HorngHChenMD

Cardiology • Rochester, MN

Echocardiography, Heart Failure & Transplantation

Professor, Internal Medicine, Mayo Medical School

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Office
200 1st Street SW
Rochester, MN 55905
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Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Cardiovascular Disease, 1997 - 2000
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1994 - 1997
Royal College of Surgeons IrelandClass of 1993

Certifications & Licensure

WI State Medical License 2014 - 2025
MN State Medical License 1996 - 2024
IA State Medical License 2014 - 2024
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine Cardiovascular Disease
National Board of EchocardiographyComprehensive TTE and TEE echocardiography

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2012
Fellow (FACC) American College of Cardiology

Clinical Trials

Cardiac Hormone Replacement With Brain Natriuretic Peptide (BNP) in Heart Failure Start of enrollment: 2000 Jan 01
Completed
Phase 1, Phase 2
BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery. Start of enrollment: 2003 Mar 01
Completed
Phase 1, Phase 2
BELIEVE Study: Nesiritide and Post Myocardial Infarction Left Ventricular Modeling Start of enrollment: 2002 Aug 01
Terminated
Phase 1
Use of Nesiritide (BNP) in Kidney Function in Patients With Congestive Heart Failure (CHF) and Kidney Failure Start of enrollment: 2005 Dec 01
Terminated
Phase 1, Phase 2
Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction Start of enrollment: 2006 Feb 01
Completed
Phase 1, Phase 2
Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function. Start of enrollment: 2008 Mar 01
Completed
Phase 1, Phase 2
Human B-type Natriuretic Peptide (BNP) (Nesiritide) to Help Heart, Kidney, and Hormonal Functions in Persons With Lower Heart Pumping Function Start of enrollment: 2006 Jun 01
Completed
Phase 1, Phase 2
Nesiritide Therapy to Preserve Function of the Left Ventricle After Myocardial Infarction Start of enrollment: 2006 Sep 01
Completed
Phase 2
Study of Low Dose Nesiritide With or Without Sildenafil in Congestive Heart Failure Patients With Renal Dysfunction Start of enrollment: 2009 Feb 01
Terminated
Phase 1
The Effects of Decreasing the Lasix Dose on the Cardiorenal System Start of enrollment: 2009 Jul 01
Completed
Phase 1, Phase 2
Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure Start of enrollment: 2012 Feb 01
Completed
Phase 1, Phase 2
CR Aim #2 - AT1 Receptor Blockade & ACE Inhibition Effect on Humoral Function Start of enrollment: 2012 Feb 01
Completed
Phase 1, Phase 2
Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2) Start of enrollment: 2014 Jan 09
Completed
Phase 1, Phase 2
Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Diastolic Cardiomyopathy (Aim3) Start of enrollment: 2014 Mar 01
Completed
Phase 1, Phase 2
PDD in Type 2 Diabetes w/wo Diastolic Dysfunction Start of enrollment: 2018 May 01
Recruiting
Phase 2
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Publications & Presentations

