GregoryEPlautzMD

Pediatric Hematology & Oncology • Cleveland, OH

Professor of Pediatrics, Case West Res University

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Office
9500 Euclid Ave
Cleveland, OH 44195
Phone(800) 223-2273
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Education & Training

University of Michigan Hospitals and Health CentersFellowship, Pediatric Hematology/Oncology, 1987 - 1990
Johns Hopkins UniversityResidency, Pediatrics, 1984 - 1987
Indiana University School of MedicineClass of 1984

Certifications & Licensure

OH State Medical License 1994 - 2016

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2010-2014
America's Top Doctors for Cancer Castle Connolly, 2009-2013

Publications & Presentations

PubMed

5 citations
Chylopericardium and chylothorax: unusual mechanical complications of central venous catheters.
Alkayed, K., Plautz, G. E., Gowans, K., Rosenthal, G. L., Soldes, O. S., Qureshi, A. M.> ;Pediatrics international : official journal of the Japan Pediatric Society. 2013 May 18
1 citation
Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer.
Cata, J. P., Bauer, M., Sokari, T., Ramirez, M. F., Mason, D. P., Plautz, G. E., Kurz, A.> ;Journal of clinical anesthesia. 2013 May 11
Tumor-primed, in vitro-activated CD4+ effector T cells establish long-term memory without exogenous cytokine support or ongoing antigen exposure.
Wang, L., Plautz, G. E.> ;Journal of immunology (Baltimore, Md. : 1950). 2010 Apr 13
Mechanism of third signals provided by IL-12 and OX-40R ligation in eliciting therapeutic immunity following dendritic-tumor fusion vaccination.
Hideyuki Kuriyama, Satoshi Watanabe, Jorgen Kjaergaard, Hidemasa Tamai, Rongxiu Zheng, Andrew D. Weinberg, Hong-Ming Hu, Peter A. Cohen, Gregory E. Plautz, Suyu Shu> ;Cellular Immunology. 2006 Sep 1
26 citations
Host lymphodepletion augments T cell adoptive immunotherapy through enhanced intratumoral proliferation of effector cells.
Wang, L., Shu, S., Plautz, G. E.> ;Cancer research. 2005 Oct 19
19 citations
Active immunotherapy for advanced intracranial murine tumors by using dendritic cell-tumor cell fusion vaccines.
Kjaergaard, J., Wang, L., Kuriyama, H., Shu, S., Plautz, G. E.> ;Journal of neurosurgery. 2005 Aug 27
Adoptive immunotherapy of cancer with polyclonal, 108-fold hyperexpanded, CD4+ and CD8+ T cells
Li-Xin Wang, Wen Xin Huang, Hallie Graor, Peter A. Cohen, Julian A. Kim, Suyu Shu, Gregory E. Plautz> ;Journal of Translational Medicine. 2004 Nov 26
13 citations
Memory T Cells Originate from Adoptively Transferred Effectors and Reconstituting Host Cells after Sequential Lymphodepletion and Adoptive Immunotherapy
Li-Xin Wang, Jorgen Kjaergaard, Peter A. Cohen, Suyu Shu, Gregory E. Plautz> ;Journal of Immunology. 2004 Mar 15
8 citations
Considerations on clinical use of T cell immunotherapy for cancer
Gregory E. Plautz, Peter A. Cohen, Suyu Shu> ;Archivum Immunologiae Et Therapiae Experimentalis. 2003 Jan 1
24 citations
Tumor-induced L-selectinhigh suppressor T cells mediate potent effector T cell blockade and cause failure of otherwise curative adoptive immunotherapy.
Peng, L., Kjaergäard, J., Plautz, G. E., Awad, M., Drazba, J. A., Shu, S., Cohen, P. A.> ;Journal of immunology (Baltimore, Md. : 1950). 2002 Oct 23
Potent Effector Function of Tumor-Sensitized L-Selectinlow T Cells against Subcutaneous Tumors Requires LFA-1 co-Stimulation:
Brook M. Seeley, Steve W. Barthel, Wyatt C. To, Jorgen Kjaergaard, Suyu Shu, Gregory E. Plautz> ;Otolaryngology-Head and Neck Surgery. 2001 Apr 1
T-cell adoptive therapy of tumors: mechanisms of improved therapeutic performance.
Liaomin Peng, Peter A. Cohen, Jorgen Kjaergaard, Gregory E. Plautz, James H. Finke, Gary K. Koski, Brian J. Czerniecki, Suyu Shu> ;Critical Reviews in Immunology. 2001 Jan 1
3 citations
