JohnJTreanorMD

Infectious Disease • Rochester, NY

Chief of the Infectious Diseases Division of the Department of Medicine at the University of Rochester Medical Center

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Office
601 Elmwood Ave
Box Med
Rochester, NY 14642
Phone+1 585-275-5871

Fax+1 585-273-1055
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Education & Training

University of RochesterFellowship, Infectious Disease, 1982 - 1985
University of Vermont Medical CenterResidency, Internal Medicine, 1979 - 1981
University of Rochester School of Medicine and DentistryClass of 1979

Certifications & Licensure

NY State Medical License 1982 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease

Clinical Trials

Immunogenicity and Safety of Trivalent Recombinant Hemagglutinin Influenza Vaccine in Healthy Adults Start of enrollment: 2004 Nov 01
Completed
Phase 2, Phase 3
Immunogenicity, Safety, Reactogenicity, Efficacy, Effectiveness and Lot Consistency of FluBlok Start of enrollment: 2007 Sep 15
Completed
Phase 3
Phase 1 Safety and Immunogenicity Study in Healthy Adults of VAX125, a Recombinant HA-flagellin Influenza Vaccine Start of enrollment: 2008 Jul 01
Completed
Phase 1
Phase 1 Norwalk Vaccine Study Start of enrollment: 2008 Nov 01
Completed
Phase 1
Safety and Immunogenicity of Live Influenza A Vaccine for Avian Influenza H7N7 Start of enrollment: 2010 Jul 01
Completed
Phase 1
Effects of Age on Response to the 2009 H1N1 Virus Vaccine Start of enrollment: 2010 Mar 01
Completed
Phase 1, Phase 2
Effect of Age and Prior Immunity on Response to H1N1 Vaccines in Children Start of enrollment: 2010 Mar 01
Withdrawn
Phase 4
Safety and Immunogenicity of PanBlok Influenza Vaccine in Healthy Adults Start of enrollment: 2010 Jun 01
Completed
Phase 1, Phase 2
Evaluation of the Safety and Immunogenicity of a Live Attenuated Virus Vaccine for the Prevention of H2N3 Influenza Start of enrollment: 2010 Sep 01
Completed
Phase 1
Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) Versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications Start of enrollment: 2010 Sep 01
Completed
Phase 2
Evaluating the Safety and Immune Response of an H7N7 Vaccine in Healthy Adults Start of enrollment: 2012 Mar 01
Completed
Phase 1
Norovirus Bivalent-Vaccine Efficacy Study Start of enrollment: 2012 Jul 16
Completed
Phase 1, Phase 2
Safety and Immunogenicity of PanBlok Influenza Vaccine in Healthy Adults Start of enrollment: 2012 May 01
Completed
Phase 1, Phase 2
Study of Immune Responses in Healthy Adults Receiving Live Influenza Virus Vaccines Start of enrollment: 2012 Sep 01
Completed
Phase 1
Age and Response to Flu Vaccines Start of enrollment: 2017 Dec 14
Completed
Phase 4
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Publications & Presentations

