JosephBrianHiattMD

PubMed

• Molecular phenotyping of small cell lung cancer using targeted cfDNA profiling of transcriptional regulatory regions.
  Joseph B Hiatt, Anna-Lisa Doebley, Henry U Arnold, Mohamed Adil, Holly Sandborg, Thomas W Persse, Minjeong Ko, Feinan Wu, Alvaro Quintanal Villalonga, Rafael Santana-D...> ;Science Advances. 2024 Apr 12
• 23 citations
  Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.
  Joseph B Hiatt, Holly Sandborg, Sarah M Garrison, Henry U Arnold, Sheng-You Liao, Justin P Norton, Travis J Friesen, Feinan Wu, Kate D Sutherland, Hugh Y Rienhoff, Ren...> ;Clinical Cancer Research. 2022 Oct 14
• Improving the efficacy of immunotherapy in small cell lung cancer: Leveraging recent scientific discoveries and tumor-specific antigens.
  Joseph B Hiatt, Perrin E Romine, Daniel Y Wu> ;Seminars in Oncology. 2022 Jul 2
• 435 citations
  Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V. Rezelj, Svenja Ulferts, Hannes Braberg, Alexander S. Jureka, Kirsten Obernier, Jeffrey Z. Guo, Jyoti Batra,...> ;Science. 2020 Dec 4
• 652 citations
  The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
  Mehdi Bouhaddou, Danish Memon, Bjoern Meyer, Kris M. White, Veronica V. Rezelj, Miguel Correa Marrero, Benjamin J. Polacco, James E. Melnyk, Svenja Ulferts, Robyn M. K...> ;Cell. 2020 Aug 6
• 111 citations
  Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies
  Theodore L. Roth, P. Jonathan Li, Franziska Blaeschke, Jasper F. Nies, Ryan Apathy, Cody T. Mowery, Ruby Yu, Michelle L.T. Nguyen, Youjin V. Lee, Anna Truong, Joseph H...> ;Cell. 2020 Apr 30
• 2774 citations
  A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
  David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Sw...> ;Nature. 2020 Apr 30
• 219 citations
  A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
  David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, ...> ;Biorxiv. 2020 Mar 22
• 56 citations
  Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.
  Anastasia Selyutina, Mirjana Persaud, Lacy M Simons, Angel Bulnes-Ramos, Cindy Buffone, Alicia Martinez-Lopez, Viviana Scoca, Francesca Di Nunzio, Joseph Hiatt, Alexan...> ;Cell Reports. 2020 Mar 17
• 64 citations
  Large dataset enables prediction of repair after CRISPR–Cas9 editing in primary T cells
  Ryan T. Leenay, Amirali Aghazadeh, Joseph Hiatt, David Tse, Theodore L. Roth, Eric Shifrut, Judd F. Hultquist, Nevan J. Krogan, Zhenqin Wu, Giana Cirolia, Hera Canaj, ...> ;Nature Biotechnology. 2019 Jul 29
• 31 citations
  ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection
  Ruth Hüttenhain, Jiewei Xu, Lily Burton, David E. Gordon, Judd F. Hultquist, Jeffrey R. Johnson, Laura Satkamp, Joseph Hiatt, David Y. Rhee, Kheewoong Baek, David C. C...> ;Cell Host & Microbe. 2019 Jul 10
• 81 citations
  CRISPR–Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV–host factor interactions
  Judd F. Hultquist, Joseph Hiatt, Kathrin Schumann, Michael J. McGregor, Theodore L. Roth, Paige Haas, Jennifer A. Doudna, Alexander Marson, Nevan J. Krogan> ;Nature Protocols. 2019 Jan 1
• 12 citations
  CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling
  Si-Han Chen, Gwendolyn M. Jang, Ruth Hüttenhain, David E. Gordon, Dan Du, Billy W. Newton, Jeffrey R. Johnson, Joseph Hiatt, Judd F. Hultquist, Tasha L. Johnson, Yi Li...> ;The EMBO Journal. 2018 Sep 14
• 27 citations
  Fatal enteric plexus neuropathy after one dose of ipilimumab plus nivolumab: a case report.