PubMed

1 citations
MANP in Hypertension With Metabolic Syndrome: Proof-of-Concept Study of Natriuretic Peptide-Based Therapy for Cardiometabolic Disease.
Ma, X., Iyer, S., Scott, C., Bailey, K., Johnson, B., Benike, S., Cabassi, A., Burnett, J., Cannone, V., McKie, P., Chen, H., Miller, W.> ;JACC. Basic to Translational Science. 2024 Jan 1
Community Paramedic Home Care Program for Acute Decompensated Heart Failure: A Pilot Study.
Sara Severson, Angela Fink, Rozalina McCoy, Chad Liedl, Patti Bieber, Michael Juntunen, Horng Chen, Grace Lin> ;Circulation. Cardiovascular Quality and Outcomes. 2023 Sep 1
The Cardiorenal Effects of Chronic Phosphodiesterase-V Inhibition in Preclinical Diastolic Dysfunction (Stage B Heart Failure).
Shravya Vinnakota, Fadi W Adel, Paul M McKie, Christopher G Scott, Horng H Chen> ;Journal of Cardiac Failure. 2023 Oct 1
Evidence for Angiotensin II as a Naturally Existing Suppressor for the Guanylyl Cyclase A Receptor and Cyclic GMP Generation.
Xiao Ma, Seethalakshmi R Iyer, Xiaoyu Ma, Shawn H Reginauld, Yang Chen, Shuchong Pan, Ye Zheng, Dante G Moroni, Yue Yu, Lianwen Zhang, Valentina Cannone, Horng H Chen,...> ;International Journal of Molecular Sciences. 2023 May 10
EVIDENCE FOR ANGIOTENSIN II AS A NATURALLY EXISTING SUPPRESSOR FOR THE NATRIURETIC PEPTIDE SYSTEM.
Xiao Ma, Seethalakshmi R Iyer, Xiaoyu Ma, Shawn H Reginauld, Yang Chen, Shuchong Pan, Ye Zheng, Dante Moroni, Yue Yu, Lianwen Zhang, Valentina Cannone, Horng H Chen, C...> ;Biorxiv. 2023 Jan 27
22 citations
Natriuretic peptide pathways in heart failure: further therapeutic possibilities.
S Jeson Sangaralingham, Michaela Kuhn, Valentina Cannone, Horng H Chen, John C Burnett> ;Cardiovascular Research. 2023 Feb 3
8 citations
Assessing intrinsic renal sodium avidity in acute heart failure: implications in predicting and guiding decongestion.
Pieter Martens, Horng H Chen, Frederik H Verbrugge, Jeffrey T Testani, Wilfried Mullens, W H Wilson Tang> ;European Journal of Heart Failure. 2022 Oct 1
1 citations
Incidence of Preclinical Heart Failure in a Community Population.
Kathleen A Young, Christopher G Scott, Richard J Rodeheffer, Horng H Chen> ;Journal of the American Heart Association. 2022 Aug 2
3 citations
MANP (M-Atrial Natriuretic Peptide) Reduces Blood Pressure and Furosemide-Induced Increase in Aldosterone in Hypertension.
Nina A Dzhoyashvili, Seethalakshmi R Iyer, Horng H Chen, John C Burnett Jr> ;Hypertension. 2022 Apr 1
Outcomes of Patients With Diabetes Versus Patients Without Diabetes Hospitalized With Acute Heart Failure.
Siu-Hin Wan, Joshua P Slusser, David O Hodge, Horng H Chen> ;The American Journal of Cardiology. 2022 Feb 15
1 citations
Cardiorenal Effects of Long-Term Phosphodiesterase V Inhibition in Pre-Heart Failure.
Scott A Hubers, Siu-Hin Wan, Fadi W Adel, Sherry L Benike, John C Burnett Jr, Christopher Scott, Horng H Chen> ;Journal of the American Heart Association. 2022 Jan 18
4 citations
Insulin Therapy is Associated With Increased Myocardial Interstitial Fibrosis and Cardiomyocyte Apoptosis in a Rodent Model of Experimental Diabetes.
Fadi W Adel, Ye Zheng, Siu-Hin Wan, Christie Greason, Shuchong Pan, Syed Ameenuddin, Horng H Chen> ;Frontiers in Physiology. 2022 Jan 1
3 citations
Prognostic Value of Urinary and Plasma C-Type Natriuretic Peptide in Acute Decompensated Heart Failure.
Xiao Ma, Yang Chen, Shawn Reginauld, Christopher G. Scott, Seethalakshmi R. Iyer, Jacob J. Schaefer, Tomoko Ichiki, Horng H. Chen, Andrew D. Rule, John C. Burnett, S. ...> ;JACC. Heart Failure. 2021 Sep 1
1 citations
Effects of phosphodiesterase V inhibition alone and in combination with BNP on cardiovascular and renal response to volume load in human preclinical diastolic dysfunct...
Siu-Hin Wan, Paul M. McKie, Joshua P. Slusser, John C. Burnett, David O. Hodge, Horng H. Chen> ;Physiological Reports. 2021 Aug 1
2 citations
Progression of Preclinical Heart Failure: A Description of Stage A and B Heart Failure in a Community Population
Kathleen A Young, Christopher G. Scott, Richard J. Rodeheffer, Horng H. Chen> ;Circulation. Cardiovascular Quality and Outcomes. 2021 May 6
13 citations
First-in-Human Study of MANP: A Novel ANP (Atrial Natriuretic Peptide) Analog in Human Hypertension.
Horng H. Chen, Siu-Hin Wan, Seethalakshmi R. Iyer, Valentina Cannone, S. Jeson Sangaralingham, Joel Nuetel, John C. Burnett> ;Hypertension. 2021 Feb 5
Trimethylamine-N-Oxide: The Link Between Loop Diuretics and Cardiovascular Outcomes?
Fadi W. Adel, Horng H. Chen> ;JACC. Basic to Translational Science. 2021 Feb 1
4 citations
Implications of peripheral oedema in heart failure with preserved ejection fraction: a heart failure network analysis.
Marat Fudim, Nicolas Ashur, Aaron D. Jones, Andrew P. Ambrosy, Bradley A. Bart, Javed Butler, Horng H. Chen, Stephen J. Greene, Yogesh N.V. Reddy, Margaret M. Redfield...> ;ESC Heart Failure. 2021 Feb 1
4 citations
B-type natriuretic peptide and cardiac remodelling after myocardial infarction: a randomised trial
Scott A. Hubers, John A. Schirger, S. Jeson Sangaralingham, Yang Chen, John C. Burnett, David O. Hodge, Horng H. Chen> ;Heart. 2021 Mar 1
5 citations
Annexin A1 is a Potential Novel Biomarker of Congestion in Acute Heart Failure.
Fadi W. Adel, Aruna Rikhi, Siu I.U.H.I.N. Wan, Seethalakshmi R. Iyer, Hrishikesh Chakraborty, Steven McNulty, W.H. Wilson Tang, G. Michael Felker, Michael M. Givertz, ...> ;Journal of Cardiac Failure. 2020 May 27
1 citations
Neprilysin in HFrEF: Differential Regulation of Tissue Versus Circulating Neprilysin.
Horng H. Chen, John C. Burnett> ;JACC. Basic to Translational Science. 2020 Jul 1
25 citations
The Importance of Natriuretic Peptides in Cardiometabolic Diseases
Shravya Vinnakota, Horng H Chen> ;Journal of the Endocrine Society. 2020 May 15
15 citations
Long-term blood pressure lowering and cGMP-activating actions of the novel ANP analog MANP
Yang Chen, Jacob J. Schaefer, Seethalakshmi R. Iyer, Gerald E. Harders, Shuchong Pan, S. Jeson Sangaralingham, Horng H. Chen, Margaret M. Redfield, John C. Burnett> ;American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2020 Apr 1
32-Year-Old Man With Dyspnea on Exertion and Dizziness.
Fadi W. Adel, Sarvenaz Sarvie Esmaeilzadeh, Horng H. Chen> ;Mayo Clinic Proceedings. 2020 Apr 1
20 citations
Diabetes Mellitus Is an Independent Predictor for the Development of Heart Failure: A Population Study.
Michael D. Klajda, Christopher G. Scott, Richard J. Rodeheffer, Horng H. Chen> ;Mayo Clinic Proceedings. 2020 Jan 1
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Journal Articles

