JoshiJAlumkalMD

PubMed

• Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers.
  Ailin Zhang, Nathan A Lau, Alicia Wong, Lisha G Brown, Ilsa M Coleman, Navonil De Sarkar, Dapei Li, Diana C DeLucia, Mark P Labrecque, Holly M Nguyen, Jennifer L Conne...> ;Cancer Research Communications. 2023 Nov 20
• 3 citations
  LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function.
  Anbarasu Kumaraswamy, Zhi Duan, Diana Flores, Chao Zhang, Archana Sehrawat, Ya-Mei Hu, Olivia A Swaim, Eva Rodansky, William K Storck, Joshua A Kuleape, Karan Bedi, Ra...> ;JCI Insight. 2023 Aug 8
• 4 citations
  The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer.
  Arian Lundberg, Meng Zhang, Rahul Aggarwal, Haolong Li, Li Zhang, Adam Foye, Martin Sjöström, Jonathan Chou, Kevin Chang, Thaidy Moreno-Rodriguez, Raunak Shrestha, Avi...> ;Cancer Research. 2023 Aug 15
• 13 citations
  The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.
  Luo, J., Martin Sjöström, Shuang G Zhao, Samuel Levy, Meng Zhang, Yuhong Ning, Raunak Shrestha, Arian Lundberg, Cameron Herberts, Adam Foye, Rahul Aggarwal, Junjie T H...> ;Cancer Research. 2022 Nov 2
• 2 citations
  Metastatic prostate cancer diagnosed by fine-needle aspiration: Contemporary cytopathologic and biomarker assessment with clinical correlates.
  Richard L Cantley, Xiaoming Wang, Zachery R Reichert, Arul M Chinnaiyan, Rahul Mannan, Xuhong Cao, Daniel E Spratt, Ulka N Vaishampayan, Joshi J Alumkal, Todd M Morgan...> ;Cancer Cytopathology. 2023 Feb 1
• 10 citations
  Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity.
  Thomas C Westbrook, Xiangnan Guan, Eva Rodansky, Diana Flores, Chia Jen Liu, Aaron M Udager, Radhika A Patel, Michael C Haffner, Ya-Mei Hu, Duanchen Sun, Tomasz M Beer...> ;Nature Communications. 2022 Sep 15
• 1 citations
  A Phase I Trial of Neoadjuvant Stereotactic Body Radiotherapy Prior to Radical Prostatectomy for Locally Advanced Prostate Cancer.
  Liat Hammer, Ralph Jiang, Jason Hearn, Jack Lashbrook, Amyre Mitchell, Stephanie Daignault-Newton, Robert T Dess, William C Jackson, Zachery Reichert, Joshi J Alumkal,...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Jan 1
• 8 citations
  Modeling Androgen Deprivation Therapy-Induced Prostate Cancer Dormancy and Its Clinical Implications.
  Xin Dong, Hui Xue, Fan Mo, Yen-Yi Lin, Dong Lin, Nelson K Y Wong, Yingqiang Sun, Scott Wilkinson, Anson T Ku, Jun Hao, Xinpei Ci, Rebecca Wu, Anne Haegert, Rebecca Sil...> ;Molecular Cancer Research. 2022 May 4
• 18 citations
  Understanding Drug Sensitivity and Tackling Resistance in Cancer.
  Jeffrey W Tyner, Franziska Haderk, Anbarasu Kumaraswamy, Linda B Baughn, Brian Van Ness, Song Liu, Himangi Marathe, Joshi J Alumkal, Trever G Bivona, Keith Syson Chan,...> ;Cancer Research. 2022 Apr 15
• 4 citations
  Tribbles 2 pseudokinase confers enzalutamide resistance in prostate cancer by promoting lineage plasticity.
  Jitender Monga, Indra Adrianto, Craig Rogers, Shirish Gadgeel, Dhananjay Chitale, Joshi J Alumkal, Himisha Beltran, Amina Zoubeidi, Jagadananda Ghosh> ;The Journal of Biological Chemistry. 2022 Feb 1
• 3 citations
  Randomized, Open-Label Phase 2 Study of Apalutamide plus Androgen Deprivation Therapy versus Apalutamide Monotherapy versus Androgen Deprivation Monotherapy in Patient...
  Rahul Aggarwal, Joshi J Alumkal, Russell Z Szmulewitz, Celestia S Higano, Alan H Bryce, Angela Lopez-Gitlitz, Sharon A McCarthy, Branko Miladinovic, Kelly McQuarrie, S...> ;Prostate Cancer. 2022 Jan 1
• 9 citations
  The Role of Epigenetic Change in Therapy-Induced Neuroendocrine Prostate Cancer Lineage Plasticity.
  William K Storck, Allison M May, Thomas C Westbrook, Zhi Duan, Colm Morrissey, Joel A Yates, Joshi J Alumkal> ;Frontiers in Endocrinology. 2022 Jan 1
• 4 citations
  Multigene Profiling of Circulating Tumor Cells (CTCs) for Prognostic Assessment in Treatment-Naïve Metastatic Hormone-Sensitive Prostate Cancer (mHSPC).
