JohnPManisMD

PubMed

• 5 citations
  Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors.
  Sai Luo, Changbin Jing, Adam Yongxin Ye, Sven Kratochvil, Christopher A Cottrell, Ja-Hyun Koo, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Himanshu Batra, Edwa...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Jan 3
• 9 citations
  Development of a double shmiR lentivirus effectively targeting both BCL11A and ZNF410 for enhanced induction of fetal hemoglobin to treat β-hemoglobinopathies.
  Boya Liu, Christian Brendel, Divya S Vinjamur, Yu Zhou, Chad Harris, Meaghan McGuinness, John P Manis, Daniel E Bauer, Haiming Xu, David A Williams> ;Molecular Therapy. 2022 Aug 3
• Form follows function for freeze-dried platelets.
  Jonathan A Stefely, John P Manis> ;American Journal of Hematology. 2022 Mar 1
• 10 citations
  Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion.
  Yuping Fan, Yan Teng, Fabien Loison, Aiming Pang, Anongnard Kasorn, Xinqi Shao, Cunling Zhang, Qian Ren, Hongbo Yu, Yi Zheng, Jose A. Cancelas, John P. Manis, Li Chai,...> ;Science Translational Medicine. 2021 Jul 28
• 168 citations
  Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease
  Erica B. Esrick, Leslie Lehmann, Alessandra Biffi, Maureen Achebe, Christian Brendel, Marioara F. Ciuculescu, Heather Daley, Brenda L. MacKinnon, Emily Morris, Amy Fed...> ;The New England Journal of Medicine. 2021 Jan 21
• 2 citations
  Parameters affecting successful stem cell collections for genetic therapies in sickle cell disease.
  David G. Justus, John P. Manis> ;Transfusion and Apheresis Science. 2021 Jan 10
• 29 citations
  Preclinical Evaluation of a Novel Lentiviral Vector Driving Lineage-Specific BCL11A Knockdown for Sickle Cell Gene Therapy.
  Christian Brendel, Olivier Negre, Michael Rothe, Swaroopa Guda, Geoff Parsons, Chad E. Harris, Meaghan McGuinness, Daniela Abriss, Alla V. Tsytsykova, Denise Klatt, Ma...> ;Molecular Therapy. Methods & Clinical Development. 2020 Jun 12
• 166 citations
  Therapeutic base editing of human hematopoietic stem cells.
  Jing Zeng, Yuxuan Wu, Chunyan Ren, Jasmine Bonanno, Anne H. Shen, Devlin Shea, Jason Michael Gehrke, Kendell Clement, Kevin Luk, Qiuming Yao, Rachel Kim, Scot A. Wolfe...> ;Nature Medicine. 2020 Mar 16
• 9 citations
  Serine/threonine phosphatase PP2A is essential for optimal B cell function
  Esra Meidan, Hao Li, Wen Liang Pan, Michihito Kono, Shuilian Yu, Vasileios C. Kyttaris, Christina Ioannidis, Noe Rodriguez Rodriguez, José C. Crispín, Sokratis A. Apos...> ;JCI Insight. 2020 Mar 12
• 269 citations
  Highly efficient therapeutic gene editing of human hematopoietic stem cells.
  Yuxuan Wu, Jing Zeng, Benjamin P. Roscoe, Pengpeng Liu, Qiuming Yao, Cicera R. Lazzarotto, M. Kendell Clement, Mitchel A. Cole, Kevin Luk, Cristina Baricordi, Anne H. ...> ;Nature Medicine. 2019 Mar 25
• 10 citations
  Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.
  Kutay Karatepe, Haiyan Zhu, Xiaoyu Zhang, Rongxia Guo, Hiroto Kambara, Fabien Loison, Peng Liu, Hongbo Yu, Qian Ren, Xiao Luo, John P. Manis, Tao Cheng, Fengxia Ma, Yu...> ;Stem Cell Reports. 2018 Nov 13
• 51 citations
  Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients.
  Erica B. Esrick, John P. Manis, Heather Daley, Cristina Baricordi, Helene Trebeden-Negre, Francis J. Pierciey, Myriam Armant, Sarah Nikiforow, Matthew M. Heeney, Wendy...> ;Blood Advances. 2018 Oct 9
• 1 citations
  Evaluation of the Role of stat3 in Antibody and TH17-Mediated Responses to Pneumococcal Immunization and Infection by Use of a Mouse Model of Autosomal Dominant Hyper-...
