JasonShohetMDPh.D.

PubMed

• Longitudinal evaluation of serum microRNAs as biomarkers for neuroblastoma burden and therapeutic p53 reactivation.
  Alan Van Goethem, Jill Deleu, Nurten Yigit, Celine Everaert, Myrthala Moreno-Smith, Sanjeev A Vasudevan, Fjoralba Zeka, Fleur Demuynck, Eveline Barbieri, Frank Spelema...> ;NAR Cancer. 2023 Mar 1
• 17 citations
  KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma.
  Alexandra D'Oto, Jie Fang, Hongjian Jin, Beisi Xu, Shivendra Singh, Anoushka Mullasseril, Victoria Jones, Ahmed Abu-Zaid, Xinyu von Buttlar, Bailey Cooke, Dongli Hu, J...> ;Nature Communications. 2021 Dec 10
• 7 citations
  Systematic review of the receptor tyrosine kinase superfamily in neuroblastoma pathophysiology.
  Esteban Javier Rozen, Jason Matthew Shohet> ;Cancer Metastasis Reviews. 2021 Oct 30
• 3 citations
  Is high-risk neuroblastoma induction chemotherapy possible without G-CSF? A pilot study of safety and treatment delays in the absence of primary prophylactic hematopoi...
  Sarah B. Whittle, Valeria Smith, Allison Silverstein, Margaret Parmeter, Charles G. Minard, M. Brooke Bernhardt, Peter E. Zage, Rajkumar Venkatramani, Jed G. Nuchtern,...> ;Pediatric Blood & Cancer. 2020 Jul 30
• 18 citations
  Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients
  Fjoralba Zeka, Anneleen Decock, Alan Van Goethem, Katrien Vanderheyden, Fleur Demuynck, Tim Lammens, Hetty Helsmoortel, Joëlle Vermeulen, Rosa Noguera, Ana P. Berbegal...> ;JCI Insight. 2018 Dec 6
• 2 citations
  Correction: MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.
  Saurabh Agarwal, Giorgio Milazzo, Kimal Rajapakshe, Ronald J. Bernardi, Zaowen Chen, Barbieri Eveline, Jan Koster, Giovanni Perini, Cristian Coarfa, Jason M. Shohet> ;Oncotarget. 2018 Jul 6
• 74 citations
  Neuroblastoma pathogenesis: deregulation of embryonic neural crest development.
  Julie A. Tomolonis, Saurabh Agarwal, Jason M. Shohet> ;Cell and Tissue Research. 2018 May 1
• 25 citations
  MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma
  Saurabh Agarwal, Giorgio Milazzo, Kimal Rajapakshe, Ronald J. Bernardi, Zaowen Chen, Eveline Barberi, Jan Koster, Giovanni Perini, Cristian Coarfa, Jason M. Shohet> ;Oncotarget. 2018 Apr 17
• 38 citations
  A physiologically relevant 3D collagen-based scaffold-neuroblastoma cell system exhibits chemosensitivity similar to orthotopic xenograft models.
  Caroline M. Curtin, John Nolan, Ross Conlon, Larissa Deneweth, Ciara Gallagher, Ying J Tan, Brenton Cavanagh, Ahmad Zaki Asraf, Harry Harvey, Suzanne F. C. Miller-Dela...> ;Acta Biomaterialia. 2018 Apr 1
• 20 citations
  p53 Nongenotoxic Activation and mTORC1 Inhibition Lead to Effective Combination for Neuroblastoma Therapy
  Myrthala Moreno-Smith, Anna Lakoma, Zaowen Chen, Ling Tao, Kathleen A. Scorsone, Linda Schild, Kevin Aviles-Padilla, Rana Nikzad, Yankai Zhang, Rikhia Chakraborty, Jan...> ;Clinical Cancer Research. 2017 Nov 1
• 5 citations
  EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma
  Wenjing Sun, Yesenia Rojas, Hao Wang, Yang Yu, Yongfeng Wang, Zhenghu Chen, Kimal Rajapakshe, Xin Xu, Wei Huang, Saurabh Agarwal, Roma H. Patel, Sarah E. Woodfield, Ya...> ;Oncotarget. 2017 Oct 21
• 17 citations
  Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma.
  Alan Van Goethem, Nurten Yigit, Myrthala Moreno-Smith, Sanjeev A. Vasudevan, Eveline Barbieri, Franki Speleman, Jason M. Shohet, Jo Vandesompele, Tom Van Maerken> ;Oncotarget. 2017 Jul 4
• Neuroblastoma.
  Shohet, J.,Foster, J.> ;BMJ. 2017 May 05
• 16 citations
  CD114: A New Member of the Neural Crest-Derived Cancer Stem Cell Marker Family.
