IvanJFussMD

Pediatric Gastroenterology • Bethesda, MD

Pediatric Nutrition

National Institutes of Health

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Office
10 center DR
CRC Blg 5west-3864
Bethesda, MD 20892
Phone+1 301-496-9662

Fax+1 301-402-2240
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Education & Training

National Institutes of Health Clinical CenterFellowship, Allergy and Immunology, 1993 - 1995
Children's Hospital Los AngelesResidency, Pediatrics, 1987 - 1992
Westchester Medical CenterInternship, Transitional Year, 1986 - 1987
New York Medical CollegeClass of 1986

Certifications & Licensure

CA State Medical License 1988 - 2025
MD State Medical License 1993 - 2024

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2008

Clinical Trials

Immune Regulation in Ulcerative Colitis or Crohn s Disease Start of enrollment: 1998 Aug 07
Recruiting
Immune System and Gut Abnormalities in Patients With Common Variable Immunodeficiency With and Without Gastrointestinal Symptoms Start of enrollment: 2001 Apr 16
Completed
Bone Marrow Stromal Cells for Inflammatory Bowel Diseases Start of enrollment: 2013 Jan 27
Terminated
Phase 1
Study of Safety, Tolerability, and Efficacy of Ustekinumab for Symptomatic Gastrointestinal Inflammation Associated With Common Variable Immunodeficiency Start of enrollment: 2015 Oct 19
Completed
Phase 1, Phase 2
An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab Start of enrollment: 2017 Oct 30
Recruiting
Phase 1, Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Prospective evaluation of patients with non-cirrhotic portal hypertension: A single centre study.
Maria Mironova, Harish Gopalakrishna, Gracia Maria Viana Rodriguez, Jaha Norman-Wheeler, Shani Scott, Julian Hercun, Bernadette Redd, Nehna Abdul Majeed, Asif A Hitawa...> ;Alimentary Pharmacology & Therapeutics. 2024 Apr 17
7 citations
Nodular regenerative hyperplasia in X-linked agammaglobulinemia: An underestimated and severe complication
Cristiane J Nunes-Santos, Christopher Koh, Anjali Rai, Keith Sacco, Beatriz E. Marciano, David E. Kleiner, Jamie Marko, Jenna R.E. Bergerson, Michael Stack, Maria M. R...> ;The Journal of Allergy and Clinical Immunology. 2021 Jun 1
3 citations
Recurrent Nodular Regenerative Hyperplasia Following Liver Transplantation in Common Variable Immunodeficiency
Julian Hercun, Esha Parikh, David E. Kleiner, Ivan J. Fuss, Gulbu Uzel, Warren Strober, Christopher Koh, Steven M. Holland, Theo Heller> ;Hepatology. 2021 Feb 27
55 citations
Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β-mediated colitis.
Liming Mao, Atsushi Kitani, Eitaro Hiejima, Kim Montgomery-Recht, Wenchang Zhou, Ivan J. Fuss, Warren Strober> ;The Journal of Clinical Investigation. 2020 Apr 1
2 citations
Purification of T Cell Populations
Ivan J. Fuss> ;Current Protocols in Immunology. 2020 Mar 1
42 citations
RICK/RIP2 is a NOD2-independent nodal point of gut inflammation.
Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Toshiharu Sakurai, Yoriaki Komeda, Tomoyuki Nagai, Atsushi Kitani, Masaki Tajima, Ivan J. Fuss, Masatoshi Kudo, Warren St...> ;International Immunology. 2019 Sep 18
45 citations
CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont
Natalia Shulzhenko, Xiaoxi Dong, Dariia Vyshenska, Renee L. Greer, Manoj Gurung, Stephany Vasquez-Perez, Ekaterina Peremyslova, Stanislav V. Sosnovtsev, Martha Quezado...> ;Clinical Immunology. 2018 Dec 1
144 citations
The Role of NLRP3 and IL-1β in the Pathogenesis of Inflammatory Bowel Disease.
Liming Mao, Atsushi Kitani, Warren Strober, Ivan J. Fuss> ;Frontiers in Immunology. 2018 Nov 5
2 citations
Suppression effect on IFN‑γ of adipose tissue‑derived mesenchymal stem cells isolated from β2‑microglobulin‑deficient mice
Junko Masuda, Eiji Takayama, Tatsuo Ichinohe, Warren Strober, Masako Mizuno‑Kamiya, Tomokatsu Ikawa, Atsushi Kitani, Harumi Kawaki, Ivan J. Fuss, Hiroshi Kawamoto, Aki...> ;Experimental and Therapeutic Medicine. 2018 Nov 1
9 citations
Spleen and Liver Volumetrics as Surrogate Markers of Hepatic Venous Pressure Gradient in Patients With Noncirrhotic Portal Hypertension
Ohad Etzion, Varun Takyar, Victor Novack, Ahmed M. Gharib, Raissa Canales, Akeem Adebogun, Eric Matsumoto, Jason L. Eccleston, David E. Kleiner, Sergio D. Rosenzweig, ...> ;Hepatology Communications. 2018 Jul 16
