JeffreyDBrowningMD

Nutrition

Chair and Associate Professor, Department of Clinical Nutrition, School of Health Professionals and Associate Professor, Division of Digestive and Liver Diseases, Department of Internal Medicine and The Advanced Imaging Research Center, The University of Texas Southwestern Medical Center

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Office
5323 Harry Hines Blvd
Dallas, TX 75390
Phone(214) 648-1520
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Education & Training

University of Texas Southwestern Medical CenterFellowship, National Institutes of Health, 2003 - 2005
University of Texas Southwestern Medical CenterFellowship, Gastroenterology, 2002 - 2003
University of Texas Southwestern Medical CenterFellowship, Hepatology , 2001 - 2002
University of Alabama Medical CenterResidency, Internal Medicine, 1998 - 2001
University of Texas Southwestern Medical SchoolClass of 1998

Certifications & Licensure

TX State Medical License 2001 - 2021
AL State Medical License 1999 - 2001
American Board of Internal Medicine Gastroenterology
National Board of Physicians and Surgeons Gastroenterology
National Board of Physicians and Surgeons Internal Medicine

Awards, Honors, & Recognition

Holder, Lancaster Family Fund in Gastroenterology University of Texas Southwestern Medical School
Tenure University of Texas Southwestern Medical School, 2012
Disease Oriented Clinical Scholar University of Texas Southwestern Medical School, 2006-2009
Diplomate American Board of Internal Medicine, Gastroenterology, 2005
Research Excellence in GI and Liver (REGAL) Award 2005
NIH Training Fellowship 2003-2005
Postdoctoral Fellowship American Liver Foundation, 2003
Fellow Reporters Program American Gastroenterology Association/Wyeth-Ayerst, 2002
Diplomate American Board of Internal Medicine, 2001
Ben Friedman Award for Excellence in Teaching University of Alabama, Birmingham, 1999, 2001
Glenn Cobb Award University of Alabama, Birmingham, 1999
Distinguished Service Award American Heart Association, 1986
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Clinical Trials

Mitochondrial Function in Patients With Severe Liver Disease Start of enrollment: 2015 Oct 01
HIV Acquired Lipodystrophy (HAL) Classification, Measurement and Fat Response to Thiazolidinedione (TZD) (Pioglitazone) Start of enrollment: 2009 Oct 01Michael Limerick, RN, PhD
Determination of the Effect of Extreme Dietary Carbohydrate Restriction on Hepatic Glucose Production Start of enrollment: 2005 Jan 01Browning, J.D.

