JohnNagiKheirMD

Pediatrics • Boston, MA

Pediatric Critical Care Medicine, Pediatric Cardiac Critical Care, Pediatric Cardiology

Assistant in Pediatrics, Boston Children's Hospital

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Office
300 Longwood Ave
Enders 1212
Boston, MA 02115
Phone+1 617-355-7327

Fax+1 617-734-0453
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Education & Training

Children's Hospital/Boston Medical CenterFellowship, Pediatric Cardiology, 2009 - 2010
Children's Hospital/Boston Medical CenterFellowship, Pediatric Critical Care Medicine, 2006 - 2009
Cincinnati Children's Hospital Medical CenterResidency, Pediatrics, 2002 - 2006
University of Virginia School of MedicineClass of 2002

Certifications & Licensure

MA State Medical License 2006 - 2025
NH State Medical License 2023 - 2025
OH State Medical License 2002 - 2006
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Critical Care Medicine

Clinical Trials

Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study) Start of enrollment: 2012 Dec 01
Completed
Not Applicable
Validation of a Novel Oxygen Consumption Measurement Technique in Neonates Start of enrollment: 2017 Jul 05
Completed
Safety of Inhaled Hydrogen Gas Mixtures in Healthy Volunteers Start of enrollment: 2020 Oct 26
Completed
Phase 1
Hydrogen's Feasibility and Safety as a Therapy in ECPR Start of enrollment: 2024 Mar 04
Recruiting
Phase 1
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Arch watch: current approaches and opportunities for improvement.
Levy, P., Braudis, N., Friedman, K., Thomas, A., Sperotto, F., Valencia, E., DiNardo, J., Kheir, J., Sperotto, F.> ;Journal of Perinatology. 2024 Mar 1
Impact of Dexmedetomidine Infusion on Opioid and Benzodiazepine Doses in Ventilated Pediatric Patients in the Cardiac Intensive Care Unit.
Reuth Nir, Francesca Sperotto, Manasee Godsay, Minmin Lu, John N Kheir> ;Paediatric Drugs. 2023 Nov 1
3 citations
A microfluidic device for real-time on-demand intravenous oxygen delivery.
Ashwin Kumar Vutha, Ryan Patenaude, Alexis Cole, Rajesh Kumar, John N Kheir, Brian D Polizzotti> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Mar 29
12 citations
Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults
Alexis R. Cole, Francesca Sperotto, James A. DiNardo, Stephanie Carlisle, Michael J. Rivkin, Lynn A. Sleeper, John N. Kheir> ;Critical Care Explorations. 2021 Oct 8
8 citations
Modeling severe functional impairment or death following ECPR in pediatric cardiac patients: Planning for an interventional trial.
Francesca Sperotto, Kwannapas Saengsin, Amy R. Danehy, Manasee Godsay, Diana L. Geisser, Michael J. Rivkin, Angela Amigoni, Ravi R. Thiagarajan, John N. Kheir> ;Resuscitation. 2021 Aug 10
3 citations
Development of Care Curves Following the Stage 1 Palliation: A Comparison of Intensive Care Among 5 Centers
Francesca Sperotto, Jesse A. Davidson, Melissa N Smith-Parrish, Justin J. Elhoff, Anjuli Sinha, Joshua J. Blinder, Daniel E. Ehrmann, Bradley S. Marino, John N. Kheir> ;Journal of the American Heart Association. 2021 Jun 1
Commentary: Hydrogen: Lightweight molecule takes on a heavyweight problem.
John N. Kheir, James A. DiNardo> ;The Journal of Thoracic and Cardiovascular Surgery. 2021 May 7
58 citations
Socioeconomic and Racial and/or Ethnic Disparities in Multisystem Inflammatory Syndrome.
Karina Javalkar, Victoria K. Robson, Lukas K. Gaffney, Amy M. Bohling, Puneeta Arya, Sarah Servattalab, Jordan E Roberts, Jeffrey I. Campbell, Sepehr Sekhavat, Jane W....> ;Pediatrics. 2021 Feb 18
2 citations
Shock Index, Coronary Perfusion Pressure, and Rate Pressure Product As Predictors of Adverse Outcome After Pediatric Cardiac Surgery.
Francesca Sperotto, Peter C. Laussen, Joshua W. Salvin, Akash Bachu, John N. Kheir> ;Pediatric Critical Care Medicine. 2021 Jan 1
1 citations
Avoidable Serum Potassium Testing in the Cardiac ICU: Development and Testing of a Machine-Learning Model.
Bhaven B Patel, Francesca Sperotto, Mathieu Molina, Satoshi Kimura, Marlon Delgado, Mauricio Santillana, John N. Kheir> ;Pediatric Critical Care Medicine. 2021 Apr 1
3 citations
Vein of Galen Malformation.
Erika G. Cordova, John N. Kheir, Darren B. Orbach, Carol E. Barnewolt, Judy A. Estroff, Philip T. Levy> ;Neoreviews. 2020 Oct 1
6 citations
