KimoStineMD

Pediatric Hematology & Oncology • Little Rock, AR

Professor, Pediatrics, University of Arkansas COM

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Office
Arkansas Children's Hospital
1 Children's Way
Little Rock, AR 72202
Phone+1 501-263-2621
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Education & Training

Duke University HospitalFellowship, Pediatric Hematology/Oncology, 1985 - 1989
University of Kansas School of MedicineResidency, Pediatrics, 1982 - 1985
University of Kansas School of MedicineClass of 1982

Certifications & Licensure

AR State Medical License 1991 - 2025
NC State Medical License 1989 - 1992
LA State Medical License 1989 - 1991
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Interleukin-2 in Treating Children Who Have Undergone Bone Marrow Transplantation for Acute Myeloid Leukemia Start of enrollment: 1998 Mar 01
Completed
Phase 1
Dose-Response Study of Recombinant Factor VIII Manufactured Protein-Free (rAHF-PFM) in Patients With Hemophilia A Start of enrollment: 2006 Feb 02
Completed
Phase 4
Safety, Efficacy and Pharmacokinetics of GreenGene™ F to Previously Treated Patients With Severe Hemophilia A Start of enrollment: 2013 Mar 01
Unknown status
Phase 3
ICON1: Treatment Decisions and Outcomes in Pediatric Refractory ITP Start of enrollment: 2013 Aug 01
Completed
Safety and Efficacy Extension Study of GreenGene™ F in Previously Treated Patients Diagnosed With Severe Hemophilia A Start of enrollment: 2014 Jan 01
Unknown status
Phase 3
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis Start of enrollment: 2016 Nov 02
Recruiting
Phase 2, Phase 3
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

