JanaPortnowMD

Oncology • Duarte, CA

Hematologic Oncology, Neuro-Oncology

Physician

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Office
Medical Oncology and Therapeutics Research
1500 East Duarte Road
Duarte, CA 91010
Phone+1 626-256-4673

Fax+1 626-301-8233
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Education & Training

Johns Hopkins UniversityFellowship, Hematology and Medical Oncology, 1999 - 2002
Temple University HospitalResidency, Internal Medicine, 1994 - 1997
University of Rochester School of Medicine and DentistryClass of 1994

Certifications & Licensure

CA State Medical License 2002 - 2024
MD State Medical License 1998 - 2003
PA State Medical License 1995 - 1998
American Board of Internal Medicine Medical Oncology

Clinical Trials

Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer Start of enrollment: 2006 Dec 01
Active, not recruiting
Phase 3
High-Dose Methotrexate and Leucovorin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Start of enrollment: 2005 Jul 12
Completed
Phase 2
Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Start of enrollment: 2005 Jan 01
Completed
Phase 1
Temozolomide in Treating Patients With Primary Brain Tumors or Metastatic Brain Tumors Start of enrollment: 2006 Jan 01
Completed
Phase 1
Radiation Therapy, Arsenic Trioxide, and Temozolomide in Treating Patients With Newly Diagnosed High-Grade Glioma Start of enrollment: 2008 Apr 01
Completed
Phase 1
A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Start of enrollment: 2008 Jun 01
Completed
Phase 1
Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM) Start of enrollment: 2009 Jun 01
Completed
Phase 3
A Study of a Retroviral Replicating Vector Combined With a Prodrug Administered to Patients With Recurrent Malignant Glioma Start of enrollment: 2010 Jul 01
Completed
Phase 1
A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas Start of enrollment: 2010 Aug 01
Completed
Phase 1
Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases Start of enrollment: 2010 Dec 01
Completed
Phase 1
Imaging Trial With I-124-CLR1404 in Patients With Newly Diagnosed or Recurrent Glioblastoma Start of enrollment: 2014 Feb 01
Terminated
Phase 2
Phase 2 Study to Investigate the Efficacy and Safety of Aldoxorubicin in Subjects With Glioblastoma Start of enrollment: 2014 Mar 01
Completed
Phase 2
Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas Start of enrollment: 2014 Oct 07
Completed
Phase 1
Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas Start of enrollment: 2016 Mar 07
Active, not recruiting
Phase 1
HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases Start of enrollment: 2018 Aug 31
Recruiting
Phase 1
Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM Start of enrollment: 2020 Dec 08
Active, not recruiting
Not Applicable
Roles: Contact
Low Dose Versus Standard Dose Dexamethasone for Reduction of Swelling in Patients With Primary or Metastatic Brain Tumors Start of enrollment: 2022 Apr 09
Recruiting
Phase 2
Roles: Contact, Principal Investigator
Multiple Doses of Neural Stem Cell Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas Start of enrollment: 2023 May 02
Recruiting
Phase 1
Roles: Contact, Principal Investigator
Dexamethasone and Azeliragon for Management of Post-Resection Cerebral Edema in Patients With Glioblastoma Start of enrollment: 2024 Aug 15
Not yet recruiting
Phase 1
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Author Correction: Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial.
Christine E Brown, Jonathan C Hibbard, Darya Alizadeh, M Suzette Blanchard, Heini M Natri, Dongrui Wang, Julie R Ostberg, Brenda Aguilar, Jamie R Wagner, Jinny A Paul,...> ;Nature Medicine. 2024 Mar 21
3 citations
Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial.
Christine E Brown, Jonathan C Hibbard, Darya Alizadeh, M Suzette Blanchard, Heini M Natri, Dongrui Wang, Julie R Ostberg, Brenda Aguilar, Jamie R Wagner, Jinny A Paul,...> ;Nature Medicine. 2024 Apr 1
2 citations
NCCN CNS tumor guidelines update for 2023.