Publications & Presentations

PubMed

Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver.
Fletcher JA, Deja S, Satapati S, Fu X, Burgess SC, Browning JD> ;JCI insight. 2019-04-23
Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.
Cappel, D. A.,Deja, S.,Duarte, JAG.,Kucejova, B.,Iñigo, M.,Fletcher, J. A.,Fu, X.,Berglund, E. D.,Liu, T.,Elmquist, J. K.,Hammer, S.,Mishra, P.,Browning, J. D.,Burgess...> ;Cell Metab.. 2019 Apr 23
Crohn's Disease is Associated with an Increased Prevalence of Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study using Magnetic Resonance Proton Density Fat Fr...
McHenry, S.,Sharma, Y.,Tirath, A.,Tsai, R.,Mintz, A.,Fraum, T. J.,Salter, A.,Browning, J. D.,Flores, A. G.,Davidson, N. O.,Fowler, K. J.,Ciorba, M. A.,Deepak, P.> ;Clin. Gastroenterol. Hepatol.. 2019 Mar 17
Fatty liver disrupts glycerol metabolism in gluconeogenic and lipogenic pathways in humans.
Jin ES, Browning JD, Murphy RE, Malloy CR> ;Journal of lipid research. 2018-07-27
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Park...> ;J Clin Invest. 2016 Apr 01
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Park...> ;J Clin Invest. 2015 Dec
Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate.
Burgess, S. C.,Merritt, M. E.,Jones, J. G.,Browning, J. D.,Sherry, A. D.,Malloy, C. R.> ;Nat. Med.. 2015 Feb 06
A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice.
Duarte, J. A.,Carvalho, F.,Pearson, M.,Horton, J. D.,Browning, J. D.,Jones, J. G.,Burgess, S. C.> ;J. Lipid Res.. 2014 Oct 02
Influence of Liver Triglycerides on Suppression of Glucose Production by Insulin in Men.
Jin, E. S.,Szuszkiewicz-Garcia, M.,Browning, J. D.,Baxter, J. D.,Abate, N.,Malloy, C. R.> ;J. Clin. Endocrinol. Metab.. 2014 Sep 25
Fat and iron quantification in the liver: past, present, and future.
Yokoo, T.,Browning, J. D.> ;Top Magn Reson Imaging. 2014 Apr 03
Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease.
Lambert, J. E., Lambert, J. E., Ramos-Roman, M. A., Ramos-Roman, M. A., Browning, J. D., Browning, J. D., Parks, E. J., Parks, E. J.> ;Gastroenterology. 2013 Dec 10
Common Genetic Variants and Non-Alcoholic Fatty Liver Disease.
Browning, J. D.> ;Clin. Gastroenterol. Hepatol.. 2013 Sep
Metabolomics, stable isotopes, and A-beta+ ketosis-prone diabetes.
Ramos-Roman MA, Burgess SC, Browning JD> ;Diabetes. 2013 Mar
Use of 2H2O for Estimating Rates of Gluconeogenesis: Determination and correction of error due to transaldolase exchange.
Browning, J. D., Burgess, S. C.> ;Am J Physiol Endocrinol Metab. 2012 Dec 1
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.
Satapati, S., Sunny, N. E., Kucejova, B., Fu, X., He, T. T., Méndez-Lucas, A., Shelton, J. M., Perales, J. C., Browning, J. D., Burgess, S. C.> ;J Lipid Res. 2012 Jun
Adiponectin as an Independent Predictor of the Presence and Degree of Hepatic Steatosis in the Dallas Heart Study.
Turer, A. T., Browning, J. D., Ayers, C. R., Das, S. R., Khera, A., Vega, G. L., Grundy, S. M., Scherer, P. E.> ;J Clin Endocrinol Metab. 2012 Jun
Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease.
Sunny, N.E., Parks, E.J., Browning, J.D., Burgess, S.C.> ;Cell Metab. 2011 Dec 7
The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men.
Browning, J.D., Baxter, J., Satapati, S., Burgess, S.C.> ;J Lipid Res. 2012 Mar
T(2) measurement of J-coupled metabolites in the human brain at 3T.
Ganji, S.K., Banerjee, A., Patel, A.M., Zhao, Y.D., Dimitrov, I.E., Browning, J.D., Sherwood Brown, E., Maher, E.A., Choi, C.> ;NMR Biomed. 2012 Apr
Hepatic triglyceride content in individuals with reduced intestinal cholesterol absorption due to variants in NPC1L1.
Ramirez, R., Cohen, J.C., Hobbs, H.H., Browning, J.D.> ;Hepatology. 2011 Aug
Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction.
Browning, J.D., Baker, J.A., Rogers, T., Davis, J., Satapati, S., Burgess, S.C.> ;Am J Clin Nutr. 2011 May
Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans.
Browning, J.D., Horton, J.D.> ;J Lipid Res. 2010 Nov
Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease.
Browning, J.D., Cohen, J.C., Hobbs, H.H.> ;Hepatology. 2010 Oct
Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.
Sunny, N.E., Satapati, S., Fu, X., He, T., Mehdibeigi, R., Spring-Robinson, C., Duarte, J., Potthoff, M.J., Browning, J.D., Burgess, S.C.> ;Am J Physiol Endocrinol Metab. 2010 Jun
Colonoscopy: an unusual complication.
Alder, A.C., Scott, D.L., Browning, J.D.> ;Gastroenterology. 2010 Feb
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Authored Content

Dallas Steatosis Index Identifies Patients with NAFLDJanuary 2020

Press Mentions

Fatty Livers Are in OverdriveMay 06, 2017 11:00
Prevalence of Nonalcoholic Fatty Liver Disease Varies by EthnicityMay 06, 2017 11:00

Grant Support

The Role Of Mitochondrial Dysfunction In Non-Alcoholic Fatty Liver DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2011–2012
Non-Alcoholic Fatty Liver Disease Ethnicity And Hepatic MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases2006–2010
Hepatic Carbohydrate Metabolism In The Young And ElderlyNational Center For Research Resources2006–2007
Extreme Dietary Carbohydrate Restriction Effect On Hepatic Glucose ProductionNational Center For Research Resources2006–2007
Determination Of Metformin And Insulin Effect On Hepatic Triglyceride ContentNational Center For Research Resources2005–2007