HelenLyonMD

PubMed

• 203 citations
  A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
  Keri L. Monda, Gary K. Chen, Kira C. Taylor, Cameron D. Palmer, Todd L. Edwards, Leslie A. Lange, Maggie C.Y. Ng, Adebowale Adeyemo, Matthew A. Allison, Lawrence F. Bi...> ;Nature Genetics. 2013 Jun 1
• 9 citations
  Replication and fine mapping of asthma-associated loci in individuals of African ancestry.
  David B. Kantor, Cameron D. Palmer, Taylor Young, Yan Meng, Zofia K. Z. Gajdos, Helen N. Lyon, Alkes L. Price, Samuela Pollack, Stephanie J. London, Laura R. Loehr, Le...> ;Human Genetics. 2013 May 12
• 37 citations
  Genetic Variants of TSLP and Asthma in an Admixed Urban Population
  M. Liu, Linda Rogers, Qinyi Cheng, Yongzhao Shao, Maria Elena Fernandez-Beros, Joel N. Hirschhorn, Helen N. Lyon, Zofia K. Z. Gajdos, Sailaja Vedantam, Peter K. Greger...> ;Plos One. 2011 Sep 22
• 18 citations
  Does a short breastfeeding period protect from FTO-induced adiposity in children?
  George Dedoussis, Mary Yannakoulia, Nicholas J. Timpson, Yannis Manios, Stavroula Kanoni, Robert A. Scott, Constantina Papoutsakis, Panos Deloukas, Yannis P. Pitsiladi...> ;International Journal of Pediatric Obesity. 2011 Jun 30
• 15 citations
  An age-dependent diet-modified effect of the PPARγ Pro12Ala polymorphism in children.
  George Dedoussis, Yannis Manios, Georgia Kourlaba, Stavroula Kanoni, Vasiliki Lagou, Johannah L. Butler, Constantina Papoutsakis, Robert A. Scott, Mary Yannakoulia, Ya...> ;Metabolism. 2011 Apr 1
• 3 citations
  The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA.
  Charleston W. K. Chiang, Zofia K. Z. Gajdos, Joshua M. Korn, Johannah L. Butler, Rachel Hackett, Candace Guiducci, Thutrang T. Nguyen, Rainford J. Wilks, Terrence Forr...> ;Human Genetics. 2011 Mar 22
• 138 citations
  Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
  Ervin R. Fox, J. Hunter Young, Yali Li, Albert W. Dreisbach, Brendan J. Keating, Solomon K. Musani, Kiang Liu, Alanna C. Morrison, Santhi K. Ganesh, Abdullah Kutlar, V...> ;Human Molecular Genetics. 2011 Mar 4
• 48 citations
  Interrogating local population structure for fine mapping in genome-wide association studies
  Huaizhen Qin, Nathan Morris, Sun J. Kang, Mingyao Li, Bamidele Tayo, Helen N. Lyon, Joel N. Hirschhorn, Richard S. Cooper, Xiaofeng Zhu> ;Bioinformatics. 2010 Dec 1
• 15 citations
  Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica
  Rajat M. Gupta, Kenechi Ejebe, Johannah L. Butler, Guillaume Lettre, Helen N. Lyon, Candace Guiducci, Rainford J. Wilks, Franklyn I. Bennett, Terrence Forrester, B. Ta...> ;Human Genetics. 2010 Sep 14
• 40 citations
  Obesity and diabetes genetic variants associated with gestational weight gain
  Alison M. Stuebe, Helen Lyon, Amy H. Herring, Joyee Ghosh, Alison Wise, Kari E. North, Anna Maria Siega-Riz> ;American Journal of Obstetrics and Gynecology. 2010 Sep 1
• 67 citations
  Fine-mapping of the association with obesity at the FTO locus in African-derived populations
  Mohamed T. Hassanein, Helen N. Lyon, Thutrang T. Nguyen, Ermeg L. Akylbekova, Kevin M. Waters, Guillaume Lettre, Bamidele O. Tayo, Terrence Forrester, Daniel F. Sarpon...> ;Human Molecular Genetics. 2010 Jul 15
• 77 citations
  Genome-wide association of anthropometric traits in African- and African-derived populations
  Sun J. Kang, Charleston W. K. Chiang, Cameron D. Palmer, Bamidele O. Tayo, Guillaume Lettre, Johannah L. Butler, Rachel Hackett, Adebowale Adeyemo, Candace Guiducci, I...> ;Human Molecular Genetics. 2010 Jul 1
• 183 citations
  Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
  Rachel M. Freathy, Dennis O. Mook-Kanamori, Ulla Sovio, Inga Prokopenko, Nicholas J. Timpson, Diane J. Berry, Nicole M. Warrington, E. Widen, Jouke-Jan Hottenga, Marik...> ;Nature Genetics. 2010 May 1
• 40 citations
  Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples.
