James(J.T.)LinkMDPhD

PubMed

• Immunotherapy Progress in Mismatch Repair-Deficient Colorectal Cancer and Future Therapeutic Challenges.
  Link JT, Overman MJ> ;Cancer journal (Sudbury, Mass.).
• 48 citations
  Discovery and Metabolic Stabilization of Potent and Selective 2-Amino-N-(adamant-2-yl) Acetamide 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors
  Rohde Jeffrey J, Marina A. Pliushchev, Bryan K. Sorensen, Dariusz Wodka, Qi Shuai, Jiahong Wang, Steven Fung, Katina Monzon, William J. Chiou, Liping Pan, Xiaoqing Den...> ;Journal of Medicinal Chemistry. 2007 Jan 11
• 50 citations
  Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.
  Thomas W. von Geldern, Noah Tu, Philip R. Kym, J.T. Link, Jae Hwan-Soo, Chunqiu Lai, Theresa Apelqvist, Patrik Rhönnstad, Lars Hagberg, Konrad F. Koehler, Marlena Gryn...> ;Journal of Medicinal Chemistry. 2004 Aug 12
• 20 citations
  Biaryl amide glucagon receptor antagonists.
  Ravi Kurukulasuriya, James T. Link, Jyoti R. Patel, Jae Hwan-Soo, M. Winn, Jeffrey R Rohde, Nelson Grihalde, Chun W Lin, Christopher A. Ogiela, Andrew L. Adler, Christ...> ;Bioorganic & Medicinal Chemistry Letters. 2004 May 3
• Pharmacological regulation of hepatic glucose production.
  Link JT> ;Current opinion in investigational drugs (London, England : 2000).
• 78 citations
  Enantioselective total synthesis of quadrigemine C and psycholeine.
  Alec D. Lebsack, J. T. Link, Larry E. Overman, Brian A. Stearns> ;Journal of the American Chemical Society. 2002 Jul 10
• 24 citations
  Stereoselection in the prins-pinacol synthesis of 2,2-disubstituted 4-acyltetrahydrofurans. Enantioselective synthesis of (-)-citreoviral.
  Naoyuki Hanaki, J. T. Link, David W. C. MacMillan, Larry E. Overman, William G. Trankle, Julie A. Wurster> ;Organic Letters. 2000 Jan 27
• 28 citations
  Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.
  J.T. Link, Bryan Sorensen, Jyoti R. Patel, Marlena Grynfarb, Annika Goos-Nilsson, Jiahong Wang, Steven Fung, Denise Wilcox, Brad Zinker, Phong Nguyen, Bach Hickman, Ja...> ;Journal of Medicinal Chemistry. 2005 Jul 13
• 2 citations
  Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator
  Noah Tu, J.T. Link, Bryan K. Sorensen, Maurice Emery, Marlena Grynfarb, Annika Goos-Nilsson, Bach Nguyen> ;Bioorganic & Medicinal Chemistry Letters. 2004 Aug 16
• 11 citations
  Synthesis, activity, metabolic stability, and pharmacokinetics of glucocorticoid receptor modulator–statin hybrids
  J.T. Link, Bryan K. Sorensen, Chunqiu Lai, Jiahong Wang, Steven Fung, Daisy Deng, Maurice Emery, Sherry Carroll, Marlena Grynfarb, Annika Goos-Nilsson, Thomas W. von G...> ;Bioorganic & Medicinal Chemistry Letters. 2004 Aug 16
• Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators.
  Link JT, Sorensen BK, Patel J, Arendsen D, Li G, Swanson S, Nguyen B, Emery M, Grynfarb M, Goos-Nilsson A> ;Bioorganic & medicinal chemistry letters.
• Discovery of novel nonsteroidal glucocorticoid receptor modulators.
  Link JT, Sorensen BK, Patel J, Emery M, Grynfarb M, Goos-Nilsson A> ;Bioorganic & medicinal chemistry letters.
• 9 citations
  An evaluation of a C-glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist.
  Bryan K. Sorensen, J.T. Link, Thomas W. von Geldern, Maurice Emery, Jiahong Wang, Bach Hickman, Marlena Grynfarb, Annika Goos-Nilsson, Sherry Carroll> ;Bioorganic & Medicinal Chemistry Letters. 2003 Jul 21
