JohnHLeeMD

Otolaryngology (ENT) • El Segundo, CA

Head & Neck Oncologic Surgery

Surgeon/Scientist

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Office
2040 E Mariposa Ave
El Segundo, CA 90245
Phone+1 213-266-5600
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Education & Training

University of Iowa Hospitals and ClinicsResidency, Otolaryngology - Head and Neck Surgery, 1998 - 2002
University of Iowa Hospitals and ClinicsInternship, Transitional Year, 1995 - 1996
University of Minnesota Medical SchoolClass of 1995

Certifications & Licensure

SD State Medical License Active through 2025
ND State Medical License 2013 - 2020
CA State Medical License 2017 - 2020
IA State Medical License 1995 - 2011
American Board of Otolaryngology - Head and Neck Surgery Otolaryngology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Fellow (FAAO-HNS) American Academy of Otolaryngology - Head and Neck Surgery
Fellow (FACS) American College of Surgeons

Clinical Trials

Study of DCA (Dichloroacetate) in Combination With Cisplatin and Definitive Radiation in Head and Neck Carcinoma Start of enrollment: 2011 May 01
Completed
Phase 2
The Midwest Head and Neck Cancer Consortium Multi-Institutional Parathyroid Registry Start of enrollment: 2010 Jun 09
Completed

