Dr. Shanafelt's clinical and scientific interests are focused on the treatment of patients with chronic lymphocytic leukemia (CLL). CLL is the most common leukemia in adults and, although treatable, it is currently an incurable illness. Dr. Shanafelt's research on CLL spans the continuum from the laboratory to the clinic. He is currently the principle investigator on multiple clinical trials testing new treatments for patients with CLL as well as being involved in the design and conduct of CLL trials for the Eastern Cooperative Oncology Group. His laboratory work involves identifying prognostic tools that help predict which CLL patients will experience a more aggressive disease course as well as research to identify new compounds for treating the disease. The mechanism of action of promising compounds are further explored in different micro-environments to evaluate in vivo modulators of drug induced killing/apoptosis. Promising candidate drugs are then taken in to phase I/II clinical trials for patients with CLL. Dr. Shanafelt's other academic interest is physician well-being and its impact on patient care. He is the director of the Mayo Clinic Department of Medicine Program on Physician Well-being, a clinical laboratory evaluating personal and organizational factors that contribute to physician satisfaction. His research in this area has involved physicians at all stages of their career from medical school to practice had has include several multi-center and national studies. This research is intended to identify personal and organizational factors that can be modified in order to promote physician well-being and enhance the quality of care physicians deliver.
Education & Training
Mayo School of Graduate Medical EducationFELLOWSHIP
University of WashingtonRESIDENCY
University of Colorado Denver School of MedicineMEDICAL_SCHOOL
Washington State UniversityOTHER_TRAINING
Washington State UniversityOTHER_TRAINING
Certifications & Licensure
CA State Medical License2017 - 2022
ID State Medical License2014 - 2018
ND State Medical License2014 - 2017
CO State Medical License2013 - 2019
MO State Medical License2013 - 2018
KY State Medical License2013 - 2018
FL State Medical License2013 - 2016
NH State Medical License2013 - 2019
MI State Medical License2013 - 2018
IL State Medical License2013 - 2017
MT State Medical License2013 - 2019
IA State Medical License2013 - 2017
AZ State Medical License2013 - 2018
GA State Medical License2013 - 2017
MN State Medical License2001 - 2017
American Board of Internal MedicineInternal Medicine
American Board of Internal MedicineHematology
American Board of Internal MedicineMedical Oncology
Kleinstern, G., Rishi, A., Achenbach, S. J., Rabe, K. G., Kay, N. E., Shanafelt, T. D., Ding, W., Leis, J. F., Norman, A. D., Call, T. G., Cerhan, J. R., Parikh, S. A....> ;Journal of the American Academy of Dermatology. 2020 Jul 19
Marshall, A. L., Dyrbye, L. N., Shanafelt, T. D., Sinsky, C. A., Satele, D., Trockel, M., Tutty, M., West, C. P.> ;Academic medicine : journal of the Association of American Medical Colleges. 2020 May 28
Kleinstern, G., O'Brien, D. R., Li, X., Tian, S., Kabat, B. F., Rabe, K. G., Norman, A. D., Yan, H., Vachon, C. M., Boddicker, N. J., Call, T. G., Parikh, S. A., Bruin...> ;American journal of hematology. 2020 Apr 13
Ahmed, A. A., Ramey, S. J., Dean, M. K., Takita, C., Schwartz, D., Wilson, L. D., Vapiwala, N., Thomas, C. R., Shanafelt, T. D., Deville, C., Jagsi, R., Holliday, E.> ;JCO oncology practice. 2020 Apr 11
Hlubocky, F. J., Taylor, L. P., Marron, J. M., Spence, R. A., McGinnis, M. M., Brown, R. F., McFarland, D. C., Tetzlaff, E. D., Gallagher, C. M., Rosenberg, A. R., Pop...> ;JCO oncology practice. 2020 Apr 1
Parikh, S. A., Achenbach, S. J., Call, T. G., Rabe, K. G., Ding, W., Leis, J. F., Kenderian, S. S., Chanan-Khan, A. A., Koehler, A. B., Schwager, S. M., Muchtar, E., F...> ;Cancer medicine. 2020 Mar 19
Sinsky, C. A., Rule, A., Cohen, G., Arndt, B. G., Shanafelt, T. D., Sharp, C. D., Baxter, S. L., Tai-Seale, M., Yan, S., Chen, Y., Adler-Milstein, J., Hribar, M.> ;Journal of the American Medical Informatics Association : JAMIA. 2020 Feb 7
Outcomes Of Chronic Lymphocytic Leukemia Patients With Richter Syndrome.