  Charleston W. K. Chiang, Zofia K. Z. Gajdos, Joshua M. Korn, Finny G Kuruvilla, Johannah L. Butler, Rachel Hackett, Candace Guiducci, Thutrang T. Nguyen, Rainford J. W...> ;Plos Genetics. 2010 Mar 5
• 55 citations
  Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?
  Iris M. Heid, Cornelia Huth, Ruth J. F. Loos, Florian Kronenberg, Vera Adamkova, Sonia S. Anand, Kristin G. Ardlie, Heike Biebermann, Peter Bjerregaard, Heiner Boeing,...> ;Plos Genetics. 2009 Oct 23
• 36 citations
  On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects
  Stijn Vansteelandt, Sylvie Goetgeluk, Sharon M. Lutz, Irwin D. Waldman, Helen Lyon, Eric E. Schadt, Scott T. Weiss, Christoph Lange> ;Genetic Epidemiology. 2009 Jul 1
• 502 citations
  Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
  Cecilia M. Lindgren, Iris M. Heid, Joshua C. Randall, Claudia Lamina, Valgerdur Steinthorsdottir, Lu Qi, Elizabeth K. Speliotes, Gudmar Thorleifsson, Cristen J. Willer...> ;Plos Genetics. 2009 Jun 1
• 1413 citations
  Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
  Cristen J. Willer, Elizabeth K. Speliotes, Ruth J. F. Loos, Shengxu Li, Cecilia M. Lindgren, Iris M. Heid, Sonja I. Berndt, Amanda F. Elliott, Anne U. Jackson, Claudia...> ;Nature Genetics. 2009 Jan 1
• 16 citations
  Peroxisome proliferator-activated receptor-gamma (PPARgamma) Pro12Ala polymorphism and risk for pediatric obesity.
  George Dedoussis, Nikoleta Vidra, Johannah L. Butler, Constantina Papoutsakis, Mary Yannakoulia, Joel N. Hirschhorn, Helen N. Lyon> ;Clinical Chemistry and Laboratory Medicine. 2009 Jan 1
• 111 citations
  On the replication of genetic associations: timing can be everything!
  Jessica Lasky-Su, Helen N. Lyon, Valur Emilsson, Iris M. Heid, Cliona Molony, Benjamin A. Raby, Ross Lazarus, Barbara J. Klanderman, Manuel E. Soto-Quiros, Lydiana Avi...> ;American Journal of Human Genetics. 2008 Apr 11
• 78 citations
  The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.
