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300 Pasteur DrPalo Alto, CA 94305
Phone+1 507-284-2511
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Summary
- Dr. Shanafelt's clinical and scientific interests are focused on the treatment of patients with chronic lymphocytic leukemia (CLL). CLL is the most common leukemia in adults and, although treatable, it is currently an incurable illness. Dr. Shanafelt's research on CLL spans the continuum from the laboratory to the clinic. He is currently the principle investigator on multiple clinical trials testing new treatments for patients with CLL as well as being involved in the design and conduct of CLL trials for the Eastern Cooperative Oncology Group. His laboratory work involves identifying prognostic tools that help predict which CLL patients will experience a more aggressive disease course as well as research to identify new compounds for treating the disease. The mechanism of action of promising compounds are further explored in different micro-environments to evaluate in vivo modulators of drug induced killing/apoptosis. Promising candidate drugs are then taken in to phase I/II clinical trials for patients with CLL. Dr. Shanafelt's other academic interest is physician well-being and its impact on patient care. He is the director of the Mayo Clinic Department of Medicine Program on Physician Well-being, a clinical laboratory evaluating personal and organizational factors that contribute to physician satisfaction. His research in this area has involved physicians at all stages of their career from medical school to practice had has include several multi-center and national studies. This research is intended to identify personal and organizational factors that can be modified in order to promote physician well-being and enhance the quality of care physicians deliver.
Education & Training
Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Hematology and Medical Oncology, 2001 - 2005
University of WashingtonResidency, Internal Medicine, 1998 - 2001
University of Colorado School of Medicine Anschutz Medical CampusClass of 1998
Washington State UniversityBA, Business Administration, Summa Cum Laude, 1990 - 1994- Washington State UniversityBA, Business Administration, Summa Cum Laude, 1990 - 1994
Certifications & Licensure
NH State Medical License 2013 - Present
CA State Medical License 2017 - 2028
CO State Medical License 2013 - 2019
MT State Medical License 2013 - 2019
AZ State Medical License 2013 - 2018
ID State Medical License 2014 - 2018
KY State Medical License 2013 - 2018
American Board of Internal Medicine Internal Medicine- American Board of Internal Medicine Hematology
- American Board of Internal Medicine Medical Oncology
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Awards, Honors, & Recognition
- CMS Meaningful Use Stage 2 Certification Mayo Clinic Electronic Notes, Mayo Clinic, 2013-2017
- CMS Meaningful Use Stage 2 Certification Centricity Patient Online, GE Healthcare, 2013-2017
- CMS Meaningful Use Stage 2 Certification Mayo Clinic Incorporate Lab Results, Mayo Clinic, 2013-2017
Clinical Trials
- American Ginseng in Treating Patients With Cancer-Related Fatigue Start of enrollment: 2005 Oct 01
- Green Tea Extract in Treating Patients With Stage 0, Stage I, or Stage II Chronic Lymphocytic Leukemia Start of enrollment: 2005 Aug 01
- Sunitinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Start of enrollment: 2007 Aug 01
Publications & Presentations
PubMed
- Pragmatic Parental Support to Mitigate Burnout Among Pregnant and Postpartum Trainees: A Randomized Clinical Trial.Atziri Rubio-Chavez, Ekaterina L Koelliker, Emma A Askew, Tait D Shanafelt, Christopher P Landrigan
JAMA. 2026-05-13 - Associations and Differences Between Occupational Burnout and Depression in Large Studies of U.S. Physicians.Tait D Shanafelt, Colin P West, Liselotte N Dyrbye, Christine Sinsky, Michael Tutty
Academic Medicine. 2026-05-08 - 1 citationsPhysician Intent to Reduce Hours and Intent to Leave Organizations.Lisa Rotenstein, Purva Shah, Roger Brown, Heather Farley, Tait Shanafelt
JAMA Network Open. 2026-05-01
Journal Articles
- Assessment of the Association of Leadership Behaviors of Supervising Physicians with Personal-Organizational Values Alignment Among Staff PhysiciansTait D Shanafelt, Rick Majzun, Mickey Trockel, JAMA Network Open
- Assessment of Physician Sleep and Wellness, Burnout, and Clinically Significant Medical ErrorsMickey T Trockel, Susannah G Rowe, Mariah A Quinn, Daniel Marchalik, Patricia Normand, Mila Felder, Jessica C Dudley, Tait D Shanafelt, JAMA Network Open
- Association of Physician Burnout with Suicidal Ideation and Medical ErrorsTait D Shanafelt, Christine A Sinsky, Mickey T Trockel, JAMA Network Open
Books/Book Chapters
Abstracts/Posters
- Developmental DNA Methylation Subtype Predicts Progression to Treatment and Survival in High-Count Monoclonal B LymphocytosisTait D. Shanafelt, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
- The AKT Inhibitor MK2206 In Combination With Rituximab and Bendamustine Is Tolerable and Active In Relapsed Or Refractory Chronic Lymphocytic Leukemia: Results From a ...Wei Ding, MD, PhD, Shanafelt TD, Clive S. Zent, MD, Jose F. Leis, MD, PhD, Betsy R. LaPlant, Timothy G. Call, MD, Curtis A Hanson, Charles Erlichmanm, Thomas Habermann..., ASH Annual Meeting, 1/1/2013
- CD49d Is The Strongest Flow Cytometry-Based Predictor Of Overall Survival In Chronic Lymphocytic Leukemia.Pietro Bulian, MD, Shanafelt TD, Chris Fegan, MBBS, Antonella Zucchetto, Lilla Cro, PhD, Holger Nuckel, MD, Luca Baldini, Antonina Kurtova, MS, Alessandra Ferrajoli, M..., Blood, ASH Annual Meeting, 1/1/2013
Lectures
- 50th Annual Louis F. Bishop Keynote: Reducing Burnout and Promoting Engagement: Individual and Organizational Approaches to Physician Well-being2019 ACC Scientific Session & Expo, New Orleans - 3/16/2019
- Clinician Wellness Intensive I Featuring the 50th Annual Louis F. Bishop Keynote2019 ACC Scientific Session & Expo, New Orleans - 3/16/2019
- Ibrutinib-Based Therapy Improves Anti-Tumor T Cell Killing Function Allowing Effective Pairing with Anti-PD-L1 Immunotherapy Compared to Traditional FCR Chemoimmunothe...2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Authored Content
- Burnout, Depression, Career Satisfaction, and Work-Life Integration by Physician Race/EthnicityAugust 2020
- Resilience and Burnout Among Physicians and the General US Working PopulationJuly 2020
- Resilience and Burnout Among Physicians and the General US Working PopulationJuly 2020
Press Mentions
Burnout Requires Attention, Advocacy for Research & MoreOctober 30th, 2025- WATCH: Reclaiming the Meaning of Medicine — a Conversation with Dr. Mary BrandtOctober 23rd, 2025
- Healing the Healers: How Technology Helps Physician BurnoutSeptember 26th, 2025
Grant Support
- Prevalence, etiology, and clinical implications of low count monoclonal B-cell lymphocytosis (MBL)MAYO CLINIC ROCHESTER2018–2029
- Outcomes for CLL patients treated with novel therapyMAYO CLINIC ROCHESTER2021–2026
- The Role Of Oxidative Stress In CLL B-Cell ApoptosisNational Cancer Institute2006–2010
Professional Memberships
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