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James Crowe, MD, Pediatric Infectious Disease, Nashville, TN, Vanderbilt University Medical Center

JamesCroweMD

Pediatric Infectious Disease • Nashville, TN

Professor, Pediatrics, Vanderbilt University School of Medicine

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Summary

  • I am Professor of Pediatrics, Pathology, Microbiology and Immunology, Ann Scott Carell Chair, and Director of the Vanderbilt Vaccine Center. My laboratory has a broad portfolio of work in the area of human immunology and immune repertoires, with an aim to discovery of mechanisms important to development of new vaccines. We have worked in East and West Africa, and has research collaborations ongoing with investigators in Uganda, Democratic Republic of the Congo, Nigeria, Sri Lanka, Chile and other international sites. I am the Director of the Human Immunome Project, an ambitious effort to identify the sequence of all transcripts for adaptive immune receptors on the planet. I am an elected member of the National Academy of Medicine, and have been the recipient of a number of major investigator awards for research, including the Judson Daland Prize of the American Philosophical Society, the Oswald Avery Award of the IDSA, the E. Mead Johnson Award for Excellence in Pediatrics, the Outstanding Investigator Award of the American Federation for Medical Research, the Norman J. Siegel Award of the American Pediatric Society and the inaugural Merck Future Insight Prize. I am an elected Fellow of AAM, AAAS, ASCI and AAP, IDSA, APS and others.

    • Unraveling the Mystery of Immunity | Dr. James Crowe, Jr. | TEDxNashville

    World pandemics of infection are occurring at an ever increasing pace - bird flu, SARS, MERS, chikungunya, Ebola, Zika viruses. Which is the bigger foe, the wor

    Researchers characterize antibodies that block H5N1 influenza viral transmission

    H5N1 avian influenza is a highly pathogenic virus that has been responsible for several outbreaks of bird flu in humans over the past decade.

    Vanderbilt Researchers Develop Potential Treatment for Chikungunya

    In late 2013 the Caribbean had its first case of the mosquito-bourne chikungunya virus. Vanderbilt researchers race for the cure.

    Vanderbilt researchers Isolate Ebola-Fighting Human Antibodies for Possible Trea

    Vanderbilt University researchers in Nashville have isolated Ebola-fighting human antibodies - the first of its kind - that could lead to a new treatment.

Education & Training

  • University of North Carolina Hospitals
    University of North Carolina HospitalsResidency, Pediatrics, 1987 - 1990
  • University of North Carolina at Chapel Hill School of Medicine
    University of North Carolina at Chapel Hill School of MedicineClass of 1987
  • Davidson College
    Davidson CollegeBS, Pre-Med, Magna Cum Laude, 1983

Certifications & Licensure

  • TN State Medical License
    TN State Medical License 1995 - 2025
  • NC State Medical License
    NC State Medical License 1989 - 1999
  • American Board of Pediatrics Pediatric Infectious Diseases

Awards, Honors, & Recognition

  • Future Insight Prize Merck KGaA, 2019
  • Distinguished Medical Alumnus Award UNC School of Medicine, Chapel Hill, NC, 2018
  • Samuel Rosenthal Prize for Excellence in Academic Pediatrics Samuel Rosenthal Foundation, 2017
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Publications & Presentations

PubMed

Journal Articles

  • Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis  
    Hotard AL, Lee S, Currier MG, Crowe JE Jr, Sakamoto K, Newcomb DC, Peebles RS Jr, Plemper RK, Moore ML, Journal of Virology, 1/1/2015
  • Mechanism of human antibody-mediated neutralization of Marburg virus  
    Flyak, AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdht ZA, Slaughter JC, Sapparapu G, Ksiazek TG, Ward AB, Ollmann Saphire E, Bukreyev A..., Cell, 1/1/2015
  • Structural basis for Marburg and Ebola virus cross-reactivity by a human survivor antibody  
    Hashiguchi T, Fusco ML, Bornholdht ZA, Lee JE, Murin CD, Flyak AI, Li S, Matsuoka R, Kohda D, Yanagi Y, Sanner M, Ward AB, Crowe JE Jr, Ollmann Saphire E, Cell, 1/1/2015
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Books/Book Chapters