83 citations
An increase in LRRK2 suppresses autophagy and enhances Dectin-1–induced immunity in a mouse model of colitis
Tetsuya Takagawa, Atsushi Kitani, Ivan J. Fuss, Beth Levine, Steven R. Brant, Inga Peter, Masaki Tajima, Shiro Nakamura, Warren Strober> ;Science Translational Medicine. 2018 Jun 6
59 citations
Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn’s disease
Liming Mao, Atsushi Kitani, Morgan Similuk, Andrew J. Oler, Lindsey Albenberg, Judith R. Kelsen, Atiye Aktay, Martha Quezado, Michael Yao, Kim Montgomery-Recht, Ivan J...> ;The Journal of Clinical Investigation. 2018 May 1
13 citations
Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities
Junko Masuda, Eiji Takayama, Warren Strober, Ayano Satoh, Yuji Morimoto, Yasuko Honjo, Tatsuo Ichinohe, Shin Ichi Tokuno, Toshiaki Ishizuka, Takahiro Nakata, Akifumi M...> ;Oncology Reports. 2017 Jul 1
89 citations
BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency
Behdad Afzali, Juha Grönholm, Jana Vandrovcova, Charlotte O'Brien, Hong-Wei Sun, Ine Vanderleyden, Fred P. Davis, Ahmad Khoder, Yu Zhang, Ahmed N. Hegazy, Alejandro V....> ;Nature Immunology. 2017 May 22
180 citations
Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism
Renee L. Greer, Xiaoxi Dong, Ana Carolina Franco de Moraes, Ryszard A. Zielke, Gabriel Fernandes, Ekaterina Peremyslova, Stephany Vasquez-Perez, Alexi A. Schoenborn, E...> ;Nature Communications. 2016 Nov 14
6 citations
Ataxia telangiectasia associated with nodular regenerative hyperplasia.
Ki Lee Milligan, Karen Schirm, Stephanie A. Leonard, Ashleigh A. Hussey, Anahita Agharahimi, David E. Kleiner, Ivan J. Fuss, Shilpa Lingala, Theo Heller, Sergio D. Ros...> ;Journal of Clinical Immunology. 2016 Sep 26
3 citations
Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting
Junko Masuda, Hiroshi Kawamoto, Warren Strober, Eiji Takayama, Akifumi Mizutani, Hiroshi Murakami, Tomokatsu Ikawa, Atsushi Kitani, Narumi Maeno, Tsukasa Shigehiro, Ay...> ;Applied Biochemistry and Biotechnology. 2016 Jul 12
430 citations
Experimental Models of Inflammatory Bowel Diseases
Patricia Kiesler, Ivan J. Fuss, Warren Strober> ;Cellular and Molecular Gastroenterology and Hepatology. 2015 Mar 1
16 citations
Dynamic changes in E-protein activity regulate T reg cell development
Ping Gao, Xiaojuan Han, Qi Zhang, Zhiqiong Yang, Ivan J. Fuss, Timothy G. Myers, Paul J. Gardina, Fuping Zhang, Warren Strober> ;The Journal of Experimental Medicine. 2014 Dec 15
62 citations
IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis
Ivan J. Fuss, Bharat H. Joshi, Zhiqiong Yang, Heba A. Degheidy, Stefan Fichtner-Feigl, Heitor Siffert Pereira de Souza, Florian Rieder, Franco Scaldaferri, Anja Schirb...> ;Gut. 2014 Nov 1
73 citations
Cellular and molecular mechanisms underlying NOD2 risk‐associated polymorphisms in Crohn's disease
Warren Strober, Naoki Asano, Ivan J. Fuss, Atsushi Kitani, Tomohiro Watanabe> ;Immunological Reviews. 2014 Jul 1
24 citations
Transcription of RORγt in developing Th17 cells is regulated by E-proteins
Fuping Zhang, Ivan J. Fuss, Zhiqiong Yang, Warren Strober> ;Mucosal Immunology. 2014 May 1
53 citations
NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.
Tomohiro Watanabe, Naoki Asano, Guangxun Meng, Kouhei Yamashita, Yasuyuki Arai, Toshiharu Sakurai, Masatoshi Kudo, Ivan J. Fuss, Atsushi Kitani, Tooru Shimosegawa, Tsu...> ;Mucosal Immunology. 2014 Mar 26
44 citations
Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice.
Sandra M. Blois, Gisela Sulkowski, Irene Tirado-González, James Warren, Nancy Freitag, Burghard F. Klapp, Daniel B. Rifkin, Ivan J. Fuss, Warren Strober, Gabriela S. D...> ;Mucosal Immunology. 2014 Mar 1
206 citations
Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection
John R. Grainger, Elizabeth A. Wohlfert, Ivan J. Fuss, Nicolas Bouladoux, Michael H. Askenase, Fanny Legrand, Lily Koo, Jason M. Brenchley, Iain D. C. Fraser, Yasmine ...> ;Nature Medicine. 2013 Jun 1
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IvanJFussMD

Dr. Fuss is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Viewing the full profile is available to verified healthcare professionals only.