HaydarFrangoulMD

Pediatric Hematology & Oncology • Nashville, TN

Professor of Pediatrics, Vanderbilt University

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Office
330 23rd Ave N
Suite 450
Nashville, TN 37203
Phone+1 615-342-7339

Fax+1 615-342-7340
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Education & Training

University of WashingtonFellowship, Pediatric Hematology/Oncology, 1996 - 1999
Duke University HospitalFellowship, Pediatric Hematology/Oncology, 1990 - 1993
American University of Beirut Faculty of MedicineClass of 1990

Certifications & Licensure

TN State Medical License 1999 - 2025
WV State Medical License 1993 - 2000
NC State Medical License 1993 - 1999
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
Nashville Lifestyles Magazine Castle Connolly, 2011, 2013-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013

Clinical Trials

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2001 Oct 18
Active, not recruiting
Phase 3
Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant and Cyclophosphamide, Mycophenolate Mofetil, Tacrolimus, and Sirolimus in Treating Patients With Primary Immunodeficiency Disorders or Noncancerous Inherited Disorders Start of enrollment: 2006 May 24
Terminated
Phase 2
Single vs Double Umbilical Cord Blood Transplants in Children With High Risk Leukemia and Myelodysplasia (BMT CTN 0501) Start of enrollment: 2006 Dec 01
Completed
Phase 3
Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by a Donor Stem Cell Transplant in Treating Patients With Immunodeficiency or Other Nonmalignant Inherited Disorders Start of enrollment: 2006 Jun 01
Completed
Phase 2
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies Start of enrollment: 2008 Jul 17
Recruiting
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Start of enrollment: 2000 Nov 06
Recruiting
Clofarabine and Low Dose Total Body Irradiation as a Preparative Regimen for Stem Cell Transplant in Leukemia. Start of enrollment: 2010 Jan 29
Completed
Phase 1
Presence of Donor-Derived DNA in Semen Samples From Cancer Survivors Who Underwent Donor Stem Cell Transplant Start of enrollment: 2010 Feb 01
Terminated
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Start of enrollment: 2011 Apr 04
Completed
Phase 3
A Study Of Panobinostat In Children With Refractory Hematologic Malignancies Start of enrollment: 2011 Mar 01
Completed
Phase 1
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) Start of enrollment: 2011 Oct 01
Recruiting
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL Start of enrollment: 2011 Dec 01
Terminated
Phase 1, Phase 2
Efficacy of Granulocyte Colony Stimulating Factor (GCSF) In Patients With Dystrophic Epidermolysis Bullosa Start of enrollment: 2012 Feb 01
Completed
Phase 2
Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Start of enrollment: 2012 Jun 01
Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes Start of enrollment: 2012 Dec 11
Completed
Phase 2
Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Start of enrollment: 2013 Feb 12
Completed
Phase 2
Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients. Start of enrollment: 2013 Aug 20
Completed
Phase 2
Pilot Study of Stem Cell Transplantation for Children and Young Adults With Refractory Crohn's Disease. Start of enrollment: 2014 Aug 01
Withdrawn
Not Applicable
Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma Start of enrollment: 2019 Jul 08
Active, not recruiting
Phase 2
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Publications & Presentations

