GregoryEPlautzMD

Pediatric Hematology & Oncology • Cleveland, OH

Professor of Pediatrics, Case West Res University

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Office
9500 Euclid Ave
Cleveland, OH 44195
Phone+1 800-223-2273
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Education & Training

University of Michigan Health SystemFellowship, Pediatric Hematology/Oncology, 1987 - 1990
Johns Hopkins UniversityResidency, Pediatrics, 1984 - 1987
Indiana University School of MedicineClass of 1984

Certifications & Licensure

OH State Medical License 1994 - 2016

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2010-2014
America's Top Doctors for Cancer Castle Connolly, 2009-2013

Publications & Presentations

PubMed

1367 citations
Fulminant Myocarditis with Combination Immune Checkpoint Blockade
Douglas B. Johnson, Justin M. Balko, Margaret L. Compton, Spyridon Chalkias, Joshua M. Gorham, Yaomin Xu, Mellissa Hicks, Igor Puzanov, Matthew R Alexander, Tyler L. B...> ;The New England Journal of Medicine. 2016 Nov 2
5 citations
Cerebral venous sinus thrombosis in a child with iron-deficiency anemia
Partha S. Ghosh, Gregory E. Plautz, Russell Cerejo, Manikum Moodley> ;Acta Neurologica Belgica. 2014 Jun 1
53 citations
Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer
Juan P. Cata, Maria Bauer, Telemate Sokari, Maria F. Ramirez, David P. Mason, Gregory E. Plautz, Andrea Kurz> ;Journal of Clinical Anesthesia. 2013 Jun 1
14 citations
Chylopericardium and chylothorax: unusual mechanical complications of central venous catheters.
Khaldoun Alkayed, Gregory E. Plautz, Kate Gowans, Geoffrey L. Rosenthal, Oliver S. Soldes, Athar M. Qureshi> ;Pediatrics International. 2013 Apr 1
12 citations
Metastatic osteosarcoma to the stomach and ascending colon in a pediatric patient causing gastrointestinal hemorrhage
Jonathan Moses, Neil Gibson, Thomas Plesec, Gregory E. Plautz, Marsha Kay, Oliver S. Soldes> ;Journal of Pediatric Surgery. 2013 Apr 1
5 citations
T cells sensitized with breast tumor progenitor cell vaccine have therapeutic activity against spontaneous HER2/neu tumors.
Li-Xin Wang, Gregory E. Plautz> ;Breast Cancer Research and Treatment. 2012 Jul 1
5 citations
Tumor-Primed, In Vitro-Activated CD4+ Effector T Cells Establish Long-Term Memory without Exogenous Cytokine Support or Ongoing Antigen Exposure
Li-Xin Wang, Gregory E. Plautz> ;Journal of Immunology. 2010 May 15
45 citations
Adoptive transfer of tumor-primed, in vitro-activated, CD4+ T effector cells (TEs) combined with CD8+ TEs provides intratumoral TE proliferation and synergistic antitu...
Li-Xin Wang, Suyu Shu, Mary L. Disis, Gregory E. Plautz> ;Blood. 2007 Jun 1
19 citations
Mechanism of third signals provided by IL-12 and OX-40R ligation in eliciting therapeutic immunity following dendritic-tumor fusion vaccination.
H Kuriyama, Satoshi Watanabe, Jorgen Kjaergaard, Hidemasa Tamai, Rongxiu Zheng, Andrew D. Weinberg, Hong-Ming Hu, Peter A. Cohen, Gregory E. Plautz, Suyu Shu> ;Cellular Immunology. 2006 Sep 1
51 citations
Host lymphodepletion augments T cell adoptive immunotherapy through enhanced intratumoral proliferation of effector cells.
Li-Xin Wang, Suyu Shu, Gregory E. Plautz> ;Cancer Research. 2005 Oct 15
42 citations
Active immunotherapy for advanced intracranial murine tumors by using dendritic cell-tumor cell fusion vaccines.
Jorgen Kjaergaard, Li-Xin Wang, H Kuriyama, Suyu Shu, Gregory E. Plautz> ;Journal of Neurosurgery. 2005 Jul 1
27 citations
Adoptive immunotherapy of cancer with polyclonal, 108-fold hyperexpanded, CD4+ and CD8+ T cells
Li-Xin Wang, Wen Xin Huang, Hallie Graor, Peter A. Cohen, Julian A Kim, Suyu Shu, Gregory E. Plautz> ;Journal of Translational Medicine. 2004 Nov 26
23 citations
Memory T Cells Originate from Adoptively Transferred Effectors and Reconstituting Host Cells after Sequential Lymphodepletion and Adoptive Immunotherapy
Li-Xin Wang, Jorgen Kjaergaard, Peter A. Cohen, Suyu Shu, Gregory E. Plautz> ;Journal of Immunology. 2004 Mar 15
