JoshuaHLipschutzMD

PubMed

• β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage.
  Semenikhina, M., Fedoriuk, M., Stefanenko, M., Klemens, C., Cherezova, A., Marshall, B., Levchenko, V., Ilatovskaya, D., Staruschenko, A., Palygin, O., Hall, G., Solan...> ;Clinical Science. 2023 Dec 22
• High water intake induces primary cilium elongation in renal tubular cells.
  Min Jung Kong, Sang Jun Han, Sung Young Seu, Ki-Hwan Han, Joshua H Lipschutz, Kwon Moo Park> ;Kidney Research and Clinical Practice. 2023 Nov 7
• 2 citations
  Shortening of primary cilia length is associated with urine concentration in the kidneys.
  Min Jung Kong, Sang Jun Han, Sung Young Seu, Ki-Hwan Han, Joshua H Lipschutz, Kwon Moo Park> ;Kidney Research and Clinical Practice. 2023 May 1
• Breaking New Ground: The Crucial Role of Animal Research in the Advancement of Rhabdomyolysis-Induced AKI Treatment and Prevention.
  Marharyta Semenikhina, Joshua H Lipschutz, Oleg Palygin> ;Function. 2023 Jan 1
• 1 citations
  Hydrogen sulfide, a gaseous signaling molecule, elongates primary cilia on kidney tubular epithelial cells by activating extracellular signal-regulated kinase.
  Sang Jun Han, Jee In Kim, Joshua H. Lipschutz, Kwon Moo Park> ;The Korean Journal of Physiology & Pharmacology. 2021 Nov 1
• 4 citations
  Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair.
  Ashish K. Solanki, Ehtesham Arif, Pankaj Srivastava, Christopher M. Furcht, Bushra Rahman, Pei Wen, Avinash Singh, Lawrence B. Holzman, Wayne R. Fitzgibbon, Milos N. B...> ;The Journal of Biological Chemistry. 2021 Sep 1
• 2 citations
  Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual F...
  Bärbel Rohrer, Manas R. Biswal, Elisabeth Obert, Yujing Dang, Yanhui Su, Xiaofeng Zuo, Ben Fogelgren, Altaf A. Kondkar, Glenn P. Lobo, Joshua H. Lipschutz> ;International Journal of Molecular Sciences. 2021 May 11
• 10 citations
  A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish.
  Ashish K. Solanki, Altaf A. Kondkar, Joseph Fogerty, Yanhui Su, Seok-Hyung Kim, Joshua H. Lipschutz, Deepak Nihalani, Brian D. Perkins, Glenn P. Lobo> ;Cells. 2020 Apr 29
• 9 citations
  Desert Hedgehog-Primary Cilia Cross Talk Shapes Mitral Valve Tissue by Organizing Smooth Muscle Actin
  Diana Fulmer, Katelynn Toomer, Janiece Glover, Lilong Guo, Kelsey Moore, Reece Moore, Rebecca Stairley, Cortney Gensemer, Sameer Abrol, Mary Kate Rumph, Faith Emetu, J...> ;Developmental Biology. 2020 Mar 6
• 6 citations
  The Use of High-Throughput Transcriptomics to Identify Pathways with Therapeutic Significance in Podocytes
  Ashish K. Solanki, Pankaj Srivastava, Bushra Rahman, Joshua H. Lipschutz, Deepak Nihalani, Ehtesham Arif> ;International Journal of Molecular Sciences. 2019 Dec 31
• 15 citations
  Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content
  Xiaofeng Zuo, Sang Ho Kwon, Michael G. Janech, Yujing Dang, Steven D. Lauzon, Ben Fogelgren, Noemi Polgar, Joshua H. Lipschutz> ;The Journal of Biological Chemistry. 2019 Dec 13
• 31 citations
  Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis
  Diana Fulmer, Katelynn Toomer, Lilong Guo, Kelsey Moore, Janiece Glover, Reece Moore, Rebecca Stairley, Glenn P. Lobo, Xiaofeng Zuo, Yujing Dang, Yanhui Su, Ben Fogelg...> ;Circulation. 2019 Oct 15
• 8 citations
  The role of the exocyst in renal ciliogenesis, cystogenesis, tubulogenesis, and development.
  Joshua H. Lipschutz> ;Kidney Research and Clinical Practice. 2019 Sep 30
• 14 citations
  The motor protein Myo1c regulates transforming growth factor-β-signaling and fibrosis in podocytes