  Peter E. Zage, Sarah B. Whittle, Jason M. Shohet> ;Journal of Cellular Biochemistry. 2017 Feb 1
• 11 citations
  Depletion of tRNA-halves enables effective small RNA sequencing of low-input murine serum samples
  Alan Van Goethem, Nurten Yigit, Celine Everaert, Myrthala Moreno-Smith, Liselot Mus, Eveline Barbieri, Frank Speleman, Pieter Mestdagh, Jason M. Shohet, Tom Van Maerke...> ;Scientific Reports. 2016 Nov 30
• 12 citations
  Heterogeneous Uptake of Nanoparticles in Mouse Models of Pediatric High-Risk Neuroblastoma
  Ketan B. Ghaghada, Zbigniew Starosolski, Anna Lakoma, Caterina C. Kaffes, Saurabh Agarwal, Khannan K. Athreya, Jason M. Shohet, Eugene S. Kim, Ananth Annapragada> ;Plos One. 2016 Nov 18
• 17 citations
  Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma
  Saurabh Agarwal, Rajib Ghosh, Zaowen Chen, Anna Lakoma, Preethi H. Gunaratne, Eugene S. Kim, Jason M. Shohet> ;Oncotarget. 2016 Mar 16
• 72 citations
  WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
  Yuting Sun, Jessica L. Bell, Daniel R. Carter, Samuele Gherardi, Rebecca C. Poulos, Giorgio Milazzo, Jason W. H. Wong, Rima Al-awar, Andrew E. Tee, Pei Y. Liu, Bing Bi...> ;Cancer Research. 2015 Dec 1
• 16 citations
  Reactivation of p53 via MDM2 inhibition.
  Eugene S. Kim, Jason M. Shohet> ;Cell Death & Disease. 2015 Oct 22
• 41 citations
  Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma
  Dominik Bogen, Jun S. Wei, David O. Azorsa, Pinar Ormanoglu, Eugen Buehler, Rajarshi Guha, Jonathan M. Keller, Lesley A. Mathews Griner, Marc Ferrer, Young K. Song, Ho...> ;Oncotarget. 2015 Oct 21
• 36 citations
  MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma
  Anneleen Beckers, Gert Van Peer, Daniel R. Carter, Moritz Gartlgruber, Carl Herrmann, Saurabh Agarwal, Hetty Helsmoortel, Kristina Althoff, Jan J. Molenaar, Belamy B. ...> ;Cancer Letters. 2015 Sep 28
• 2 citations
  G-CSF Is a Cancer Stem Cell-Specific Growth Factor-Response.
  Eugene S. Kim, Saurabh Agarwal, Jason M. Shohet> ;Cancer Research. 2015 Sep 15
• 48 citations
  The MDM2 small-molecule inhibitor RG7388 leads to potent tumor inhibition in p53 wild-type neuroblastoma.
  Anna Lakoma, Eveline Barbieri, Saurabh Agarwal, Jeremy R. Jackson, Zaowen Chen, Y Kim, M McVay, Jason M. Shohet, Eugene S. Kim> ;Cell Death Discovery. 2015 Aug 24
• 27 citations
  NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis.
  Yan Shi, Irene T. Ma, Roma H. Patel, Xiao-Ying Shang, Zhenghu Chen, Yi-Jue Zhao, Jin Cheng, Yihui Fan, Yesenia Rojas, Eveline Barbieri, Yang Yu, Jingling Jin, Eugene S...> ;Cell Death & Disease. 2015 Aug 6
• 9 citations
  CD114 Expression Mediates Melanoma Tumor Cell Growth and Treatment Resistance
  Linna Zhang, Saurabh Agarwal, Jason M. Shohet, Peter E. Zage> ;Anticancer Research. 2015 Jul 1
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Other

• Clinical presentation, diagnosis, and staging evaluation of neuroblastoma 
  Shohet JM, Russell HV, Nuchtern JG
  http://www.uptodate.com/contents/clinical-presentation-diagnosis-and-staging-evaluation-of-neuroblas
  UpToDate, Wolters Kluwer Health - 2012-05-30
• Epidemiology, pathogenesis, and pathology of neuroblastoma 
  Shohet JM, Russell HV, Nuchtern JG
  http://www.uptodate.com/contents/epidemiology-pathogenesis-and-pathology-of-neuroblastoma
  UpToDate, Wolters Kluwer Health - 2012-05-29
• Treatment and prognosis of neuroblastoma 
  Shohet JM, Russell HV, Nuchtern JG
  http://www.uptodate.com/contents/treatment-and-prognosis-of-neuroblastoma
  UpToDate, Wolters Kluwer Health - 2013-03-27