PubMed

Autologous gene therapy for hemoglobinopathies: From bench to patient's bedside.
Franco Locatelli, Marina Cavazzana, Haydar Frangoul, Josu de la Fuente, Mattia Algeri, Roland Meisel> ;Molecular Therapy. 2024 Mar 7
2 citations
Defining curative endpoints for transfusion-dependent β-thalassemia in the era of gene therapy and gene editing.
Corbacioglu, S., Locatelli, F., Hobbs, W., Walters, M., Frangoul, H.> ;American Journal of Hematology. 2024 Mar 1
Defining curative endpoints for sickle cell disease in the era of gene therapy and gene editing.
Franco Locatelli, Selim Corbacioglu, William Hobbs, Haydar Frangoul, Mark C Walters> ;American Journal of Hematology. 2024 Mar 1
2 citations
An integrated therapeutic approach to sickle cell disease management beyond infancy.
Jean-Antoine Ribeil, Galia Pollock, Haydar Frangoul, Martin H Steinberg> ;American Journal of Hematology. 2023 Jul 1
4 citations
Gene editing for sickle cell disease and transfusion dependent thalassemias- A cure within reach.
Michael J Eckrich, Haydar Frangoul> ;Seminars in Hematology. 2023 Jan 1
5 citations
Clinical Characteristics and Outcomes of COVID-19 in Pediatric and Early Adolescent and Young Adult Hematopoietic Stem Cell Transplant Recipients: A Cohort Study.
Neel S Bhatt, Akshay Sharma, Andrew St Martin, Muhammad Bilal Abid, Valerie I Brown, Miguel Angel Diaz Perez, Haydar Frangoul, Shahinaz M Gadalla, Megan M Herr, Maxwel...> ;Transplantation and Cellular Therapy. 2022 Oct 1
Correction to: Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cel...
Mary Elizabeth Percival, Hai-Lin Wang, Mei-Jie Zhang, Wael Saber, Marcos de Lima, Mark R. Litzow, Partow Kebriaei, Hisham Abdel-Azim, Kehinde Adekola, Mahmoud Aljurf, ...> ;Bone Marrow Transplantation. 2021 Sep 1
8 citations
Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a...
Aleksandr Lazaryan, Michelle Dolan, Mei-Jie Zhang, Hai-Lin Wang, Mohamed A Kharfan-Dabaja, David I Marks, Nelli Bejanyan, Edward Copelan, Navneet S Majhail, Edmund K W...> ;Haematologica. 2021 Aug 1
15 citations
Safety, Tolerability, and Population Pharmacokinetics of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients.
Antonio Arrieta, Michael Neely, J. Christopher Day, Susan R. Rheingold, Paul K. Sue, William J Muller, Lara Danziger-Isakov, Julie Chu, Inci Yildirim, Grace A. McComse...> ;Antimicrobial Agents and Chemotherapy. 2021 May 24
5 citations
Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation.
Mary-Elizabeth Percival, Hai-Lin Wang, Mei-Jie Zhang, Wael Saber, Marcos de Lima, Mark Litzow, Partow Kebriaei, Hisham Abdel-Azim, Kehinde Adekola, Mahmoud Aljurf, Ulr...> ;Bone Marrow Transplantation. 2021 Sep 1
Correction: Impact of autologous blood transfusion after bone marrow harvest on unrelated donor's health and outcome: a CIBMTR analysis.
Nosha Farhadfar, Hemant S Murthy, Brent R Logan, Jennifer A Sees, Mouhab Ayas, Minoo Battiwalla, Amer M Beitinjaneh, Saurabh Chhabra, Miguel Angel Diaz, Katie Engles, ...> ;Bone Marrow Transplantation. 2021 Feb 1
442 citations
CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia.
Haydar Frangoul, David Altshuler, M Domenica Cappellini, Yi-Shan Chen, Jennifer Domm, Brenda K Eustace, Juergen Foell, Josu de la Fuente, Stephan Grupp, Rupert Handgre...> ;The New England Journal of Medicine. 2021 Jan 21
19 citations
Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia.
Anna Hecht, Julia Meyer, Astrid Behnert, Eric Wong, Farid F. Chehab, Adam B. Olshen, Aaron Hechmer, Catherine Aftandilian, Rukhmi Bhat, Sung Won Choi, Satheesh Chonat,...> ;Haematologica. 2020 Dec 30
2 citations
Impact of autologous blood transfusion after bone marrow harvest on unrelated donor's health and outcome: a CIBMTR analysis.
Nosha Farhadfar, Hemant S Murthy, Brent R Logan, Jennifer A Sees, Mouhab Ayas, Minoo Battiwalla, Amer M Beitinjaneh, Saurabh Chhabra, Miguel Angel Diaz, Katie Engles, ...> ;Bone Marrow Transplantation. 2020 Nov 1
28 citations
Neighborhood-Poverty and Pediatric Allogeneic Hematopoietic Cell Transplantation Outcomes: A CIBMTR Analysis
Kira Bona, Ruta Brazauskas, Naya He, Leslie Lehmann, Hisham Abdel-Azim, Ibrahim Ahmed, A. Samer Al-Homsi, Mahmoud Aljurf, Staci D. Arnold, Sherif M. Badawy, Minoo Batt...> ;Blood. 2021 Jan 28
