John A.EdwardsMD

PubMed

• 102 citations
  A Fungal Immunotherapeutic Vaccine (NDV-3A) for Treatment of Recurrent Vulvovaginal Candidiasis-A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial.
  John E. Edwards, Michael M. Schwartz, Clint S. Schmidt, Jack D. Sobel, Paul Nyirjesy, Florian Schodel, Erica Marchus, Mary Lizakowski, Elizabeth A DeMontigny, Jesse Ho...> ;Clinical Infectious Diseases. 2018 Jun 1
• 60 citations
  Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis
  Teclegiorgis Gebremariam, Lin Lin, Mingfu Liu, Dimitrios P. Kontoyiannis, Samuel W. French, John E. Edwards, Scott G. Filler, Ashraf S. Ibrahim> ;The Journal of Clinical Investigation. 2016 Jun 1
• 47 citations
  Nonredundant Roles of Interleukin-17A (IL-17A) and IL-22 in Murine Host Defense against Cutaneous and Hematogenous Infection Due to Methicillin-Resistant Staphylococcu...
  Liana C. Chan, Siyang Chaili, Scott G. Filler, Kevin Barr, Huiyuan Wang, Deborah Kupferwasser, John E. Edwards, Yan Q. Xiong, Ashraf S. Ibrahim, Lloyd S. Miller, Clint...> ;Infection and Immunity. 2015 Nov 1
• 45 citations
  Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection
  Michael R. Yeaman, Scott G. Filler, Siyang Chaili, Kevin Barr, Huiyuan Wang, Deborah Kupferwasser, John P. Hennessey, Yue Fu, Clint S. Schmidt, John E. Edwards, Yan Q....> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Dec 23
• 69 citations
  NDV-3 protects mice from vulvovaginal candidiasis through T- and B-cell immune response.
  Ashraf S. Ibrahim, Guanpingsheng Luo, Teclegiorgis Gebremariam, Hongkyu Lee, Clint S. Schmidt, John P. Hennessey, Samuel W. French, Michael R. Yeaman, Scott G. Filler,...> ;Vaccine. 2013 Nov 12
• 110 citations
  The high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis
  Ashraf S. Ibrahim, Teclegiorgis Gebremariam, Lin Lin, Guanpingsheng Luo, Mohamed I. Husseiny, Christopher D. Skory, Yue Fu, Samuel W. French, John E. Edwards, Brad Spe...> ;Molecular Microbiology. 2010 Aug 1
• 49 citations
  The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis
  Ashraf S. Ibrahim, Teclegiorgis Gebremariam, Samuel W. French, John E. Edwards, Brad Spellberg> ;The Journal of Antimicrobial Chemotherapy. 2010 Feb 1
• 52 citations
  Antimicrobial Agents for Complicated Skin and Skin-Structure Infections: Justification of Noninferiority Margins in the Absence of Placebo-Controlled Trials
  Brad Spellberg, George H. Talbot, Helen W. Boucher, John S. Bradley, David N. Gilbert, W. Michael Scheld, John E. Edwards, John G. Bartlett> ;Clinical Infectious Diseases. 2009 Aug 1
• The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Summary and comments.
  János Sinkó, Bart Jan Kullberg, John E. Edwards, Elias Anaissie> ;The Journal of Antimicrobial Chemotherapy. 2009 May 1
• 315 citations
  Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis.
  Caitlin Reed, Richard Bryant, Ashraf S. Ibrahim, John E. Edwards, Scott G. Filler, Robert J. Goldberg, Brad Spellberg> ;Clinical Infectious Diseases. 2008 Aug 1
• 14 citations
  Optimization of a myeloid cell transfusion strategy for infected neutropenic hosts.
  Brad Spellberg, Mary Collins, Valentina Avanesian, Mayela Gomez, John E. Edwards, Christopher R. Cogle, David Applebaum, Yue Fu, Ashraf S. Ibrahim> ;Journal of Leukocyte Biology. 2007 Mar 1
• 47 citations
  Candida albicans protein kinase CK2 governs virulence during oropharyngeal candidiasis.
  Lisa Y. Chiang, Donald C. Sheppard, Vincent M. Bruno, Aaron P. Mitchell, John E. Edwards, Scott G. Filler> ;Cellular Microbiology. 2007 Jan 1
• 92 citations
  Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosis.
