
Luke J Engelking MD PhD, AGAF (He/Him)
Associate Professor, Co-Medical Director Cancer Genetics Program
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5323 Harry Hines BoulevardDallas, TX 75390
Phone+1 214-648-8088
Fax+1 214-648-8804
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Summary
- Dr. Engelking a physician-scientist gastroenterologist, genetic cancer specialist, investigator, and educator. He serves as the Co-Medical Director of UT Southwestern's Cancer Genetics program and its Genetic Cancer Prevention Clinic, where he is accepting new patient referrals (ph: 214-645-2563; f: 214-645-2562).
He leads clinic, endoscopy, and research programs focused on hereditary syndromes of GI cancer risk and polyposis, such as Lynch syndrome and Familial Adenomatous Polyposis syndrome. The overarching goal of these programs is cancer prevention care for patients and their families with inherited forms of GI cancers, particularly colorectal cancer. He has completed intensive training from City of Hope and is a certified genetic cancer risk assessment specialist.
He completed joint MD/PhD training (2000-2007) at UT Southwestern in Dallas, where he studied cholesterol metabolism under Nobel Laureates Goldstein and Brown. He next completed internal medicine training at Massachusetts General Hospital (2007-2010), an affiliate of Harvard Medical School, and then returned to UT Southwestern for a clinical and research fellowship in gastroenterology (2010-2014). He is now an Associate Professor of Internal Medicine and the Harold C. Simmons Comprehensive Cancer Center. He served as interim Associate Dean of Medical Student Research and Scholarly Activity. His basic science laboratory studied various aspects of lipid metabolism in digestive organs and GI tract neoplasms, supported by research grants from NIH and CPRIT. He has authored numerous high impact research manuscripts published in Journal of Clinical Investigation, Cell Metabolism, and elsewhere.
Education & Training
University of Texas Southwestern Medical CenterFellowship, Gastroenterology, 2010 - 2014
Mass General Brigham/Massachusetts General HospitalResidency, Internal Medicine, 2007 - 2010
University of Texas Southwestern Medical SchoolClass of 2007
Certifications & Licensure
TX State Medical License 2010 - 2026
MA State Medical License 2009 - 2012
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Gastroenterology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2015-2017
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2015-2017
- Research Scholar in Liver Disease Award Gilead Sciences, Inc., 2015
Clinical Trials
- Safety and Efficacy of EndoBarrier in Subjects With Type 2 Diabetes Who Are Obese Start of enrollment: 2012 Dec 01
- Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP) Start of enrollment: 2023 Jul 10
Publications & Presentations
PubMed
- Lynch syndrome integrative epidemiology and genetics (LINEAGE): rationale for cohort design.Swati G Patel, Holli A Loomans-Kropp, Zachariah H Foda, Bryson W Katona, Suzi Birz
Familial Cancer. 2026-05-06 - 178 citationsInterplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice.Albert G. Linden, Shili Li, Hwa Y. Choi, Fei Fang, Masashi Fukasawa
Journal of Lipid Research. 2018-01-15 - 12 citationsCholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine.Shunxing Rong, Jeffrey G. McDonald, Luke J. Engelking
Journal of Lipid Research. 2017-10-01
Press Mentions
Engelking seeks to balance research and medicineJanuary 19th, 2023
American Gastroenterological Association selects 18 future leaders March 23rd, 2022
Journal of Lipid Research Names New Junior Associate EditorsMarch 31st, 2021
Grant Support
- T35 NEI Medical Student Summer Research TrainingUT SOUTHWESTERN MEDICAL CENTER2018–2030
- T35 NIAAA Summer Research ProgramUT SOUTHWESTERN MEDICAL CENTER2023–2028
- SREBP-Mediated Regulation of Intestinal Epithelial HomeostasisUT SOUTHWESTERN MEDICAL CENTER2019–2025
- SREBP-2- Dependent Oncometabolites and Intestinal TumorigenesisCancer Prevention & Research Institute of Texas2020–2023
- SREBP-Mediated Lipid Regulation in the IntestineNIDDK2014–2019
Committees
- Member, CGA-IGC - Research Committee 2025 - Present
- Member, American Gastroenterogical Association - Publications Committee 2024 - Present
Professional Memberships
- Member
- Member
- American Society for Biochemistry and Molecular BiologyMember
- Collaborative Group of the Americas on Inherited Gastrointestinal CancerMember
External Links
- UTSW Faculty Pagehttp://profiles.utsouthwestern.edu/profile/35166/luke-engelking.html
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