design for Behavioral Regulation in People With Dementia Start of enrollment: 2021 Jan 25
Completed
Not Applicable
Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type Start of enrollment: 2022 Nov 01
Recruiting
Phase 3
Roles: Contact, Principal Investigator
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium Start of enrollment: 2021 Sep 29
Recruiting
Roles: Contact
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Publications & Presentations

PubMed

National Trends of Vascular Risk Factor Control Among Stroke Survivors: From the National Health and Nutrition Examination Survey 2009 to 2020.
Hend Mansoor, Daniel Manion, Kara J Swafford, Gregory Jicha, Daniela Moga> ;Journal of the American Heart Association. 2024 Mar 19
1 citations
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort.
Winford, E., Lutshumba, J., Martin, B., Wilcock, D., Nikolajczyk, B., Stowe, A., Bachstetter, A., Jicha, G.> ;Biorxiv. 2023 Nov 28
Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol.
Ahmed A Bahrani, Erin L Abner, Charles S DeCarli, Justin M Barber, Abigail C Sutton, Pauline Maillard, Francisco Sandoval, Konstantinos Arfanakis, Yung-Chuan Yang, Arn...> ;Journal of Alzheimer's Disease. 2023 Jan 1
Surprising Synergy Between Cerebrovascular and Lewy Body Disease in Parkinsonism.
Peter T Nelson, Gregory A Jicha> ;Neurology. 2023 Aug 15
Feasibility of Telehealth Occupational Therapy for Behavioral Symptoms of Adults With Dementia: Randomized Controlled Trial.
Elizabeth K Rhodus, Carolyn Baum, Richard Kryscio, Changrui Liu, Rosmy George, MaryEllen Thompson, Kimberly Lowry, Beth Coy, Justin Barber, Heather Nichols, Alexandra ...> ;The American Journal of Occupational Therapy. 2023 Jul 1
5 citations
When Alzheimer's is LATE: Why Does it Matter?
Peter T Nelson, Julie A Schneider, Gregory A Jicha, Michael Tran Duong, David A Wolk> ;Annals of Neurology. 2023 Aug 1
2 citations
Rapid, scalable assay of amylin-β amyloid co-aggregation in brain tissue and blood.
Deepak Kotiya, Noah Leibold, Nirmal Verma, Gregory A Jicha, Larry B Goldstein, Florin Despa> ;The Journal of Biological Chemistry. 2023 May 1
A blunted T17 cytokine signature in women with mild cognitive impairment: insights from inflammatory profiling of a community-based cohort of older adults.
Adam D Bachstetter, Jenny Lutshumba, Edric Winford, Erin L Abner, Barbra J Martin, Jordan P Harp, Linda J Van Eldik, Frederick A Schmitt, Donna M Wilcock, Ann M Stowe,...> ;Brain Communications. 2023 Jan 1
3 citations
Preclinical Alzheimer Disease and the Electronic Health Record: Balancing Confidentiality and Care.
Seth A Gale, Judith Heidebrink, Joshua Grill, Jonathan Graff-Radford, Gregory A Jicha, William Menard, Milap Nowrangi, Susie Sami, Shirley Sirivong, Sarah Walter, Jaso...> ;Neurology. 2022 Nov 29
1 citations
Frontotemporal neurofibrillary tangles and cerebrovascular lesions are associated with autism spectrum behaviors in late-life dementia.
Elizabeth K Rhodus, Justin Barber, Richard J Kryscio, Erin L Abner, Ahmed A Bahrani, Kristine E Shady Lewis, Brandi Carey, Peter T Nelson, Linda J Van Eldik, Gregory A...> ;Journal of Neurology. 2022 Sep 1
21 citations
Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis.
Kathryn M Gauthreaux, Merilee A Teylan, Yuriko Katsumata, Charles Mock, Jessica E Culhane, Yen-Chi Chen, Kwun C G Chan, David W Fardo, Adam J Dugan, Matthew D Cykowski...> ;Neurology. 2022 Apr 5
18 citations
Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy...
Zachary Winder, Tiffany L Sudduth, Sonya Anderson, Ela Patel, Janna Neltner, Barbara J Martin, Katherine E Snyder, Erin L Abner, Gregory A Jicha, Peter T Nelson, Donna...> ;Alzheimer's & Dementia. 2023 Jan 1
5 citations
Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele.
Jozsef Gal, Yuriko Katsumata, Haining Zhu, Sukanya Srinivasan, Jing Chen, Lance Allen Johnson, Wang-Xia Wang, Lesley Renee Golden, Donna M Wilcock, Gregory A Jicha, Ma...> ;The American Journal of Pathology. 2022 Mar 1
1 citations
Primitive Reflexes and Dementia in Adults With Down Syndrome.
Jordan Harp, Lisa Koehl, Kathryn Van Pelt, Elizabeth Head, Gregory Jicha, William Robertson, Donita Lightner, Ira Lott, Frederick Schmitt> ;Neurology. Clinical Practice. 2022 Feb 1