6 citations
The Impact of Donor Type on Outcomes and Cost of Allogeneic Hematopoietic Cell Transplantation for Pediatric Leukemia: A Merged Center for International Blood and Marr...
Staci D. Arnold, Ruta Brazauskas, Naya He, Yimei Li, Matthew Hall, Yoshiko Atsuta, Jignesh Dalal, Theresa Hahn, Nandita Khera, Carmem Bonfim, Shahrukh K. Hashmi, Susan...> ;Biology of Blood and Marrow Transplantation. 2020 Sep 1
10 citations
Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a...
Aleksandr Lazaryan, Michelle Dolan, Mei-Jie Zhang, Hai-Lin Wang, Mohamed A Kharfan-Dabaja, David I Marks, Nelli Bejanyan, Edward Copelan, Navneet S Majhail, Edmund K W...> ;Haematologica. 2020 May 1
23 citations
Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction.
Jeffrey M. Verboon, Dilnar Mahmut, Ah Ram Kim, Mitsutoshi Nakamura, Nour J. Abdulhay, Satish K. Nandakumar, Namrata Gupta, Thomas E. Akie, Amy E. Geddis, Becky Manes, ...> ;Journal of Clinical Immunology. 2020 Apr 17
20 citations
HLA-Haploidentical Hematopoietic Cell Transplantation for Treatment of Nonmalignant Diseases Using Nonmyeloablative Conditioning and Post-Transplant Cyclophosphamide
Kanwaldeep K. Mallhi, Meera A. Srikanthan, Kelsey Baker, Haydar Frangoul, Troy R. Torgerson, Aleksandra Petrovic, Amy E. Geddis, Paul A. Carpenter, K. Scott Baker, Bre...> ;Biology of Blood and Marrow Transplantation. 2020 Jul 1
14 citations
Veno-occlusive disease after high-dose busulfan-melphalan in neuroblastoma.
Tal Schechter, Evelio Perez-Albuerne, Tiffany F. Lin, Meredith S. Irwin, Mohammed Sh. Essa, Ami V. Desai, Haydar Frangoul, Gregory A. Yanik, L. Lee Dupuis, David A. Ja...> ;Bone Marrow Transplantation. 2020 Mar 1
11 citations
The Concentration of Total Nucleated Cells in Harvested Bone Marrow for Transplantation Has Decreased over Time
Nicole L. Prokopishyn, Brent R. Logan, Deidre M. Kiefer, Jennifer A. Sees, Pintip Chitphakdithai, Ibrahim Ahmed, Paolo Anderlini, Amer Beitinjaneh, Christopher Bredeso...> ;Biology of Blood and Marrow Transplantation. 2019 Jul 1
11 citations
Survival Trends in Infants Undergoing Allogeneic Hematopoietic Cell Transplant.
Suhag Parikh, Prakash Satwani, Kwang Woo Ahn, Natasha Sahr, Caitrin Fretham, Allistair Abraham, Vaibhav Agrawal, Jeffery J. Auletta, Hisham Abdel-Azim, Edward A. Copel...> ;JAMA Pediatrics. 2019 May 1
6 citations
Molecular and epidemiologic characterization of Wilms tumor from Baghdad, Iraq
Hannah M. Phelps, Mazin Faisal Al-Jadiry, Natasha M Corbitt, Janene Pierce, Bingshan Li, Qiang Wei, Raina R Flores, Hernan Correa, Stefania Uccini, Haydar Frangoul, Ad...> ;World Journal of Pediatrics. 2018 Aug 28
16 citations
Comparison of pediatric allogeneic transplant outcomes using myeloablative busulfan with cyclophosphamide or fludarabine.
Andrew C. Harris, Jaap Jan Boelens, Kwang Woo Ahn, Mingwei Fei, Allistair Abraham, Andrew S. Artz, Christopher C. Dvorak, Haydar Frangoul, Cesar O. Freytes, Robert Pet...> ;Blood Advances. 2018 Jun 12
14 citations
Haploidentical hematopoietic stem cell transplant for patients with sickle cell disease using thiotepa, fludarabine, thymoglobulin, low dose cyclophosphamide, 200 cGy ...
Haydar Frangoul, Misty Evans, Julie Isbell, Katie Bruce, Jennifer Domm> ;Bone Marrow Transplantation. 2018 Jan 16
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Journal Articles

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and Β-thalassemia
Haydar Frangoul, Jennifer Domm, Stephan Grupp, Rupert Handgretinger, The New England Journal of Medicine
Veno-Occlusive Disease After High-Dose Busulfan–Melphalan in Neuroblastoma
Gregory Yanik, Morris Kletzel, Stephan Grupp, David Jacobsohn, Christopher C Dvorak, Alix E Seif, Mark Ranalli, Haydar Frangoul, Nature

Press Mentions

His Sickle Cell Disease Brought Agony. Gene Therapy Is Bringing HopeApril 28th, 2023
A New NormalSeptember 22nd, 2022
Patients Treated with CRISPR Still "Cured" Three Years LaterJune 21st, 2022
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Hospital Affiliations

TriStar Centennial Medical CenterNashville, Tennessee

HaydarFrangoulMD

Dr. Frangoul is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Press Mentions

Hospital Affiliations

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