HerbertHenrySamuelsMD

Endocrinology • New York, NY

Professor, Biochemistry and Molecular Pharmacology, New York University School of Medicine

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Office
550 1st Ave
New York, NY 10016
Phone+1 212-263-6279

Fax+1 212-263-7133
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Education & Training

NYU Grossman School of MedicineResidency, Internal Medicine, 1969 - 1970
Jacobi Medical Center/Albert Einstein College of MedicineResidency, Internal Medicine, 1965 - 1967
New York University School of MedicineClass of 1965

Certifications & Licensure

NY State Medical License 1966 - 2024

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1975

Publications & Presentations

PubMed

13 citations
Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration.
Irena Pastar, Olivera Stojadinovic, Andrew P. Sawaya, Rivka C. Stone, Linsey E. Lindley, Nkemcho Ojeh, Sasa Vukelic, Herbert H. Samuels, Marjana Tomic-Canic> ;Journal of Cellular Physiology. 2016 Nov 1
13 citations
Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain.
Sharmistha Das, Kay T. Yeung, Muktar A. Mahajan, Herbert H. Samuels> ;BMC Cancer. 2014 Nov 20
10 citations
A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli.
Alexander A. Tinnikov, Herbert H. Samuels> ;Plos One. 2013 Apr 15
123 citations
Microcephaly Gene Links Trithorax and REST/NRSF to Control Neural Stem Cell Proliferation and Differentiation
Yawei J. Yang, Andrew E. Baltus, Rebecca S. Mathew, Elisabeth A. Murphy, Gilad D. Evrony, Dilenny M. Gonzalez, Estee P. Wang, Christine A. Marshall-Walker, Brenda J. B...> ;Cell. 2012 Nov 21
46 citations
A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2.
Kay T. Yeung, Sharmistha Das, Jin Zhang, Alejandro Lomniczi, Sergio R. Ojeda, Chong Feng Xu, Thomas A. Neubert, Herbert H. Samuels> ;Molecular and Cellular Biology. 2011 Jun 1
5 citations
Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate.
Ritu Goyanka, Sharmistha Das, Herbert H. Samuels, Timothy Cardozo> ;Protein Engineering, Design & Selection. 2010 Nov 1
47 citations
Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor.
Sasa Vukelic, Olivera Stojadinovic, Irena Pastar, Constantinos Vouthounis, Agata Krzyzanowska, Sharmistha Das, Herbert H. Samuels, Marjana Tomic-Canic> ;The Journal of Biological Chemistry. 2010 Jan 15
69 citations
Identification and Characterization of a Novel Nuclear Protein Complex Involved in Nuclear Hormone Receptor-mediated Gene Regulation
Shivani Garapaty, Chong-Feng Xu, Patrick Trojer, Muktar A. Mahajan, Thomas A. Neubert, Herbert H. Samuels> ;The Journal of Biological Chemistry. 2009 Mar 20
29 citations
Identification of a Novel Pathway That Selectively Modulates Apoptosis of Breast Cancer Cells
Alexander A. Tinnikov, Kay T. Yeung, Sharmistha Das, Herbert H. Samuels> ;Cancer Research. 2009 Feb 15
37 citations
Components of the CCR4-NOT Complex Function as Nuclear Hormone Receptor Coactivators via Association with the NRC-interacting Factor NIF-1
Shivani Garapaty, Muktar A. Mahajan, Herbert H. Samuels> ;The Journal of Biological Chemistry. 2008 Mar 14
45 citations
Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development
Muktar A. Mahajan, Herbert H. Samuels> ;Nuclear Receptor Signaling. 2008 Feb 1
25 citations
Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors.
Sharmistha Das, Matthieu Schapira, Marjana Tomic-Canic, Ritu Goyanka, Timothy Cardozo, Herbert H. Samuels> ;Molecular Endocrinology. 2007 Nov 1
9 citations
Nuclear Receptor Coregulator (NRC): Mapping of the Dimerization Domain, Activation of p53 and STAT-2, and Identification of the Activation Domain AD2 Necessary for Nuc...
Muktar A. Mahajan, Audrey Murray, David E. Levy, Herbert H. Samuels> ;Molecular Endocrinology. 2007 May 29
9 citations
The Nuclear Receptor Interacting Factor-3 Transcriptional Coregulator Mediates Rapid Apoptosis in Breast Cancer Cells through Direct and Bystander-Mediated Events
Sharmistha Das, Jerome C. Nwachukwu, Dangsheng Li, Anthony I. Vulin, Sonia Martinez-Caballero, Kathleen W. Kinnally, Herbert H. Samuels> ;Cancer Research. 2007 Feb 15
3 citations
Direct identification of proteins from T47D cells and murine brain tissue by matrix-assisted laser desorption/ionization post-source decay/collision-induced dissociation.
Paul H. Pevsner, Frederick Naftolin, Dean E. Hillman, Douglas C. Miller, Ahmed Fadiel, Alexander Kogus, Arnold Stern, Herbert H. Samuels> ;Rapid Communications in Mass Spectrometry. 2007 Feb 15
22 citations
Role of PSF-TFE3 oncoprotein in the development of papillary renal cell carcinomas
Mukul Mathur, Herbert H. Samuels> ;Oncogene. 2007 Jan 11
124 citations
International Union of Pharmacology. LIX. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Thyroid Hormone Receptors
Frédéric Flamant, John D. Baxter, Douglas Forrest, Samuel Refetoff, Herbert H. Samuels, Tom S. Scanlan, Björn Vennström, Jacques Samarut> ;Pharmacological Reviews. 2006 Dec 1
21 citations
The N-Terminal A/B Domain of the Thyroid Hormone Receptor-β2 Isoform Influences Ligand-Dependent Recruitment of Coactivators to the Ligand-Binding Domain
Henghe Tian, Muktar A. Mahajan, Chun Tung Wong, Ioanis Habeos, Herbert H. Samuels> ;Molecular Endocrinology. 2006 Sep 1
62 citations
Nuclear Hormone Receptor Coregulator: Role in Hormone Action, Metabolism, Growth, and Development
Muktar A. Mahajan, Herbert H. Samuels> ;Endocrine Reviews. 2005 Jun 1
129 citations
Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis.
Olubunmi Afonja, Dominique Juste, Sharmistha Das, Sachiko Matsuhashi, Herbert H. Samuels> ;Oncogene. 2004 Oct 21
46 citations
The Nuclear Hormone Receptor Coactivator NRC Is a Pleiotropic Modulator Affecting Growth, Development, Apoptosis, Reproduction, and Wound Repair
Muktar A. Mahajan, Sharmistha Das, Hong Zhu, Marjana Tomic-Canic, Herbert H. Samuels> ;Molecular and Cellular Biology. 2004 Jun 1
28 citations
The NRIF3 Family of Transcriptional Coregulators Induces Rapid and Profound Apoptosis in Breast Cancer Cells
Dangsheng Li, Sharmistha Das, Tatsuya Yamada, Herbert H. Samuels> ;Molecular and Cellular Biology. 2004 May 1
36 citations
Novel roles of retinoid X receptor (RXR) and RXR ligand in dynamically modulating the activity of the thyroid hormone receptor/RXR heterodimer.
Dangsheng Li, Tatsuya Yamada, Fang Wang, A. Igor Vulin, Herbert H. Samuels> ;The Journal of Biological Chemistry. 2004 Feb 27
28 citations
PSF-TFE3 oncoprotein in papillary renal cell carcinoma inactivates TFE3 and p53 through cytoplasmic sequestration
Mukul Mathur, Sharmistha Das, Herbert H. Samuels> ;Oncogene. 2003 Aug 7
117 citations
Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking
Matthieu Schapira, Bruce M. Raaka, Sharmistha Das, Li Fan, Maxim Totrov, Zhiguo Zhou, Stephen R. Wilson, Ruben Abagyan, Herbert H. Samuels> ;Proceedings of the National Academy of Sciences of the United States of America. 2003 Jun 10
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Grant Support

