JohnLNilesMD

Nephrology • Boston, MA

Assistant Professor, Nephrology, Harvard Medical School

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Office
101 Merrimac St
1st Floor
Boston, MA 02114
Phone+1 617-726-4132

Fax+1 617-726-4213
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Education & Training

Brigham and Women's Hospital/Massachusetts General HospitalFellowship, Nephrology, 1987 - 1988
Massachusetts General HospitalResidency, Internal Medicine, 1984 - 1986
Johns Hopkins UniversityResidency, Internal Medicine, 1981 - 1984
Oregon Health and Science University School of MedicineClass of 1981

Certifications & Licensure

NH State Medical License 2019 - 2025
MA State Medical License 1985 - 2025
ME State Medical License 2019 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Nephrology

Awards, Honors, & Recognition

Boston Magazine Castle Connolly, 2013

Clinical Trials

Maintenance of ANCA Vasculitis Remission by Intermittent Rituximab Dosing Start of enrollment: 2016 Jun 01
Terminated
Phase 4

Publications & Presentations

PubMed

6 citations
Renal Recovery for Patients with ANCA-Associated Vasculitis and Low eGFR in the ADVOCATE Trial of Avacopan.
Frank B Cortazar, John L Niles, David R W Jayne, Peter A Merkel, Annette Bruchfeld, Huibin Yue, Thomas J Schall, Pirow Bekker> ;Kidney International Reports. 2023 Apr 1
3 citations
Association of renal transplantation with reduced risk of myocardial infarction and ischemic stroke in ANCA-associated vasculitis: An observational cohort study.
Claire Cook, April Jorge, Xiaoqing Fu, John L. Niles, Anushya Jeyabalan, Reza Zonozi, John H. Stone, Yuqing Zhang, Hyon K. Choi, Zachary S. Wallace> ;Seminars in Arthritis and Rheumatism. 2021 Sep 26
4 citations
Inflammatory vaginitis in women on long-term rituximab treatment for autoimmune disorders.
Laura J. Yockey, Sarah Dowst, Reza Zonozi, Noah Huizenga, Patrick Murphy, Karen Laliberte, Jillian Rosenthal, John L. Niles, Caroline M. Mitchell> ;BMC Women's Health. 2021 Aug 5
9 citations
Eculizumab and Complement Activation in Anti−glomerular Basement Membrane Disease
Pravarut Nithagon, Frank B. Cortazar, Sujal I. Shah, Astrid Weins, Karen Laliberte, Anushya Jeyabalan, John L. Niles, Reza Zonozi> ;Kidney International Reports. 2021 Jul 12
15 citations
Combination of Rituximab, Low-Dose Cyclophosphamide, and Prednisone for Primary Membranous Nephropathy: A Case Series With Extended Follow Up.
Reza Zonozi, Karen Laliberte, Noah Huizenga, Jillian K. Rosenthal, Anushya Jeyabalan, A. Bernard Collins, Frank B. Cortazar, John L. Niles> ;American Journal of Kidney Diseases. 2021 Jun 24
Sunken Nose.
Reza Zonozi, John L Niles> ;The New England Journal of Medicine. 2021 Apr 8
8 citations
Treatment of Gemcitabine-Induced Thrombotic Microangiopathy Followed by Gemcitabine Rechallenge With Eculizumab.
Orhan Efe, Lipika Goyal, Aralee Galway, Andrew X. Zhu, John L. Niles, Reza Zonozi> ;Kidney International Reports. 2021 Mar 6
21 citations
Incidence, Clinical Features, and Outcomes of Late‐Onset Neutropenia From Rituximab for Autoimmune Disease
Reza Zonozi, Zachary S. Wallace, Karen Laliberte, Noah Huizenga, Jillian Rosenthal, Eugene P. Rhee, Frank B. Cortazar, John L. Niles> ;Arthritis & Rheumatology. 2021 Feb 1
41 citations
Adjunctive Treatment With Avacopan, an Oral C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Peter A. Merkel, John L. Niles, Richard A.H. Jimenez, Robert Spiera, Brad H. Rovin, Andrew S. Bomback, Christian Pagnoux, Antonia Potarca, Thomas J. Schall, Pirow Bekk...> ;ACR Open Rheumatology. 2020 Nov 1
11 citations
Long-Term Safety of Rituximab in Granulomatosis With Polyangiitis and in Microscopic Polyangiitis
Peter A. Merkel, John L. Niles, Lester E. Mertz, P.B. Lehane, Pooneh Pordeli, Felix Erblang> ;Arthritis Care & Research. 2021 Aug 13
1 citations