Sameer Parikh, Tschumper, Diane F. Jelinek, PhD, Neil E. Kay, MD, Susan L Slager, PhD, Kari G. Rabe, MS and Shanafelt TD, MD, Blood, ASH Annual Meeting, 1/1/2013
Chronic Graft Vs Host Disease Is The Strongest Predictor Of Outcome After Reduced Intensity Conditioning Stem Cell Transplantation In Chronic Lymphocytic Leukemia and ...
Saad Kenderian MD, Neil Kay, MD, Wei Ding, MD, PhD, Mark R. Litzow, MD, Kari G. Rabe, MS, William Hogan, MD and Shanafelt TD, Blood, ASH Annual Meeting, 1/1/2013
Genomic Landscape and Clonal Heterogeneity Underlying Progression and Relapse In Chronic Lymphocytic Leukemia (CLL).
Juhi Ojha, PhD, Jackline ayres-Silva, Charla Secreto, Scott Van Wier, Susan L Slager, PhD, Rafael Fonseca, M.D., Shanafelt TD, Neil E. Kay, MD and Esteban Braggio, Ph.D., Blood, ASH Annual Meeting, 1/1/2013
Hypogammaglobulinemia In Patients With Previously Untreated Chronic Lymphocytic Leukemia: Clinical Correlates and Outcomes.
Sameer A. Parikh, MD, Shanafelt TD, Kari G. Rabe, MS, Wei Ding, MD, PhD, Timothy G. Call, MD, Susan Schwager, Diane F. Jelinek, PhD, Neil Kay, MD, Jose F Leis MD, Blood, ASH Annual Meeting, 1/1/2013
Hodgkin Transformation Of Chronic Lymphocytic Leukemia (CLL): Mayo Clinic Experience.
Sameer A. Parikh, MD. Kari Rabe, Wei Ding, Timothy G. Call, Clive S Zent, Susan Schwager, Neil E kay, Jose F Leis, Susan L Slager, Shanafelt TD, Blood, ASH Annual Meeting, 1/1/2013
Variability Of Performance Status Assessment Between Patients With Hematologic Malignancies and Their Physicians.
Cristine Allmer, Matthew J Maurer, Shanafelt TD, James R Cerhan, Brian K Link, Carrie A Thompson, Blood, ASH Annual Meeting, 1/1/2013
Clonal Evolution In Patients With Previously Untreated Chronic Lymphocytic Leukemia.
Sameer A. Parikh, MD, Kari G. Rabe, MS, Blood, ASH Annual Meeting, 1/1/2013
Heritable Predisposition To Richter Syndrome In Patients With Chronic Lymphocytic Leukemia.
Sameer A. Parikh, MD, Susan L Slager, PhD, Kari G. Rabe, MS, Blood, ASH Annual Meeting, 1/1/2013
Renal disease in patients with chronic lymphocytic leukemia.
Shanafelt TD, Kari Rabe, Curtis Hanson, Timothy Call, Susan Schwager, Sameer Parikh, Samih Nasr, Nelson Leung, Blood, ASH Annual Meeting, 1/1/2013
Minimal residual disease (mrd) detection in chronic lymphocytic leukemia (cll): flow cytometry (fc) or immunohistochemistry (ihc)?