  Jacob S. Appelbaum, Joseph B. Hiatt, Gideon Steinbach, F. Marc Stewart, Hannah Thomas, Paul Nghiem, Raj P. Kapur, John A. Thompson, Shailender Bhatia> ;Journal for Immunotherapy of Cancer. 2018 Aug 31
• 25 citations
  Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7
  Sakaorat Lertjuthaporn, Claudia Cicala, Donald Van Ryk, Matthew Liu, Jason Yolitz, Danlan Wei, Fatima Nawaz, Allison Doyle, Brooke Horowitch, Chung Park, Shan Lu, Yang...> ;Plos Pathogens. 2018 Aug 28
• 482 citations
  Reprogramming human T cell function and specificity with non-viral genome targeting
  Theodore L. Roth, Cristina Puig-Saus, Ruby Yu, Eric Shifrut, Julia Carnevale, P. Jonathan Li, Joseph Hiatt, Justin Saco, Paige Krystofinski, Han Li, Victoria Tobin, Da...> ;Nature. 2018 Jul 11
• 30 citations
  Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device
  Annamaria Mocciaro, Theodore L. Roth, Hayley M. Bennett, Magali Soumillon, Abhik Shah, Joseph Hiatt, Kevin T. Chapman, Alexander Marson, Grégory Lavieu> ;Communications Biology. 2018 May 3
• 226 citations
  PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia
  Laura A. Jansen, Ghayda Mirzaa, Gisele E. Ishak, Joseph B. Hiatt, William H. Roden, Sonya A. Gunter, Susan L. Christian, Sarah Collins, Carissa Adams, Jean Baptiste Ri...> ;Brain. 2015 Jun 1
• 52 citations
  Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes
  Akash Kumar, Evan A. Boyle, Mari Tokita, Andrei M. Mikheev, Michelle C Sanger, Emily J. Girard, John R. Silber, Luis F. Gonzalez-Cuyar, Joseph B. Hiatt, Andrew Adey, C...> ;Genome Biology. 2014 Dec 3
• 111 citations
  Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.
  Siddappa N. Byrareddy, Brianne Kallam, James Arthos, Claudia Cicala, Fatima Nawaz, Joseph Hiatt, Ellen N. Kersh, Janet M. McNicholl, Debra L. Hanson, Keith A. Reimann,...> ;Nature Medicine. 2014 Dec 1
• 239 citations
  Recurrent de novo mutations implicate novel genes underlying simplex autism risk
  Brian J. O'Roak, Holly A.F. Stessman, Evan A. Boyle, Kali Witherspoon, Benjamin L. Martin, Craig M. Lee, Laura Vives, Carl Baker, Joseph B. Hiatt, Deborah A. Nickerson...> ;Nature Communications. 2014 Nov 24
• 70 citations
  The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression
  Katija Jelicic, Raffaello Cimbro, Fatima Nawaz, Da-Wei Huang, Xin Zheng, Jun Yang, Richard A Lempicki, Massimiliano Pascuccio, Donald Van Ryk, Catherine Schwing, Josep...> ;Nature Immunology. 2013 Dec 1
• 238 citations
  The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line
  Andrew Adey, Joshua N. Burton, Joseph B. Hiatt, Alexandra P. Lewis, Beth Martin, Ruolan Qiu, Choli Lee, Jay Shendure> ;Nature. 2013 Aug 8
• 64 citations
  Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species.
  Keith R Bradnam, Joseph N Fass, Anton Alexandrov, Paul Baranay, Michael Bechner, Inanç Birol, Sébastien Boisvert, Jarrod A Chapman, Guillaume Chapuis, Rayan Chikhi, Ha...> ;Gigascience. 2013 Jul 22
• 251 citations
  Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variation.
  Joseph B. Hiatt, Colin C. Pritchard, Stephen J. Salipante, Brian J. O'Roak, Jay Shendure> ;Genome Research. 2013 May 1
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