Joseph Anthony Califano III MD

PubMed

• Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer.
  Takuya Nakagawa, Jens Luebeck, Kaiyuan Zhu, Joshua T Lange, Roman Sasik
  Nature Communications. 2025-03-26
• Tumor-intrinsic and immune-related features associated with treatment failure in human papillomavirus-related oropharyngeal cancer.
  Malay K Sannigrahi, Lovely Raghav, Dominick J Rich, Travis P Schrank, Joseph A Califano
  Journal of the National Cancer Institute. 2025-03-11
• Clinicopathologic Features of Oral Verrucous Carcinoma: A Systematic Review and Meta-Analysis.
  Steven Duncan, Andrey Finegersh, Ryan K Orosco, Nathaniel Wu, Kevin T Brumund
  The Annals of Otology, Rhinology, and Laryngology. 2025-03-01

Journal Articles

• Integrated Time Course Omics Analysis Distinguishes Immediate Therapeutic Response from Acquired Resistance  
  Joseph A Califano, Christine H Chung, BioMed Central
• The Epidermal Growth Factor Receptor Axis: Support for a New Target for Oral Premalignancy  
  Rosin MP, Califano JA, Cancer Prev Res, 6/22/2010
• Combination effects of salvianolic acid B with low-dose celecoxib on inhibition of head and neck squamous cell carcinoma growth in vitro and in vivo  
  Zhao Y, Hao Y, Ji H, Fang Y, Guo Y, Sha W, Zhou Y, Pang X, Southerland WM, Califano JA, Gu X, Cancer Prev Res, 6/1/2010
• EIF2C is overexpressed and amplified in head and neck squamous cell carcinoma  
  Chang SS, Smith I, Glazer C, Hennessey P, Califano JA, ORL J Otorhinolaryngol Relat Spec, 1/1/2010
• Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and nec...  
  Smith IM, Mithani SK, Mydlarz WK, Chang SS, Califano JA, ORL J Otorhinolaryngol Relat Spec, 1/1/2010
• Polymorphisms in KCNE1 or KCNE3 are not associated with Meniere disease in the Caucasian population  
  Campbell CA, Della Santina CC, Meyer NC, Smith NB, Myrie OA, Stone EM, Fukushima K, Califano JA, Carey JP, Hansen MR, Gantz BJ, Minor LB, Smith RJ, Am J Med Genet A, 1/1/2010
• Level V involvement in patients with early T-stage,node-positive oropharyngeal carcinoma  
  Pattani KM, Califano JA, Sanguineti G, Laryngoscope, 8/17/2009
• Defining the Risk of Involvement for Each Neck Nodal Level in Patients With Early T-Stage Node-Positive Oropharyngeal Carcinoma  
  Sanguineti G, Califano JA, Stafford E, Fox J, Koch W, Tufano R, Sormani MP,Forastiere A, Int J Radiat Oncol Biol Phys, 8/1/2009
• p53 mutation is rare in oral mucosa brushings from patients previously treated for a head and neck squamous cell carcinoma  
  Acha-Sagredo A, Ruesga MT, Rodriguez C, Aguirregaviria JI, Pancorbo MM, Califano JA, Aguirre JM, Oral Oncol, 8/1/2009
• Malignant melanoma  
  Califano JA, Nance M, Facial Plast Surg Clin North Am, 8/1/2009
• Human papillomavirus and head and neck squamous cell carcinoma: recent evidence and clinical implications  
  Hennessey PT, Westra WH, Califano JA, J Dent Res, 4/1/2009
• Mitochondrial Mutations Contribute to HIF1{alpha} Accumulation via Increased Reactive Oxygen Species and Up-regulated Pyruvate Dehydrogenease Kinase 2 in Head and Neck...  
  Sun W, Zhou S, Chang SS, McFate T, Verma A, Califano JA, Clin Cancer Res, 1/15/2009
• Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer  
  Smith IM, Glazer CA, Mithani SK, Ochs MF, Sun W, Bhan S, Vostrov A, Abdullaev Z, Lobanenkov V, Gray A, Liu C, Chang SS, Ostrow KL, Westra WH, Begum S, Dhara M, Califan..., PLoS One, 1/1/2009
• Positive Sentinel Lymph Nodes are a Negative Prognostic Factor for Survival in T1-2 Oral/Oropharyngeal Cancer: A Long-Term Study on 103 Patients  
  Pattani KM, Califano JA, Ann Surg Oncol, 11/19/2008
• Clinical and molecular characteristics of squamous cell carcinomas from fanconianemia patients  
  van Zeeburg HJ, Snijders PJ, Wu T, Gluckman E, Soulier J, Surralles J,Castella M, van der Wal JE, Wennerberg J, Califano JA, Velleuer E, Dietrich R,Ebell W, Bloemena E..., J Natl Cancer Inst, 11/19/2008
• Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivovia cyclooxygenase-2 and apoptotic pathways  
  Hao Y, Xie T, Korotcov A, Zhou Y, Pang X, Shan L, Ji H, Sridhar R, Wang P, Califano JA, Gu X, Int J Cancer, 11/19/2008
• Molecular techniques and genetic alterations in head and neck cancer  
  Ha PK, Chang SS, Glazer CA, Califano JA, Sidransky D, Oral Oncol, 7/30/2008
• Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice  
  Glazer CA, Chang SS, Ha PK, Califano JA, Oral Oncol, 7/30/2008
• Current status of biomarkers in head and neck cancer  
  Chang SS, Califano JA, J Surg Oncol, 6/15/2008
• Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis  
  Chatterjee A, Chang X, Nagpal JK, Chang S, Upadhyay S, Califano JA, Trink B, Sidransky D, Oncogene, 6/12/2008
• Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation  
  Woo J, Lee J, Chae YK, Kim MS, Baek JH, Park JC, Park MJ, Smith IM, Trink B, Ratovitski E, Lee T, Park B, Jang SJ, Soria JC, Califano JA, Sidransky D, Moon C, Cancer Lett, 6/8/2008
• Nonsynonymous somatic mitochondrial mutations occur in the majority of cutaneous melanomas  
  Mithani SK, Smith IM, Topalian SL, Califano JA, Melanoma Res, 6/1/2008
• Consensus statement on the classification and terminology of neck dissection  
  Robbins KT, Shaha AR, Medina JE, Califano JA, Wolf GT, Ferlito A, Som PM, Day TA; Committee for Neck Dissection Classification, American Head and Neck Society, Arch Otolaryngol Head Neck Surg, 5/1/2008
• Genome-wide promoter analysis uncovers portions of the cancer methylome  
  Hoque MO, Kim MS, Ostrow KL, Liu J, Wisman GB, Park HL, Poeta ML, Jeronimo C, Henrique R, Lendvai A, Schuuring E, Begum S, Rosenbaum E, Ongenaert M, Yamashita K, Calif..., Cancer Res, 4/15/2008
• Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma  
  Chuang AY, Chuang TC, Chang S, Zhou S, Begum S, Westra WH, Ha PK, Koch WM, Califano JA, Oral Oncol, 3/6/2008
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Books/Book Chapters