Hyperbaric polymer microcapsules for tunable oxygen delivery.
Tien Nguyen, Yifeng Peng, Raymond P. Seekell, John N. Kheir, Brian D. Polizzotti> ;Journal of Controlled Release. 2020 Aug 14
11 citations
Complete Heart Block, Severe Ventricular Dysfunction, and Myocardial Inflammation in a Child With COVID-19 Infection.
Iqbal El-Assaad, M Indriati Hood-Pishchany, John Kheir, Kshitij Mistry, Avika Dixit, Olha Halyabar, Douglas Y Mah, Colin Meyer-Macaulay, Henry Cheng> ;JACC. Case Reports. 2020 Jul 15
WITHDRAWN: Complete Heart Block, Severe Ventricular Dysfunction and Myocardial Inflammation in a Child with COVID-19 Infection.
Iqbal El Assaad, M Indriati Hood-Pishchany, John Kheir, Kshitij Mistry, Avika Dixit, Olha Halyabar, Douglas Y Mah, Colin Meyer-Macaulay, Henry Cheng> ;JACC. Case Reports. 2020 May 27
8 citations
Red Blood Cell Transfusion After Stage I Palliation Is Associated With Worse Clinical Outcomes
Felina K. Mille, Aditya Badheka, Priscilla Yu, Xuemei Zhang, David F. Friedman, John N. Kheir, Sarah J. van den Bosch, Antonio G. Cabrera, Javier J. Lasa, Hannah Katco...> ;Journal of the American Heart Association. 2020 May 18
Value of provocative electrophysiology testing in the management of pediatric patients after congenital heart surgery.
Audrey Dionne, John N. Kheir, Kimberlee Gauvreau, John K. Triedman, Dominic Abrams, Mark E. Alexander, Elizabeth S. DeWitt, Douglas Y. Mah, Edward P. Walsh, Vassilios ...> ;Pacing and Clinical Electrophysiology. 2020 Apr 24
3 citations
Development of a Respiratory Support Score as a Visualization Tool in Intensive Care
Anjuli Sinha, Sarah J. van den Bosch, Kelsey Pozerski, Lingyu Zhou, John N. Kheir> ;Respiratory Care. 2020 Sep 1
20 citations
Fontan with lateral tunnel is associated with improved survival compared with extracardiac conduit.
Viktoria Weixler, David Zurakowski, John N. Kheir, Alvise Guariento, Aditya K. Kaza, Christopher W. Baird, Pedro J. del Nido, Sitaram M. Emani> ;The Journal of Thoracic and Cardiovascular Surgery. 2020 Apr 1
Impact of the superior cavopulmonary anastomosis on cerebral oxygenation
Nikhil Thatte, Lingyu Zhou, John N. Kheir> ;Cardiology in the Young. 2020 Mar 16
15 citations
Value of Troponin Testing for Detection of Heart Disease in Previously Healthy Children.
Audrey Dionne, John N. Kheir, Lynn A. Sleeper, Jesse J. Esch, Roger E. Breitbart> ;Journal of the American Heart Association. 2020 Feb 18
3 citations
Sensitivity of a Next-Generation NIRS Device to Detect Low Mixed Venous Oxyhemoglobin Saturations in the Single Ventricle Population
Marie-Helene Gagnon, Barry D. Kussman, Lingyu Zhou, James A. DiNardo, John N. Kheir> ;Anesthesia and Analgesia. 2020 Jan 20
13 citations
Safety of inhaled hydrogen gas in healthy mice
Alexis R. Cole, Ali Raza, Humera Ahmed, Brian D. Polizzotti, Robert F. Padera, Nick Andrews, John N. Kheir> ;Medical Gas Research. 2019 Jul 1
10 citations
Intravenous Amiodarone and Sotalol Impair Contractility and Cardiac Output, but Procainamide Does Not: A Langendorff Study:
Charles Mackin, Elizabeth S. DeWitt, Katherine J. Black, Xiaoqi Tang, Brian D. Polizzotti, Sarah J. van den Bosch, Mark E. Alexander, John N. Kheir> ;Journal of Cardiovascular Pharmacology and Therapeutics. 2019 May 1
15 citations
Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine
Alexis R. Cole, Dorothy A. Perry, Ali Raza, Arthur Nedder, Elizabeth Pollack, William Regan, Sarah J. van den Bosch, Brian D. Polizzotti, Edward Yang, Daniel Davila, O...> ;JACC. Basic to Translational Science. 2019 Mar 27
Reply to Li, J "The Fick principle remains accurate to calculate cardiac output under hyperoxia".
John N. Kheir, James A. DiNardo> ;Acta Anaesthesiologica Scandinavica. 2019 Mar 25
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Authored Content

Effects of an Anticoagulation Protocol on the Incidence of Bleeding and Thrombosis in Postoperative Infants in the Cardiac Intensive Care UnitMay 2018

Press Mentions

Accelerating Access to Health Through Philanthropic Investment: Thinking Beyond the Initial InvestmentOctober 17th, 2019
Inhaled Hydrogen Could Protect the Brain During Heart-Lung BypassApril 29th, 2019
From the LiteratureMarch 6th, 2018
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Hospital Affiliations

Boston Children's HospitalBoston, Massachusetts