PubMed

2 citations
Broadly Reactive IgG Responses to Heterologous H5 Prime-Boost Influenza Vaccination Are Shaped by Antigenic Relatedness to Priming Strains.
Jiong Wang, Dongmei Li, Sheldon Perry, Shannon P. Hilchey, Alexander Wiltse, John J. Treanor, Mark Y. Sangster, Martin S. Zand> ;Mbio. 2021 Jul 6
4 citations
Gaps in Serologic Immunity against Contemporary Swine-Origin Influenza A Viruses among Healthy Individuals in the United States.
Joshua N. Lorbach, Theresa Fitzgerald, Carolyn Nolan, Jacqueline M. Nolting, John J. Treanor, David J. Topham, Andrew S. Bowman> ;Viruses. 2021 Jan 18
1 citations
A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.
Andrew Cox, Jordana Schmierer, Josephine D'Angelo, Andrew W. Smith, Dustyn Levenson, John J. Treanor, Baek Kim, Stephen Dewhurst> ;Viruses. 2020 Oct 31
13 citations
Viewpoint of a WHO Advisory Group Tasked to Consider Establishing a Closely-monitored Challenge Model of Coronavirus Disease 2019 (COVID-19) in Healthy Volunteers
Myron M. Levine, Salim Abdullah, Yaseen M. Arabi, Delese Mimi Darko, Anna P. Durbin, Vicente Estrada, Euzebiusz Jamrozik, Peter G. Kremsner, Rosanna Lagos, Punnee Piti...> ;Clinical Infectious Diseases. 2021 Jun 1
20 citations
Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in hum...
K A Richards, S Moritzky, I Shannon, T Fitzgerald, H Yang, A Branche, D J Topham, J J Treanor, J Nayak, Andrea J Sant> ;NPJ Vaccines. 2020 Jan 1
14 citations
A phase 2 study of the bivalent VLP norovirus vaccine candidate in older adults; impact of MPL adjuvant or a second dose.
John J. Treanor, Jim Sherwood, Jakob P Cramer, Nancy Le Cam Bouveret, Stella Lin, Frank Baehner, Astrid Borkowski, Nor investigators> ;Vaccine. 2020 Aug 10
25 citations
Characterizing Emerging Canine H3 Influenza Viruses
Luis Martinez-Sobrido, Pilar Blanco-Lobo, Laura Rodriguez, Theresa Fitzgerald, Hanyuan Zhang, Phuong T. M. Nguyen, Christopher S. Anderson, Jeanne Holden-Wiltse, Sanju...> ;Plos Pathogens. 2020 Apr 14
2 citations
History of Live, Attenuated Influenza Vaccine.
John J. Treanor> ;Journal of the Pediatric Infectious Diseases Society. 2020 Mar 19
18 citations
Evidence That Blunted CD4 T-Cell Responses Underlie Deficient Protective Antibody Responses to Influenza Vaccines in Repeatedly Vaccinated Human Subjects
Katherine A. Richards, Ian Shannon, John J. Treanor, Hongmei Yang, Jennifer L. Nayak, Andrea J. Sant> ;The Journal of Infectious Diseases. 2020 Jun 29
13 citations
Monoclonal Antibody Responses after Recombinant Hemagglutinin Vaccine versus Subunit Inactivated Influenza Virus Vaccine: a Comparative Study.
Carole Henry, Anna-Karin E. Palm, Henry A. Utset, Min Huang, Irvin Y. Ho, Nai-Ying Zheng, Theresa Fitzgerald, Karlynn E. Neu, Yao-Qing Chen, Florian Krammer, John J. T...> ;Journal of Virology. 2019 Oct 15
59 citations
Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans.
Surender Khurana, Megan Hahn, Elizabeth M. Coyle, Lisa R. King, Tsai-Lien Lin, John J. Treanor, Andrea J. Sant, Hana Golding> ;Nature Communications. 2019 Jul 26
5 citations
Continuous Readout versus Titer-Based Assays of Influenza Vaccine Trials: Sensitivity, Specificity, and False Discovery Rates
Dongmei Li, Jiong Wang, Jessica Garigen, John J. Treanor, Martin S. Zand> ;Computational and Mathematical Methods in Medicine. 2019 May 8
4 citations
Improved Specificity and False Discovery Rates for Multiplex Analysis of Changes in Strain-Specific Anti-Influenza IgG.
Dongmei Li, Jiong Wang, John J. Treanor, Martin S. Zand> ;Computational and Mathematical Methods in Medicine. 2019 Apr 15
41 citations
Broad Hemagglutinin-Specific Memory B Cell Expansion by Seasonal Influenza Virus Infection Reflects Early-Life Imprinting and Adaptation to the Infecting Virus.
Brenda L Tesini, Preshetha Kanagaiah, Jiong Wang, Megan Hahn, Jessica L. Halliley, Francisco A. Chaves, Phuong Thanh Nguyen, Aitor Nogales, Marta L. DeDiego, Christoph...> ;Journal of Virology. 2019 Apr 3
95 citations
Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.
Carole Henry, Nai Ying Zheng, Min Huang, Alexandra Cabanov, Karla Thatcher Rojas, Kaval Kaur, Sarah F. Andrews, Anna Karin E. Palm, Yao Qing Chen, Yang Li, Katerina Ho...> ;Cell Host & Microbe. 2019 Mar 13
11 citations
Differences in the influenza-specific CD4 T cell immunodominance hierarchy and functional potential between children and young adults.
Ian Shannon, Chantelle L. White, Amy Murphy, Xing Qiu, John J. Treanor, Jennifer L. Nayak> ;Scientific Reports. 2019 Jan 28
Influenza Challenge and the Challenge of Drug Development.
John J. Treanor> ;The Journal of Infectious Diseases. 2019 Jan 7
26 citations
First-in-human randomized controlled trial of an oral, replicating adenovirus 26 vector vaccine for HIV-1.
Kathryn E. Stephenson, Michael C. Keefer, Catherine A. Bunce, Doreen Frances, Peter Abbink, Lori F. Maxfield, George H. Neubauer, Joseph P. Nkolola, Lauren Peter, Chri...> ;Plos One. 2018 Nov 14
17 citations
Population Serologic Immunity to Human and Avian H2N2 Viruses in the United States and Hong Kong for Pandemic Risk Assessment.
Tara M Babu, Ranawaka A.P.M. Perera, Joseph T. Wu, Theresa Fitzgerald, Carolyn Nolan, Benjamin J. Cowling, Scott Krauss, John J. Treanor, Malik Peiris> ;The Journal of Infectious Diseases. 2018 Aug 24
375 citations
Influenza.
Florian Krammer, Gavin J D Smith, Ron A M Fouchier, Malik Peiris, Katherine Kedzierska, Peter C Doherty, Peter Palese, Megan L Shaw, John Treanor, Robert G Webster, Ad...> ;Nature Reviews. Disease Primers. 2018 Jun 28
22 citations
Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus-Specific CD4+ T-Cell R...
Katherine A. Richards, John J. Treanor, Jennifer L. Nayak, Andrea J. Sant> ;The Journal of Infectious Diseases. 2018 Aug 24
4 citations
What Happens Next Depends on What Happened First.
John J. Treanor> ;Clinical Infectious Diseases. 2018 Oct 30
19 citations
Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice.
Jiong Wang, Shannon P. Hilchey, Marta L. DeDiego, Sheldon Perry, Ollivier Hyrien, Aitor Nogales, Jessica Garigen, Fatima Amanat, Nelson Huertas, Florian Krammer, Luis ...> ;Plos One. 2018 Apr 11
246 citations
Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies
Yao Qing Chen, Teddy John Wohlbold, Nai Ying Zheng, Min Huang, Yunping Huang, Karlynn E. Neu, Jiwon Lee, Hongquan Wan, Karla Thatcher Rojas, Ericka Kirkpatrick, Carole...> ;Cell. 2018 Apr 5
9 citations
Safety and Immunogenicity of a Recombinant Influenza Vaccine: A Randomized Trial
Lisa M. Dunkle, Ruvim Izikson, Peter A. Patriarca, Karen L. Goldenthal, Manon M.J. Cox, John J. Treanor> ;Pediatrics. 2018 May 1
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Press Mentions

It's Time for Your 2019 Flu Shot: Why October Is the Best MonthAugust 26th, 2019
Can You Get the Flu Shot Too Early?September 12th, 2018
Family Flu Alert: Nasal Spray No Longer an Option for KidsOctober 27th, 2017
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Hospital Affiliations

Rochester General HospitalRochester, New York