JordanU.GuttermanMD

PubMed

• Can natural selection and druggable targets synergize? Of nutrient scarcity, cancer, and the evolution of cooperation.
  Neil W. Blackstone, Jordan U. Gutterman> ;Bioessays. 2021 Feb 1
• 12 citations
  Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling.
  Christian M. Garrido, Karen M. Henkels, Kristen M. Rehl, Hong Liang, Yong Zhou, Jordan U. Gutterman, Kwang-Jin Cho> ;Scientific Reports. 2020 Jun 4
• 118 citations
  In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs
  Ayalew Tefferi, Hagop M. Kantarjian, S. Vincent Rajkumar, Larry Baker, J L Abkowitz, John W. Adamson, Ranjana H. Advani, James P. Allison, Karen H. Antman, Robert C. B...> ;Mayo Clinic Proceedings. 2015 Aug 1
• 12 citations
  Glycosylation facilitates transdermal transport of macromolecules.
  Christopher J. Pino, Jordan U. Gutterman, Daniel Vonwil, Samir Mitragotri, V. Prasad Shastri> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Dec 26
• 15 citations
  The anticancer plant triterpenoid, avicin d, regulates glucocorticoid receptor signaling: Implications for cellular metabolism
  Valsala Haridas, Zhi-Xiang Xu, Doug Kitchen, Anna Jiang, Peter C. Michels, Jordan U. Gutterman> ;Plos One. 2011 Nov 21
• 16 citations
  Red blood cell permeabilization by hypotonic treatments, saponin, and anticancer avicins.
  Mauricio Arias, Jairo Quijano, Valsala Haridas, Jordan U. Gutterman, Victor V. Lemeshko> ;Biochimica Et Biophysica Acta. 2010 Jun 1
• 13 citations
  Natural triterpenoid avicins selectively induce tumor cell death
  Huibo Wang, Valsala Haridas, Jordan U. Gutterman, Zhi-Xiang Xu> ;Communicative & Integrative Biology. 2010 May 1
• 37 citations
  Avicin D, a Plant Triterpenoid, Induces Cell Apoptosis by Recruitment of Fas and Downstream Signaling Molecules into Lipid Rafts
  Zhi-Xiang Xu, Tian Ding, Valsala Haridas, Fiona Connolly, Jordan U. Gutterman> ;Plos One. 2009 Dec 31
• 22 citations
  Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities.
  Valsala Haridas, Goshi Nishimura, Zhi-Xiang Xu, Fiona Connolly, Margaret Hanausek, Zbigniew Walaszek, Robert Zoltaszek, Jordan U. Gutterman> ;Plos One. 2009 May 18
• 32 citations
  Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells.
  Chunlei Zhang, Baoqiang Li, Amos Gaikwad, Valsala Haridas, Zhi-Xiang Xu, Jordan U. Gutterman, Madeleine Duvic> ;The Journal of Investigative Dermatology. 2008 Nov 1
• Three catalytic lives linked by the Lasker Awards.
  Jordan U. Gutterman, Neen Hunt> ;Nature Medicine. 2008 Oct 1
• 84 citations
  A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase
  Zhi-Xiang Xu, Jiyong Liang, Valsala Haridas, Amos Gaikwad, Fiona Connolly, Gordon B. Mills, Jordan U. Gutterman> ;Cell Death and Differentiation. 2007 Aug 10
• 45 citations
  Avicins, a novel plant-derived metabolite lowers energy metabolism in tumor cells by targeting the outer mitochondrial membrane.
  Valsala Haridas, Xiaoxian Li, Takatsugu Mizumachi, Masahiro Higuchi, Viktor V. Lemeshko, Marco Colombini, Jordan U. Gutterman> ;Mitochondrion. 2007 May 1
• 816 citations
  The Energy Sensing LKB1-AMPK Pathway Regulates p27kip1 Phosphorylation Mediating the Decision to Enter Autophagy or Apoptosis
  Jiyong Liang, Shan H. Shao, Zhi-Xiang Xu, Bryan T. Hennessy, Zhiyong Ding, Michelle D. Larrea, Seiji Kondo, Daniel J. Dumont, Jordan U. Gutterman, Cheryl L. Walker, Jo...> ;Nature Cell Biology. 2007 Feb 1
• 39 citations
  Avicins, natural anticancer saponins, permeabilize mitochondrial membranes.