• 66 citations
  Potential Drug Targets and Progress Towards Pharmacologic Inhibition of Hepatic Glucose Production
  James T. Link, David Madar, Z. Pei, S. J. Richards, Rohde Jeffrey J, A. J. Souers, Bruce G. Szczepankiewicz> ;Current Medicinal Chemistry. 2003 Jan 1
• 46 citations
  Prospects for pharmacologic inhibition of hepatic glucose production.
  James T. Link, David Madar, Z. Pei, Rohde Jeffrey J, S. J. Richards, A. J. Souers, Bruce G. Szczepankiewicz> ;Current Medicinal Chemistry. 2003 Jan 1
• 13 citations
  Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relation...
  Zhonghua Pei, Zhili Xin, Gang Liu, Yihong Li, Edward B. Reilly, Nathan L. Lubbers, Jeffery R. Huth, J.T. Link, Thomas W. von Geldern, Bryan F. Cox, Sandra Leitza, Yi G...> ;Journal of Medicinal Chemistry. 2001 Aug 2
• Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists.
  Link JT, Sorensen B, Liu G, Pei Z, Reilly EB, Leitza S, Okasinski G> ;Bioorganic & medicinal chemistry letters.
• 87 citations
  Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of ...
  Gang Liu, J.T. Link, Zhonghua Pei, Edward B. Reilly, Sandra Leitza, Bach Nguyen, Kennan C. Marsh, Gregory F. Okasinski, Thomas W. von Geldern, Mark Ormes, and Kerry Fo...> ;Journal of Medicinal Chemistry. 2000 Oct 19
• 71 citations
  The oncologic burden of hepatitis C virus infection: A clinical perspective.
  Harrys A. Torres, Terri Lynn Shigle, James T. Link, Felipe Samaniego, Ahmed Kaseb, Vincent Mallet> ;CA. 2017 Sep 1
• 15 citations
  Relationship between Body Mass Index and Insulin Resistance in Patients Treated with Second Generation Antipsychotic Agents
  Sun H. Kim, Lilla Nikolics, Fahim Abbasi, James T. Link, Gerald M. Reaven, Steven E. Lindley> ;Journal of Psychiatric Research. 2010 Jun 1
• 36 citations
  Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.
  Jyoti R. Patel, Qi Shuai, Jürgen Dinges, M. Winn, Marina A. Pliushchev, Steven Fung, Katina Monzon, William J. Chiou, Jiahong Wang, Liping Pan, Seble Wagaw, Kenneth M....> ;Bioorganic & Medicinal Chemistry Letters. 2007 Feb 1
• 45 citations
  Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
  Bryan K. Sorensen, Martin Winn, Jeff Rohde, Qi Shuai, Jiahong Wang, Steven Fung, Katina Monzon, William J. Chiou, DeAnne Stolarik, Hovis M. Imade, Liping Pan, Xiaoqing...> ;Bioorganic & Medicinal Chemistry Letters. 2007 Jan 15
• 17 citations
  Discovery of potent and selective inhibitors of 11β-HSD1 for the treatment of metabolic syndrome
  Richards Steven J, Bryan K. Sorensen, Jae Hwan-Soo, M. Winn, Yixian Chen, Jiahong Wang, Steven Fung, Katina Monzon, Ernst U. Frevert, Peer B. Jacobson, Hing L. Sham, J...> ;Bioorganic & Medicinal Chemistry Letters. 2006 Dec 15
• 23 citations
  Adamantane 11-β-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction
  Bryan K. Sorensen, Jeff Rohde, Jiahong Wang, Steven Fung, Katina Monzon, William J. Chiou, Liping Pan, Xiaoqing Deng, DeAnne Stolarik, Ernst U. Frevert, Peer B. Jacobs...> ;Bioorganic & Medicinal Chemistry Letters. 2006 Dec 1
• 17 citations
  Discovery of orally active butyrolactam 11β-HSD1 inhibitors
  Vince Yeh, Ravi Kurukulasuriya, Steven Fung, Katina Monzon, William Chiou, Jiahong Wang, DeAnne Stolarik, Hovis M. Imade, Robin Shapiro, Victoria Knourek-Segel, Eugene...> ;Bioorganic & Medicinal Chemistry Letters. 2006 Nov 1
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Journal Articles