10 citations
Considerations on clinical use of T cell immunotherapy for cancer
Gregory E. Plautz, Peter A. Cohen, Suyu Shu> ;Archivum Immunologiae Et Therapiae Experimentalis. 2003 Jan 1
39 citations
Tumor-induced L-selectinhigh suppressor T cells mediate potent effector T cell blockade and cause failure of otherwise curative adoptive immunotherapy.
Liaomin Peng, Jorgen Kjaergaard, Gregory E. Plautz, Mohamed Awad, Judith A. Drazba, Suyu Shu, Peter A. Cohen> ;Journal of Immunology. 2002 Nov 1
24 citations
Adoptive Immunotherapy of Advanced Tumors with CD62 L-Selectinlow Tumor-Sensitized T Lymphocytes Following Ex Vivo Hyperexpansion
Li Xin Wang, Bing Guan Chen, Gregory E. Plautz> ;Journal of Immunology. 2002 Sep 15
9 citations
Potent Effector Function of Tumor-Sensitized L-Selectinlow T Cells against Subcutaneous Tumors Requires LFA-1 co-Stimulation:
Brook M. Seeley, Steve W. Barthel, Wyatt C. To, Jorgen Kjaergaard, Suyu Shu, Gregory E. Plautz> ;Otolaryngology--Head and Neck Surgery. 2001 Apr 1
41 citations
T-cell adoptive therapy of tumors: mechanisms of improved therapeutic performance.
Peter A. Cohen, Liaomin Peng, Jorgen Kjaergaard, Gregory E. Plautz, James H. Finke, Gary K. Koski, Brian J. Czerniecki, Suyu Shu> ;Critical Reviews in Immunology. 2001 Jan 1
39 citations
T Cell-Mediated Tumor Rejection Displays Diverse Dependence Upon Perforin and IFN-γ Mechanisms That Cannot Be Predicted From In Vitro T Cell Characteristics
Liaomin Peng, John C. Krauss, Gregory E. Plautz, Shigehiko Mukai, Suyu Shu, Peter A. Cohen> ;Journal of Immunology. 2000 Dec 15
27 citations
Helper-Independent, L-Selectinlow CD8+ T Cells with Broad Anti-Tumor Efficacy Are Naturally Sensitized During Tumor Progression
Liaomin Peng, Jorgen Kjaergaard, Gregory E. Plautz, David E. Weng, Suyu Shu, Peter A. Cohen> ;Journal of Immunology. 2000 Nov 15
47 citations
Systemic Adoptive T-Cell Immunotherapy in Recurrent and Metastatic Carcinoma of the Head and Neck: A Phase 1 Study
Wyatt C. To, Benjamin G. Wood, John C. Krauss, Marshall Strome, Ramon M. Esclamado, Pierre Lavertu, David Dasko, Julian A. Kim, Gregory E. Plautz, Ben E. Leff, Vanessa...> ;Archives of Otolaryngology--Head & Neck Surgery. 2000 Oct 1
34 citations
Cross-Presentation of Tumor Antigens to Effector T Cells Is Sufficient to Mediate Effective Immunotherapy of Established Intracranial Tumors
Gregory E. Plautz, Shigehiko Mukai, Peter A. Cohen, Suyu Shu> ;Journal of Immunology. 2000 Oct 1
124 citations
T cell adoptive immunotherapy of newly diagnosed gliomas.
Gregory E. Plautz, David W. Miller, Gene H. Barnett, Glen Stevens, Scott Maffett, Julian Kim, Peter A. Cohen, Suyu Shu> ;Clinical Cancer Research. 2000 Jun 1
95 citations
CD4+ T cells in adoptive immunotherapy and the indirect mechanism of tumor rejection.
Peter A. Cohen, Liaomin Peng, Gregory E. Plautz, Julian A. Kim, David E. Weng, Suyu Shu> ;Critical Reviews in Immunology. 2000 Jan 1
2 citations
Allogeneic class I major histocompatibility complex gene transfer in murine neuroblastoma in vivo.
Hiroyuki Ishida, Yasufumi Kaneda, Shuich Yamane, Tadashi Sawada, Gregory E. Plautz, Takafumi Matsumura> ;Anticancer Research. 1999 Nov 1
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Grant Support

Dendritic Cell-Brain Tumor Stem Cell Fusion VaccinesNational Cancer Institute2007–2011
T Cell Immunotherapy Of Pediatric Brain TumorsNational Cancer Institute2004–2005
T Cell Immunotherapy Of Pediatric Brain TumorsNational Cancer Institute2002–2003
T Cell Immunotherapy Of Pediatric Brain TumorsNational Cancer Institute2002
Characteristics Of T Cells Mediating Tumor ImmunotherapyNational Cancer Institute1997–1999
Cloning Of Tumor Antigens Recognized By Cytotoxic T CellNational Cancer Institute1994–1995
Cloning Of Tumor Antigens Recognized By Cytotoxic T CellNational Cancer Institute1992–1994
Cloning &Analysis Of Nf-Kb An Enhancer Binding ProteinNational Institute Of General Medical Sciences1989–1990