JannNSarkariaMD

PubMed

• Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization.
  Jiajia Chen, Daniel J Laverty, Surabhi Talele, Ashwin Bale, Brett L Carlson, Kendra A Porath, Katrina K Bakken, Danielle M Burgenske, Paul A Decker, Rachael A Vaubel, ...> ;Science Translational Medicine. 2024 Feb 14
• 1 citations
  From the Operating Room to the Laboratory: Role of the Neuroscience Tissue Biorepository in the Clinical, Translational, and Basic Science Research Pipeline.
  Quiñones-Hinojosa, A., Basil, A., Moniz-Garcia, D., Suarez-Meade, P., Ramos, A., Jentoft, M., Middlebrooks, E., Grewal, S., Abode-Iyamah, K., Bydon, M., Sarkaria, J., ...> ;Mayo Clinic Proceedings. 2024 Feb 1
• 3 citations
  Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM.
  Petronek, M., Monga, V., Bodeker, K., Kwofie, M., Lee, C., Mapuskar, K., Stolwijk, J., Zaher, A., Wagner, B., Smith, M., Vollstedt, S., Brown, H., Chandler, M., Lorack...> ;Clinical Cancer Research. 2024 Jan 17
• Differential distribution of the DNA-PKcs inhibitor peposertib selectively radiosensitizes patient-derived melanoma brain metastasis xenografts.
  Ji, J., Dragojevic, S., Callaghan, C., Smith, E., Talele, S., Zhang, W., Connors, M., Mladek, A., Hu, Z., Bakken, K., Sarkaria, P., Carlson, B., Burgenske, D., Decker,...> ;Molecular Cancer Therapeutics. 2024 Jan 15
• GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress.
  Zhou, W., Zhao, Z., Lin, A., Yang, J., Xu, J., Wilder-Romans, K., Yang, A., Li, J., Solanki, S., Speth, J., Walker, N., Scott, A., Wang, L., Wen, B., Andren, A., Zhang...> ;Cancer Discovery. 2024 Jan 12
• Differential HOMetabolism among Glioblastoma Subtypes Confers Variable Responses to Pharmacological Ascorbate Therapy Combined with Chemoradiation.
  Zaher, A., Mapuskar, K., Spitz, D., Petronek, M., Sarkaria, J., Allen, B.> ;International Journal of Molecular Sciences. 2023 Dec 5
• Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1.
  Anna D Staniszewska, Domenic Pilger, Sonja J Gill, Kunzah Jamal, Natacha Bohin, Sofia Guzzetti, Jacob Gordon, Gregory Hamm, Gill Mundin, Giuditta Illuzzi, Andy Pike, L...> ;Clinical Cancer Research. 2024 Apr 1
• 3 citations
  CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia‑induced invasion and therapeutic resistance.
  Jan C Lumibao, Payton L Haak, Vladimir L Kolossov, Jee-Wei Emily Chen, Jeremy Stutchman, Alejandra Ruiz, Mayandi Sivaguru, Jann N Sarkaria, Brendan A C Harley, Andrew ...> ;International Journal of Oncology. 2023 Nov 1
• Delivery versus Potency in Treating Brain Tumors: BI-907828, a MDM2-p53 Antagonist with Limited BBB Penetration but Significant In Vivo Efficacy in Glioblastoma.
  Wenjuan Zhang, Rachael A Vaubel, Ju-Hee Oh, Ann C Mladek, Surabhi Talele, Wenqiu Zhang, Katie L Waller, Danielle M Burgenske, Jann N Sarkaria, William F Elmquist> ;Molecular Cancer Therapeutics. 2024 Jan 3
• How Much is Enough? Impact of Efflux Transporters on Drug delivery Leading to Efficacy in the Treatment of Brain Tumors.
  Wenjuan Zhang, Ju-Hee Oh, Wenqiu Zhang, Sneha Rathi, Jiayan Le, Surabhi Talele, Jann N Sarkaria, William F Elmquist> ;Pharmaceutical Research. 2023 Nov 1
• 1 citations
  A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma.
  Wan-Hsin Lin, Ryan W Feathers, Lisa M Cooper, Laura J Lewis-Tuffin, Jiaxiang Chen, Jann N Sarkaria, Panos Z Anastasiadis> ;JCI Insight. 2023 Jul 10
• Spectral flow cytometry identifies distinct nonneoplastic plasma extracellular vesicle phenotype in glioblastoma patients.
  Abudumijiti Zack Aibaidula, Cori E Fain, Luz Cumba Garcia, Annelise Wier, Samantha M Bouchal, Megan M Bauman, Mi-Yeon Jung, Jann N Sarkaria, Aaron J Johnson, Ian F Parney> ;Neuro-Oncology Advances. 2023 Jul 7
• 3 citations
  MDM2 Inhibition in the Treatment of Glioblastoma: From Concept to Clinical Investigation.
  Karolina I Pellot Ortiz, Julian S Rechberger, Leo F Nonnenbroich, David J Daniels, Jann N Sarkaria> ;Biomedicines. 2023 Jul 2
• Dosimetric patterns of failure in the era of novel chemoradiotherapy in newly-diagnosed glioblastoma patients.
  Maasa H Seaberg, Tomas Kazda, Ryan S Youland, Nadia N Laack, Deanna H Pafundi, S Keith Anderson, Jann N Sarkaria, Evanthia Galanis, Paul D Brown, Debra H Brinkmann> ;Radiotherapy and Oncology. 2023 Nov 1
• 2 citations
  Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas.
  Riviere-Cazaux, C., Carlstrom, L., Rajani, K., Munoz-Casabella, A., Rahman, M., Gharibi-Loron, A., Brown, D., Miller, K., White, J., Himes, B., Jusue-Torres, I., Ikram...> ;Communications Biology. 2023 Jun 20
• 1 citations
  WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models.
  Jason E Conage-Pough, Sylwia A Stopka, Ju-Hee Oh, Ann C Mladek, Danielle M Burgenske, Michael S Regan, Gerard Baquer, Paul A Decker, Brett L Carlson, Katrina K Bakken,...> ;Neuro-Oncology Advances. 2023 May 27
• 5 citations
  Glycan Node Analysis Detects Varying Glycosaminoglycan Levels in Melanoma-Derived Extracellular Vesicles.
  Jenifer Pendiuk Goncalves, Sierra A Walker, Jesús S Aguilar Díaz de León, Yubo Yang, Irina Davidovich, Sara Busatto, Jann Sarkaria, Yeshayahu Talmon, Chad R Borges, Jo...> ;International Journal of Molecular Sciences. 2023 May 9
• 1 citations
  Main Manuscript for Cell migration simulator-based biomarkers for glioblastoma.
  Jay Hou, Mariah McMahon, Jann N Sarkaria, Clark C Chen, David J Odde> ;Biorxiv. 2023 Feb 24
• 14 citations
  Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy.
  Simona Migliozzi, Young Taek Oh, Mohammad Hasanain, Luciano Garofano, Fulvio D'Angelo, Ryan D Najac, Alberto Picca, Franck Bielle, Anna Luisa Di Stefano, Julie Lerond,...> ;Nature Cancer. 2023 Feb 1
• 18 citations
  Alliance A071401: Phase II Trial of Focal Adhesion Kinase Inhibition in Meningiomas With SomaticMutations.
  Priscilla K Brastianos, Erin L Twohy, Elizabeth R Gerstner, Timothy J Kaufmann, A John Iafrate, Jochen Lennerz, Suriya Jeyapalan, David E Piccioni, Varun Monga, Camilo...> ;Journal of Clinical Oncology. 2023 Jan 20
• 9 citations
  Cardiopulmonary Toxicity Following Intensity-Modulated Proton Therapy (IMPT) Versus Intensity-Modulated Radiation Therapy (IMRT) for Stage III Non-Small Cell Lung Cancer.
  Yu, N., DeWees, T., Voss, M., Breen, W., Chiang, J., Ding, J., Daniels, T., Owen, D., Olivier, K., Garces, Y., Park, S., Sarkaria, J., Yang, P., Savvides, P., Ernani, ...> ;Clinical Lung Cancer. 2022 Dec 1
• 5 citations
  Modeling Therapy-Driven Evolution of Glioblastoma with Patient-Derived Xenografts.
  Matthew McCord, Elizabeth Bartom, Kirsten Burdett, Aneta Baran, Frank D Eckerdt, Irina V Balyasnikova, Kathleen McCortney, Thomas Sears, Shi-Yuan Cheng, Jann N Sarkari...> ;Cancers. 2022 Nov 9
• 1 citations
  Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors.
  Surabhi Talele, Wenjuan Zhang, Jiajia Chen, Shiv K Gupta, Danielle M Burgenske, Jann N Sarkaria, William F Elmquist> ;The Journal of Pharmacology and Experimental Therapeutics. 2022 Oct 1
• 3 citations
  Perivascular Stromal Cells Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche Model.
  Mai T Ngo, Jann N Sarkaria, Brendan A C Harley> ;Advanced Science. 2022 Nov 1
• 5 citations
  Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts.
  Kendra A Porath, Michael S Regan, Jessica I Griffith, Sonia Jain, Sylwia A Stopka, Danielle M Burgenske, Katrina K Bakken, Brett L Carlson, Paul A Decker, Rachael A Va...> ;Neuro-Oncology Advances. 2022 Aug 24
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Journal Articles

• Integrated Mapping of Pharmacokinetics and Pharmacodynamics in a Patient-Derived Xenograft Model of Glioblastoma  
  Jann Sarkaria, MD, Nature
• A Novel Enhancer Regulates MGMT Expression and Promotes Temozolomide Resistance in Glioblastoma  
  Ian F Parney, Fredric B Meyer, Caterina Giannini, Jann N Sarkaria, Nature