Hans-PeterKiemMD

PubMed

• Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells.
  Radtke, S., Perez, A. M., Venkataraman, R., Reddy, S., Haworth, K. G., Humbert, O., Kiem, H., Peterson, C. W.> ;Journal of visualized experiments : JoVE. 2019 Mar 5
• TALEN-Mediated Gene Editing of <i>HBG</i> in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction.
  Lux, C. T., Pattabhi, S., Berger, M., Nourigat, C., Flowers, D. A., Negre, O., Humbert, O., Yang, J. G., Lee, C., Jacoby, K., Bernstein, I., Kiem, H., Scharenberg, A.,...> ;Molecular therapy. Methods &amp; clinical development. 2019 Feb 2
• MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells.
  Radtke, S.,Chan, Y. Y.,Sippel, T. R.,Kiem, H. P.,Rongvaux, A.> ;Exp. Hematol.. 2018 Dec 28
• Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice.
  Kuhlmann, A., Haworth, K. G., Barber-Axthelm, I. M., Ironside, C., Giese, M. A., Peterson, C. W., Kiem, H.> ;Molecular therapy : the journal of the American Society of Gene Therapy. 2018 Nov 6
• Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2.
  Humbert, O., Laszlo, G. S., Sichel, S., Ironside, C., Haworth, K. G., Bates, O. M., Beddoe, M. E., Carrillo, R. R., Kiem, H., Walter, R. B.> ;Leukemia. 2018 Oct 7
• Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.
  Colonna, L.,Peterson, C. W.,Schell, J. B.,Carlson, J. M.,Tkachev, V.,Brown, M.,Yu, A.,Reddy, S.,Obenza, W. M.,Nelson, V.,Polacino, P. S.,Mack, H.,Hu, S. L.,Zeleski, K....> ;Nat Commun. 2018 Oct 27
• Sorting Out the Best: Enriching Hematopoietic Stem Cells for Gene Therapy and Editing.
  Radtke, S.,Humbert, O.,Kiem, H. P.> ;Mol. Ther.. 2018 Sep 18
• Screening Clinical Cell Products for Replication Competent Retrovirus: The National Gene Vector Biorepository Experience.
  Cornetta, K.,Duffy, L.,Feldman, S. A.,Mackall, C. L.,Davila, M. L.,Curran, K. J.,Junghans, R. P.,Tang, J. Y.,Kochenderfer, J. N.,O'Cearbhaill, R.,Archer, G.,Kiem, H. P...> ;Mol Ther Methods Clin Dev. 2018 Sep 14
• Minimal conditioning in Fanconi anemia promotes multi-lineage marrow engraftment at 10-fold lower cell doses.
  Haworth, K. G., Ironside, C., Ramirez, M. A., Weitz, S., Beard, B. C., Schwartz, J. D., Adair, J. E., Kiem, H.> ;The journal of gene medicine. 2018 Aug 22
• Novel lineage depletion preserves autologous blood stem cells for gene therapy of Fanconi anemia complementation group A.
  Adair, J. E., Chandrasekaran, D., Sghia-Hughes, G., Haworth, K. G., Woolfrey, A. E., Burroughs, L. M., Choi, G. Y., Becker, P. S., Kiem, H.> ;Haematologica. 2018 Jul 7
• HIV infection results in clonal expansions containing integrations within pathogenesis-related biological pathways.
  Haworth, K. G.,Schefter, L. E.,Norgaard, Z. K.,Ironside, C.,Adair, J. E.,Kiem, H. P.> ;JCI Insight. 2018 Jul 13
• Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase.
  Paul, B.,Ibarra, GSR.,Hubbard, N.,Einhaus, T.,Astrakhan, A.,Rawlings, D. J.,Kiem, H. P.,Peterson, C. W.> ;Mol Ther Methods Clin Dev. 2018 Jul 25
• Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy.
  Humbert, O., Chan, F., Rajawat, Y. S., Torgerson, T. R., Burtner, C. R., Hubbard, N. W., Humphrys, D., Norgaard, Z. K., O'Donnell, P., Adair, J. E., Trobridge, G. D., ...> ;Blood advances. 2018 May 4
• A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice.
  Wang, H.,Richter, M.,Psatha, N.,Li, C.,Kim, J.,Liu, J.,Ehrhardt, A.,Nilsson, S. K.,Cao, B.,Palmer, D.,Ng, P.,Izsvák, Z.,Haworth, K. G.,Kiem, H. P.,Papayannopoulou, T.,...> ;Mol Ther Methods Clin Dev. 2017 Dec 20
• A Nonhuman Primate Transplantation Model to Evaluate Hematopoietic Stem Cell Gene Editing Strategies for β-Hemoglobinopathies.
  Humbert, O.,Peterson, C. W.,Norgaard, Z. K.,Radtke, S.,Kiem, H. P.> ;Mol Ther Methods Clin Dev. 2017 Dec 26
• Cell and Gene Therapy for HIV Cure.
  Peterson, C. W., Kiem, H.> ;Current topics in microbiology and immunology. 2017 Dec 20
• Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS.
  Zhen, A.,Peterson, C. W.,Carrillo, M. A.,Reddy, S. S.,Youn, C. S.,Lam, B. B.,Chang, N. Y.,Martin, H. A.,Rick, J. W.,Kim, J.,Neel, N. C.,Rezek, V. K.,Kamata, M.,Chen, I...> ;PLoS Pathog.. 2017 Dec 29
• A Distinct Hematopoietic Stem Cell Population for Rapid Multilineage Engraftment in Nonhuman Primates
  Hans-Peter Kiem, MD> ;Science Magazine. 2017 Nov 03
• 4 citations
  CCR5-edited gene therapies for HIV cure: Closing the door to viral entry.
  Haworth, K. G., Peterson, C. W., Kiem, H.> ;Cytotherapy. 2017 Jul 29
• In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
  Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy E, Singh M, Izsvák Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem H, Ehrhardt A, Papayannopoulou ...> ;Blood. 2016-11-03
• Devouring the Hematopoietic Stem Cell: Setting the Table for Marrow Cell Transplantation.
  Cowan MJ, Kiem H> ;Mol. Ther.. 2016-11-01
• Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.
  Adair JE, Waters T, Haworth KG, Kubek SP, Trobridge GD, Hocum JD, Heimfeld S, Kiem H> ;Nat Commun. 2016-10-20
• Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.
  Gori JL, Butler JM, Kunar B, Poulos MG, Ginsberg M, Nolan DJ, Norgaard ZK, Adair JE, Rafii S, Kiem H> ;Stem Cells Transl Med. 2016-10-14
• Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.
  Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A, Kiem H, Rawlings DJ> ;Mol Ther Nucleic Acids. 2016-08-23
• Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cells.
  Humbert O, Gisch DW, Wohlfahrt ME, Adams AB, Greenberg PD, Schmitt TM, Trobridge GD, Kiem H> ;Mol. Ther.. 2016-08-01
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