• DeVita, Hellman, and Rosenberg's Cancer: Principles of Practice of Oncology 
  Chapter: Molecular Biology of Head and Neck Cancer. 
  Agrawal N, Califano JA, and Ha PWolters Kluwer Lippincott Williams and WilkinsEdition 9th,2011
• Ballenger's Otorhinolaryngology-Head and Neck Surgery 
  Chapter: Molecular diagnostic approaches to head and neck cancer. 
  Smith I and Califano JAEditors: Snow et al.BC Decker2009
• Otolaryngology-Head and Neck Surgery 
  Chapter: Molecular Biology of Head and Neck Cancer. 
  Ha, P, Goldenberg, D, Walpoe, M, Califano JAEditors: Cummings, et al.Mosby2004
• Endocrine Surgery of the Head and Neck 
  Chapter: Surgical Evaluation and Management of Goiter. 
  Califano JA, Kraus DEditors: Pellitteri, PK.Singular2002
• Oxford Textbook of Surgery 
  Chapter: Salivary Glands. 
  Califano JA, Eisele DOxford Press2001
• The Practice of General Surgery 
  Chapter: Salivary Glands. 
  Califano JA, Shah JEditors: Bland, KI.WB Saunders Company2001
• Prognostic Factors in Cancer 
  Chapter: Prognostic Factors for Salivary Gland Cancer. 
  Califano JA, Spiro REditors: Gospodarowicz, M.Springer, New YorkEdition 2nd,2001
• Multiple Primary Cancers 
  Chapter: Molecular Analysis of Tumors. 
  Califano JA, Sidransky DEditors: Neugut, AI, Robinson, E, Meadows AT.Lippincott Williams & Wilkins1999
• Head and Neck Cancer: A Multidisciplinary Approach 
  Chapter: Molecular Biology of Head and Neck Cancer. 
  Califano JA, Sidransky DEditors: Harrison L, Hong, WK, Sessions R.Lippincott-Raven Publishers1998
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Lectures