Case 14-2020: A 37-Year-Old Man with Joint Pain and Eye Redness
Lucia Sobrin, John H. Stone, Ambrose J. Huang, John L. Niles, Rosalynn M. Nazarian> ;The New England Journal of Medicine. 2020 Apr 29
15 citations
The Fate of Plasma Exchange and Glucocorticoid Dosing in ANCA-Associated Vasculitis After PEXIVAS
Frank B. Cortazar, John L. Niles> ;American Journal of Kidney Diseases. 2020 Apr 8
16 citations
Treatment of Aggressive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis With Eculizumab.
Noah Huizenga, Reza Zonozi, Jillian Rosenthal, Karen Laliberte, John L. Niles, Frank B. Cortazar> ;Kidney International Reports. 2020 Apr 1
7 citations
Phospholipase A2 receptor–associated membranous nephropathy in a patient with IgG4-related disease: A case report
Saif A. Muhsin, Ricard Masia, Rex Neal Smith, Zachary S. Wallace, Cory A. Perugino, John H. Stone, John L. Niles, Frank B. Cortazar> ;Medicine. 2019 May 1
18 citations
Continuous B-cell depletion in frequently relapsing, steroid-dependent and steroid-resistant nephrotic syndrome
Frank B. Cortazar, Jillian Rosenthal, Karen Laliberte, John L. Niles> ;Clinical Kidney Journal. 2019 Apr 1
13 citations
Renal Involvement in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Reza Zonozi, John L. Niles, Frank B. Cortazar> ;Rheumatic Diseases Clinics of North America. 2018 Sep 7
10 citations
Improved survival with renal transplantation for end-stage renal disease due to granulomatosis with polyangiitis: data from the United States Renal Data System
Zachary S. Wallace, Rachel Wallwork, Yuqing Zhang, Na Lu, Frank B. Cortazar, John L. Niles, Eliot Heher, John H. Stone, Hyon K. Choi> ;Annals of the Rheumatic Diseases. 2018 Sep 1
16 citations
Reducing glucocorticoid duration in ANCA-associated vasculitis: A pilot trial.
Eli M. Miloslavsky, John L. Niles, Zachary S. Wallace, Frank B. Cortazar, Ana Paula Fernandes, Karen Laliberte, John H. Stone> ;Seminars in Arthritis and Rheumatism. 2018 Oct 1
8 citations
Subglottic Stenosis in Granulomatosis With Polyangiitis: The Role of Laryngotracheal Resection.
Christina L. Costantino, John L. Niles, Cameron D. Wright, Douglas J. Mathisen, Ashok Muniappan> ;The Annals of Thoracic Surgery. 2018 Jan 1
51 citations
Combination Therapy With Rituximab and Cyclophosphamide for Remission Induction in ANCA Vasculitis.
Frank B. Cortazar, Saif A. Muhsin, William F. Pendergraft, Zachary S. Wallace, Colleen Dunbar, Karen Laliberte, John L. Niles> ;Kidney International Reports. 2017 Nov 14
19 citations
Combination therapy with rituximab, low-dose cyclophosphamide, and prednisone for idiopathic membranous nephropathy: a case series
Frank B. Cortazar, David E. Leaf, Charles T. Owens, Karen Laliberte, William F. Pendergraft, John L. Niles> ;BMC Nephrology. 2017 Feb 1
49 citations
Effect of Continuous B Cell Depletion With Rituximab on Pathogenic Autoantibodies and Total IgG Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Frank B. Cortazar, William F. Pendergraft, Julia Wenger, Charles T. Owens, Karen Laliberte, John L. Niles> ;Arthritis & Rheumatology. 2017 May 1
65 citations
Nephrotoxic Effects of Common and Emerging Drugs of Abuse
William F. Pendergraft, Leal Herlitz, Denyse Thornley-Brown, Mitchell H. Rosner, John L. Niles> ;Clinical Journal of the American Society of Nephrology. 2014 Nov 7
82 citations
Long-Term Maintenance Therapy Using Rituximab-Induced Continuous B-Cell Depletion in Patients with ANCA Vasculitis
William F. Pendergraft, Frank B. Cortazar, Julia Wenger, A. Murphy, Eugene P. Rhee, Karen Laliberte, John L. Niles> ;Clinical Journal of the American Society of Nephrology. 2014 Apr 7
86 citations
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis
William F. Pendergraft, John L. Niles> ;Current Opinion in Rheumatology. 2014 Jan 1
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