Jae Joung, MD, Pathology, Charlestown, MA, Massachusetts General Hospital


Pathology Charlestown, MA

Clinical Pathology

Associate Professor of Pathology, Massachusetts General Hospital

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  • Office

    149 13th Street, Room 6019
    Molecular Pathology Unit, Massachusetts General Hospital
    Charlestown, MA 02129
    Phone(617) 726-5695
    Fax(617) 726-5684
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Education & Training

  • Massachusetts General Hospital
    Massachusetts General HospitalResidency, Anatomic and Clinical Pathology, 1996 - 1999
  • Harvard Medical School
    Harvard Medical SchoolClass of 1996
  • Harvard University
    Harvard UniversityPhD, Genetics, 1996
  • Harvard College
    Harvard CollegeAB, Biochemical Sciences, Magna Cum Laude, 1987

Certifications & Licensure

  • MA State Medical License
    MA State Medical License 2000 - 2019
  • American Board of Pathology Clinical Pathology

Awards, Honors, & Recognition

  • Elected Member American Association of University Pathologists (Pluto Society), 2013
  • Burroughs Wellcome Lecturer East Carolina University, 2013
  • The Jim & Ann Orr MGH Research Scholar Massachusetts General Hospital, 2011
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Publications & Presentations


Journal Articles

  • Defining CRISPR–Cas9 Genome-Wide Nuclease Activities with CIRCLE-Seq  
    Jae Joung, MD, Nature
  • Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo  
    Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR, Nat Biotechnol., 10/30/2014
  • Towards a functional understanding of variants for molecular diagnostics using genome editing  
    Tsai SQ, Iafrate AJ, Joung JK, Nat Med., 10/8/2014
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Books/Book Chapters


  • Precise Genome Editing Directed by ssODNs and TAL Effector Nucleases (TALENs) or RNA-guided Nucleases (RGNs).
    Tsai SQ, Reyon D, Khayter C, Fu Y, Maeder ML, Hwang WY, Peterson RT, Yeh JR, Sander J, Joung JK, Keystone Conference: Precision Genome Engineering and Synthetic Biology: Designing Genomes and Pathways (Selected for Oral Presentation), Breckenridge, CO, 1/1/2013
  • Precise Modification of Human Genes Directed by Single-stranded DNA Oligonucleotides and TALENs or RNA-guided Nucleases (RGNs).
    Tsai SQ, Reyon D, Khayter C, Joung JK, American Society of Gene and Cell Therapy Annual Meeting (Selected for Oral Presentation), Salt Lake City, UT, 1/1/2013
  • High-throughput gene editing in human cells enabled by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly of TALENs.
    Reyon D, Tsai SQ, Khayter C, Foden JA, Sander JD, Joung JK, American Society of Gene & Cell Therapy Annual Meeting (Selected for Oral presentation), Philadelphia, PA, 1/1/2012
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  • Targeted Genome and Epigenome Editing Using CRISPR-Cas and TALE Technologies 
    University of California Berkeley, CA - 1/1/2014
  • Targeted Genome & Epigenome Editing Technologies 
  • Targeted Genome & Epigenome Editing Using Engineered CRISPR & TALE Technologies 
    Nassau, Bahamas - 1/1/2014
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  • Studies of Prokaryotic Transcriptional Activator Synergy and Dimerization Specificity. (Thesis) 
    Joung JK, Harvard University
    Cambridge, MA - 1/1/1996

Hospital Affiliations