HeatherAnnWakeleeMD

Oncology • Stanford, CA

Thoracic Cancer

Professor, Medicine - Oncology, Stanford University, Stanford Cancer Institute

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Office
300 Pasteur Dr
Stanford, CA 94305
Phone+1 650-498-6000
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Summary

Dr. Heather Wakelee is an oncologist in Stanford, CA and is affiliated with Stanford Health Care and is a Professor of Medicine and Chief of the Division of Oncology at Stanford University. She received her medical degree from Johns Hopkins University School of Medicine and has been in practice over 20 years. She specializes in thoracic cancers.

Education & Training

Stanford Health Care-Sponsored Stanford UniversityFellowship, Medical Oncology, 2000 - 2004
Stanford Health Care-Sponsored Stanford UniversityResidency, Internal Medicine, 1996 - 1999
Johns Hopkins University School of MedicineClass of 1996

Certifications & Licensure

CA State Medical License 1997 - 2025
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2013

Clinical Trials

Phase 2 Trial of Bevacizumab in Combination With Pemetrexed Start of enrollment: 2006 Mar 01
Completed
Phase 2
Phase II Docetaxel / Carboplatin / XRT + Surgical Resection in Stage III NSCLC Start of enrollment: 2003 Mar 01
Terminated
Phase 2
Phase II Bevacizumab, Gemcitabine and Carboplatin in Newly Diagnosed Non-Small Cell Lung Cancer Start of enrollment: 2006 Jun 01
Completed
Phase 2
Chemotherapy With or Without Bevacizumab in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-small Cell Lung Cancer That Was Removed By Surgery Start of enrollment: 2007 Jun 01
Active, not recruiting
Phase 3
Identification of Circulating Tumor Cells in the Peripheral Blood of Lung Cancer Patients Start of enrollment: 2007 Feb 01
Completed
Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma Start of enrollment: 2002 Feb 01
Terminated
BLP25 Liposome Vaccine and Bevacizumab After Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Stage IIIA or Stage IIIB Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery Start of enrollment: 2011 Jan 17
Completed
Phase 2
Phase I Vorinostat Concurrent With Stereotactic Radiosurgery (SRS) in Brain Metastases From Non-Small Cell Lung Cancer Start of enrollment: 2009 Jun 01
Completed
Phase 1
4D-CT-based Ventilation Imaging for Adaptive Functional Guidance in Radiotherapy Start of enrollment: 2009 Dec 01
Terminated
Early Phase 1
Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer Start of enrollment: 2010 Oct 25
Completed
Phase 3
A Phase 2 Study of Amrubicin in Relapsed or Refractory Thymic Malignancies Start of enrollment: 2011 Jun 01
Completed
Phase 2
Docetaxel, Cisplatin, and Cetuximab (TPC) in Palliative Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck (SCCHN) Start of enrollment: 2011 Oct 01
Completed
Phase 2
Phase 1 Erlotinib and Dovitinib (TKI258) in Advanced Non-small Cell Lung Cancer (NSCLC) Start of enrollment: 2012 Jul 01
Terminated
Phase 1
Talactoferrin in Treating Patients With Relapsed or Refractory Non-Small Cell Lung Cancer or Squamous Cell Head and Neck Cancer Start of enrollment: 2012 May 01
Terminated
Phase 1
Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung Cancer Start of enrollment: 2012 Jun 01
Completed
Phase 1, Phase 2
Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancer Start of enrollment: 2012 Sep 28
Completed
Phase 1, Phase 2
Expanded Treatment Protocol With LDK378 in ALK(+) NSCLC
No longer available
Phase 1 Trial of Hu5F9-G4, a CD47-targeting Antibody Start of enrollment: 2014 Aug 01
Completed
Phase 1
Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities Start of enrollment: 2020 Dec 16
Recruiting
Phase 1, Phase 2
Roles: Contact
Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors Start of enrollment: 2018 Jun 25
Recruiting
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Personalized Accelerated ChEmoRadiation (PACER) for Lung Cancer: Protocol for a Bayesian Optimal Phase I/II Trial.
Caressa Hui, Eleanor Brown, Samantha Wong, Millie Das, Heather Wakelee, Joel Neal, Kavitha Ramchandran, Nathaniel J Myall, Daniel Pham, Lei Xing, Yong Yang, Nataliya K...> ;Clinical Lung Cancer. 2024 Mar 1