T Cell-Mediated Tumor Rejection Displays Diverse Dependence Upon Perforin and IFN-γ Mechanisms That Cannot Be Predicted From In Vitro T Cell Characteristics
Liaomin Peng, John C. Krauss, Gregory E. Plautz, Shigehiko Mukai, Suyu Shu, Peter A. Cohen> ;Journal of Immunology. 2000 Dec 15
Helper-Independent, L-Selectinlow CD8+ T Cells with Broad Anti-Tumor Efficacy Are Naturally Sensitized During Tumor Progression
Liaomin Peng, Jorgen Kjaergaard, Gregory E. Plautz, David E. Weng, Suyu Shu, Peter A. Cohen> ;Journal of Immunology. 2000 Nov 15
18 citations
Cross-Presentation of Tumor Antigens to Effector T Cells Is Sufficient to Mediate Effective Immunotherapy of Established Intracranial Tumors
Gregory E. Plautz, Shigehiko Mukai, Peter A. Cohen, Suyu Shu> ;Journal of Immunology. 2000 Oct 1
115 citations
T cell adoptive immunotherapy of newly diagnosed gliomas.
Gregory E. Plautz, David W. Miller, Gene H. Barnett, Glen Stevens, Scott Maffett, Julian Kim, Peter A. Cohen, Suyu Shu> ;Clinical Cancer Research. 2000 Jun 1
CD4+ T cells in adoptive immunotherapy and the indirect mechanism of tumor rejection.
Peter A. Cohen, Liaomin Peng, Gregory E. Plautz, Julian A. Kim, David E. Weng, Suyu Shu> ;Critical Reviews in Immunology. 2000 Jan 1
30 citations
T-cell adoptive immunotherapy of metastatic renal cell carcinoma.
Plautz, G. E., Bukowski, R. M., Novick, A. C., Klein, E. A., Kursh, E. D., Olencki, T. E., Yetman, R. J., Pienkny, A., Sandstrom, K., Shu, S.> ;Urology. 1999 Oct 8
18 citations
Critical role of CD11a (LFA-1) in therapeutic efficacy of systemically transferred antitumor effector T cells.
Mukai, S., Kagamu, H., Shu, S., Plautz, G. E.> ;Cellular immunology. 1999 Mar 24
2 citations
Ex vivo activation of tumor-draining lymph node T cells reverses defects in signal transduction molecules.
Liu, J., Finke, J., Krauss, J. C., Shu, S., Plautz, G. E.> ;Cancer immunology, immunotherapy : CII. 1998 Aug 5
74 citations
Systemic T cell adoptive immunotherapy of malignant gliomas
Gregory E. Plautz, Gene H. Barnett, David W. Miller, Bruce H. Cohen, Richard A. Prayson, John C. Krauss, Mark G. Luciano, Debra B. Kangisser, Suyu Shu> ;Journal of Neurosurgery. 1998 Jul 1
36 citations
Treatment of murine gliomas by adoptive transfer of ex vivo activated tumor-draining lymph node cells.
Plautz, G. E., Touhalisky, J. E., Shu, S.> ;Cellular immunology. 1997 Jun 15
3 citations
Defining the synergistic effects of irradiation and T-cell immunotherapy for murine intracranial tumors.
Plautz, G. E., Inoue, M., Shu, S.> ;Cellular immunology. 1996 Aug 1
1 citation
Generation of therapeutic T-lymphocytes after in vivo tumor transfection with an allogeneic class I major histocompatibility complex gene.
Wahl, W. L., Strome, S. E., Nabel, G. J., Plautz, G. E., Cameron, M. J., San, H., Fox, B. A., Shu, S., Chang, A. E.> ;Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy. 1995 Jan 1
2 citations
Gene transfer and vascular disease.
Nabel, E. G., Pompili, V. J., Plautz, G. E., Nabel, G. J.> ;Cardiovascular research. 1994 Apr 1
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Grant Support

Dendritic Cell-Brain Tumor Stem Cell Fusion VaccinesNational Cancer Institute2007–2011
T Cell Immunotherapy Of Pediatric Brain TumorsNational Cancer Institute2004–2005
T Cell Immunotherapy Of Pediatric Brain TumorsNational Cancer Institute2002–2003
T Cell Immunotherapy Of Pediatric Brain TumorsNational Cancer Institute2002
Characteristics Of T Cells Mediating Tumor ImmunotherapyNational Cancer Institute1997–1999
Cloning Of Tumor Antigens Recognized By Cytotoxic T CellNational Cancer Institute1994–1995
Cloning Of Tumor Antigens Recognized By Cytotoxic T CellNational Cancer Institute1992–1994
Cloning &Analysis Of Nf-Kb An Enhancer Binding ProteinNational Institute Of General Medical Sciences1989–1990