  Victor V. Lemeshko, Valsala Haridas, Jairo C. Quijano Pérez, Jordan U. Gutterman> ;Archives of Biochemistry and Biophysics. 2006 Oct 15
• 20 citations
  Adjuvant immunotherapy and chemoimmunotherapy in colorectal cancer of the Dukes' C classification. Preliminary clinical results.
  Giora M. Mavligit, Jordan U. Gutterman, Michael A. Burgess, Nayerh Khankhanian, G. Burton Seibert, John F. Speer, Richard C. Reed, Andre V. Jubert, Richard C. Martin, ...> ;Cancer. 2006 Jun 28
• 16 citations
  Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast
  Jordan U. Gutterman, Hong T. Lai, Peirong Yang, Valsala Haridas, Amos Gaikwad, Stevan Marcus> ;Proceedings of the National Academy of Sciences of the United States of America. 2005 Sep 6
• 38 citations
  Avicinylation (thioesterification): A protein modification that can regulate the response to oxidative and nitrosative stress
  Valsala Haridas, Sung-Oog Kim, Goshi Nishimura, Alfred Hausladen, Jonathan S. Stamler, Jordan U. Gutterman> ;Proceedings of the National Academy of Sciences of the United States of America. 2005 Jul 19
• 33 citations
  Proapoptotic Triterpene Electrophiles (Avicins) Form Channels in Membranes: Cholesterol Dependence
  Xiao Xian Li, Bridgette Davis, Valsala Haridas, Jordan U. Gutterman, Marco Colombini> ;Biophysical Journal. 2005 Apr 1
• 33 citations
  Triterpenoid Electrophiles (Avicins) Suppress Heat Shock Protein-70 and X-Linked Inhibitor of Apoptosis Proteins in Malignant Cells by Activation of Ubiquitin Machiner...
  Amos Gaikwad, Ann Poblenz, Valsala Haridas, Chunlei Zhang, Madeleine Duvic, Jordan U. Gutterman> ;Clinical Cancer Research. 2005 Mar 1
• 14 citations
  Mitochondria as integrators of information in an early-evolving animal: insights from a triterpenoid metabolite
  Neil W. Blackstone, Molly M. Kelly, Valsala Haridas, Jordan U. Gutterman> ;Proceedings. Biological Sciences. 2005 Mar 7
• 71 citations
  Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery
  Valsala Haridas, Margaret Hanausek, Goshi Nishimura, Holly Soehnge, Amos Gaikwad, Maciej Narog, Erick Spears, Robert Zoltaszek, Zbigniew Walaszek, Jordan U. Gutterman> ;The Journal of Clinical Investigation. 2004 Jan 1
• 44 citations
  Isolation and structures of avicins D and G: in vitro tumor-inhibitory saponins derived from Acacia victoriae.
  Gamini S. Jayatilake, Delano R. Freeberg, Zhengjie Liu, Richheimer Steve L, Mary E. Blake, David T. Bailey, Valsala Haridas, Jordan U. Gutterman> ;Journal of Natural Products. 2003 Jun 1
• 10 citations
  Metabolomics of Plant Saponins: Bioprospecting Triterpene Glycoside Diversity with Respect to Mammalian Cell Targets
  Lokesh Joshi, Joyce Van Eck, Kristin Mayo, Regina Di Silvestro, Mary E. Blake, Thumballi Ganapathi, Valsala Haridas, Jordan U. Gutterman, Charles J. Arntzen> ;Omics. 2002 Jan 1
• 99 citations
  Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-κB by inhibiting both its nuclear localization and abi...
  Valsala Haridas, Charles J. Arntzen, Jordan U. Gutterman> ;Proceedings of the National Academy of Sciences of the United States of America. 2001 Sep 25
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