1 citations
Giroctocogene fitelparvovec gene therapy for severe hemophilia A: 104-week analysis of the phase 1/2 Alta study.
Andrew D Leavitt, Barbara A Konkle, Kimo C Stine, Nathan Visweshwar, Thomas J Harrington, Adam Giermasz, Steven Arkin, Annie Fang, Frank Plonski, Anne Yver, Florence G...> ;Blood. 2024 Feb 29
3 citations
MicroRNA-34a-5p as a promising early circulating preclinical biomarker of doxorubicin-induced chronic cardiotoxicity.
Varsha G Desai, Vikrant Vijay, Taewon Lee, Tao Han, Carrie L Moland, Bounleut Phanavanh, Eugene H Herman, Kimo Stine, James C Fuscoe> ;Journal of Applied Toxicology. 2022 Sep 1
4 citations
Doxorubicin-induced delayed-onset subclinical cardiotoxicity in mice
Varsha G. Desai, Vikrant Vijay, Tao Han, Carrie L. Moland, Bounleut Phanavanh, Taewon Lee, Kelly Davis, Levan Muskhelishvili, Kimo C. Stine, James C. Fuscoe> ;Journal of Applied Toxicology. 2021 Oct 20
1 citations
A Novel Germline TP53 Mutation in a Patient With Li-Fraumeni Syndrome: Resolving a Variant of Uncertain Significance
David P. Douglass, Kimo C. Stine, Jason E. Farrar> ;Journal of Pediatric Hematology/oncology. 2021 Feb 25
36 citations
Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primar...
Francesca Minoia, Francesca Bovis, Sergio Davì, Antonella Insalaco, Kai Lehmberg, Susan Shenoi, Sheila Weitzman, Graciela Espada, Yi-Jin Gao, Jordi Anton, Toshiyuki Ki...> ;The Journal of Pediatrics. 2017 Oct 1
55 citations
Thrombopoietin Receptor Agonist Use in Children: Data from the Pediatric ITP Consortium of North America ICON2 Study
Cindy E. Neunert, Jenny M. Despotovic, Kristina M. Haley, Michele P. Lambert, Kerri Nottage, Kristin A. Shimano, Carolyn M. Bennett, Robert J. Klaassen, Kimo C. Stine,...> ;Pediatric Blood & Cancer. 2016 Aug 1
7 citations
Nutlin‐3 treatment spares cisplatin‐induced inhibition of bone healing while maintaining osteosarcoma toxicity
Kimo C. Stine, Elizabeth C. Wahl, Lichu Liu, Robert A. Skinner, Jaclyn VanderSchilden, Robert C. Bunn, Corey O. Montgomery, James Aronson, David L. Becton, Richard W. ...> ;Journal of Orthopaedic Research. 2016 Feb 26
2 citations
Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia.
Elliot Stieglitz, Amaro Taylor-Weiner, Tiffany Y. Chang, Laura C. Gelston, Yong Dong Wang, Tali Mazor, Emilio Esquivel, Ariel Yu, Sara Seepo, Scott R. Olsen, Mara Rose...> ;Nature Genetics. 2016 Jan 1
190 citations
The genomic landscape of juvenile myelomonocytic leukemia.
Elliot Stieglitz, Amaro Taylor-Weiner, Tiffany Y. Chang, Laura C. Gelston, Yong Dong Wang, Tali Mazor, Emilio Esquivel, Ariel Yu, Sara Seepo, Scott R. Olsen, Mara Rose...> ;Nature Genetics. 2015 Nov 1
3 citations
Risk organ + LCH gets the one-two punch?
Kimo C. Stine> ;Blood. 2015 Sep 17
46 citations
Dissecting the heterogeneity of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
Francesca Minoia, Sergio Davì, AnnaCarin Horne, Francesca Bovis, Erkan Demirkaya, Jonathan D Akikusa, Nuray Aktay Ayaz, Sulaiman M. Al-Mayouf, Patrizia Barone, B. Bica...> ;The Journal of Rheumatology. 2015 Jun 1
50 citations
Long-term use of the thrombopoietin-mimetic romiplostim in children with severe chronic immune thrombocytopenia (ITP).
James B. Bussel, Loan Hsieh, George R. Buchanan, Kimo C. Stine, Ram Kalpatthi, David J. Gnarra, Richard H. Ho, Kun Nie, Melissa Eisen> ;Pediatric Blood & Cancer. 2015 Feb 1
23 citations
von Willebrand factor multimers in pediatric extracorporeal membrane oxygenation support
Sanjiv Pasala, Richard T. Fiser, Kimo C. Stine, Christopher J. Swearingen> ;ASAIO Journal. 2014 Jul 1
23 citations
Cisplatin inhibits bone healing during distraction osteogenesis.
Kimo C. Stine, Elizabeth C. Wahl, Lichu Liu, Robert A. Skinner, Jacquelyn VanderSchilden, Robert C. Bunn, Corey O. Montgomery, Larry J. Suva, James Aronson, David L. B...> ;Journal of Orthopaedic Research. 2014 Mar 1
33 citations
A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A
Jérôme Lane, Paul J. McLaren, Lucy Dorrell, Kevin V. Shianna, Amanda Stemke, Kimberly Pelak, Stephen Moore, Johannes Oldenburg, Maria Teresa Alvarez-Roman, Anne Angeli...> ;Human Molecular Genetics. 2013 May 1
5 citations
Case studies in the management of refractory bleeding in patients with haemophilia A and inhibitors
Leonard A. Valentino, G. Allen, Joan Cox Gill, A. Hurlet, Barbara A. Konkle, Cindy A. Leissinger, L. Luchtman-Jones, Jerry S. Powell, Mark T. Reding, Kimo C. Stine> ;Haemophilia. 2013 May 1
25 citations
Response to steroids predicts response to rituximab in pediatric chronic immune thrombocytopenia.
Rachael F. Grace, Carolyn M. Bennett, A. Kim Ritchey, Michael Jeng, Courtney D. Thornburg, Michele P. Lambert, Michelle Neier, Michael Recht, Manjusha Kumar, Victor Bl...> ;Pediatric Blood & Cancer. 2012 Feb 1
Bleeding disorders: when is normal bleeding not normal?
Kimo C. Stine, David L. Becton> ;The Journal of the Arkansas Medical Society. 2009 Aug 1
21 citations
Bleeding symptoms and laboratory correlation in patients with severe von Willebrand disease.
Ara Metjian, C. Wang, Suman L. Sood, Adam Cuker, S. M. Peterson, J. M. Soucie, Barbara A. Konkle, Marjorie A. Boyd, Glen Roy, Edwin N. Forman, Jean Marandola, Alan C. ...> ;Haemophilia. 2009 Jul 10
42 citations
Cardiomyopathy in Children With Down Syndrome Treated for Acute Myeloid Leukemia: A Report From the Children's Oncology Group Study POG 9421
Maureen M. O'Brien, Jeffrey W. Taub, Myron Chang, Gita Massey, Kimo C. Stine, Susana C. Raimondi, David L. Becton, Yaddanapudi Ravindranath, Gary V. Dahl> ;Journal of Clinical Oncology. 2008 Jan 20
13 citations
Consensus on a core curriculum in American training programs in pediatric hematology-oncology: a report from the ASPHO Training Committee.
C. Hastings, Daniel S. Wechsler, K. C. Stine, D. K. Graham, Thomas C. Abshire> ;Pediatric Hematology and Oncology. 2007 Oct 1
25 citations
Surgical interventions in a cohort of patients with haemophilia A and inhibitors: an experiential retrospective chart review.
Eric H. Kraut, Louis M. Aledort, S. Arkin, Kimo C. Stine, W.-Y. Wong> ;Haemophilia. 2007 Sep 1
15 citations
Use of FEIBA for invasive or surgical procedures in patients with severe hemophilia A or B with inhibitors.
Kimo C. Stine, Dixie Shrum, David L. Becton> ;Journal of Pediatric Hematology/oncology. 2007 Apr 1
11 citations
Treatment of deep vein thrombosis with enoxaparin in pediatric cancer patients receiving chemotherapy.
Kimo C. Stine, Robert L. Saylors, Suzanne Saccente, David L. Becton> ;Clinical and Applied Thrombosis/hemostasis. 2007 Apr 1
A patient with hyperuricemia and renal failure:question
Kimo C. Stine, Patrick D. Walker, Mohammad Ilyas, Yihan Wang, Richard T. Blaszak> ;Pediatric Nephrology. 2007 Mar 24
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Abstracts/Posters

Updated Follow-up of the Alta Study, a Phase 1/2, Open Label, Adaptive, Dose-Ranging Study to Assess the Safety and Tolerability of SB-525 Gene Therapy in Adult Patien...
Kimo Stine, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Press Mentions

ASH 2020: Update for the Alta Study, a Phase 1/2 Gene Therapy Trial of Giroctocogene Fitelparvovec (SB-525) in Adults with Severe Hemophilia ADecember 18th, 2020