A Phase 1/2 Study to Evaluate the Safety and Activity of Nivolumab in Combination With Vorolanib, a Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor, in Pa...
Beckermann, K., El Osta, B., Sanborn, R., Selvaggi, G., Whisenant, J., Heimann-Nichols, E., Berry, L., Hsu, C., Shyr, Y., Horn, L., Bestvina, C., Borghaei, H., Lammers...> ;JTO Clinical and Research Reports. 2024 Feb 1
Consolidation Osimertinib Versus Durvalumab Versus Observation After Concurrent Chemoradiation in Unresectable EGFR-Mutant NSCLC: A Multicenter Retrospective Cohort St...
D'Aiello, A., Owen, D. H., Amin H Nassar, So Yeon Kim, Jacqueline V Aredo, Jamie Feng, Frances Shepherd, Chao Xu, David Kaldas, Jhanelle E Gray, Thomas J Dilling, Joel...> ;Journal of Thoracic Oncology. 2024 Jan 24
Phenotyping EMT and MET cellular states in lung cancer patient liquid biopsies at a personalized level using mass cytometry.
Trope, W., Trope, W., Loukia G Karacosta, Danny Pancirer, Jordan S Preiss, Jalen A Benson, Winston Trope, Joseph B Shrager, Arthur Wai Sung, Joel W Neal, Sean C Bendal...> ;Scientific Reports. 2023 Dec 8
Chemotherapy and immunotherapy in early-stage NSCLC: neoadjuvant vs adjuvant therapy.
Heather Wakelee> ;Clinical Advances in Hematology & Oncology. 2023 Dec 1
Real-World Efficacy and Safety of Amivantamab for EGFR-Mutant NSCLC.
Wang, K., Du, R., Myall, N., Lewis, W., Uy, N., Hong, L., Skoulidis, F., Byers, L., Tsao, A., Cascone, T., Pozadzides, J., Tu, J., Negrao, M., Gibbons, D., Park, K., R...> ;Journal of Thoracic Oncology. 2024 Mar 1
Patient Selection and Outcomes for Hypofractionated Accelerated Radiation and Concurrent Chemotherapy for Non-Small-Cell Lung Cancer.
Caressa Hui, Cesar Marquez, Brianna Lau, Millie Das, Nathaniel J Myall, Mohana Roy, Heather A Wakelee, Joel W Neal, Nataliya Kovalchuk, Alex Chin, Maximilian Diehn, Bi...> ;Clinical Lung Cancer. 2024 Mar 1
Disparities in outcomes between Black and White patients in North America with thoracic malignancies and COVID-19 infection (TERAVOLT).
Laura Burns, Chih-Yuan Hsu, Jennifer G Whisenant, Melina E Marmarelis, Carolyn J Presley, Karen L Reckamp, Hina Khan, Mary Jo Fidler, Christine M Bestvina, Julie Brahm...> ;Lung Cancer. 2023 Dec 1
Second Primary Lung Cancer Among Lung Cancer Survivors Who Never Smoked.
Eunji Choi, Chloe C Su, Julie T Wu, Jacqueline V Aredo, Joel W Neal, Ann N Leung, Leah M Backhus, Natalie S Lui, Loïc Le Marchand, Daniel O Stram, Su-Ying Liang, Iona ...> ;JAMA Network Open. 2023 Nov 1
5 citations
Risk Model-Based Lung Cancer Screening and Racial and Ethnic Disparities in the US.
Eunji Choi, Victoria Y Ding, Sophia J Luo, Kevin Ten Haaf, Julie T Wu, Jacqueline V Aredo, Lynne R Wilkens, Neal D Freedman, Leah M Backhus, Ann N Leung, Rafael Meza, ...> ;JAMA Oncology. 2023 Dec 1
Asian American Women's Experiences of Discrimination and Health Behaviors during the COVID-19 Pandemic.
Katarina Wang, Alice Guan, Janice Seto, Debora L Oh, Kathie Lau, Christine Duffy, Esperanza Castillo, Valerie McGuire, Michelle Wadhwa, Clifford G Tepper, Heather A Wa...> ;Journal of Immigrant and Minority Health. 2024 Apr 1
Risk model-based management for second primary lung cancer among lung cancer survivors through a validated risk prediction model.
Eunji Choi, Sophia J Luo, Victoria Y Ding, Julie T Wu, Ashok V Kumar, Jason Wampfler, Martin C Tammemägi, Lynne R Wilkens, Jacqueline V Aredo, Leah M Backhus, Joel W N...> ;Cancer. 2024 Mar 1
1 citations
Comparison of SP263 and 22C3 immunohistochemistry PD-L1 assays for clinical efficacy of adjuvant atezolizumab in non-small cell lung cancer: results from the randomize...
Caicun Zhou, Minu K Srivastava, Hao Xu, Enriqueta Felip, Heather Wakelee, Nasser Altorki, Martin Reck, Rüdiger Liersch, Anna Kryzhanivska, Satoshi Oizumi, Hiroshi Tana...> ;Journal for Immunotherapy of Cancer. 2023 Oct 1
4 citations
Individualized Stereotactic Ablative Radiotherapy for Lung Tumors: The iSABR Phase 2 Nonrandomized Controlled Trial.
Michael F Gensheimer, Harriet Gee, Hiroki Shirato, Hiroshi Taguchi, John M Snyder, Alexander L Chin, Lucas K Vitzthum, Peter G Maxim, Heather A Wakelee, Joel Neal, Mil...> ;JAMA Oncology. 2023 Nov 1