  Zachery R Reichert, Tadas Kasputis, Srinivas Nallandhighal, Sophia M Abusamra, Amy Kasputis, Saloni Haruray, Yugang Wang, Shamara Williams, Udit Singhal, Ajjai Alva, F...> ;International Journal of Molecular Sciences. 2021 Dec 21
• 98 citations
  Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data
  Duanchen Sun, Xiangnan Guan, Amy E. Moran, Ling-Yun Wu, David Z. Qian, Pepper Schedin, Mu Shui Dai, Alexey V. Danilov, Joshi J. Alumkal, Andrew Adey, Paul T. Spellman,...> ;Nature Biotechnology. 2021 Nov 11
• 18 citations
  Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer.
  Rahul Aggarwal, Nicholas R. Rydzewski, Li Zhang, Adam Foye, Won Kim, Kyle T Helzer, Hamza Bakhtiar, S. Laura Chang, Marc D. Perry, Martin E. Gleave, Robert E. Reiter, ...> ;JAMA Oncology. 2021 Nov 1
• 15 citations
  RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer.
  Mark P. Labrecque, Lisha G. Brown, Ilsa Coleman, Bryce Lakely, Nicholas J. Brady, John K. Lee, Holly M. Nguyen, Dapei Li, Brian Hanratty, Michael C. Haffner, David S. ...> ;Cancer Research. 2021 Sep 15
• 26 citations
  BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program.
  Dae Hwan Kim, Duanchen Sun, William K. Storck, Katherine Welker Leng, Chelsea Jenkins, Daniel J. Coleman, David A. Sampson, Xiangnan Guan, Anbarasu Kumaraswamy, Eva S....> ;Clinical Cancer Research. 2021 Jun 18
• 19 citations
  The heterogeneity of prostate cancers lacking AR activity will require diverse treatment approaches.
  Mark P. Labrecque, Joshi J. Alumkal, Ilsa Coleman, Peter S. Nelson, Colm Morrissey> ;Endocrine-Related Cancer. 2021 Aug 1
• 27 citations
  Recent Advances in Epigenetic Biomarkers and Epigenetic Targeting in Prostate Cancer
  Anbarasu Kumaraswamy, Katherine R. Welker Leng, Thomas C. Westbrook, Joel A. Yates, Shuang G. Zhao, Christopher P. Evans, Felix Y. Feng, Todd M. Morgan, Joshi J. Alumkal> ;European Urology. 2021 Mar 27
• 68 citations
  Intermediate clinical endpoints for surrogacy in localised prostate cancer: an aggregate meta-analysis.
  L.A. Gharzai, Ralph Jiang, David G. Wallington, Gavin P. Jones, S. Birer, Neil K. Jairath, E. Jaworski, Matthew R. McFarlane, Brandon A. Mahal, Paul L. Nguyen, Howard ...> ;The Lancet. Oncology. 2021 Mar 1
• 6 citations
  De novo neuroendocrine transdifferentiation in primary prostate cancer–a phenotype associated with advanced clinico-pathologic features and aggressive outcome
  Eman Abdulfatah, Zachery R. Reichert, Matthew S. Davenport, Arul M. Chinnaiyan, Vipulkumar Dadhania, Xiaoming Wang, Rahul Mannan, Lakshmi P. Kunju, Brent K. Hollenbeck...> ;Medical Oncology. 2021 Feb 14
• 41 citations
  Prostate Radiotherapy With Adjuvant Androgen Deprivation Therapy (ADT) Improves Metastasis-Free Survival Compared to Neoadjuvant ADT: An Individual Patient Meta-Analysis.
  Daniel E. Spratt, Shawn Malone, Soumyajit Roy, Scott Grimes, Libni Eapen, Scott C. Morgan, Julia Malone, Julia Craig, Robert T. Dess, William C. Jackson, Holly E. Hart...> ;Journal of Clinical Oncology. 2021 Jan 10
• 2 citations
  A CHIP in the Armor of Cell-Free DNA-Based Predictive Biomarkers for Prostate Cancer.
  Zachery R. Reichert, Morgan Jones, Joshi J. Alumkal> ;JAMA Oncology. 2021 Jan 1
• 33 citations
  Enzalutamide response in a panel of prostate cancer cell lines reveals a role for glucocorticoid receptor in enzalutamide resistant disease.
  Rebecca Smith, Moqing Liu, Tiera Liby, Nora Bayani, Elmar Bucher, Kami E. Chiotti, Daniel S. Derrick, Anne Chauchereau, Laura M. Heiser, Joshi J. Alumkal, Heidi S. Fei...> ;Scientific Reports. 2020 Dec 10
• 45 citations
  Accelerating precision medicine in metastatic prostate cancer.
  Joaquin Mateo, Rana R. McKay, Wassim Abida, Rahul Aggarwal, Joshi J. Alumkal, Ajjai Alva, Felix Y. Feng, Xin Gao, Julie N. Graff, Maha Hussain, Fatima Karzai, Bruce Mo...> ;Nature Cancer. 2020 Nov 17
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Journal Articles

• Maintenance and Pharmacologic Targeting of ROR1 Protein Levels via UHRF1 in T(1;19) Pre-B-ALL  
  Joshi Alumkal, MD, Nature