  Caitlin Reed, Ashraf S. Ibrahim, John E. Edwards, Irwin Walot, Brad Spellberg> ;Antimicrobial Agents and Chemotherapy. 2006 Nov 1
• 20 citations
  Comparison of antifungal treatments for murine fusariosis
  Brad Spellberg, Julie Schwartz, Yue Fu, Valentina Avanesian, Jill Adler-Moore, John E. Edwards, Ashraf S. Ibrahim> ;The Journal of Antimicrobial Chemotherapy. 2006 Nov 1
• 108 citations
  Deferiprone iron chelation as a novel therapy for experimental mucormycosis
  Ashraf S. Ibrahim, John E. Edwards, Yue Fu, Brad Spellberg> ;The Journal of Antimicrobial Chemotherapy. 2006 Nov 1
• 7 citations
  Antifungal Prophylaxis Is Effective against Murine Invasive Pulmonary Aspergillosis
  Gunter Rieg, Brad Spellberg, Julie Schwartz, Yue Fu, John E. Edwards, Donald C. Sheppard, Ashraf S. Ibrahim> ;Antimicrobial Agents and Chemotherapy. 2006 Aug 1
• 57 citations
  The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocomprom...
  Brad Spellberg, Ashraf S. Ibrahim, Valentina Avenissian, Scott G. Filler, Carter L. Myers, Yue Fu, John E. Edwards> ;Infection and Immunity. 2005 Sep 1
• 174 citations
  Mice with Disseminated Candidiasis Die of Progressive Sepsis
  Brad Spellberg, Ashraf S. Ibrahim, John E. Edwards, Scott G. Filler> ;The Journal of Infectious Diseases. 2005 Jul 15
• 35 citations
  A phagocytic cell line markedly improves survival of infected neutropenic mice
  Brad Spellberg, Mary Collins, Samuel W. French, John E. Edwards, Yue Fu, Ashraf S. Ibrahim> ;Journal of Leukocyte Biology. 2005 Aug 1
• 132 citations
  Combination Therapy with Amphotericin B Lipid Complex and Caspofungin Acetate of Disseminated Zygomycosis in Diabetic Ketoacidotic Mice
  Brad Spellberg, Yue Fu, John E. Edwards, Ashraf S. Ibrahim> ;Antimicrobial Agents and Chemotherapy. 2005 Feb 1
• 143 citations
  Caspofungin Inhibits Rhizopus oryzae 1,3-β-d-Glucan Synthase, Lowers Burden in Brain Measured by Quantitative PCR, and Improves Survival at a Low but Not a High Dose d...
  Ashraf S. Ibrahim, Joel Bowman, Valentina Avanessian, Keturah Brown, Brad Spellberg, John E. Edwards, Cameron M. Douglas> ;Antimicrobial Agents and Chemotherapy. 2005 Feb 1
• 58 citations
  Vaccination with Recombinant N-Terminal Domain of Als1p Improves Survival during Murine Disseminated Candidiasis by Enhancing Cell-Mediated, Not Humoral, Immunity
  Ashraf S. Ibrahim, Brad Spellberg, Valentina Avenissian, Yue Fu, Scott G. Filler, John E. Edwards> ;Infection and Immunity. 2005 Feb 1
• 163 citations
  Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasis
  Hyunsook Park, Carter L. Myers, Donald C. Sheppard, Quynh T. Phan, Angela A. Sanchez, John E. Edwards, Scott G. Filler> ;Cellular Microbiology. 2004 Dec 13
• 13 citations
  Susceptibility to Thrombin-Induced Platelet Microbicidal Protein Is Associated with Increased Fluconazole Efficacy against Experimental Endocarditis Due to Candida alb...
  Michael R. Yeaman, Darwin Cheng, Bhavesh Desai, Leon Iri Kupferwasser, Yan-Qiong Xiong, Kimberly D. Gank, John E. Edwards, Arnold S. Bayer> ;Antimicrobial Agents and Chemotherapy. 2004 Aug 1
• 8 citations
  Development of a vaccine for invasive aspergillosis.
  Donald C. Sheppard, John E. Edwards> ;Clinical Infectious Diseases. 2004 Apr 15
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