  Jarred B. McAteer, Sabrina Prudente, Simonetta Bacci, Helen N. Lyon, Joel N. Hirschhorn, Vincenzo Trischitta, Jose C. Florez> ;Diabetes. 2008 Apr 1
• 2151 citations
  Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
  Richa Saxena, Benjamin F. Voight, Valeriya Lyssenko, Noël P. Burtt, Paul I.W. de Bakker, Hong Chen, Jeffrey J. Roix, Sekar Kathiresan, Joel N. Hirschhorn, Mark J. Daly...> ;Science. 2007 Jun 1
• 41 citations
  Association studies of BMI and type 2 diabetes in the neuropeptide y pathway - A possible role for NPY2R as a candidate gene for type 2 diabetes in men
  Catarina D. Campbell, Helen N. Lyon, James Nemesh, Jared A. Drake, Tiinamaija Tuomi, Daniel Gaudet, Xiaofeng Zhu, Richard S. Cooper, Kristin G. Ardlie, Leif Groop, Joe...> ;Diabetes. 2007 May 1
• 62 citations
  Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity
  Helen N. Lyon, Jose C. Florez, Todd Bersaglieri, Richa Saxena, Wendy Winckler, Peter Almgren, Ulf Lindblad, Tiinamaija Tuomi, Daniel Gaudet, Xiaofeng Zhu, Richard S. C...> ;Diabetes. 2006 Nov 1
• 175 citations
  Transferability of tag SNPs in genetic association studies in multiple populations
  Paul I.W. de Bakker, Noël P. Burtt, Robert R. Graham, Candace Guiducci, Roman Yelensky, Jared A. Drake, Todd Bersaglieri, Kathryn L. Penney, Johannah L. Butler, Stanto...> ;Nature Genetics. 2006 Oct 22
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Journal Articles

• Variants in ADCY5 and near CCNL1 Are Associated with Fetal Growth and Birth Weight  
  Early Growth Genetics Consortium. Freathy RM, et. al, Nat Genet, 1/1/2010
• Peroxisome Proliferator-activated Receptor-gamma (PPARgamma) Pro12Ala Polymorphism and Risk for Pediatric Obesity  
  Dedoussis GV, Vidra N, Butler J, Papoutsakis C, Yannakoulia M, Hirschhorn JN, Lyon HN, Clin Chem Lab Med, 1/1/2009
• The Association of a SNP Upstream of INSIG2 with Body Mass Index Is Reproduced in Several but Not All Cohorts  
  Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters GB, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen TT, Scherag A, Pf..., PLoS Genet, 1/1/2007
• Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research Genome-Wide Association Analysis Id...  
  Science, 1/1/2007
• A Common Genetic Variant Is Associated with Adult and Childhood Obesity  
  Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R..., Science, 1/1/2006
• Common Variants in the ENPP1 Gene Are Not Reproducibly Associated with Diabetes or Obesity  
  Lyon HN, Florez JC, Bersaglieri T, Saxena R, Winckler W, Almgren P, Lindblad U, Tuomi T, Gaudet D, Zhu X, Cooper R, Ardlie KG, Daly MJ, Altshuler D, Groop L, Hirschhor..., Diabetes, 1/1/2006
• Genetics of Common Forms of Obesity: A Brief Overview  
  Lyon HN, Hirschhorn JN, Am J Clin Nutr, 1/1/2005
• Demonstrating Stratification in a European American Population  
  Campbell CD, Ogburn EL, Lunetta KL, Lyon HN, Freedman ML, Groop LC, Altshuler D, Ardlie KG, Hirschhorn JN, Nat Genet, 1/1/2005
• IL10 Gene Polymorphisms Are Associated with Asthma Phenotypes in Children  
  Lyon H, Lange C, Lake S, Silverman EK, Randolph AG, Kwiatkowski D, Raby BA, Lazarus R, Weiland KM, Laird N, Weiss ST, Genet Epidemiol, 1/1/2004
• Multiple Congenital Anomalies Associated with in Utero Exposure of Phenytoin: Possible Hypoxic Ischemic Mechanism?  
  Lyon HN, Holmes LB, Huang T, Birth Defects Res A Clin Mol Teratol, 1/1/2003
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Books/Book Chapters

• Nelson Textbook of Pediatrics 
  Chapter: Chapter 82: Genetics of Common Disorders 
  Helen N. Lyon and Bruce R. KorfEditors: Robert M. Kliegman, MD, Richard E. Behrman, MD, Hal B. Jenson, MD and Bonita F. Stanton, MD.ElsevierEdition 18th,2007
• Principles and Practice of Clinical Research 
  Chapter: Chapter 29: Human Genome Project, Genomics, and Clinical Research 
  Page 405 - 420Helen N. Lyon and Bruce R. KorfElsevier, San Diego, CAEdition 2nd,2007