IskraPusicMD

Oncology • Saint Louis, MO

Hematologic Oncology

Assistant Professor, Internal Medicine, Medical Oncology, Washington University School of Medicine

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Office
4921 Parkview Pl
7th Fl Siteman Cancer Center
Saint Louis, MO 63110
Phone+1 314-454-8339
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Education & Training

SUNY Downstate Health Sciences UniversityFellowship, Hematology and Medical Oncology, 2004 - 2007
SUNY Health Science Center at BrooklynResidency, Internal Medicine, 2001 - 2004
University of Zagreb Faculty of MedicineClass of 1997

Certifications & Licensure

IL State Medical License 2020 - 2026
MO State Medical License 2008 - 2025
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Decitabine Maintenance for Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndrome (MDS) Post Transplant Start of enrollment: 2009 Dec 01
Completed
Phase 1
Cytokine-induced Memory-like NK Cells in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) Start of enrollment: 2014 Aug 11
Terminated
Phase 1, Phase 2
Study of Melphalan HCl for Injection (Propylene Glycol-free), Carmustine, Etoposide, Cytarabine (BEAM Regimen) and Autologous Stem Cell Transplantation for Lymphoma Start of enrollment: 2014 Mar 19
Completed
Phase 2
Allogeneic or Haploidentical Stem Cell Transplant Followed By High-Dose Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Start of enrollment: 2014 Feb 28
Terminated
Phase 1
Non-inferiority Study of XM02 Filgrastim (Granix) and Filgrastim (Neupogen) in Combination With Plerixafor for Autologous Stem Cell Mobilization in Patients With Multiple Myeloma or Non-Hodgkin Lymphoma Start of enrollment: 2014 Aug 20
Completed
Phase 2
A Study of Granix to Disrupt the Bone Marrow Microenvironment in Patients With Multiple Myeloma Undergoing Autologous Transplantation Start of enrollment: 2015 Jan 20
Terminated
Phase 2
Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203) Start of enrollment: 2014 Aug 01
Completed
Phase 2
Phase I Study of Bortezomib With G-CSF for Stem Cell Mobilization in Patients With Multiple Myeloma Start of enrollment: 2015 Feb 20
Completed
Phase 1
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Publications & Presentations