Publications & Presentations

PubMed

37 citations
Efficient ADCC killing of meningioma by avelumab and a high-affinity natural killer cell line, haNK
Amber J. Giles, Shuyu Hao, Michelle R Padget, Hua Song, Wei Zhang, John Lynes, Victoria Sanchez, Yang Liu, Jinkyu Jung, Xiaoyu Cao, Rika Fujii, Randy L. Jensen, David ...> ;JCI Insight. 2019 Oct 17
11 citations
CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation
Seung-Phil Shin, Ah Ra Goh, Hyeon-Gu Kang, Seok-Jun Kim, Jong-Kwang Kim, Kyung-Tae Kim, John H. Lee, Yong-Soo Bae, Yuh-Seog Jung, Sang-Jin Lee> ;Cancers. 2019 Oct 17
13 citations
Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington's Disease.
Daniel D. Child, John H. Lee, Christine Pascua, Yong Hong Chen, Alex Mas Monteys, Beverly L. Davidson> ;Cell Reports. 2018 Apr 24
Mouse model of post-surgical primary tumor recurrence and regional lymph node metastasis progression in HPV-related head and neck cancer.
Mermod, M.,Hiou-Feige, A.,Bovay, E.,Roh, V.,Sponarova, J.,Bongiovanni, M.,Vermeer, D. W.,Lee, J. H.,Petrova, T. V.,Rivals, J. P.,Monnier, Y.,Tolstonog, G. V.,Simon, C.> ;Int. J. Cancer. 2018 Jan 10
27 citations
Tumor-associated fatigue in cancer patients develops independently of il1 signaling
Aaron J. Grossberg, Elisabeth G. Vichaya, D.L. Christian, Jessica M. Molkentine, Daniel W. Vermeer, Phillip S. Gross, Paola D. Vermeer, John H. Lee, Robert Dantzer> ;Cancer Research. 2017 Dec 7
28 citations
Reolysin and Histone Deacetylase Inhibition in the Treatment of Head and Neck Squamous Cell Carcinoma.
Alena Cristina Jaime-Ramirez, Jun Ge Yu, Enrico Caserta, Ji Young Yoo, Jianying Zhang, Tae Jin Lee, Craig C. Hofmeister, John H. Lee, Bhavna Kumar, Quintin Pan, Pawan ...> ;Molecular Therapy Oncolytics. 2017 Jun 16
74 citations
Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14
Louis Cicchini, Joseph A. Westrich, Tao Xu, Daniel W. Vermeer, Jennifer N. Berger, Eric T. Clambey, Denis Lee, John I. Song, Paul F. Lambert, Robert O. Greer, John H. ...> ;Mbio. 2016 Jul 6
9 citations
mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer
Joseph D. Coppock, John H. Lee> ;World Journal of Otorhinolaryngology - Head and Neck Surgery. 2016 Jun 1
17 citations
mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC.
Joseph D. Coppock, Paola D. Vermeer, Daniel W. Vermeer, Kimberly M. Lee, W. Keith Miskimins, William C. Spanos, John H. Lee> ;Oncotarget. 2016 Mar 23
23 citations
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis
Daniel W. Vermeer, Joseph D. Coppock, Erliang Zeng, Kimberly M. Lee, William C. Spanos, Michael D. Onken, Ravindra Uppaluri, John H. Lee, Paola D. Vermeer> ;Oncotarget. 2016 Mar 22
Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression.
Vichaya, E. G.,Molkentine, J. M.,Vermeer, D. W.,Walker, A. K.,Feng, R.,Holder, G.,Luu, K.,Mason, R. M.,Saligan, L.,Heijnen, C. J.,Kavelaars, A.,Mason, K. A.,Lee, J. H....> ;Behav. Brain Res.. 2015 Oct 18
42 citations
An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression and reduction in PD-L1 expression.
Adrian Rice, Yvette Latchman, Joseph P. Balint, John H. Lee, Elizabeth Gabitzsch, Frank R. Jones> ;Cancer Gene Therapy. 2015 Sep 1
25 citations
CD200: Association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma
Yuh-Seog Jung, Paola D. Vermeer, Daniel W. Vermeer, Sang Jin Lee, Ah Ra Goh, Hyun Joo Ahn, John H. Lee> ;Head & Neck. 2015 Mar 1
6 citations
Low-dose cisplatin converts the tumor microenvironment into a permissive state for HSVtk-induced antitumor immunity in HPV16-related tonsillar carcinoma.
Ah Ra Goh, Seung Pil Shin, Na Rae Jung, Chang Hwan Ryu, Hyeon Seok Eom, John H. Lee, Kyungho Choi, Sang-Jin Lee, Yuh S. Jung> ;Cancer Letters. 2015 Jan 28
112 citations
Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes
John H. Lee, Luis Tecedor, Yong Hong Chen, Alex Mas Monteys, Matthew J. Sowada, Leslie M. Thompson, Beverly L. Davidson> ;Neuron. 2015 Jan 21
17 citations
CD137 Enhancement of HPV Positive Head and Neck Squamous Cell Carcinoma Tumor Clearance
Christopher T. Lucido, Paola D. Vermeer, Bryant G. Wieking, Daniel W. Vermeer, John H. Lee> ;Vaccines. 2014 Dec 10
EphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity.
Colbert, P. L.,Vermeer, D. W.,Wieking, B. G.,Lee, J. H.,Vermeer, P. D.> ;Oncotarget. 2014 Dec 02
13 citations
Rhes suppression enhances disease phenotypes in Huntington's disease mice.
John H. Lee, Matthew J. Sowada, Ryan L. Boudreau, Andrea M. Aerts, Daniel R. Thedens, Peg Nopoulos, Beverly L. Davidson> ;Journal of Huntington's Disease. 2014 Jan 1
11 citations
Targeting ERBB receptors shifts their partners and triggers persistent ERK signaling through a novel ERBB-EFNB1 complex
Paola D. Vermeer, Paul L. Colbert, Bryant G. Wieking, Daniel W. Vermeer, John H. Lee> ;Cancer Research. 2013 Sep 15
81 citations
SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation
Jacqueline G. O’Rourke, Jaclyn R. Gareau, Joseph Ochaba, Wan Song, Tamás Raskó, David Reverter, John H. Lee, Alex Mas Monteys, Judit Pallos, Lisa Mee, Malini Vashishth...> ;Cell Reports. 2013 Jul 25
31 citations
Improved Clearance during Treatment of HPV-Positive Head and Neck Cancer through mTOR Inhibition
Joseph D. Coppock, Bryant G. Wieking, Alfredo A. Molinolo, J. Silvio Gutkind, W. Keith Miskimins, John H. Lee> ;Neoplasia. 2013 Jun 1
78 citations
Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer
Daniel W. Vermeer, William C. Spanos, Paola D. Vermeer, Annie M. Bruns, Kimberly M. Lee, John H. Lee> ;International Journal of Cancer. 2013 Jul 1
28 citations
Human papillomavirus in oropharyngeal squamous cell carcinomas in korea: Use of G1 cycle markers as new prognosticators
Weon Seo Park, Junsun Ryu, Kwan Ho Cho, Moon Kyung Choi, Sung Ho Moon, Tak Yun, Byung–Sam Chun, Geon Kook Lee, Hyun–Joo Ahn, John H. Lee, Paola D. Vermeer, Yuh-Seog Jung> ;Head & Neck. 2012 Oct 1
34 citations
A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors
Bryant G. Wieking, Daniel W. Vermeer, William C. Spanos, Kimberly M. Lee, Paola D. Vermeer, Walter T. Lee, Younong Xu, Elizabeth Gabitzsch, Stephanie Balcaitis, Joseph...> ;Cancer Gene Therapy. 2012 Aug 24
20 citations
ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers.
Paola D. Vermeer, Megan Bell, Kimberly M. Lee, Daniel W. Vermeer, Byrant G. Wieking, Erhan Bilal, Gyan Bhanot, Ronny Drapkin, Shridar Ganesan, Aloysius J. Klingelhutz,...> ;Plos One. 2012 Jan 18
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