John B Fiveash MD

Central Nervous System Cancer

Professor, Radiation Oncology, University of Alabama School of Medicine Senior Vice Chair Department of Radiation Oncology

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2000 6th Ave SBirmingham, AL 35233
Phone+1 205-934-9999
Fax+1 205-975-0784

Summary

Residency Program Director

Education & Training

Medical College of GeorgiaResidency, Radiation Oncology, 1994 - 1997
HCA Healthcare/Mercer University School of Medicine/Memorial Health University Medical CenterInternship, Internal Medicine, 1993 - 1994
Medical College of Georgia at Augusta UniversityClass of 1993

Certifications & Licensure

AL State Medical License 1998 - 2025
MI State Medical License 1997 - 2001
GA State Medical License 1996 - 1999
SC State Medical License 1995 - 1996
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2012-2014
America's Top Doctors for Cancer Castle Connolly, 2011-2013
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012

Clinical Trials

131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma Start of enrollment: 2004 Nov 01
Unknown status
Phase 2
131-I-TM-601 Study in Adults With Solid Tumors Start of enrollment: 2006 Aug 01
Completed
Phase 1
Gossypol (AT-101) and Temozolomide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Start of enrollment: 2007 Feb 01
Completed
Phase 1
Gossypol in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme Start of enrollment: 2008 Jan 01
Completed
Phase 2
A Phase II Study of Spinal Radiosurgery Start of enrollment: 2005 Apr 01
Completed
Not Applicable
Phase II Study of Gamma Knife Radiosurgery and Temozolomide for Brain Metastases Start of enrollment: 2002 Jul 01
Completed
Phase 2
A Study of 131I-TM601 in Adults With Recurrent Malignant Glioma Start of enrollment: 2008 Aug 01
Unknown status
Phase 1, Phase 2
Dose Escalation/De-escalation Study of Pre-operative Stereotactic Radiosurgery for Brain Metastases(RAD 1002) Start of enrollment: 2010 Oct 01
Completed
Phase 1
Safety Study of ²¹²Pb-TCMC-Trastuzumab Radio Immunotherapy Start of enrollment: 2011 Jul 01
Completed
Phase 1
Natural History of Brain Function, Quality of Life, and Seizure Control in Patients With Brain Tumor Who Have Undergone Surgery Start of enrollment: 2011 Oct 01
Completed
Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma Start of enrollment: 2012 Dec 20
Completed
Phase 2
Pilot Trial Evaluating Stereotactic Body Radiotherapy With Integrated Boost for Clinically Localized Prostate Cancer (RAD 1203) Start of enrollment: 2013 Feb 01
Completed
Not Applicable
A Dose Escalation Trial of Five Fraction Stereotactic Radiation Therapy for Brain Metastases Start of enrollment: 2018 Jul 30
ACTIVE_NOT_RECRUITING
NA
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Publications & Presentations

PubMed

HyperArc Automated Stereotactic Radiosurgery Planning Enables Accurate a Priori Fractionation Scheme Selection via Adherence to HyTEC Toxicity Thresholds.
Joel A Pogue, John Fiveash, Rex Cardan, Christopher Willey, Natalie Viscariello
Advances in Radiation Oncology. 2025-11-01
Frameless linac-based radiosurgery for benign intracranial tumors treated with HyperArc: analysis of tumor control and toxicity.
Whitney S Hotsinpiller, Evan M Thomas, Ian Tsekouras, Richard A Popple, Markus Bredel
Journal of Neuro-Oncology. 2025-10-21
Tumor Treating Fields (TTFields) therapy after stereotactic radiosurgery for brain metastases from non-small cell lung cancer: final results of the phase 3 METIS study.
Minesh P Mehta, Vinai Gondi, Manmeet Singh Ahluwalia, David Roberge, Terence Tai Weng Sio
International Journal of Radiation Oncology, Biology, Physics. 2025-09-29

Press Mentions

Uab First in U.s. To Use Hyperarc High-Definition Radiotherapy on Brain CancerNovember 26th, 2017
UAB to Bring Proton Therapy for Advanced Cancer Treatment to BirminghamFebruary 16th, 2017
The University of Alabama at Birmingham and Proton International Moving Forward to Develop State’s First Proton Treatment CenterFebruary 16th, 2017