Software Application Profile: dynamicLM-a tool for performing dynamic risk prediction using a landmark supermodel for survival data under competing risks.
Anya H Fries, Eunji Choi, Julie T Wu, Justin H Lee, Victoria Y Ding, Robert J Huang, Su-Ying Liang, Heather A Wakelee, Lynne R Wilkens, Iona Cheng, Summer S Han> ;International Journal of Epidemiology. 2023 Dec 25
Overall Survival Among Patients With De Novo Stage IV Metastatic and Distant Metastatic Recurrent Non-Small Cell Lung Cancer.
Chloe C Su, Julie T Wu, Eunji Choi, Nathaniel J Myall, Joel W Neal, Allison W Kurian, Henning Stehr, Douglas Wood, Solomon M Henry, Leah M Backhus, Ann N Leung, Heathe...> ;JAMA Network Open. 2023 Sep 5
1 citations
The International Association for the Study of Lung Cancer Early Lung Imaging Confederation Open-Source Deep Learning and Quantitative Measurement Initiative.
Stephen Lam, Murry W Wynes, Casey Connolly, Kazuto Ashizawa, Sukhinder Atkar-Khattra, Chandra P Belani, Domenic DiNatale, Claudia I Henschke, Bruno Hochhegger, Claudio...> ;Journal of Thoracic Oncology. 2024 Jan 1
1 citations
Optimizing Lung Cancer Screening With Risk Prediction: Current Challenges and the Emerging Role of Biomarkers.
Julie Tsu-Yu Wu, Heather A Wakelee, Summer S Han> ;Journal of Clinical Oncology. 2023 Sep 20
21 citations
Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC.
Marcelo V Negrao, Haniel A Araujo, Giuseppe Lamberti, Alissa J Cooper, Neal S Akhave, Teng Zhou, Lukas Delasos, J Kevin Hicks, Mihaela Aldea, Gabriele Minuti, Jacobi H...> ;Cancer Discovery. 2023 Jul 7
4 citations
Early-Stage Lung Cancer: Using Circulating Tumor DNA to Get Personal.
Christine M Bestvina, Marina C Garassino, Joel W Neal, Heather A Wakelee, Maximilian Diehn, Everett E Vokes> ;Journal of Clinical Oncology. 2023 Sep 1
12 citations
Predicting benefit from immune checkpoint inhibitors in patients with non-small-cell lung cancer by CT-based ensemble deep learning: a retrospective study.
Maliazurina B Saad, Lingzhi Hong, Muhammad Aminu, Natalie I Vokes, Pingjun Chen, Morteza Salehjahromi, Kang Qin, Sheeba J Sujit, Xuetao Lu, Elliana Young, Qasem Al-Tas...> ;The Lancet. Digital Health. 2023 Jul 1
Phase II Randomized Trial of Carboplatin, Pemetrexed, and Bevacizumab With and Without Atezolizumab in Stage IV Nonsquamous Non-Small-Cell Lung Cancer Patients Who Har...
J Nicholas Bodor, Jyoti D Patel, Heather A Wakelee, Benjamin P Levy, Hossein Borghaei, Bruna Pellini, Michael R Costello, Jonathan E Dowell, Gene Finley, Chao H Huang,...> ;Clinical Lung Cancer. 2023 Nov 1
Pulmonary Hemorrhage in Patients Treated With Thoracic Stereotactic Ablative Radiotherapy and Antiangiogenic Agents.
Brianna C Lau, Yufan F Wu, Hyunsoo J No, Ryan B Ko, Max D Devine, Millie S Das, Joel W Neal, Heather A Wakelee, Kavitha Ramchandran, Michael F Gensheimer, Maximilian D...> ;Journal of Thoracic Oncology. 2023 Jul 1
Brief Report: High Levels of CD47 Expression in Thymic Epithelial Tumors.
Thomas Yang Sun, Brandon Nguyen, Simon B Chen, Yasodha Natkunam, Sukhmani Padda, Matt van de Rijn, Robert West, Joel W Neal, Heather Wakelee, Jonathan W Riess> ;JTO Clinical and Research Reports. 2023 Apr 1
6 citations
Osimertinib in NSCLC With Atypical-Activating Mutations: A Retrospective Multicenter Study.
Jingran Ji, Jacqueline V Aredo, Andrew Piper-Vallillo, Laura Huppert, Julia K Rotow, Hatim Husain, Susan Stewart, Rosemary Cobb, Heather A Wakelee, Collin M Blakely, M...> ;JTO Clinical and Research Reports. 2023 Mar 1
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Journal Articles

Predictive Biomarkers for Response to EGFR-Directed Monoclonal Antibodies for Advanced Squamous Cell Lung Cancer
D R Spigel, E S Kim, S S Ramalingam, M A Socinski, C Obasaju, C J Langer, R B Natale, P D Bonomi, H Wakelee, Annals of Oncology

Lectures

Immunotherapies in Thymic Malignancies
ASCO Annual Meeting 2019 - Chicago, IL - 6/3/2019

Press Mentions

How Genes and Genetic Biomarkers Affect Lung CancerApril 21st, 2023
Podcast 299: Lung Cancer and Atezolizumab — Results from the IMpower010 TrialAugust 9th, 2022
Top-Rated Abstracts Presented During Presidential SymposiumAugust 8th, 2022
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