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients with Heart Failure with Preserved Ejection Fraction
Gregory D Lewis, David J Whellan, Martin M LeWinter, Margaret M Redfield, Andrew L Smith, Eugene Braunwald, Michael M Givertz, Adrian F Hernandez, Sanjiv J Shah, Horng..., JAMA

Other

Natriuretic peptide measurement in heart failure
Chen HH, Colucci WS
http://www.uptodate.com/contents/natriuretic-peptide-measurement-in-heart-failure
UpToDate, Wolters Kluwer Health - 2012-04-20
Natriuretic peptide measurement in non-heart failure settings
Chen HH, Colucci WS
http://www.uptodate.com/contents/natriuretic-peptide-measurement-in-non-heart-failure-settings
UpToDate, Wolters Kluwer Health - 2013-01-28

Press Mentions

Diabetes an Independent Risk Factor for Heart FailureJanuary 3rd, 2020
Diabetes Is an Independent Risk Factor for Development of Heart Failure, Study ShowsJanuary 2nd, 2020
Diabetes Is an Independent Predictor for Heart Failure - Docwire NewsJanuary 2nd, 2020
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Grant Support

Cardiovascular Peptides And Myocardial InfarctionNational Heart, Lung, And Blood Institute2012
Protein Therapeutics To Prevent Heart Failure Post Myocardial InfarctionNational Heart, Lung, And Blood Institute2010–2011
Human Cardiorenal SyndromeNational Heart, Lung, And Blood Institute2009–2011
Natriuretic Peptide System As Therapy In Human Preclinical LV DysfunctionNational Heart, Lung, And Blood Institute2007–2009
ANP As Therapy In Human Preclinical LV DysfunctionNational Heart, Lung, And Blood Institute2005–2006
Cardiac Hormone Replacement With SQ BNP: A Novel Therapeutic StrategyNational Center For Research Resources2005
Cardiac Hormone Replacement--Bnp, Novel Therapy For CHFNational Center For Research Resources2004
Angiotensin II Regulation Of Renal Function In Patients W/ Mild CHF On DiureticsNational Center For Research Resources1999