JonathanGhergurovichMDPhD

PubMed

• G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer.
  Taijin Lan, Sara Arastu, Samuel Wang, Jarrick Lam, Wenping Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M Ghergurovich, Ch...> ;Biorxiv. 2023 Oct 9
• 6 citations
  Methionine synthase supports tumour tetrahydrofolate pools.
  Jonathan M. Ghergurovich, Xincheng Xu, Joshua Z Wang, Lifeng Yang, Rolf-Peter Ryseck, Lin Wang, Joshua D. Rabinowitz> ;Nature Metabolism. 2021 Nov 1
• 24 citations
  Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer
  Jonathan M. Ghergurovich, Jessica D. Lang, Maren K Levin, Natalia Briones, Salvatore Facista, Claudius Mueller, Alexis J. Cowan, Matthew J. McBride, Esther San Roman R...> ;Med. 2021 Jun 11
• 63 citations
  SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
  Juan Carlos García-Cañaveras, Olga Lancho, Gregory S. Ducker, Jonathan M. Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, Sonia Minuzzo, Stefano Indraccolo, Hahn Kim...> ;Leukemia. 2021 Feb 1
• 35 citations
  Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation
  Yang Zhang, Yi Xu, Wenyun Lu, Jonathan M. Ghergurovich, Lili Guo, Ian A. Blair, Joshua D. Rabinowitz, Xiaolu Yang> ;Cell Metabolism. 2021 Jan 5
• 27 citations
  Glucose-6-phosphate dehydrogenase is not essential for K-Ras-driven tumor growth or metastasis
  Jonathan M. Ghergurovich, Mark Esposito, Zihong Chen, Joshua Z Wang, Vrushank Bhatt, Taijin Lan, Eileen White, Yibin Kang, Jessie Yanxiang Guo, Joshua D. Rabinowitz> ;Cancer Research. 2020 Sep 15
• 93 citations
  Serine Catabolism Feeds NADH when Respiration Is Impaired.
  Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shi...> ;Cell Metabolism. 2020 Apr 7
• 87 citations
  A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway
  Jonathan M. Ghergurovich, Juan Carlos García-Cañaveras, Joshua Wang, Emily Schmidt, Zhaoyue Zhang, Tara TeSlaa, Harshel Patel, Li Chen, Emily C. Britt, Marta Piqueras-...> ;Nature Chemical Biology. 2020 Jan 1
• 98 citations
  T Cell Activation Depends on Extracellular Alanine.
  Noga Ron-Harel, Jonathan M. Ghergurovich, Giulia Notarangelo, Martin W. LaFleur, Yoshiki Tsubosaka, Arlene H. Sharpe, Joshua D. Rabinowitz, Marcia C. Haigis> ;Cell Reports. 2019 Sep 17
• 77 citations
  Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.
  Noga Ron-Harel, Giulia Notarangelo, Jonathan M. Ghergurovich, Joao A. Paulo, Peter T. Sage, Daniel Ditzel Santos, F. Kyle Satterstrom, Steven P. Gygi, Joshua D. Rabino...> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Dec 26
• 186 citations
  As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
  Natalya N. Pavlova, Sheng Hui, Jonathan M. Ghergurovich, Jing Fan, Andrew M. Intlekofer, Richard M. White, Joshua D. Rabinowitz, Craig B. Thompson, Ji Zhang> ;Cell Metabolism. 2018 Feb 6
• 913 citations
  Glucose feeds the TCA cycle via circulating lactate.
  Sheng Hui, Jonathan M. Ghergurovich, Raphael J. Morscher, Cholsoon Jang, Xin Teng, Wenyun Lu, Lourdes A Esparza, Tannishtha Reya, Le Zhan, Jessie Yanxiang Guo, Eileen ...> ;Nature. 2017 Nov 2
• 152 citations
  Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma
  Gregory S. Ducker, Jonathan M. Ghergurovich, Nello Mainolfi, Vipin Suri, Stephanie K. Jeong, Sophia Hsin-Jung Li, Adam Friedman, Mark Manfredi, Zemer Gitai, Hahn Kim, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Oct 24
• 43 citations
  Erratum: Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway (Cell Metabolism (2016) 23(6) (1140–1153)(S1550413116301681)(10...
  Gregory S. Ducker, Li Chen, Raphael J. Morscher, Jonathan M. Ghergurovich, Mark Esposito, Xin Teng, Yibin Kang, Joshua D. Rabinowitz> ;Cell Metabolism. 2016 Oct 11
• 248 citations
  Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation
  Noga Ron-Harel, Daniel Ditzel Santos, Jonathan M. Ghergurovich, Peter T. Sage, Anita Reddy, Scott B. Lovitch, Noah Dephoure, F. Kyle Satterstrom, Michal Sheffer, Jessi...> ;Cell Metabolism. 2016 Jul 12
• 117 citations
  Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.
  Gregory S Ducker, Li Chen, Raphael J Morscher, Jonathan M Ghergurovich, Mark Esposito, Xin Teng, Yibin Kang, Joshua D Rabinowitz> ;Cell Metabolism. 2016 Jun 14
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