JohnHWeissMD

Neurology • Orange, CA

Hospital/Neurohospitalist

Professor, Neurology, University of California, Irvine College of Medicine

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Office
Uci Medical Center
101 The City Drive South
Orange, CA 92868
Phone+1 714-456-8978
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Education & Training

Stanford Health Care-Sponsored Stanford UniversityResidency, Neurology, 1984 - 1987
Stanford Health Care-Sponsored Stanford UniversityInternship, Internal Medicine, 1983 - 1984
Stanford University School of MedicineClass of 1983

Certifications & Licensure

CA State Medical License 1984 - 2024
American Board of Psychiatry and Neurology Neurology

Publications & Presentations

PubMed

4 citations
Blocking Mitochondrial ZnAccumulation after Ischemia Reduces Mitochondrial Dysfunction and Neuronal Injury.
Yuliya V Medvedeva, Hong Z Yin, Afsheen Bazrafkan, Andriy Yeromin, Eli J Weiss-Hung, Edward Sharman, Alyssa P Avilez, Niki Maki, Masih A Rafi, Guilian Tian, Yama Akbar...> ;The Journal of Neuroscience. 2022 Jun 29
6 citations
VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy.
Cheng Cheng, Lan Weiss, Henri Leinonen, Alyaa Shmara, Hong Z Yin, Timothy Ton, Annie Do, Jonathan Lee, Lac Ta, Eshanee Mohanty, Jesse Vargas, John Weiss, Krzysztof Pal...> ;Journal of Translational Medicine. 2022 Jan 8
19 citations
The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction.
Hilary Y. Liu, Jenna R. Gale, Ian J. Reynolds, John H. Weiss, Elias Aizenman> ;Biomedicines. 2021 Apr 29
4 citations
Editorial: Excitotoxicity Turns 50. The Death That Never Dies.
Alberto Granzotto, John H Weiss, Stefano L Sensi> ;Frontiers in Neuroscience. 2021 Jan 1
33 citations
Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration.
Sung G. Ji, Yuliya V. Medvedeva, John H. Weiss> ;Experimental Neurology. 2020 Mar 1
11 citations
Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and...
Hong Z. Yin, Hwai-Lee Wang, Sung G. Ji, Yuliya V. Medvedeva, Guilian Tian, Afsheen Bazrafkan, Niki Maki, Yama Akbari, John H. Weiss> ;Journal of Neuropathology and Experimental Neurology. 2019 Jul 1
28 citations
Mitochondrial Zn2+ Accumulation: A Potential Trigger of Hippocampal Ischemic Injury.
Sung G. Ji, Yuliya V. Medvedeva, Hwai-Lee Wang, Hong Z. Yin, John H. Weiss> ;The Neuroscientist. 2019 Apr 1
18 citations
Zn2+-induced disruption of neuronal mitochondrial function: Synergism with Ca2+, critical dependence upon cytosolic Zn2+ buffering, and contributions to neuronal injury.
Sung G. Ji, John H. Weiss> ;Experimental Neurology. 2018 Jan 24
25 citations
Inflammation-induced GluA1 trafficking and membrane insertion of Ca2+ permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3...
Gustaf Wigerblad, J.R. Huie, Hong Zhen Yin, Mathias Leinders, Rory Pritchard, Fred J. Koehrn, Wen Hua Xiao, Gary J. Bennett, Richard L. Huganir, Adam R. Ferguson, John...> ;Experimental Neurology. 2017 Jul 1
58 citations
Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged E...
Yuliya V. Medvedeva, Sung G. Ji, Hong Z. Yin, John H. Weiss> ;The Journal of Neuroscience. 2017 Jan 18
33 citations
Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.
Hong Z. Yin, Stephen Yu, Cheng-I Hsu, Joe Liu, Allan Acab, Richard Wu, Anna Tao, Benjamin J. Chiang, John H. Weiss> ;Experimental Neurology. 2014 Nov 1
6 citations
Training stem cells for treatment of malignant brain tumors
Shengwen Calvin Li, Mustafa H. Kabeer, Long T Vu, Vic Keschrumrus, Hong Zhen Yin, Brent A. Dethlefs, Jiang F Zhong, John H. Weiss, William G Loudon> ;World Journal of Stem Cells. 2014 Sep 26
40 citations
Intramitochondrial Zn2 + accumulation via the Ca2 + uniporter contributes to acute ischemic neurodegeneration
Yuliya V. Medvedeva, John H. Weiss> ;Neurobiology of Disease. 2014 Aug 1
42 citations
Mechanisms of Rapid Reactive Oxygen Species Generation in Response to Cytosolic Ca2+ or Zn2+ Loads in Cortical Neurons
Aaron Clausen, Taylor McClanahan, Sung G. Ji, John H. Weiss> ;Plos One. 2013 Dec 10
1 citations
Cultivating stem cells for treating amyotrophic lateral sclerosis.
Shengwen Calvin Li, Hong Zhen Yin, William G Loudon, John H. Weiss> ;World Journal of Stem Cells. 2012 Dec 26
38 citations
TNF-α triggers rapid membrane insertion of Ca2+ permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury
Hong Z. Yin, Cheng-I. Hsu, Stephen Yu, Shyam Rao, Linda S. Sorkin, John H. Weiss> ;Experimental Neurology. 2012 Dec 1
50 citations
The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology
Angèle Nalbandian, Katrina J. Llewellyn, Masashi Kitazawa, Hong Z. Yin, Mallikarjun Badadani, Negar Khanlou, Robert Edwards, Christopher Nguyen, Jogeshwar Mukherjee, T...> ;Plos One. 2012 Sep 28
22 citations
Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall
Shengwen Calvin Li, Long T Vu, Hector W Ho, Hong Zhen Yin, Vic Keschrumrus, Qiang Lu, Jun Wang, Heying Zhang, Zhiwei Ma, Alexander Stover, John H. Weiss, Philip H. Sch...> ;Cancer Cell International. 2012 Sep 20
54 citations
Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice
Hong Z. Yin, Angèle Nalbandian, Hsu Ci, Li S, Katrina J. Llewellyn, Tahseen Mozaffar, Virginia Kimonis, John H. Weiss> ;Cell Death & Disease. 2012 Aug 16
46 citations
A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse.
Angèle Nalbandian, Katrina J. Llewellyn, Mallikarjun Badadani, Hong Z. Yin, Christopher Nguyen, Veeral Katheria, Giles D. J. Watts, Jogeshwar Mukherjee, Jouni Vesa, Vi...> ;Muscle & Nerve. 2013 Feb 1
63 citations
17β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion.
Jiabin Guo, Sue P. Duckles, John H. Weiss, Xuejun Li, Diana N. Krause> ;Free Radical Biology & Medicine. 2012 Jun 1
10 citations
Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures
Hong Z. Yin, John H. Weiss> ;Brain Research. 2012 Apr 11
64 citations
Ca2+ Permeable AMPA Channels in Diseases of the Nervous System
John H. Weiss> ;Frontiers in Molecular Neuroscience. 2011 Nov 14
125 citations
Zinc: new clues to diverse roles in brain ischemia.
C. William Shuttleworth, John H. Weiss> ;Trends in Pharmacological Sciences. 2011 Aug 1
23 citations
Sensitive and selective detection of zinc ions in neuronal vesicles using PYDPY1, a simple turn-on dipyrrin
Yujiang Mei, Christopher J. Frederickson, Leonard J. Giblin, John H. Weiss, Yuliya V. Medvedeva, Paul A. Bentley> ;Chemical Communications. 2011 Jun 14
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Grant Support

