
John M. Routes MD
Clinical & Laboratory Immunology
Professor Emeritus of Pediatrics, Medicine, Microbiology and Molecular Genetics
Join to View Full Profile
9200 W Wisconsin AveMilwaukee, WI 53226
Phone+1 414-414-3000
Fax+1 414-805-7790
Dr. Routes is on Doximity
As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.
- Gain access to free telehealth tools, such as our “call shielding” and one-way patient texting.
- Connect with colleagues in the same hospital or clinic.
- Read the latest clinical news, personalized to your specialty.
Summary
- Dr. John Routes is a Professor Emeritus based in Milwaukee, Wisconsin, specializing in Allergy and Immunology, with subspecialty expertise in Clinical and Laboratory Immunology. He completed his fellowship in Allergy and Immunology at the University of Colorado School of Medicine and National Jewish Health, and his residency in Internal Medicine at the University of Utah Health. He is affiliated with the Medical College of Wisconsin, where he served as Section Chief of Allergy and Clinical Immunology. Dr. Routes has served on numerous NIH study sections, including as chair of two study sections, and served as a voting member of advisory committees of the U.S. Food and Drug Administration. His research focuses on inborn errors of immunity (IEI), including immune-related lung disease. He has published important work on severe combined immunodeficiency, common variable immunodeficiency, and vaccination in patients with IEI, and has led multiple clinical trials in this field. His honors include past president of the Clinical Immunology Society, the Distinguished Service Award from the Clinical Immunology Society, and the “Pioneer in Newborn Screening – Dream Maker Award” from the Jeffrey Modell Foundation.
Education & Training
University of Colorado School of Medicine/National Jewish Health (Adult)Fellowship, Allergy and Immunology, 1985 - 1989
University of Utah HealthResidency, Internal Medicine, 1981 - 1984
Indiana University School of MedicineClass of 1981
Certifications & Licensure
WI State Medical License 2006 - 2023
CO State Medical License 1985 - 2009
UT State Medical License 1982 - 1990
American Board of Allergy and Immunology Allergy & Immunology
American Board of Internal Medicine Internal Medicine
Awards, Honors, & Recognition
- Fellow Clinical Immunology Society Clinical Immunology Society, 2022
- America's Top Doctors Castle Connolly, 2009-2022
- Best Doctors Best Doctors, Inc., 2007-2022
Clinical Trials
- Natural History Study of SCID Disorders Start of enrollment: 2010 Sep 02
- Patients Treated for SCID (1968-Present) Start of enrollment: 2011 May 15
- Novel Testing Procedures Start of enrollment: 2016 Apr 01
Publications & Presentations
PubMed
- Systematic functional validation of IKAROS variants from patients and laboratory-generated mutations.Hye Sun Kuehn, Agustin Alejandro Gil Silva, Natchanun Klangkalya, Ana Esteve-Sole, Shubham Goel
Blood Advances. 2025-12-11 - 6 citationsMaintenance of X chromosome inactivation after T cell activation requires NF-κB signaling.Katherine S Forsyth, Natalie E Toothacre, Nikhil Jiwrajka, Amanda M Driscoll, Lindsey A Shallberg
Science Immunology. 2024-10-04 - 4 citationsCOVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report.John McDonnell, Kimberley Cousins, M Elizabeth M Younger, Adam Lane, Hassan Abolhassani
Journal of Clinical Immunology. 2024-04-05
Journal Articles
- Rituximab and antimetabolite treatment of granulomatous and lymphocytic interstitial lung disease in common variable immunodeficiencyJames W. Verbsky, MD, Mary K. Hintermeyer, RN, APNP, Pippa M. Simpson, PhD, Mingen Feng, MS, Jody Barbeau, BS, Nagarjun Rao, MD,e Carlyne D. Cool, MD, Luis A. Sosa-Loz..., Journal Allergy Clinical Immunology, 2/7/2021
Other
- Pulmonary complications of primary immunodeficienciesRoutes JM, Verbsky, J
http://www.uptodate.com/contents/pulmonary-complications-of-primary-immunodeficiencies
UpToDate, Wolters Kluwer Health - 2021-01-05
Grant Support
- GLILD in CVIDNational Institute of Allergy and Infectious Diseases (NIAID)2014–Present
- Jeffrey Modell Diagnostic and Research Center for Primary ImmunodeficienciesJeffrey Modell Foundation2009–2022
- Lymphoproliferative Disorders In Primary ImmunodeficienciesNational Cancer Institute2008–2012
- Anti-Tumorigenic Activity Of Adenovirus E1ANational Cancer Institute2007–2011
- AMID In Apoptosis And P53-Mediated Downstream EffectsNational Cancer Institute2005
Committees
- Co-Chairman, World Allergy Organization Special Committee on Immunodeficiency 2013 - Present
- Consultant and Voting Member, FDA Medical Devices Panel 2012 - Present
- Member, NIH: Loan Repayment Program 2010 - Present
- Member, NIH Study Section-Investigations in Primary Immunodeficiency 2009 - Present
- Consultant and Voting Member, FDA Immunology Devices Panel 2006 - Present
Professional Memberships
- Fellow
- Fellow
- Member
- Clinical Immunology SocietyFellow
- American Association of Immunologists (AAI)Member
External Links
- CHW Physician Directoryhttp://www.chw.org/physician-directory/r/routes-john-m/
Viewing the full profile is available to verified healthcare professionals only.
Find your profile and take control of your online presence:









