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Luke Engelking, MD, Gastroenterology, Dallas, TX

Luke J Engelking MD PhD, AGAF (He/Him)


Associate Professor, Co-Medical Director Cancer Genetics Program

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  • 5323 Harry Hines BoulevardDallas, TX 75390

  • Phone+1 214-648-8088

  • Fax+1 214-648-8804

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Summary

  • Dr. Engelking a physician-scientist gastroenterologist, genetic cancer specialist, investigator, and educator. He serves as the Co-Medical Director of UT Southwestern's Cancer Genetics program and its Genetic Cancer Prevention Clinic, where he is accepting new patient referrals (ph: 214-645-2563; f: 214-645-2562).


    He leads clinic, endoscopy, and research programs focused on hereditary syndromes of GI cancer risk and polyposis, such as Lynch syndrome and Familial Adenomatous Polyposis syndrome. The overarching goal of these programs is cancer prevention care for patients and their families with inherited forms of GI cancers, particularly colorectal cancer. He has completed intensive training from City of Hope and is a certified genetic cancer risk assessment specialist.


    He completed joint MD/PhD training (2000-2007) at UT Southwestern in Dallas, where he studied cholesterol metabolism under Nobel Laureates Goldstein and Brown. He next completed internal medicine training at Massachusetts General Hospital (2007-2010), an affiliate of Harvard Medical School, and then returned to UT Southwestern for a clinical and research fellowship in gastroenterology (2010-2014). He is now an Associate Professor of Internal Medicine and the Harold C. Simmons Comprehensive Cancer Center. He served as interim Associate Dean of Medical Student Research and Scholarly Activity. His basic science laboratory studied various aspects of lipid metabolism in digestive organs and GI tract neoplasms, supported by research grants from NIH and CPRIT. He has authored numerous high impact research manuscripts published in Journal of Clinical Investigation, Cell Metabolism, and elsewhere.

Education & Training

  • University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical CenterFellowship, Gastroenterology, 2010 - 2014
  • Mass General Brigham/Massachusetts General Hospital
    Mass General Brigham/Massachusetts General HospitalResidency, Internal Medicine, 2007 - 2010
  • University of Texas Southwestern Medical School
    University of Texas Southwestern Medical SchoolClass of 2007

Certifications & Licensure

  • TX State Medical License
    TX State Medical License 2010 - 2026
  • MA State Medical License
    MA State Medical License 2009 - 2012
  • Internal Medicine
    American Board of Internal Medicine Internal Medicine
  • Gastroenterology
    American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

  • CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2015-2017
  • CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2015-2017
  • Research Scholar in Liver Disease Award Gilead Sciences, Inc., 2015

Clinical Trials

Publications & Presentations

PubMed

Press Mentions

  • Engelking seeks to balance research and medicine
    Engelking seeks to balance research and medicineJanuary 19th, 2023
  • American Gastroenterological Association selects 18 future leaders
    American Gastroenterological Association selects 18 future leaders March 23rd, 2022
  • Journal of Lipid Research Names New Junior Associate Editors
    Journal of Lipid Research Names New Junior Associate EditorsMarch 31st, 2021

Grant Support

  • T35 NEI Medical Student Summer Research TrainingUT SOUTHWESTERN MEDICAL CENTER2018–2030
  • T35 NIAAA Summer Research ProgramUT SOUTHWESTERN MEDICAL CENTER2023–2028
  • SREBP-Mediated Regulation of Intestinal Epithelial HomeostasisUT SOUTHWESTERN MEDICAL CENTER2019–2025
  • SREBP-2- Dependent Oncometabolites and Intestinal TumorigenesisCancer Prevention & Research Institute of Texas2020–2023
  • SREBP-Mediated Lipid Regulation in the IntestineNIDDK2014–2019

Committees

  • Member, CGA-IGC - Research Committee 2025 - Present
  • Member, American Gastroenterogical Association - Publications Committee 2024 - Present

Professional Memberships

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