PubMed

CML and the WHO: Why?
Ellin Berman, Neil P Shah, Michael Deninger, Jessica K Altman, Maria Amaya, Kebede Begna, Ravi Bhatia, Onyee Chan, Robert Collins, Peter Curtin, Daniel J DeAngelo, Mic...> ;Journal of Clinical Oncology. 2024 Mar 20
Chronic Myeloid Leukemia, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.
Neil P Shah, Ravi Bhatia, Jessica K Altman, Maria Amaya, Kebede H Begna, Ellin Berman, Onyee Chan, Joan Clements, Robert H Collins, Peter T Curtin, Daniel J DeAngelo, ...> ;Journal of the National Comprehensive Cancer Network. 2024 Feb 1
1 citations
Belumosudil and ruxolitinib combination for treatment of refractory chronic graft-versus-host disease.
Minor, C., DiPersio, J., Pusic, I., Lee, C., Veeraputhiran, M.> ;Bone Marrow Transplantation. 2024 Feb 1
1 citations
Anti-CD3/CD7 immunoconjugate (T-Guard) for severe, steroid-refractory GVHD: final report of BMT CTN 2002.
Gabrielle Meyers, Mehdi Hamadani, Michael Martens, Haris Ali, Patrice Chevallier, Hannah Choe, Andrew C Harris, Ernst Holler, Eric van Hooren, Willem Klaassen, Eric Le...> ;Bone Marrow Transplantation. 2023 Dec 1
Phase I-II Trial of Early Azacitidine after Matched Unrelated Donor Hematopoietic Cell Transplantation.
Ziheng Xu, Jaebok Choi, Matthew Cooper, Jeffrey King, Mark A Fiala, Jingxia Liu, Iskra Pusic, Rizwan Romee, Amanda Cashen, Meagan A Jacoby, Keith Stockerl-Goldstein, C...> ;Transplantation and Cellular Therapy. 2023 Nov 1
4 citations
Clonal hematopoiesis in survivors of childhood cancer.
Novetsky Friedman, D., Chan, I., Moskowitz, C., Li, S., Turner, K., Liu, J., Bouvier, N., Walsh, M., Spitzer, B., Kung, A., Berger, M., Cooper, M., Pusic, I., Uy, G., ...> ;Blood Advances. 2023 Aug 8
2 citations
Acute Graft-versus-Host Disease: An Update on New Treatment Options.
Dilan A Patel, Mallory Crain, Iskra Pusic, Mark A Schroeder> ;Drugs. 2023 Jul 1
3 citations
Patient-reported treatment response in chronic graft--host disease.
Annie Im, Iskra Pusic, Lynn Onstad, Carrie L Kitko, Betty K Hamilton, Amin M Alousi, Mary E Flowers, Stefanie Sarantopoulos, Paul Carpenter, Jennifer White, Sally Arai...> ;Haematologica. 2024 Jan 1
30 citations
SARS-CoV-2 Omicron boosting induces de novo B cell response in humans.
Paris, R. M., Wafaa B Alsoussi, Sameer Kumar Malladi, Julian Q Zhou, Zhuoming Liu, Baoling Ying, Wooseob Kim, Aaron J Schmitz, Tingting Lei, Stephen C Horvath, Alexand...> ;Nature. 2023 May 1
8 citations
Axatilimab for Chronic Graft-Versus-Host Disease After Failure of at Least Two Prior Systemic Therapies: Results of a Phase I/II Study.
Carrie L Kitko, Mukta Arora, Zachariah DeFilipp, Mohammad Abu Zaid, Antonio Di Stasi, Vedran Radojcic, Courtney B Betts, Lisa M Coussens, Michael L Meyers, Hope Qamoos...> ;Journal of Clinical Oncology. 2023 Apr 1
21 citations
SARS-CoV-2 Omicron boosting induces de novo B cell response in humans.
Wafaa B Alsoussi, Sameer K Malladi, Julian Q Zhou, Zhuoming Liu, Baoling Ying, Wooseob Kim, Aaron J Schmitz, Tingting Lei, Stephen C Horvath, Alexandria J Sturtz, Kath...> ;Biorxiv. 2022 Sep 22
17 citations
Letermovir Discontinuation at Day 100 After Allogeneic Stem Cell Transplant Is Associated With Increased CMV-Related Mortality.
Lawrence Wayne Liu, Alicia Yn, Feng Gao, Marissa Olson, Mallory Crain, Ramzi Abboud, Peter Westervelt, Camille Abboud, Ravi Vij, Keith Stockerl-Goldstein, Iskra Pusic,...> ;Transplantation and Cellular Therapy. 2022 Aug 1
139 citations
Germinal centre-driven maturation of B cell response to mRNA vaccination.
Wooseob Kim, Julian Q Zhou, Stephen C Horvath, Aaron J Schmitz, Alexandria J Sturtz, Tingting Lei, Zhuoming Liu, Elizaveta Kalaidina, Mahima Thapa, Wafaa B Alsoussi, A...> ;Nature. 2022 Apr 1
3 citations
Decitabine salvage for-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy.
Francesca Ferraro, Agata Gruszczynska, Marianna B Ruzinova, Christopher A Miller, Mary Elizabeth Percival, Geoffrey L Uy, Iskra Pusic, Meagan A Jacoby, Mathew J Christ...> ;Haematologica. 2022 Jul 1
50 citations
Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement.
