HymanBMussMD

Oncology • Chapel Hill, NC

Professor of Medical Oncology, University of North Carolina School of Medicine

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Office
101 Manning Dr
Chapel Hill, NC 27514
Phone+1 984-974-0000

Fax+1 984-974-2603
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Education & Training

Brigham and Women's HospitalResidency, Internal Medicine, 1972 - 1974
Brigham and Women's HospitalResidency, Internal Medicine, 1972 - 1973
Brigham and Women's HospitalResidency, Internal Medicine, 1968 - 1970
State University of New York Downstate Medical Center College of MedicineClass of 1968

Certifications & Licensure

NC State Medical License 2009 - 2025
VT State Medical License 1996 - 2014
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012
Fellow (FASCO) American Society of Clinical Oncologists, 2008
Redbook Magazine: Top Breast Cancer Doctors Castle Connolly, 2001
Whos Who in Medicine and Healthcare Marquis Whos Who
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Clinical Trials

Letrozole After Tamoxifen in Treating Women With Breast Cancer Start of enrollment: 1998 Aug 24
Completed
Phase 3
Comparison of Combination Chemotherapy Regimens in Treating Older Women Who Have Undergone Surgery for Breast Cancer Start of enrollment: 2001 Sep 01
Completed
Phase 3
Chemotherapy Decisions and Outcomes in Older Women With Newly Diagnosed Breast Cancer Start of enrollment: 2003 Aug 01
Completed
Vaginal Testosterone Cream For Atrophic Vaginitis in Women Taking Aromatase Inhibitors for Breast Cancer. Start of enrollment: 2006 Dec 01
Suspended
Phase 1, Phase 2
Registry of Older Patients With Cancer Start of enrollment: 2009 Sep 01
Recruiting
Biomarkers in Blood Samples From Older Breast Cancer Survivors Start of enrollment: 2010 Jan 01
Completed
Tolerability of the Combination of Lapatinib and Trastuzumab in Adults Age 60 or Older With HER2 Positive Locally Advanced or Metastatic Breast Cancer Start of enrollment: 2011 Apr 20
Active, not recruiting
Phase 2
Study of the P16 Gene as a Predictor of Myelosuppression in Breast Cancer Patients Start of enrollment: 2010 Dec 01
Active, not recruiting
The Hurria Older PatiEnts (HOPE) With Breast Cancer Study Start of enrollment: 2011 Sep 09
Active, not recruiting
Finding Predictors of Side Effects to Chemoradiation Treatment in Elderly Patients With Head and Neck Cancer Start of enrollment: 2012 Jul 01
Completed
Study of Outcomes After Surgery/Treatment to Treat Bladder Cancer Start of enrollment: 2012 Jul 23
Completed
Feasibility of an Evidence-based Walking Program in Cancer Pts 60+ During Chemotherapy Start of enrollment: 2012 Oct 01
Completed
Using Walk With Ease Walking Program With Men 65 and Older Being Treated for Prostate Cancer Start of enrollment: 2013 Oct 01
Terminated
The Impact of a Physical Activity Program on Biomarkers of Aging During Chemotherapy for Breast Cancer Start of enrollment: 2014 Mar 01
Completed
Physical Activity Intervention for Older Patients During Chemotherapy for Colorectal Cancer Start of enrollment: 2014 Jun 01
Completed
Not Applicable
The Effect of Walking on Fatigue After Chemotherapy in Patients 65 and Older Start of enrollment: 2014 Jun 01
Completed
Not Applicable
Impact of Home-based Aerobic and Strength Exercises During Chemotherapy for Early Breast Cancer on Biomarkers of Aging Start of enrollment: 2018 Feb 28
Recruiting
Not Applicable
Early Intervention for Impairments Identified During Comprehensive Geriatric Assessment in Patients With Bladder Cancer Start of enrollment: 2020 Jan 21
Terminated
Not Applicable
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Publications & Presentations