4 citations
Sensory Processing Abnormalities in Community-Dwelling Older Adults with Cognitive Impairment: A Mixed Methods Study.
Elizabeth K Rhodus, Elizabeth G Hunter, Graham D Rowles, Shoshana H Bardach, Kelly Parsons, Justin Barber, MaryEllen Thompson, Gregory A Jicha> ;Gerontology & Geriatric Medicine. 2022 Jan 8
6 citations
Enlarged Perivascular Spaces Are Negatively Associated With Montreal Cognitive Assessment Scores in Older Adults.
Timothy J Libecap, Valentinos Zachariou, Christopher E Bauer, Donna M Wilcock, Gregory A Jicha, Flavius D Raslau, Brian T Gold> ;Frontiers in Neurology. 2022 Jan 1
4 citations
Incident epilepsy in the cognitively normal geriatric population, irrespective of seizure control, impairs quality of life.
Saniya Pervin, Gregory A Jicha, Meriem Bensalem-Owen, Sally V Mathias> ;Epilepsy & Behavior. 2022 Jan 1
5 citations
Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge.
Peiying Liu, Dengrong Jiang, Marilyn S. Albert, Christopher E. Bauer, Arvind Caprihan, Brian T. Gold, Steven M. Greenberg, Karl G. Helmer, Kay Jann, Gregory A. Jicha, ...> ;Neuroimage. 2021 Nov 23
3 citations
Identifying dementia in Down syndrome with the Severe Impairment Battery, Brief Praxis Test and Dementia Scale for People with Learning Disabilities.
Elizabeth R. Wallace, Jordan P. Harp, K. L. Van Pelt, Lisa M. Koehl, Allison Caban-Holt, Amelia J. Anderson-Mooney, Greg Jicha, Donita Lightner, William C. Robertson, ...> ;Journal of Intellectual Disability Research. 2021 Nov 16
6 citations
The epidemiology is promising, but the trial evidence is weak. Why pharmacological dementia risk reduction trials haven't lived up to expectations, and where do we go ...
Ruth Peters, Hiroko H. Dodge, Sarah James, Gregory A. Jicha, Pierre-François Meyer, Marcus Richards, A. David Smith, Hussein N. Yassine, Erin L. Abner, Atticus H. Hain...> ;Alzheimer's & Dementia. 2021 Nov 2
13 citations
Differences in Symptomatic Presentation and Cognitive Performance Among Participants With LATE-NC Compared to FTLD-TDP.
Merilee Teylan, Charles Mock, Kathryn Gauthreaux, Jessica E. Culhane, Gregory A. Jicha, Yen-Chi Chen, Kwun Chuen Gary Chan, Walter A. Kukull, Peter T. Nelson, Yuriko K...> ;Journal of Neuropathology and Experimental Neurology. 2021 Oct 1
3 citations
Committee on High-quality Alzheimer's Disease Studies (CHADS) consensus report
Greg Jicha, Erin L. Abner, Steven E. Arnold, Maria C. Carrillo, Hiroko H. Dodge, Steven D. Edland, Keith N. Fargo, Howard Feldman, Larry B. Goldstein, James Hendrix, R...> ;Alzheimer's & Dementia. 2021 Sep 29
3 citations
Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia.
Ahmed A. Bahrani, Charles D. Smith, Justin M. Barber, Omar M. Al-Janabi, David K. Powell, Anders H. Andersen, Brandon D. Ramey, Erin L. Abner, Larry B. Goldstein, Zach...> ;Journal of Neuroscience Methods. 2021 Aug 1
23 citations
Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study.
Maria Carmona-Iragui, Daniel Alcolea, Isabel Barroeta, Laura Videla, Laia Muñoz, Kathyrn L Van Pelt, Frederick A. Schmitt, Donita Lightner, Lisa M. Koehl, Gregory A. J...> ;The Lancet. Neurology. 2021 Aug 1
29 citations
Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults.
Brian T. Gold, Xingfeng Shao, Tiffany L. Sudduth, Gregory A. Jicha, Donna M. Wilcock, Elayna R. Seago, Danny J.J. Wang> ;Alzheimer's & Dementia. 2021 May 5
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Journal Articles

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults
Matthew D Cykowski, Gregory A Jicha, JAMA Neurology
Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults
Matthew D Cykowski, Gregory A Jicha, JAMA Neurology

Authored Content

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older AdultsJune 2020

Press Mentions

UK HealthCare, Community Leaders Celebrate Opening of New Sanders-Brown ClinicJuly 26th, 2022
New MRI Technique Can Detect Early Dysfunction of the Blood-Brain Barrier with Small Vessel DiseaseMay 5th, 2021
Aging Experts from Across U.S. To Speak at Optimal Aging Conference in Louisville in AprilMarch 16th, 2021
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