HaroldFruchtMD

Gastroenterology • New York, NY

Associate Professor, Medicine, Columbia University College of Phys & Surg

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Office
161 Fort Washington Ave
New York, NY 10032
Phone+1 212-305-1021
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Education & Training

National Capital ConsortiumFellowship, Gastroenterology, 1986 - 1990
SUNY Upstate Medical UniversityFellowship, Gastroenterology, 1985 - 1986
SUNY Upstate Medical UniversityResidency, Internal Medicine, 1982 - 1985
SUNY Upstate Medical UniversityClass of 1982

Certifications & Licensure

NY State Medical License 1984 - 2026
FL State Medical License Active through 2014
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Gastroenterology

Clinical Trials

Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) and Pancreatic Function Following Surgery Start of enrollment: 2007 Sep 01
Withdrawn
Not Applicable
Comparison of Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) to Endoscopic Pancreatic Function Test (ePFT) in Diagnosing Pancreatic Exocrine Insufficiency Start of enrollment: 2012 Jun 01
Withdrawn
Not Applicable
Secretin-enhanced Magnetic Resonance Imaging (S-MRI) for Pancreatic Cancer Detection Start of enrollment: 2010 Apr 01
Withdrawn
Not Applicable
PANCREATIC DISEASE COHORT A Registry and Biospecimen Bank to Better Understand Pancreatic Disease Start of enrollment: 2004 Jul 01
Recruiting
Pancreatic Cancer Genetics Start of enrollment: 2008 Jan 01
Recruiting
Validation of a Mouse Model of Pancreatic Carcinogenesis Start of enrollment: 2009 Mar 01
Terminated
Family and Personal History of Malignancy in Intraductal Papillary Mucinous Neoplasm (IPMN) Start of enrollment: 2008 Nov 17
Completed
Use of PET Imaging to Distinguish Malignant From Benign IPMN Start of enrollment: 2009 Sep 01
Terminated
Not Applicable
Stool Testing for Pancreatic Cancer Start of enrollment: 2009 Jul 09
Completed
Frequency of Methods of Local Invasion of Pancreatic Adenocarcinoma Start of enrollment: 2009 Sep 15
Completed
Fundic Gland Polyps and Proton Pump Inhibitor (PPI) Drugs Start of enrollment: 2006 Oct 01
Terminated
Pancreatic Intraepithelial Neoplasia (PanIN) and the Association With Recurrence of Pancreatic Adenocarcinoma Start of enrollment: 2009 Mar 18
Completed
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Publications & Presentations

