JenniferO.LauchleMD

PubMed

• An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer.
  Sarat Chandarlapaty, Maura N Dickler, Jose Alejandro Perez Fidalgo, Rafael Villanueva-Vázquez, Jennifer Giltnane, Mary Gates, Ching-Wei Chang, Sravanthi Cheeti, Jill F...> ;Clinical Cancer Research. 2023 Aug 1
• 5 citations
  Myths about diversity in clinical trials reduce return on investment for industry.
  Mohammed Suhail Chaudhry, Jessica Spahn, Shilpen Patel, Charles S Fuchs, Jennifer Lauchle, Nikheel Kolatkar, Nicole Richie, Quita Highsmith, Meghan McKenzie, Ruma Bhagat> ;Nature Medicine. 2022 Aug 1
• 1 citations
  Clinical Translation: Targeting the Estrogen Receptor.
  Ciara Metcalfe, Jennifer O Lauchle> ;Advances in Experimental Medicine and Biology. 2022 Jan 1
• 85 citations
  Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors
  Saoirse Dolly, Andrew J. Wagner, Johanna C. Bendell, Hedy L. Kindler, Lee M. Krug, Tanguy Y. Seiwert, Marjorie G. Zauderer, Martijn P. Lolkema, Doris Apt, Ru Fang Yeh,...> ;Clinical Cancer Research. 2016 Jun 15
• 16 citations
  A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies.
  Ophélia Maertens, Mila E. McCurrach, Benjamin S. Braun, Thomas De Raedt, Inbal Epstein, Tannie Q. Huang, Jennifer O. Lauchle, Hyerim Lee, Jianqiang Wu, Timothy P. Crip...> ;Cancer Research. 2017 Nov 1
• 48 citations
  Phase I study of the checkpoint kinase 1 inhibitor GDC-0575 in combination with gemcitabine in patients with refractory solid tumors
  Antoine Italiano, J. R. Infante, Geoffrey I. Shapiro, Kathleen N. Moore, Patricia LoRusso, Erika Hamilton, Sophie Cousin, Maud Toulmonde, Sophie Postel-Vinay, Sara M. ...> ;Annals of Oncology. 2017 Sep 1
• 50 citations
  Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors.
  Jeffrey R. Infante, Antoine Hollebecque, Sophie Postel-Vinay, Todd M. Bauer, Elizabeth Blackwood, Marie Evangelista, Sami Mahrus, Franklin Peale, Xuyang Lu, Srikumar S...> ;Clinical Cancer Research. 2017 May 15
• 55 citations
  A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study).
  Vicky Makker, Fernando O. Recio, Ling Ma, Ursula A. Matulonis, Jennifer O. Lauchle, Hema Parmar, Houston Gilbert, Joseph A. Ware, Rui Zhu, Shan Lu, Ling-Yuh Huw, Yulei...> ;Cancer. 2016 Nov 15
• Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.
  Tiffany Chang, Kimberly Krisman, Emily Harding Theobald, Jin Xu, Jon Akutagawa, Jennifer O Lauchle, Scott Kogan, Benjamin S Braun, Kevin Shannon> ;The Journal of Clinical Investigation. 2016 Jan 1
• 2 citations
  Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.
  Tiffany Chang, Kimberly Krisman, Emily Harding Theobald, Jin Xu, Jon Akutagawa, Jennifer O Lauchle, Scott Kogan, Benjamin S Braun, Kevin Shannon> ;The Journal of Clinical Investigation. 2013 Jan 1
• 35 citations
  Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies
  Katherine A. Rauen, Anuradha Banerjee, W. Robert Bishop, Jennifer O. Lauchle, Frank McCormick, Martin McMahon, Teri Melese, Pamela N. Munster, Sorena Nadaf, Roger J. P...> ;American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 2011 May 15
• 74 citations
  A MEK Inhibitor Abrogates Myeloproliferative Disease in Kras Mutant Mice
  Natalya Lyubynska, Matthew F. Gorman, Jennifer O. Lauchle, Wan Xing Hong, Jon Akutagawa, Kevin Shannon, Benjamin S. Braun> ;Science Translational Medicine. 2011 Mar 30
• 108 citations
  Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
  Jennifer O. Lauchle, Doris Kim, Doan T. Le, Keiko Akagi, Michael Crone, Kimberly Krisman, Kegan Warner, Jeannette M. Bonifas, Qing Li, Kristen M Coakley, Ernesto Diaz-...> ;Nature. 2009 Sep 17
• 21 citations
  β common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice
  Andrew Kim, Kelly Morgan, Diane E. Hasz, Stephen M. Wiesner, Jennifer O. Lauchle, Jennifer L. Geurts, Miechaleen D. Diers, Doan T. Le, Scott C. Kogan, Luis F. Parada, ...> ;Blood. 2007 Feb 15
• 72 citations
  Inherited predispositions and hyperactive Ras in myeloid leukemogenesis.
  Jennifer O. Lauchle, Benjamin S. Braun, Mignon L. Loh, Kevin Shannon> ;Pediatric Blood & Cancer. 2006 May 1
• 39 citations
  Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22.
  Nicole P. Curtiss, Jeannette M. Bonifas, Jennifer O. Lauchle, Jason D. Balkman, Christian P. Kratz, Brooke M. Emerling, Eric D. Green, Michelle M. Le Beau, Kevin Shannon> ;Genomics. 2005 May 1
• 145 citations
  Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder.
  Doan T. Le, Namie Kong, Yuan Zhu, Jennifer O. Lauchle, Abigail Aiyigari, Benjamin S. Braun, Endi Wang, Scott C. Kogan, Michelle M. Le Beau, Luis F. Parada, Kevin Shannon> ;Blood. 2004 Jun 1
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