Zn2+, Mitochondria And The Induction Of Ischemic NeurodegenerationNational Institute Of Neurological Disorders And Stroke2010–2012
Ampa/Kainate Receptors, Free Radicals, And Motor Neuron InjuryNational Institute Of Neurological Disorders And Stroke2006–2010
Ca2+, Zn2+ And Selective Excitotoxic NeurodegenerationNational Institute Of Neurological Disorders And Stroke2000–2002
Ampa/Kainate Receptors,Free Radicals,Motor Neuron InjuryNational Institute Of Neurological Disorders And Stroke1999–2002
Zn2+ And Calcium Permeable Ampa/Kainate ChannelsNational Institute On Aging1998–2002
Ca++ And Excitotoxic Damage Of Cultured Central NeuronsNational Institute Of Neurological Disorders And Stroke1994–1999
Chronic Neurotoxicity Of BMAA And Non-Nmda AgonistsNational Institute On Aging1994
CA2+ And Excitotoxic Damage Of Cultured Central NeuronsNational Institute Of Neurological Disorders And Stroke1992–1993
The Chronic Neurotoxicity Of BMAA And Non-Nmda AgonistsNational Institute On Aging1991–1993
Chronic Neurotoxicity Of BMAA And NON NMDA AgonistsNational Institute On Aging1992
Chronic Neurotoxicity Of BMAA And NON NMDA AgonistsNational Institute On Aging1990–1991

Hospital Affiliations

UCI HealthOrange, California