PubMed

21 citations
CDKN2A Germline Rare Coding Variants and Risk of Pancreatic Cancer in Minority Populations.
Robert R. McWilliams, Eric D. Wieben, Kari G. Chaffee, Samuel O. Antwi, Leon Raskin, Olufunmilayo I. Olopade, Donghui Li, W. Edward Highsmith, Gerardo Colon-Otero, Lau...> ;Cancer Epidemiology, Biomarkers & Prevention. 2018 Jul 23
3 citations
Self-Reported Questionnaire Detects Family History of Cancer in a Pancreatic Cancer Screening Program
Aimee L. Lucas, Adam Tarlecki, Kellie Van Beck, Casey Lipton, Arindam RoyChoudhury, Elana Levinson, Sheila Kumar, Wendy K. Chung, Harold Frucht, Jeanine M. Genkinger> ;Journal of Genetic Counseling. 2017 Aug 1
16 citations
Absence of Pancreatic Intraepithelial Neoplasia Predicts Poor Survival After Resection of Pancreatic Cancer
Benjamin Hassid, Aimee L. Lucas, Marcela Salomao, Chunhua Weng, Feng Liu, Lauren G. Khanna, Sheila Kumar, Caroline Hwang, John A. Chabot, Harold Frucht> ;Pancreas. 2014 Oct 1
197 citations
Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection.
Andrew E. Becker, Yasmín Hernández, Harold Frucht, Aimee L. Lucas> ;World Journal of Gastroenterology. 2014 Aug 28
51 citations
BRCA1 and BRCA2 germline mutations are frequently demonstrated in both high-risk pancreatic cancer screening and pancreatic cancer cohorts.
Aimee L. Lucas, Laura E. Frado, Caroline Hwang, Sheila Kumar, Lauren G. Khanna, Elana Levinson, John A. Chabot, Wendy K. Chung, Harold Frucht> ;Cancer. 2014 Jul 1
58 citations
High Prevalence of BRCA1 and BRCA2 Germline Mutations with Loss of Heterozygosity in a Series of Resected Pancreatic Adenocarcinoma and Other Neoplastic Lesions
Aimee L. Lucas, Reena Shakya, Marla Lipsyc, Elana B. Mitchel, Sheila Kumar, Caroline Hwang, Liyong Deng, Catherine DeVoe, John A. Chabot, Matthias Szabolcs, Thomas Lud...> ;Clinical Cancer Research. 2013 May 8
29 citations
Evidence for treatment and survival disparities by age in pancreatic adenocarcinoma: a population-based analysis.
Aimee L. Lucas, Harold Frucht> ;Pancreas. 2013 Mar 1
2 citations
The Prevention and Genetics of Pancreatic Cancer: A Programmatic Approach
Aimee L. Lucas, Michelle M. Chang, Marla Lipsyc, Harold Frucht> ;Methods in Molecular Biology. 2013 Jan 1
148 citations
Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.
Samuel Asfaha, Alexander Dubeykovskiy, Hiroyuki Tomita, Xiangdong Yang, Sarah Stokes, Wataru Shibata, Richard A. Friedman, Hiroshi Ariyama, Zinaida A. Dubeykovskaya, S...> ;Gastroenterology. 2013 Jan 1
16 citations
Incidence of subsequent pancreatic adenocarcinoma in patients with a history of nonpancreatic primary cancers
Russell B. McBride, Jennie Kline, Elana B. Mitchel, Aimee L. Lucas, Alfred I. Neugut, Harold Frucht, Sunil Amin> ;Cancer. 2012 Mar 1
1 citations
Strengthening the Case for Stool DNA Tests as First-Line Colorectal Cancer Screening: Are We There Yet?
Aimee L. Lucas, Caroline Hwang, Harold Frucht> ;Clinical Gastroenterology and Hepatology. 2012 Mar 1
4 citations
Physician knowledge and appropriate utilization of computed tomographic colonography in colorectal cancer screening
Matthew S. Chang, Jessica Shah, Susana Gonzalez, Joan C. Prowda, Joan M. Cheng, Elizabeth C. Verna, Don C. Rockey, Harold Frucht> ;Abdominal Imaging. 2011 Feb 12
168 citations
Pancreatic Cancer Screening in a Prospective Cohort of High-Risk Patients: A Comprehensive Strategy of Imaging and Genetics
Elizabeth C. Verna, Caroline Hwang, Peter D. Stevens, Heidrun Rotterdam, Stavros N. Stavropoulos, Carolyn D. Sy, Martin A. Prince, Wendy K. Chung, Robert L. Fine, John...> ;Clinical Cancer Research. 2010 Oct 15
22 citations
Head and neck squamous cell carcinoma in FAMMM syndrome.
Vladimir Vinarsky, Robert L. Fine, Adel Assaad, Ying Qian, John A. Chabot, Gloria H. Su, Harold Frucht> ;Head & Neck. 2009 Nov 1
86 citations
BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas
Frank Schönleben, Wanglong Qiu, Karl C. Bruckman, Nancy T. Ciau, Xiaojun Li, Margaret H. Lauerman, Harold Frucht, John A. Chabot, John D. Allendorf, Helen Remotti, Glo...> ;Cancer Letters. 2007 May 8
8 citations
Advances in the Genetic Screening, Work-up, and Treatment of Pancreatic Cancer.
Harold Frucht, Peter D. Stevens, David R. Fogelman, Elizabeth C. Verna, Johnson Chen, John A. Chabot, Robert L. Fine> ;Current Treatment Options in Gastroenterology. 2004 Oct 1
46 citations
Functional interaction of lithocholic acid conjugates with M3 muscarinic receptors on a human colon cancer cell line
Kunrong Cheng, Ying Chen, Piotr Zimniak, Jean-Pierre Raufman, Yinghua Xiao, Harold Frucht> ;Biochimica Et Biophysica Acta. 2002 Oct 9
156 citations
The Genetics of Colorectal Cancer
Paula M Calvert, Harold Frucht> ;Annals of Internal Medicine. 2002 Oct 1
169 citations
Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells
Wan Lin Yang, Harold Frucht> ;Carcinogenesis. 2001 Sep 1
30 citations
Preclinical and clinical evaluation of broccoli supplements as inducers of glutathione S-transferase activity.
Margie L. Clapper, Christine E. Szarka, Gordon R. Pfeiffer, Todd A. Graham, Andrew Balshem, Samuel Litwin, Eric B. Goosenberg, Harold Frucht, Paul F. Engstrom> ;Clinical Cancer Research. 1997 Jan 1
58 citations
Glutathione S-Transferase Activity and Glutathione S-Transferase μ Expression in Subjects with Risk for Colorectal Cancer
Christine E. Szarka, Gordon R. Pfeiffer, Susan T. Hum, Lynette C. Everley, Andrew Balshem, Dirk F. Moore, Samuel Litwin, Eric B. Goosenberg, Harold Frucht, Paul F. Eng...> ;Cancer Research. 1995 Jul 1
27 citations
Ligand binding, internalization, degradation and regulation by guanine nucleotides of bombesin receptor subtypes: A comparative study
L H Wang, Samuel A. Mantey, Jaw-Town Lin, Harold Frucht, Robert T. Jensen> ;Biochimica Et Biophysica Acta. 1993 Jan 17
104 citations
Characterization of Functional Receptors for Gastrointestinal Hormones on Human Colon Cancer Cells
Harold Frucht, Adi F. Gazdar, Park Ja, Oie H, Robert T. Jensen> ;Cancer Research. 1992 Mar 1
32 citations
Pharmacokinetics of oral and intravenous omeprazole in patients with the Zollinger-Ellison syndrome
Rakesh Vinayek, Michael A. Amantea, Paul N. Maton, Harold Frucht, Jerry D. Gardner, Robert T. Jensen> ;Gastroenterology. 1991 Jul 1
68 citations
Use of omeprazole in patients with Zollinger-Ellison syndrome.
Harold Frucht, Paul N. Maton, Robert T. Jensen> ;Digestive Diseases and Sciences. 1991 Apr 1
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