JasonEliFarrarMDFAAP(He/Him)

Pediatric Hematology & Oncology • Little Rock, AR

Associate Professor, Pediatrics, University of Arkansas COM

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Office
1 Children's Way
MS 512-10
Little Rock, AR 72202
Phone+1 501-364-1494
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Summary

Dr. Jason Farrar is a pediatric hematologist/oncologist in Little Rock, AR and is affiliated with Arkansas Children's Hospital and UAMS Medical Center. He received his medical degree from University of Arkansas for Medical Sciences (UAMS) College of Medicine, completed residency training at Children's Hospital of Wisconsin, and hematology/oncology fellowship at Johns Hopkins and the National Cancer Institute. He has been in practice 21 years. He is experienced in bone marrow failure syndromes, acute myeloid leukemia, acute lymphoblastic leukemia, and pediatric hematologic oncology. He has more than 40 publications and over 2000 citations.

Education & Training

Johns Hopkins UniversityFellowship, Pediatric Hematology/Oncology, 2003 - 2007
Pediatric Oncology Branch, National Cancer InstitutePediatric Oncology, Pediatric Oncology, 2003 - 2006
Medical College of Wisconsin Affiliated HospitalsResidency, Pediatrics, 2000 - 2003
University of Arkansas For Medical Sciences College of MedicineClass of 2000

Certifications & Licensure

AR State Medical License 2012 - 2025
MD State Medical License 2003 - 2012
WI State Medical License 2001 - 2007
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

A Phase II Dose-escalation Study Characterizing the PK of Eltrombopag in Pediatric Patients With Previously Untreated or Relapsed Severe Aplastic Anemia or Recurrent Aplastic Anemia Start of enrollment: 2017 Sep 30
Active, not recruiting
Phase 2