Training In Pharmacological SciencesNational Institute Of General Medical Sciences2004–2011
Metabolic Effects Of Thyroid HormoneNational Institute Of Diabetes And Digestive And Kidney Diseases2009
Metabolic Effects Of Thyroid HormoneNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2007
Amersham Biosciences Typhoon 9410;NeurosciencesNational Center For Research Resources2006
Amersham Biosciences Typhoon 9410: Pharmacology, Cell Biology, MicrobiologyNational Center For Research Resources2006
Amersham Biosciences Typhoon 9410: Drug AbuseNational Center For Research Resources2006
Amersham Biosciences Typhoon 9410: DiabetesNational Center For Research Resources2006
Amersham Biosciences Typhoon 9410National Center For Research Resources2006
Metabolic Effects Of Thyroid HormoneNational Institute Of Diabetes And Digestive And Kidney Diseases1996–1998
Metabolic Effects Of Thyroid HormoneNational Institute Of Diabetes And Digestive And Kidney Diseases1991–1995
Structural And Functional Analysis Of Thyroid Hormone ResistanceNational Center For Research Resources1993
Analysis Of Thyroid Hormone Receptors In Thyroid Hormone ResistanceNational Center For Research Resources1991
Glucocorticoid Receptors--Structure And FunctionNational Institute Of Diabetes And Digestive And Kidney Diseases1989–1991
Metabolic Effects Of Thyroid Hormone In Cell CultureNational Institute Of Diabetes And Digestive And Kidney Diseases1986–1990
Physiological Role Of Lymphocyte Receptors For Thyroid HormoneNational Center For Research Resources1985–1986
Photoaffinity Labeling Of Thyroid Hormone ReceptorsNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985
Multihormonal Regulation Of Growth Hormone SynthesisNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985
Metabolic Effects Of Thyroid Hormone In Cell CultureNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985