Joerg Herrmann, Daniel Lenihan, Saro Armenian, Ana Barac, Anne Blaes, Daniela Cardinale, Joseph Carver, Susan Dent, Bonnie Ky, Alexander R Lyon, Teresa López-Fernández...> ;European Heart Journal. 2022 Jan 31
1 citations
Lessons learned from early closure of a clinical trial for steroid-refractory acute GVHD.
Gabrielle Meyers, Mehdi Hamadani, Michael Martens, Haris Ali, Hannah Choe, Peter Dawson, Andrew C. Harris, Eric van Hooren, Willem Klaassen, Eric S. Leifer, Margaret L...> ;Bone Marrow Transplantation. 2021 Nov 23
35 citations
Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy.
Melissa M. Berrien-Elliott, Michelle Becker-Hapak, Amanda F. Cashen, Miriam T. Jacobs, Pamela Wong, Mark P. Foster, Ethan McClain, Sweta Desai, Patrick Pence, Sarah Co...> ;Blood. 2021 Nov 19
13 citations
Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination
Wooseob Kim, Julian Q. Zhou, Alexandria J. Sturtz, Stephen Horvath, Aaron J. Schmitz, Tingting Lei, Elizaveta Kalaidina, Mahima Thapa, Wafaa B. Al Soussi, Alem Haile, ...> ;Biorxiv. 2021 Nov 2
7 citations
Combination of dociparstat sodium (DSTAT), a CXCL12/CXCR4 inhibitor, with azacitidine for the treatment of hypomethylating agent refractory AML and MDS.
Eric Huselton, Michael P. Rettig, Kirsten Campbell, Amanda F. Cashen, John F. DiPersio, Feng Gao, Meagan A. Jacoby, Iskra Pusic, Rizwan Romee, Mark A. Schroeder, Geoff...> ;Leukemia Research. 2021 Nov 1
8 citations
Initial therapy for chronic graft-versus-host disease: analysis of practice variation and failure-free survival.
Joseph Pidala, Lynn Onstad, Paul J. Martin, Betty K. Hamilton, Corey Cutler, Carrie L. Kitko, Paul A. Carpenter, George Chen, Mukta Arora, M.E. Flowers, Sally Arai, Am...> ;Blood Advances. 2021 Nov 23
Beyond ruxolitinib in steroid-refractory acute graft-versus-host disease
Catherine J. Lee, Iskra Pusic, Bipin N. Savani> ;British Journal of Haematology. 2021 Aug 16
59 citations
Standardizing Definitions of Hematopoietic Recovery, Graft Rejection, Graft Failure, Poor Graft Function, and Donor Chimerism in Allogeneic Hematopoietic Cell Transpla...
Mohamed A. Kharfan-Dabaja, Ambuj Kumar, Ernesto Ayala, Mahmoud Aljurf, Taiga Nishihori, Rebecca A. Marsh, Lauri Burroughs, Navneet S. Majhail, A. Samer Al-Homsi, Zaid ...> ;Transplantation and Cellular Therapy. 2021 Aug 1
8 citations
Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myel...
Pinkal Desai, Janice M. Brown, Saar Gill, Melham M. Solh, Luke P. Akard, Jack W. Hsu, Celalettin Ustun, Charalambos Andreadis, Olga Frankfurt, James M. Foran, John Lis...> ;Journal of Clinical Oncology. 2021 Jun 22
8 citations
Relevance of Plasma Matrix Metalloproteinase-9 for Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplantation.
Yoshihiro Inamoto, Paul J. Martin, Lynn Onstad, Guang-Shing Cheng, Kirsten M. Williams, Iskra Pusic, Vincent T. Ho, Mukta Arora, Joseph Pidala, Mary E.D. Flowers, Ted ...> ;Transplantation and Cellular Therapy. 2021 Sep 1
256 citations
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans.
Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M Rauseo, Aaron J. Schmitz, Lena Hansen, Alem Haile, Michael K. Klebert, Iskra Pusic, Jan...> ;Nature. 2021 May 24
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Abstracts/Posters

Updated Study Results of CX-01, an Inhibitor of CXCL12/CXCR4, and Azacitidine for the Treatment of Hypomethylating Agent Refractory AML and MDSClinically Relevant Abst...
Iskra Pusic, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

The Evolving Treatment Landscape for Patients with GvHD: More Options, More Decisions, Better Outcomes!
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Investigating the Effects of Clonal Hematopoiesis in Healthy Marrow and Blood Donors on the Outcomes of Recipients Following Hematopoietic Stem Cell Transplantation
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

Mild Covid-19 Gives Longer Lasting Immunity Than Previously Believed, Claims StudyMay 28th, 2021
$3.4 Million Aids Effort to Make a Better Flu VaccineFebruary 28th, 2019