PubMed

Quantifying Chemotherapy Delivery in Older and Younger Women With Early-Stage Breast Cancer Using Longitudinal Cumulative Dose.
Joyce Pak, Kirsten A Nyrop, Hyman B Muss, Moriah K Forster, Jennifer L Lund> ;The Oncologist. 2024 Apr 4
Geriatric assessment-guided interventions for older adults with multiple myeloma: A feasibility and acceptability study.
Deal, A., Nyrop, K., Logan, M., Mangieri, N., Strayhorn, M., Miller, J., Jensen, C., Muss, H., Lichtman, E., Rubinstein, S., Tuchman, S.> ;Journal of Geriatric Oncology. 2024 Mar 1
Falls prechemotherapy and toxicity-related hospitalization during adjuvant chemotherapy for breast cancer in older women: Results from the prospective multicenter HOPE...
Jingran Ji, Marie Bae, Can-Lan Sun, Tanya M Wildes, Rachel A Freedman, Allison Magnuson, Tracey O'Connor, Beverly Moy, Heidi D Klepin, Andrew E Chapman, William P Tew,...> ;Cancer. 2024 Mar 15
Age, Body Mass Index, Tumor Subtype, and Racial and Ethnic Disparities in Breast Cancer Survival.
Marla Lipsyc-Sharf, Karla V Ballman, Jordan D Campbell, Hyman B Muss, Edith A Perez, Lawrence N Shulman, Lisa A Carey, Ann H Partridge, Erica T Warner> ;JAMA Network Open. 2023 Oct 2
Clinician perspectives on patient-centered conversations about weight management with patients with early breast cancer.
Kirsten A Nyrop, Erin A Kelly, Randall Teal, Hyman B Muss, Marjory Charlot> ;Cancer. 2023 Sep 1
2 citations
Efficacy of a Dual-Epitope Dendritic Cell Vaccine as Part of Combined Immunotherapy for HER2-Expressing Breast Tumors.
Benjamin G Vincent, Danielle M File, Karen P McKinnon, Dominic T Moore, Jeffrey A Frelinger, Edward J Collins, Joseph G Ibrahim, Lisa Bixby, Shannon Reisdorf, Sonia J ...> ;Journal of Immunology. 2023 Jul 15
Survival in Older Japanese Adults With Advanced Cancer Before and After Implementation of a Geriatric Oncology Service.
Tomohiro F Nishijima, Mototsugu Shimokawa, Masato Komoda, Fumiyasu Hanamura, Yuta Okumura, Masaru Morita, Yasushi Toh, Taito Esaki, Hyman B Muss> ;JCO Oncology Practice. 2023 Dec 1
1 citations
Body mass index and patient-reported function, quality of life and treatment toxicity in women receiving adjuvant chemotherapy for breast cancer.
Kirsten A Nyrop, Jane Monaco, Sanah Vohra, Allison M Deal, William A Wood, Shlomit S Shachar, E Claire Dees, Gretchen G Kimmick, JoEllen C Speca, Hyman B Muss> ;Supportive Care in Cancer. 2023 Mar 2
2 citations
Toxicity risk score and clinical decline after adjuvant chemotherapy in older breast cancer survivors.
Jingran Ji, Can-Lan Sun, Harvey J Cohen, Hyman B Muss, Marie Bae, Mina S Sedrak> ;Journal of the National Cancer Institute. 2023 May 8
1 citations
Emergency department visits and hospitalizations in older women treated for early stage breast cancer.
Dillon C Cockrell, Allison M Deal, Emily M Damone, Hyman B Muss, Addison Brenizer, Kirsten A Nyrop> ;Journal of Geriatric Oncology. 2023 Mar 1
2 citations
A phase II single-arm trial of memantine for prevention of cognitive decline during chemotherapy in patients with early breast cancer: Feasibility, tolerability, accep...
Zev M Nakamura, Allison M Deal, Eliza M Park, Kate E Stanton, Yesy E Lopez, Laura J Quillen, Erin O'Hare Kelly, Hillary M Heiling, Kirsten A Nyrop, Emily M Ray, E Clai...> ;Cancer Medicine. 2023 Apr 1
Infrastructure to Support Accrual of Older Adults to National Cancer Institute Clinical Trials.
Gretchen Kimmick, Mina S Sedrak, Grant Williams, Nadine J McCleary, Ashley E Rosko, Jeffrey L Berenberg, Rachel A Freedman, Mary Lou Smith, Amina Ahmed, Hyman B Muss, ...> ;Journal of the National Cancer Institute. Monographs. 2022 Dec 15
1 citations
Treatment decision conversations, symptoms, and functional status in older adults with advanced cancer: An exploratory study utilizing mixed methods.
Lorinda A Coombs, Sarah Neller, Christina Wilson, Paul Mihas, Daniel Reuland, Hyman Muss, Kathi Mooney> ;Journal of Geriatric Oncology. 2023 Mar 1
1 citations
Cross-Sectional Analysis of Clinical Trial Availability and North Carolina Neighborhood Social Vulnerability.
Shakira J Grant, Matthew Jansen, Tzy-Mey Kuo, Samuel M Rubinstein, Tanya M Wildes, Sascha A Tuchman, Hyman B Muss, Eben I Lichtman, Marjory Charlot> ;JCO Oncology Practice. 2023 Feb 1
5 citations