  • Antibodies for Infectious Diseases 
    Editors: Crowe JE Jr, Boraschi D, Rappuoli R.ASM Press, Washington, DC2015
  • Antibodies for Infectious Diseases 
    Chapter: Use of human hybridoma technology to isolate human monoclonal antibodies 
    Smith SA, Crowe JE JrEditors: Crowe JE Jr, Boraschi D, Rappuoli R.ASM PressEdition 1st,2015
  • Methods in Molecular Biology: Human Respiratory Syncytial Virus: Methods and Protocols 
    Chapter: Development of human monoclonal antibodies against respiratory syncytial virus using a high efficiency human hybridoma technique 
    Alvarado G, Crowe JE JrEditors: R.A. Tripp and P. Jorquera.Humana Press2015
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Abstracts/Posters

  • Development of Vaccines Against Diseases Caused by Respiratory Syncytial Virus and Parainfluenza Type 3 Virus
    Crowe JE Jr, World Health Organization meeting, Geneva, Switzerland, 1992; Nyon, Switzerland, 1994, 1/27/1994
  • Modern Approaches to New Vaccines Including Prevention of AIDS
    Crowe JE Jr, Cold Spring Harbor, NY, 1/20/1993
  • The Protective and Disease Enhancing Immune Response to RSV
    Crowe JE Jr, World Health Organization / National Institutes of Health / Centers for Disease Control Meeting, Bethesda, MD, 1/26/1993
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Lectures

  • Influenza 
    San Diego, CA - 1/1/2012
  • Correlates of Protection against Disease Caused by Virus Infection 
    San Diego, CA - 1/1/2012
  • Neutralizing antibodies to viruses 
    Boston, MA - 1/1/2011
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Other

  • This Week in Virology 
    Crowe JE Jr, podcast
    http://www.twiv.tv/2015/04/12/twiv-332/
    1/1/2015
  • Children’s Health Crisis 
    Crowe JE Jr, Nashville Public Television
    1/1/2012
  • Epitope mapping of neutralizing antibodies to pathogenic viruses: A critical tool for rational vaccine design and evaluation 
    Crowe JE Jr
    1/9./2015

Press Mentions

  • VUMC in the News, July 5, 2022
    VUMC in the News, July 5, 2022July 1st, 2022
  • Covid-19 Antibody Cocktail Trials Employ Varied Variant-Tracking Strategies, but Data Lag Expected Given Focus on Clinical Outcomes
    Covid-19 Antibody Cocktail Trials Employ Varied Variant-Tracking Strategies, but Data Lag Expected Given Focus on Clinical OutcomesMay 19th, 2021
  • CDC Grants $61.7M to State for Vaccine Efforts
    CDC Grants $61.7M to State for Vaccine EffortsApril 6th, 2021
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Professional Memberships

  • Infectious Disease Society of America - IDSA
    Fellow
  • American Society of Microbiology
    Fellow
  • American Society for Virology
    Member
  • Society for Pediatric Research
    Member
  • American Association of Immunologists
    Member
  • American Society for Clinical Investigation
    Fellow
  • Association of American Physicians
    Fellow
  • American Pediatric Society
    Fellow
  • American Association for the Advancement of Science
    Fellow
  • American Academy of Microbiology
    Fellow
  • International Society for Vaccines
    Member
  • Society for Mucosal Immunology
    Member
  • The Antibody Society
    Member
  • International Society for Infectious Diseases
    Member
  • Infectious Disease Society of America - IDSA
    Fellow

Hospital Affiliations

Industry Relationships

  • Founder, IDBiologicsBiotech focused on antibody discovery2017 - Present
  • Scientific Advisory Board, Rensavir2015 - Present
  • Scientific Advisory Board, Melissa Vaccines, IncVaccine company2015 - Present
  • Scientific Advisory Board, GigaGenCompany focused on advanced technology using immune repertoires2015 - Present
  • Scientific Advisory Board, CompuVaxVaccine company focused on computationally designed vaccines2014 - Present
  • Scientific Advisory Board, PaxVaxVaccine company2014 - Present
  • Founder, Corbeau BiotechBiotech focused on human antibodies for infectious diseases2010 - 2016

External Links

Dr. James Crowe, Dr. James Crowe, MD, Dr. J Crowe