Burt Nabors, Jana Portnow, Jona Hattangadi-Gluth, Craig Horbinski> ;Neuro-Oncology. 2023 Dec 8
34 citations
NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022.
Craig Horbinski, Louis Burt Nabors, Jana Portnow, Joachim Baehring, Ankush Bhatia, Orin Bloch, Steven Brem, Nicholas Butowski, Donald M Cannon, Samuel Chao, Milan G Ch...> ;Journal of the National Comprehensive Cancer Network. 2023 Jan 1
120 citations
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A P...
Linda M Liau, Keyoumars Ashkan, Steven Brem, Jian L Campian, John E Trusheim, Fabio M Iwamoto, David D Tran, George Ansstas, Charles S Cobbs, Jason A Heth, Michael E S...> ;JAMA Oncology. 2023 Jan 1
41 citations
Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions.
Julie J Miller, L Nicolas Gonzalez Castro, Samuel McBrayer, Michael Weller, Timothy Cloughesy, Jana Portnow, Ovidiu Andronesi, Jill S Barnholtz-Sloan, Brigitta G Baume...> ;Neuro-Oncology. 2023 Jan 5
51 citations
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Nimish A Mohile, Hans Messersmith, Na Tosha Gatson, Andreas F Hottinger, Andrew Lassman, Jordan Morton, Douglas Ney, Phioanh Leia Nghiemphu, Adriana Olar, Jeffery Olso...> ;Journal of Clinical Oncology. 2022 Feb 1
4 citations
Multiple Treatment Cycles of Neural Stem Cell Delivered Oncolytic Adenovirus for the Treatment of Glioblastoma.
Jennifer Batalla-Covello, Hoi Wa Ngai, Linda Flores, Marisa McDonald, Caitlyn Hyde, Joanna Gonzaga, Mohamed Hammad, Margarita Gutova, Jana Portnow, Tim Synold, David T...> ;Cancers. 2021 Dec 16
33 citations
Phase I/II trial of palbociclib, pembrolizumab and letrozole in patients with hormone receptor-positive metastatic breast cancer.
Yuan Yuan, Jin Sun Lee, Susan E. Yost, Paul Frankel, Christopher Ruel, Colt Egelston, Weihua Guo, Simran Padam, Aileen Tang, Norma Martinez, Daniel Schmolze, Cary A. P...> ;European Journal of Cancer. 2021 Jul 1
61 citations
Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.
Jawad Fares, Atique Ahmed, Ilya V. Ulasov, Adam M. Sonabend, Jason Miska, Catalina Lee-Chang, Irina V. Balyasnikova, James P. Chandler, Jana Portnow, Matthew C. Tate, ...> ;The Lancet. Oncology. 2021 Aug 1
240 citations
Central Nervous System Cancers, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology
Louis B. Nabors, Jana Portnow, Manmeet Ahluwalia, Joachim Baehring, Henry Brem, Steven Brem, Nicholas Butowski, Jian Campian, Stephen W. Clark, Andrew J. Fabiano, Pete...> ;Journal of the National Comprehensive Cancer Network. 2020 Nov 2
24 citations
Systemic Anti-PD-1 Immunotherapy Results in PD-1 Blockade on T Cells in the Cerebrospinal Fluid
Jana Portnow, Dongrui Wang, M. Suzette Blanchard, Vivi Tran, Darya Alizadeh, Renate Starr, Ramsinh Dodia, Vivian Chiu, Alfonso Brito, Julie Kilpatrick, Paige McNamara,...> ;JAMA Oncology. 2020 Dec 1
7 citations
Feasibility of intracerebrally administering multiple doses of genetically modified neural stem cells to locally produce chemotherapy in glioma patients
Jana Portnow, Behnam Badie, M. Suzette Blanchard, Julie Kilpatrick, Revathiswari Tirughana, Marianne Z. Metz, Shu Mi, Vivi Tran, Julie A. Ressler, Massimo D'Apuzzo, Ka...> ;Cancer Gene Therapy. 2021 Apr 1
27 citations
Phase I clinical trial of the combination of eribulin and everolimus in patients with metastatic triple-negative breast cancer
Jin Sun Lee, Susan E. Yost, Suzette Blanchard, Daniel Schmolze, Hongwei Holly Yin, Raju Pillai, Kim Robinson, Aileen Tang, Norma Martinez, Jana Portnow, Wei Wen, John ...> ;Breast Cancer Research. 2019 Nov 8
25 citations
Quantitative Evaluation of Intraventricular Delivery of Therapeutic Neural Stem Cells to Orthotopic Glioma.
Margarita Gutova, Linda Flores, Vikram Adhikarla, Lusine Tsaturyan, Revathiswari Tirughana, Soraya Aramburo, Marianne Z. Metz, Joanna Gonzaga, Alexander J. Annala, Tim...> ;Frontiers in Oncology. 2019 Feb 19
9 citations
Correction: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma [J Transl Med., 16, (...