Publications & Presentations

PubMed

Structural variants involving MLLT10 fusion are associated with adverse outcomes in pediatric acute myeloid leukemia.
Oussama Abla, Rhonda E Ries, Tim Triche Jr, Robert B Gerbing, Betsy Hirsch, Susana Raimondi, Todd Cooper, Jason E Farrar, Nathaniel Buteyn, Lauren M Harmon, Hong Wen, ...> ;Blood Advances. 2024 Apr 23
Reply to Z.R. McCaw et al.
Jason E Farrar, Megan Othus, Yi-Cheng Wang, Todd A Alonzo, Soheil Meshinchi> ;Journal of Clinical Oncology. 2023 Sep 20
8 citations
Comprehensive molecular and clinical characterization offusions in pediatric acute myeloid leukemia.
Eline J M Bertrums, Jenny L Smith, Lauren Harmon, Rhonda E Ries, Yi-Cheng J Wang, Todd A Alonzo, Andrew J Menssen, Karen M Chisholm, Amanda R Leonti, Katherine Tarlock...> ;Haematologica. 2023 Aug 1
4 citations
Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia.
Jason E Farrar, Jenny L Smith, Megan Othus, Benjamin J Huang, Yi-Cheng Wang, Rhonda Ries, Tiffany Hylkema, Era L Pogosova-Agadjanyan, Sneha Challa, Amanda Leonti, Timo...> ;Journal of Clinical Oncology. 2023 Jun 1
15 citations
Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia.
Benjamin J Huang, Jenny L Smith, Jason E Farrar, Yi-Cheng Wang, Masayuki Umeda, Rhonda E Ries, Amanda R Leonti, Erin Crowgey, Scott N Furlan, Katherine Tarlock, Marcos...> ;Nature Communications. 2022 Sep 19
8 citations
CPX-351 Induces Remission in Newly Diagnosed Pediatric Secondary Myeloid Malignancies.
Yixin Hu, Kenneth J. Caldwell, Mihaela Onciu, Sara M. Federico, Marta Salek, Sara Lewis, Shaohua Lei, Jinghui Zhang, Kim E. Nichols, Clifford Takemoto, Brandon M. Trip...> ;Blood Advances. 2021 Oct 28
4 citations
CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes.
Benjamin J. Huang, Jenny L. Smith, Yi-Cheng Wang, Kassra Taghizadeh, Amanda R. Leonti, Rhonda E. Ries, Yanling Liu, Pandurang Kolekar, Katherine Tarlock, Robert B. Ger...> ;Blood Advances. 2021 Dec 14
11 citations
Implementing Pharmacogenomics Testing: Single Center Experience at Arkansas Children’s Hospital
Pritmohinder S. Gill, Feliciano B. Yu, Patricia Porter-Gill, Bobby L. Boyanton, Judy C Allen, Jason E. Farrar, Aravindhan Veerapandiyan, Kevin Bielamowicz, Elizabeth A...> ;Journal of Personalized Medicine. 2021 May 11
1 citations
A Novel Germline TP53 Mutation in a Patient With Li-Fraumeni Syndrome: Resolving a Variant of Uncertain Significance
David P. Douglass, Kimo C. Stine, Jason E. Farrar> ;Journal of Pediatric Hematology/oncology. 2021 Feb 25
18 citations
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
Jie Li, Phillip M. Galbo, Weida Gong, Aaron J. Storey, Yi-Hsuan Tsai, Xufen Yu, Jeong Hyun Ahn, Yiran Guo, Samuel G. Mackintosh, Ricky D. Edmondson, Stephanie D. Byrum...> ;Nature Communications. 2021 Feb 16
6 citations
A B-cell developmental gene regulatory network is activated in infant AML.
Hamid Bolouri, Rhonda E. Ries, Laura Pardo, Tiffany A. Hylkema, Wanding Zhou, Jenny L. Smith, Amanda R. Leonti, Michael R. Loken, Jason E. Farrar, Timothy J. Triche, S...> ;Plos One. 2021 Nov 18
19 citations
Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia.
Anna Hecht, Julia Meyer, Astrid Behnert, Eric Wong, Farid F. Chehab, Adam B. Olshen, Aaron Hechmer, Catherine Aftandilian, Rukhmi Bhat, Sung Won Choi, Satheesh Chonat,...> ;Haematologica. 2020 Dec 30
12 citations
L-leucine improves anemia and growth in patients with transfusion-dependent Diamond-Blackfan anemia: Results from a multicenter pilot phase I/II study from the Diamond...
Adrianna Vlachos, Evangelia Atsidaftos, Mohammad Lutfi Lababidi, Ellen Muir, Zora R. Rogers, Waseem Alhushki, Jonathan Bernstein, Bertil Glader, Barbara Gruner, Helge ...> ;Pediatric Blood & Cancer. 2020 Dec 1
14 citations
Genotype-phenotype association and variant characterization in Diamond-Blackfan anemia caused by pathogenic variants in RPL35A
D. Matthew Gianferante, Marcin W. Wlodarski, Evangelia Atsidaftos, Lydie Da Costa, Polyxeni Delaporta, Jason E. Farrar, Frederick D. Goldman, Maryam Hussain, Antonis K...> ;Haematologica. 2020 Apr 2
36 citations
Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study.
Jenny L. Smith, Rhonda E. Ries, Tiffany A. Hylkema, Todd A. Alonzo, Robert B. Gerbing, Marianne Santaguida, Lisa Eidenschink Brodersen, Laura Pardo, Carrie L. Cummings...> ;Clinical Cancer Research. 2020 Feb 1
Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.
Bolouri, H.,Farrar, J. E.,Triche, T.,Ries, R. E.,Lim, E. L.,Alonzo, T. A.,Ma, Y.,Moore, R.,Mungall, A. J.,Marra, M. A.,Zhang, J.,Ma, X.,Liu, Y.,Liu, Y.,Auvil, JMG.,Dav...> ;Nat. Med.. 2019 Feb 02
24 citations
Increased Prevalence of Congenital Heart Disease in Children With Diamond Blackfan Anemia Suggests Unrecognized Diamond Blackfan Anemia as a Cause of Congenital Heart ...
Adrianna Vlachos, Diana S Osorio, Evangelia Atsidaftos, Jessica Kang, Mohammad Lutfi Lababidi, Howard S. Seiden, Dorota Gruber, Bertil Glader, Kenan Onel, Jason E. Far...> ;Circulation. Genomic and Precision Medicine. 2018 May 1
10 citations
Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.
Hamid Bolouri, Jason E Farrar, Timothy Triche Jr, Rhonda E Ries, Emilia L Lim, Todd A Alonzo, Yussanne Ma, Richard Moore, Andrew J Mungall, Marco A Marra, Jinghui Zhan...> ;Nature Medicine. 2018 Apr 10
217 citations
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.
Farrar, J. E., Hamid Bolouri, Jason E Farrar, Timothy Triche Jr, Rhonda E Ries, Emilia L Lim, Todd A Alonzo, Yussanne Ma, Richard Moore, Andrew J Mungall, Marco A Marr...> ;Nature Medicine. 2018 Jan 1
22 citations
A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML
Lia Gore, Timothy J. Triche, Jason E. Farrar, Daniel H. Wai, Christophe Legendre, Gerald C. Gooden, Winnie S. Liang, John D. Carpten, David W. Lee, Frank Alvaro, Marga...> ;Clinical Epigenetics. 2017 Oct 5
2 citations
Response: Making "perfect" the enemy of good.
Jason E. Farrar, Donna Neuberg, Timothy J. Triche, David M. Bodine> ;Blood. 2017 Aug 31
25 citations
Molecular convergence in ex vivo models of Diamond-Blackfan anemia.
Kelly A. O'Brien, Jason E. Farrar, Adrianna Vlachos, Stacie M. Anderson, Crystiana A. Tsujiura, Jens Lichtenberg, Lionel Blanc, Eva Atsidaftos, Abdel G. Elkahloun, Xiu...> ;Blood. 2017 Jun 8
46 citations
CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML
Julia E. Maxson, Rhonda E. Ries, Yi-Cheng Wang, Robert B. Gerbing, E. Anders Kolb, Sarah L. Thompson, Jaime M. Guidry Auvil, Marco A. Marra, Yussanne Ma, Zusheng Zong,...> ;Blood. 2016 Jun 16
111 citations
Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse.
, , , , , , , , , , , , , , , , , , > ;Cancer Research. 2016 Apr 15
48 citations
Exploiting pre-rRNA processing in Diamond Blackfan anemia gene discovery and diagnosis.
Jason E. Farrar, Paola Quarello, Ross Fisher, Kelly A. O'Brien, Anna Aspesi, Sara Parrella, Adrianna Henson, Nancy E. Seidel, Eva Atsidaftos, Supraja Prakash, Shahla B...> ;American Journal of Hematology. 2014 Oct 1
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Abstracts/Posters