• "Integrating high throughput analysis to define treatment strategies for HNSCC" 
  New York, NY - 7/29/2014
• "A transcription factor signature of HNSCC implicates STAT and NFKB activation in HPV negative tumors." 
  New York, NY - 7/29/2014
• Moderator, "Thyroid-Neck II" 
  New York, NY - 7/27/2014
• "The oncologic outcomes of patients treated with TORS." 
  Baltimore, MD - 7/24/2014
• "Innovative Surgical Techniques in Head and Neck Cancer Supportive Care" 
  Miami, FL - 6/27/2014
• "Survivorship in Head and Neck Cancer" 
  Miami, FL - 6/27/2014
• "Integrating molecular data in head and neck cancer." 
  Miami, FL - 6/7/2014
• "Sequencing/personalized therapy for head and neck cancer." 
  Baltimore, MD - 5/20/2014
• "Notch alterations as an example of signaling complexity in head and neck cancer" 
  Boston, MA - 4/28/2014
• "Molecular detection of head and neck cancer." 
  Clinica Las Condes, Santiago, Chile - 3/29/2014
• "Treatment of Oropharynx cancer." 
  Clinica Las Condes, Santiago, Chile - 3/29/2014
• "Transoral surgical approaches to head and neck cancer." 
  Clinica Las Condes, Santiago, Chile - 3/29/2014
• "Tadalafil/Cialis as immunotherapy for head and neck cancer." 
  Clinica Las Condes, Santiago, Chile - 3/29/2014
• "Sequencing the head and neck cancer genome and impact on therapy." 
  Clinica Las Condes, Santiago, Chile - 3/28/2014
• "Research Initiatives" 
  Greater Baltimore Medical Center, Baltimore, MD - 10/25/2013
• Molecular Detection of HPV positive oropharynx cancer. 
  Washington, DC - 10/25/2013
• "Current surgical techniques and refinements" 
  Greater Baltimore Medical Center, Baltimore, MD - 9/29/2013
• Management of oropharynx cancer in HPV era. 
  Brasilia, Brazil - 9/19/2013
• Surgical margins: molecular view and prognostic implications. 
  Brasilia, Brazil - 9/19/2013
• Panel Discussion: Oropharynx Cancer. 
  Brasilia, Brazil - 9/19/2013
• Panel Discussion: Robotic Surgery. 
  Brasilia, Brazil - 9/19/2013
• Tadalafil immunotherapy for head and neck cancer. 
  8/14/2013
• Grand Rounds: "Surgical Advances in Therapy for Head and Neck Cancer" 
  Winchester Hospital, Winchester, VA - 6/19/2013
• Integrating omics platforms to define opportunities for therapeutic intervention in head and neck cancer. 
  Rhodes, Greece - 4/16/2013
• "Molecular Genetics of Head and Neck Cancer" 
  University of the Basque Country, Bilbao, Spain - 11/16/2012
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Other

• "Oral Cancer" 
  Califano JA (Committee Member), The Maryland Comprehensive Cancer Control Plan
  1/1/2010
• Invited Guest Interview, "Molecular Detection of Cancer" 
  Califano JA, RCN Radio Cadena Nacional of Colombia
  2/5/2003