• A Method for Preparing C-Glycosides Related to Phlorizin  
  J. T. Link and B. K. Sorensen, Tetrahedron Letters, 2000
• Forming Cyclics with the Intramolecular Heck Reaction  
  J. T. Link and L. E. Overman, Chemtech, 1998
• Total Synthesis of Baccatin III and Taxol  
  S. J. Danishefsky, J. J. Masters, W. B. Young, J. T. Link, L. Snyder, T. V. Magee, D. K. Jung, R. C. A. Isaacs, W. G. Bornmann, C. A. Alaimo, C. A. Coburn, and M. J. D..., Journal of the American Chemical Society, 1996
• Staurosporine and ent-Staurosporine: The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles  
  J. T. Link, S. Raghavan, M. Gallant, S. J. Danishefsky, T. C. Chou, and L. M. Ballas, Journal of the American Chemical Society, 1996
• Stereocontrolled Total Syntheses of meso-Chimonanthine and meso-Calycanthine via a Novel Samarium Mediated Reductive Alkylation  
  J. T. Link and L. E. Overman, Journal of the American Chemical Society, 1996
• The First Total Synthesis of Staurosporine and ent-Staurosporine  
  J. T. Link, S. Raghavan, and S. J. Danishefsky, Journal of the American Chemical Society, 1995
• Transformations of a Baccatin III-Steroidal hybrid: Unique Reactivity Patterns in Oxidation and Reduction Reactions  
  W. B. Young, J. T. Link, J. J. Masters, L. B. Snyder, and S. J. Danishefsky, Tetrahedron Letters, 1995
• A Total Synthesis of Taxol  
  J. J. Masters, J. T. Link, L. B. Snyder, W. B. Young, and S. J. Danishefsky, Angewandte Chemie, Int. Ed. Engl., 1995
• Regioselective Imide Reduction: An Issue in the Total Synthesis of Staurosporine  
  J. T. Link and S. J. Danishefsky, Tetrahedron Letters, 1994
• Epoxides Derived from Pyranosyl Dienes: Unusually Stable Glycosyl Donors  
  J. T. Link, G. Schulte, and S. J. Danishefsky, Tetrahedron Letters, 1994
• A Stereoselective Synthesis of Indole-Beta-N-glycosides: An Application to the Synthesis of Rebeccamycin  
  M. Gallant, J. T. Link, and S. J. Danishefsky, J. Org. Chem., 1993
• The First Synthesis of a Fully Functionalized Core Structure of Staurosporine: Sequential Indolyl Glycosidation by Endo and Exo Glycals  
  J. T. Link, M. Gallant, and S. J. Danishefsky, J. Am. Chem. Soc., 1993
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Books/Book Chapters

• The Handbook of Organopalladium Chemistry for Organic Synthesis 
  Chapter: Synthesis of Natural Products via Carbopalladation 
  Page 1523 - 1560J.T. LinkEditors: Ei-ichi Negishi.John Wiley & Sons, New York2002
• Organic Reactions 
  Chapter: The Intramolecular Heck Reaction 
  Page 157 - 534J.T. Link2002
• Metal Catalyzed Cross Coupling Reactions 
  Chapter: Intramolecular Heck Reactions in Natural Products Chemistry 
  J. T. Link and L. E. Overman1998

Lectures

• Suppression of Glucocorticoid Action for the Treatment of Metabolic Disease 
  Abbott Laboratories Lecture in Organic Chemistry at Northwestern University - 5/2006
• C-Glycosides in Antidiabetic Agent Discovery 
  225th National Meeting of the American Chemical Society in New Orleans, LA - 3/2003
• Total Syntheses of meso-Chimonanthine and meso-Calycanthine: a Remarkable Samarium-Mediated Reductive Alkylation 
  213th National Meeting of the American Chemical Society in San Francisco, CA - 4/1997
• The First Total Synthesis of Staurosporine and ent-Staurosporine 
  209th National Meeting of the American Chemical Society in Anaheim - 4/1995
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