Discovery of Novel IL3RA (CD123) Isoforms By Long Read Transcriptomics, Heterogeneous Expression Among AML Patient Cohorts and the Implications for Anti-CD123 Therapeu...
Jason E. Farrar, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Structural Variants Involving MLLT10/AF10 Are Associated with Adverse Outcome in AML Regardless of the Partner Gene _ a COG/Tpaml Study
Jason E. Farrar, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
A Distinct Oncofetal B-Cell Transcriptional Program Is Activated in Infant Acute Myeloid Leukemia and Reveals Novel Therapeutic Strategies
Jason E. Farrar, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Molecular Characterization of Leukemia Evolving from Paroxysmal Nocturnal Hemoglobinuri
Jason E. Farrar, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Long Non-Coding RNAs (lncRNAs) Are Highly Associated with Disease Characteristics and Outcome in Pediatric Acute Myeloid Leukemia _ a COG and Tpaml Study
Jason E. Farrar, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Press Mentions

Arkansas Children's Hospital Becomes Nation's First Therapeutic Site in Launch of Groundbreaking Clinical Trial for Pediatric Acute LeukemiaJune 29th, 2022
‘Remarkable’ Distinctions in Pediatric Leukemia Point Toward Improved TreatmentFebruary 1st, 2023

Grant Support

Mechanisms of Erythroid Remission in Diamond Blackfan AnemiaNational Heart, Lung, And Blood Institute2020–2023
Center for Pediatric Translational ResearchNational Institute of General Medical Sciences2017–2020
Functional Analysis Of Rpl35a Alterations In Diamond Blackfan AnemiaNational Heart, Lung, And Blood Institute2009–2012