Low-Intensity Adjuvant Chemotherapy for Breast Cancer in Older Women: Results From the Prospective Multicenter HOPE Trial.
Mina S Sedrak, Can-Lan Sun, Jingran Ji, Harvey J Cohen, Cary P Gross, William P Tew, Heidi D Klepin, Tanya M Wildes, Efrat Dotan, Rachel A Freedman, Tracey O'Connor, S...> ;Journal of Clinical Oncology. 2023 Jan 10
1 citations
Physical Activity Intervention in Patients with Metastatic Breast Cancer During Active Treatment: Quality of Life and Function.
Shlomit Strulov Shachar, Hillary Heiling, Hyman B Muss, Damone Meghan, Chad W Wagoner, Allison M Deal, Kirsten A Nyrop> ;The Oncologist. 2023 Jan 18
3 citations
Perspectives of older women with early breast cancer on telemedicine during post-primary treatment.
Caroline R Buse, Erin A O'Hare Kelly, Hyman B Muss, Kirsten A Nyrop> ;Supportive Care in Cancer. 2022 Dec 1
2 citations
Does walking during chemotherapy impact p16levels in women with early breast cancer.
Maria S Kammire, Allison M Deal, Emily M Damone, Vanessa Rosen, Kirsten A Nyrop, Natalia Mitin, Hyman B Muss> ;Journal of Clinical Laboratory Analysis. 2022 Dec 1
4 citations
Inflammation and Clinical Decline After Adjuvant Chemotherapy in Older Adults With Breast Cancer: Results From the Hurria Older Patients Prospective Study.
Jingran Ji, Can-Lan Sun, Harvey J Cohen, Timothy Synold, Hyman Muss, Mina S Sedrak> ;Journal of Clinical Oncology. 2023 Jan 10
5 citations
Comprehensive geriatric assessment: Valuation and patient preferences in older Japanese adults with cancer.
Tomohiro F Nishijima, Mototsugu Shimokawa, Taito Esaki, Masaru Morita, Yasushi Toh, Hyman B Muss> ;Journal of the American Geriatrics Society. 2023 Jan 1
3 citations
A biomarker of aging, p16, predicts peripheral neuropathy in women receiving adjuvant taxanes for breast cancer.
Natalia Mitin, Kirsten A Nyrop, Susan L Strum, Anne Knecht, Lisa A Carey, Katherine E Reeder-Hayes, E Claire Dees, Trevor A Jolly, Gretchen G Kimmick, Meghan S Karutur...> ;NPJ Breast Cancer. 2022 Sep 8
5 citations
Supporting Patients with Cancer after Dobbs v. Jackson Women's Health Organization.
Andrew G Shuman, Matti S Aapro, Benjamin Anderson, Katherine Arbour, Pedro C Barata, Aditya Bardia, Eduardo Bruera, Bruce A Chabner, Herbert Chen, Edwin Choy, Pierfran...> ;The Oncologist. 2022 Aug 13
1 citations
Physical Function, Psychosocial Status, and Symptom Burden Among Adults with Plasma Cell Disorders and Associations with Quality of Life.
Christopher E Jensen, Sanah N Vohra, Kirsten A Nyrop, Allison M Deal, Matthew R LeBlanc, Shakira J Grant, Hyman B Muss, Eben I Lichtman, Samuel M Rubinstein, William A...> ;The Oncologist. 2022 Aug 5
Age and competing concerns in treatment selection for women with non-metastatic HR+ and HER2- breast cancer: Current clinical practice.
Michael K Lorentsen, Sanah Vohra, Hyman B Muss, Emily Damone, Allison M Deal, Addison Tucker Brenizer, Kirsten A Nyrop> ;Journal of Geriatric Oncology. 2022 Jul 1
Impact of community-based exercise on fatigue in early breast cancer survivors: identifying potential determinants of change.
Chad W Wagoner, Jordan T Lee, Erik D Hanson, Zachary Y Kerr, Kirsten A Nyrop, Hyman B Muss, Claudio L Battaglini> ;Breast Cancer. 2022 Nov 1
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Journal Articles

Functional Decline and Resilience in Older Women Receiving Adjuvant Chemotherapy for Breast Cancer
Aminah Jatoi, Antonio C Wolff, Harvey Jay Cohen, Rachel A Freedman, Gustav Magrinat, Julie Gralow, Gretchen Kimmick, Heidi D Klepin, Harold Burstein, Hyman Muss, Jeann..., Journal of the American Geriatrics Society

Press Mentions

Xeloda Still Inferior for Older Patients with Early Breast CancerJuly 31st, 2019
Cancer Patients, Doctors Find Healing, Health in ExerciseMay 3rd, 2019
Older Breast Cancer Patients Require Special ConsiderationSeptember 24th, 2017
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Grant Support

Cancer Center Calgb ParticipationNational Cancer Institute1998–2002
Core--Clinical Research ManagementNational Cancer Institute1997–2002
Modulation Of 5-FU Pharmacology By PALA And DipyridamoleNational Cancer Institute1994
Cccwfu Breast Cancer Research Program Planning GrantNational Cancer Institute1994
Modulation Of 5-FU Pharmacology By PALA &DipyridamoleNational Cancer Institute1993