James L. Kirkland MD

PubMed

• Foundations and Strategic Vision of the Canadian Translational Geroscience Network.
  Guy Hajj-Boutros, Andréa Faust, John Muscedere, Perry Kim, Gilles Gouspillou
  The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2025-06-10
• 7 citations
  Cellular senescence promotes macrophage-to-myofibroblast transition in chronic ischemic renal disease.
  Yu Zhao, Xiang-Yang Zhu, Wenqi Ma, Ying Zhang, Fei Yuan
  Cell Death & Disease. 2025-05-10
• 2 citations
  Senescence profiling of monoclonal gammopathies reveals paracrine senescence as a crucial defense against disease progression.
  Gabriel Alvares Borges, Marta Diaz-delCastillo, Angelo J Guilatco, Bilal Mohamad El-Masri, Fatima A Mustapha
  Leukemia. 2025-05-01

Journal Articles

• Therapeutic Approaches to Aging—Reply  
  James Kirkland, MD, JAMA
• Aging, Cell Senescence, and Chronic DiseaseEmerging Therapeutic Strategies  
  James Kirkland, MD, JAMA
• Senolytics Improve Physical Function and Increase Lifespan in Old Age  
  James L Kirkland, Nathan K LeBrasseur, S John Weroha, Vesna D Garovic, Sundeep Khosla, Allyson K Palmer, Nature

Books/Book Chapters

• Handbook of the biology of aging. 
  Chapter: Aging and adipose tissue. 
  Page 119 - 139Florido R, Tchkonia T, Kirkland JLEditors: Masoro EJ; Austad SN.Elsevier/AP, London; BurlingtonEdition 7,2011
• Adipose Tissue in Health and Disease. 
  Chapter: The Cellular, Molecular Basis of Functional Differences Among Fat Depots. 
  Page 21 - 47Thomou T, Tchkonia T, Kirkland JLEditors: Granneman JG, Leff T.Wiley-VCH2010
• Overweight and the metabolic syndrome: from bench to bedside. Volume 26. (Endocrine updates.) 
  Chapter: Current views of the fat cell as an endocrine cell: lipotoxicity. 
  Page 105 - 118Tchkonia T, Corkey BE, Kirkland JL2006

Abstracts/Posters

• Aging, inflammation and skeletal muscle.
  White TA, Zhu Y, Giorgadze N, Tchkonia T, Kirkland JL, LeBrasseur NK, FASEB J, 1/1/2012
• Establishment of an in vitro assay for high-throughput screening of pro-adipogenic agents.
  Kling R, Ravuri S, Lin YC, Bechtel J, Gough A, Philips B, Kirkland J, Marra K, Fernstrom J, Rubin P, Journal Of Tissue Engineering And Regenerative Medicine, 1/1/2012
• Senescent Cells Compromise Fat Tissue Function.
  Xu M, Zhu Y, Pirtskhalava T, Giorgadze N, Baker DJ, Jensen MD, van Deursen J, Tchkonia T, Kirkland JL, J Tissue Eng Regen Med, 1/1/2012

Lectures

• Translating Advances from the Basic Biology of Aging into Clinical Application: Opportunities and Challenges 
  Basel, Switzerland - 1/1/2014
• Obesity, Weight Loss, Diabetes, and Cellular Senescence in Seniors: Opportunities for Intervention 
  Bethesda, MD - 1/1/2014
• Molecular Basis of Organ Systems Diseases Course (GMSMM-707) 
  Boston University Graduate School, Boston, MA - 1/1/2014

Other

• Transgenic Animals Capable of Being Induced to Delete Senescent Cells 
  van Deursen J, Kirkland JL, Tchkonia T, Baker D, US 43613
  1/1/2012
• Human preadipocyte cell strains and uses therefore. 
  Kirkland JL, Tchkoniai TT, US 31635
  1/1/2002
• Human adipocyte cell populations and methods for identifying modulators of same. US Provisional Patent 
  Kirkland JL, US 377500
  1/1/2002