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Office
11475 MRB IV
2213 Garland Ave
Nashville, TN 37232Phone+1 615-343-8064- Is this information wrong?
Summary
- I am Professor of Pediatrics, Pathology, Microbiology and Immunology, Ann Scott Carell Chair, and Director of the Vanderbilt Vaccine Center. My laboratory has a broad portfolio of work in the area of human immunology and immune repertoires, with an aim to discovery of mechanisms important to development of new vaccines. We have worked in East and West Africa, and has research collaborations ongoing with investigators in Uganda, Democratic Republic of the Congo, Nigeria, Sri Lanka, Chile and other international sites. I am the Director of the Human Immunome Project, an ambitious effort to identify the sequence of all transcripts for adaptive immune receptors on the planet. I am an elected member of the National Academy of Medicine, and have been the recipient of a number of major investigator awards for research, including the Judson Daland Prize of the American Philosophical Society, the Oswald Avery Award of the IDSA, the E. Mead Johnson Award for Excellence in Pediatrics, the Outstanding Investigator Award of the American Federation for Medical Research, the Norman J. Siegel Award of the American Pediatric Society and the inaugural Merck Future Insight Prize. I am an elected Fellow of AAM, AAAS, ASCI and AAP, IDSA, APS and others.
Education & Training
- University of North Carolina HospitalsResidency, Pediatrics, 1987 - 1990
- University of North Carolina at Chapel Hill School of MedicineClass of 1987
- Davidson CollegeBS, Pre-Med, Magna Cum Laude, 1983
Certifications & Licensure
- TN State Medical License 1995 - 2025
- NC State Medical License 1989 - 1999
- American Board of Pediatrics Pediatric Infectious Diseases
Awards, Honors, & Recognition
- Future Insight Prize Merck KGaA, 2019
- Distinguished Medical Alumnus Award UNC School of Medicine, Chapel Hill, NC, 2018
- Samuel Rosenthal Prize for Excellence in Academic Pediatrics Samuel Rosenthal Foundation, 2017
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Publications & Presentations
PubMed
- Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin.Rodrigo I Santos, Philipp A Ilinykh, Colette A Pietzsch, Adam J Ronk, Kai Huang, Natalia A Kuzmina, Fuchun Zhou, James E Crowe, Alexander Bukreyev> ;Cell Reports. 2023 Oct 31
- 13 citationsComputationally Designed Cyclic Peptides Derived from an Antibody Loop Increase Breadth of Binding for Influenza VariantsAlexander M. Sevy, Iuliia M. Gilchuk, Benjamin P. Brown, Nina G. Bozhanova, Rachel S. Nargi, Mattie Jensen, Jens Meiler, James E. Crowe> ;Structure. 2020 Oct 6
- 7 citationsIdentification of Structurally Related Antibodies in Antibody Sequence Databases Using Rosetta-Derived Position-Specific ScoringJessica A. Finn, Jinhui Dong, Alexander M. Sevy, Erica H Parrish, Iuliia M. Gilchuk, Rachel S. Nargi, Morgan Scarlett-Jones, Walter Reichard, Robin G. Bombardi, Thomas...> ;Structure. 2020 Aug 11
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Journal Articles
- Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesisHotard AL, Lee S, Currier MG, Crowe JE Jr, Sakamoto K, Newcomb DC, Peebles RS Jr, Plemper RK, Moore ML, Journal of Virology, 1/1/2015
- Mechanism of human antibody-mediated neutralization of Marburg virusFlyak, AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdht ZA, Slaughter JC, Sapparapu G, Ksiazek TG, Ward AB, Ollmann Saphire E, Bukreyev A..., Cell, 1/1/2015
- Structural basis for Marburg and Ebola virus cross-reactivity by a human survivor antibodyHashiguchi T, Fusco ML, Bornholdht ZA, Lee JE, Murin CD, Flyak AI, Li S, Matsuoka R, Kohda D, Yanagi Y, Sanner M, Ward AB, Crowe JE Jr, Ollmann Saphire E, Cell, 1/1/2015
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Books/Book Chapters
Abstracts/Posters
- Development of Vaccines Against Diseases Caused by Respiratory Syncytial Virus and Parainfluenza Type 3 VirusCrowe JE Jr, World Health Organization meeting, Geneva, Switzerland, 1992; Nyon, Switzerland, 1994, 1/27/1994
- Modern Approaches to New Vaccines Including Prevention of AIDSCrowe JE Jr, Cold Spring Harbor, NY, 1/20/1993
- The Protective and Disease Enhancing Immune Response to RSVCrowe JE Jr, World Health Organization / National Institutes of Health / Centers for Disease Control Meeting, Bethesda, MD, 1/26/1993
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Lectures
- InfluenzaSan Diego, CA - 1/1/2012
- Correlates of Protection against Disease Caused by Virus InfectionSan Diego, CA - 1/1/2012
- Neutralizing antibodies to virusesBoston, MA - 1/1/2011
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Other
- This Week in VirologyCrowe JE Jr, podcast
http://www.twiv.tv/2015/04/12/twiv-332/
1/1/2015 - Children’s Health CrisisCrowe JE Jr, Nashville Public Television
1/1/2012 - Epitope mapping of neutralizing antibodies to pathogenic viruses: A critical tool for rational vaccine design and evaluationCrowe JE Jr
1/9./2015
Press Mentions
- VUMC in the News, July 5, 2022July 1st, 2022
- Covid-19 Antibody Cocktail Trials Employ Varied Variant-Tracking Strategies, but Data Lag Expected Given Focus on Clinical OutcomesMay 19th, 2021
- CDC Grants $61.7M to State for Vaccine EffortsApril 6th, 2021
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Professional Memberships
- Fellow
- American Society of MicrobiologyFellow
- American Society for VirologyMember
- Society for Pediatric ResearchMember
- American Association of ImmunologistsMember
- American Society for Clinical InvestigationFellow
- Association of American PhysiciansFellow
- American Pediatric SocietyFellow
- American Association for the Advancement of ScienceFellow
- American Academy of MicrobiologyFellow
- International Society for VaccinesMember
- Society for Mucosal ImmunologyMember
- The Antibody SocietyMember
- International Society for Infectious DiseasesMember
- Fellow
Hospital Affiliations
- Vanderbilt University Medical CenterNashville, Tennessee
- Monroe Carell Jr. Childrens HospitalNashville, Tennessee
Industry Relationships
- Founder, IDBiologicsBiotech focused on antibody discovery2017 - Present
- Scientific Advisory Board, Rensavir2015 - Present
- Scientific Advisory Board, Melissa Vaccines, IncVaccine company2015 - Present
- Scientific Advisory Board, GigaGenCompany focused on advanced technology using immune repertoires2015 - Present
- Scientific Advisory Board, CompuVaxVaccine company focused on computationally designed vaccines2014 - Present
- Scientific Advisory Board, PaxVaxVaccine company2014 - Present
- Founder, Corbeau BiotechBiotech focused on human antibodies for infectious diseases2010 - 2016
External Links
- Crowelabhttp://crowelab.org
- Vanderbilt Vaccine Centerhttp://vvcenter.org
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