Linda M. Liau, Keyoumars Ashkan, David Tran, Jian Campian, John E. Trusheim, Charles S. Cobbs, Jason Heth, Michael Salacz, Sarah A. Taylor, Stacy D. D’Andre, Fabio M. ...> ;Journal of Translational Medicine. 2018 Jun 29
170 citations
First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma.
Linda M Liau, Keyoumars Ashkan, David D Tran, Jian L Campian, John E Trusheim, Charles S Cobbs, Jason A Heth, Michael Salacz, Sarah Taylor, Stacy D D'Andre, Fabio M Iw...> ;Journal of Translational Medicine. 2018 May 29
4 citations
Early Changes in Tumor Perfusion from T1-Weighted Dynamic Contrast-Enhanced MRI following Neural Stem Cell-Mediated Therapy of Recurrent High-Grade Glioma Correlate wi...
Prativa Sahoo, Paul Frankel, Julie A. Ressler, Margarita Gutova, Alexander J. Annala, Behnam Badie, Jana Portnow, Karen S. Aboody, Massimo D'Apuzzo, Russell C. Rockne> ;Stem Cells International. 2018 Mar 14
144 citations
Central nervous system cancers, version 1.2017 featured updates to the NCCN guidelines
Louis B. Nabors, Jana Portnow, Mario Ammirati, Joachim Baehring, Henry Brem, Nicholas Butowski, Robert A. Fenstermaker, Peter A. Forsyth, Jona A. Hattangadi-Gluth, Mat...> ;Journal of the National Comprehensive Cancer Network. 2017 Nov 1
194 citations
Regional Delivery of Chimeric Antigen Receptor–Engineered T Cells Effectively Targets HER2+ Breast Cancer Metastasis to the Brain
Saul J. Priceman, Dileshni Tilakawardane, Brook Jeang, Brenda Aguilar, John P. Murad, Anthony K. Park, Wen-Chung Chang, Julie R. Ostberg, Josh Neman, Rahul Jandial, Ja...> ;Clinical Cancer Research. 2018 Jan 1
1073 citations
Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
Christine E. Brown, Darya Alizadeh, Renate Starr, Weng L, Wagner, Araceli Naranjo, Ostberg, Melvin Blanchard, Kilpatrick J, Simpson J, Kurien A, Saul J. Priceman, Xiul...> ;The New England Journal of Medicine. 2016 Dec 28
97 citations
Neural Stem Cell–Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients
Jana Portnow, Timothy W. Synold, Behnam Badie, Revathiswari Tirughana, Simon F. Lacey, Massimo D'Apuzzo, Marianne Z. Metz, Joseph Najbauer, Victoria Bedell, Tien Vo, M...> ;Clinical Cancer Research. 2017 Jun 15
114 citations
Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma.
Lee A. Wheeler, Andrea G. Manzanera, Susan Bell, Robert Cavaliere, John M. McGregor, John C. Grecula, Herbert B. Newton, Simon S. Lo, Behnam Badie, Jana Portnow, Bin S...> ;Neuro-Oncology. 2015 Nov 1
112 citations
Central Nervous System Cancers, Version 1.2015 Featured Updates to the NCCN Guidelines
Louis B. Nabors, Jana Portnow, Mario Ammirati, Joachim Baehring, Henry Brem, Paul D. Brown, Nicholas Butowski, Marc C. Chamberlain, Robert A. Fenstermaker, Allan H. Fr...> ;Journal of the National Comprehensive Cancer Network. 2015 Oct 1
487 citations
Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma
Christine E. Brown, Behnam Badie, Michael E. Barish, Lihong Weng, Julie R. Ostberg, Wen-Chung Chang, Araceli Naranjo, Renate Starr, Jamie Wagner, Christine Wright, Yub...> ;Clinical Cancer Research. 2015 Sep 15
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Press Mentions

Northwest Biotherapeutics: Data Is Done, Just Wait for ApprovalNovember 23rd, 2022
Calidi Biotherapeutics Announces FDA Authorization of IND for a Phase 1 Clinical Trial of NeuroNova in Patients with Recurrent High-Grade GliomaAugust 2nd, 2022
Mustang Bio Announces $9.28 Million Grant to Fund Phase 1 Trial of CAR T Therapy MB-103August 13th, 2019
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Grant Support

Pilot Feasibility Dose Escalation Study Using Intracerebral MicrodialysisNational Center For Research Resources2009
A Pharmacokinetic And Pharmacogenomic Study Of Patients With High-GradeNational Center For Research Resources2008–2009
A Phase I Study Of Bortezomib And Temozolomide In Patients With Refractory SolidNational Center For Research Resources2006–2009
A Pilot Feasibility Study Of Intracerebral Microdialysis To Determine The NeuroNational Center For Research Resources2007–2008