JohnAlexAllenMD

PubMed

• Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.
  Huang, H. S., Allen, J. A., Mabb, A. M., King, I. F., Miriyala, J., Taylor-Blake, B., Sciaky, N., Dutton, J. W., Lee, H. M., Chen, X., Jin, J., Bridges, A. S., Zylka, ...> ;Nature. 2012 Jan 12
• Discovery of ?-Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy.
  Allen, J.A., Yost, J.M., Setola, V., Chen, X., Sassano, M.F., Chen, M., Peterson, S., Yadav, P.N., Huang, X., Feng, B., Jensen, N.H., Che, X., Bai, X., Frye, S.V., Wet...> ;Proc Natl Acad Sci U S A. 2011 Nov 8
• Advancing drug discovery for schizophrenia.
  Marder, S.R., Roth, B., Sullivan, P.F., Scolnick, E.M., Nestler, E.J., Geyer, M.A., Welnberger, D.R., Karayiorgou, M., Guidotti, A., Gingrich, J., Akbarian, S., Buchan...> ;Ann N Y Acad Sci. 2011 Oct
• Strategies to discover unexpected targets for drugs active at G protein-coupled receptors.
  Allen, J.A., Roth, B.L.> ;Annu Rev Pharmacol Toxicol. 2011
• HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia.
  Kozikowski, A. P., Cho, S. J., Jensen, N. H., Allen, J. A., Svennebring, A. M., Roth, B. L.> ;ChemMedChem. 2010 Aug 2
• A chemical-genetic approach for precise spatio-temporal control of cellular signaling.
  Dong, S., Allen, J. A., Farrell, M., Roth, B. L.> ;Mol Biosyst. 2010 Aug
• p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling.
  Strachan, R.T., Allen, J.A., Sheffler, D.J., Roth, B.L.> ;Biochemistry. 2010 Mar 30
• Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling.
  Jones, K.A., Srivastava, D.P., Allen, J.A., Strachan, R.T., Roth, B.L., Penzes, P.> ;Proc Natl Acad Sci U S A. 2009-11-17
• Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling.
  Allen, J.A., Yu, J.Z., Dave, R.H., Bhatnagar, A., Roth, B.L., Rasenick, M.M.> ;Mol Pharmacol. 2009-11-01
• Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.
  Huang, X., Setola, V., Yadav, P.N., Allen, J.A., Rogan, S.C., Hanson, B.J., Revankar, C., Robers, M., Doucette, C., Roth, B.L.> ;Mol Pharmacol. 2009-10-01
• Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid rece...
  Yan, F., Bikbulatov, R.V., Mocanu, V., Dicheva, N., Parker, C.E., Wetsel, W.C., Mosier, P.D., Westkaemper, R.B., Allen, J.A., Zjawiony, J.K., Roth, B.L.> ;Biochemistry. 2009-07-28
• 674 citations
  Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.
  Georgia M. Alexander, Sarah C. Rogan, Atheir I. Abbas, Blaine N. Armbruster, Ying Pei, John A. Allen, Randal J. Nonneman, John Hartmann, Sheryl S. Moy, Miguel A. L. Ni...> ;Neuron. 2009 Jul 16
• Cytosolic G{alpha}s acts as an intracellular messenger to increase microtubule dynamics and promote neurite outgrowth.
  Yu, J., Dave, R.H., Allen, J.A., Sarma, T., Rasenick, M.M.> ;J Biol Chem. 2009 Apr 17
• Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases.
  Allen, J. A., Yadav, P. N., Roth, B. L.> ;Neuropharmacology. 2008 Nov
• Lipid raft microdomains and neurotransmitter signalling.
  Allen, J. A., Halverson-Tamboli, R. A., Rasenick, M. M.> ;Nat Rev Neurosci. 2007 Feb
• Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis.
  Allen, J.A., Shankara, T., Janus, P., Buck, S., Diemer, T., Hales, K.H., Hales, D.B.> ;Endocrinology. 2006 Aug
• Mitochondrial function in Leydig cell steroidogenesis.
  Hales, D.B., Allen, J.A., Shankara, T., Janus, P., Buck, S., Diemer, T., Hales, K.H.> ;Ann N Y Acad Sci. 2005 Dec
• Beta-adrenergic receptor stimulation promotes G alpha s internalization through lipid rafts: a study in living cells.
  Allen, J. A.,Yu, J. Z.,Donati, R. J.,Rasenick, M. M.> ;Mol Pharmacol. 2005 May
• A source-sink hypothesis for abyssal biodiversity.
  Rex, M. A., McClain, C. R., Johnson, N. A., Etter, R. J., Allen, J. A., Bouchet, P., Warén, A.> ;Am Nat. 2005 Feb
• Bacterial endotoxin lipopolysaccharide and reactive oxygen species inhibit Leydig cell steroidogenesis via perturbation of mitochondria.
  Allen, J.A., Diemer, T., Janus, P., Hales, K.H., Hales, D.B.> ;Endocrine. 2004 Dec
• Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis.
  Diemer, T., Allen, J.A., Hales, K.H., Hales, D.B.> ;Endocrinology. 2003 Jul
• Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo.
  Allen, J. A.,Yadav, P. N.,Setola, V.,Farrell, M.,Roth, B. L.> ;Transl Psychiatry. 2011 Jan 01
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