  Kristin Moffitt, Elaine Cheung, John P. Manis, Richard Malley> ;Infection and Immunity. 2018 May 1
• 24 citations
  Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development.
  L. M. Ott de Bruin, Marita Bosticardo, A. Barbieri, S. G. Lin, Jared H. Rowe, Pietro Luigi Poliani, K. Ching, Daniel Eriksson, Nils Landegren, Olle Kämpe, John P. Mani...> ;Blood. 2018 Jul 19
• 4 citations
  Corrigendum: Natural killer cells from patients with recombinase-activating gene and non-homologous end joining gene defects comprise a higher frequency of CD56bright ...
  Kerry Dobbs, Giovanna Tabellini, Enrica Calzoni, Ornella Patrizi, Paula Martinez, Silvia Giliani, Daniele Moratto, Waleed Al-Herz, Caterina Cancrini, Morton J. Cowan, ...> ;Frontiers in Immunology. 2017 Oct 10
• 12 citations
  DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells.
  Michel J. Massaad, Brittney Cangemi, Waleed Al-Herz, Gérard Lefranc, Alexandra F. Freeman, Sachin N. Baxi, Sevgi Keles, Ayse Metin, Majid Dasouki, Ali Sobh, Maria Kana...> ;Clinical Immunology. 2017 Oct 1
• 58 citations
  EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay
  Stefano Volpi, Yasuhiro Yamazaki, Patrick M. Brauer, Ellen van Rooijen, Atsuko Hayashida, Anne Slavotinek, Hye Sun Kuehn, Maja Di Rocco, Carlo Rivolta, Ileana Bortolom...> ;The Journal of Experimental Medicine. 2017 Feb 1
• 13 citations
  Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56NKG2ACells, and Yet ...
  Kerry Dobbs, Giovanna Tabellini, Enrica Calzoni, Ornella Patrizi, Paula Martinez, Silvia Clara Giliani, Daniele Moratto, Waleed Al-Herz, Caterina Cancrini, Morton Cowa...> ;Frontiers in Immunology. 2017 Jan 1
• Correction: Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells.
  Andrea J Hartlerode, Nicholas A Willis, Anbazhagan Rajendran, John P Manis, Ralph Scully> ;Plos Genetics. 2016 Dec 1
• 5 citations
  Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells.
  Andrea J Hartlerode, Nicholas A Willis, Anbazhagan Rajendran, John P Manis, Ralph Scully> ;Plos Genetics. 2016 Nov 1
• 51 citations
  Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity
  Michel J. Massaad, Jia Zhou, Daisuke Tsuchimoto, Janet Chou, Haifa H. Jabara, Erin Janssen, Salomé Glauzy, Brennan Olson, Henner Morbach, Toshiro K. Ohsumi, Klaus E. S...> ;The Journal of Clinical Investigation. 2016 Nov 1
• 8 citations
  Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice.
  Haifa H. Jabara, John Lee, Erin Janssen, Sumana Ullas, Kyriaki Liadaki, Lilit Garibyan, Halli Benson, Tatyana Sannikova, Richard J. Bram, Lennart Hammarström, Anthony ...> ;The Journal of Allergy and Clinical Immunology. 2017 Apr 1
• 4 citations
  Platelet refractoriness: it's not the B-all and end-all.
  John P. Manis, Leslie E. Silberstein> ;Blood. 2016 Apr 7
• 10 citations
  Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes
  Lisa Ott de Bruin, Wei Yang, Kelly Capuder, Yu Nee Lee, Maddalena Antolini, Robin M. Meyers, Martin Gellert, Kiran Musunuru, John P. Manis, Luigi D. Notarangelo> ;Oncotarget. 2016 Feb 12
• 39 citations
  A novel mutation in the POLE2 gene causing combined immunodeficiency.
  Francesco Frugoni, Kerry Dobbs, Kerstin Felgentreff, Hasan Al-Dhekri, Bandar K. Al Saud, Rand Arnaout, Afshan A. Ali, Avinash Abhyankar, Fayhan Alroqi, Silvia Giliani,...> ;The Journal of Allergy and Clinical Immunology. 2016 Feb 1
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Abstracts/Posters

• Therapeutic Base Editing of Human Hematopoietic Stem Cells
  John P Manis, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019