  Ehtesham Arif, Ashish K. Solanki, Pankaj Srivastava, Bushra Rahman, Brian R. Tash, Lawrence B. Holzman, Michael G. Janech, René Martin, Hans-Joachim Knölker, Wayne R. ...> ;Kidney International. 2019 Jul 1
• 14 citations
  Disruption of the exocyst induces podocyte loss and dysfunction
  Deepak Nihalani, Ashish K. Solanki, Ehtesham Arif, Pankaj Srivastava, Bushra Rahman, Xiaofeng Zuo, Yujing Dang, Ben Fogelgren, Damian Fermin, Christopher E. Gillies, M...> ;The Journal of Biological Chemistry. 2019 Jun 28
• 60 citations
  Primary cilia defects causing mitral valve prolapse
  Katelynn Toomer, Mengyao Yu, Diana Fulmer, Lilong Guo, Kelsey Moore, Reece Moore, Ka’la D. Drayton, Janiece Glover, Neal Peterson, Sandra Ramos-Ortiz, Alex Drohan, Bre...> ;Science Translational Medicine. 2019 May 22
• 12 citations
  The exocyst acting through the primary cilium is necessary for renal ciliogenesis, cystogenesis, and tubulogenesis.
  Xiaofeng Zuo, Glenn P. Lobo, Diana Fulmer, Lilong Guo, Yujing Dang, Yanhui Su, Daria V. Ilatovskaya, Deepak Nihalani, Bärbel Rohrer, Simon C. Body, Russell A. Norris, ...> ;The Journal of Biological Chemistry. 2019 Apr 26
• Correction to: Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing.
  Byeonghyeon Lee, Jeong-In Baek, Hyehyun Min, Seung-Hyun Bae, Kyeong-Hye Moon, Min-A Kim, Ye-Ri Kim, Ben Fogelgren, Joshua H. Lipschutz, Kyu-Yup Lee, Jinwoong Bok, Un-K...> ;Molecular Neurobiology. 2019 Jan 14
• 9 citations
  Zebrafish as models to study Ciliopathies of the Eye and Kidney
  Yi Shi, Yanhui Su, Joshua H. Lipschutz, Glenn P. Lobo> ;Clinical Nephrology and Research. 2017 Dec 1
• 5 citations
  Downregulation of exocyst Sec10 accelerates kidney tubule cell recovery through enhanced cell migration.
  Mi Ra Noh, Hee-Seong Jang, Dae-Kyu Song, Seong-Ryong Lee, Joshua H. Lipschutz, Kwon Moo Park, Jee In Kim> ;Biochemical and Biophysical Research Communications. 2018 Feb 5
• 6 citations
  Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing
  Byeonghyeon Lee, Jeong-In Baek, Hyehyun Min, Seung-Hyun Bae, Kyeong-Hye Moon, Min-A Kim, Ye-Ri Kim, Ben Fogelgren, Joshua H. Lipschutz, Kyu-Yup Lee, Jinwoong Bok, Un-K...> ;Molecular Neurobiology. 2018 Jan 11
• 7 citations
  The Retinol-Binding Protein Receptor 2 (Rbpr2) Is Required for Photoreceptor Survival and Visual Function in the Zebrafish.
  Glenn P. Lobo, Gayle J.T. Pauer, Joshua H. Lipschutz, Stephanie A. Hagstrom> ;Advances in Experimental Medicine and Biology. 2018 Jan 1
• 5 citations
  Adaptor protein CD2AP and L-type lectin LMAN2 regulate exosome cargo protein trafficking through the Golgi complex.
  Sang-Ho Kwon, Sekyung Oh, Marisa Nacke, Keith E Mostov, Joshua H Lipschutz> ;The Journal of Biological Chemistry. 2017 Oct 6
• 17 citations
  Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function.
  Amin Sagar, Ehtesham Arif, Ashish K. Solanki, Pankaj Srivastava, Michael G. Janech, Seok-Hyung Kim, Joshua H. Lipschutz, Sang Ho Kwon, Ashish, Deepak Nihalani> ;Scientific Reports. 2017 Sep 21
• 42 citations
  A role for primary cilia in aortic valve development and disease.
  Katelynn Toomer, Diana Fulmer, Lilong Guo, Alex Drohan, Neal Peterson, Paige Swanson, Brittany Brooks, Rupak Mukherjee, Simon C. Body, Joshua H. Lipschutz, Andy Wessel...> ;Developmental Dynamics. 2017 Aug 1
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Journal Articles

• Novel MAPK-dependent and independent tubulogenesis genes identified via microarray analysis of 3D-cultured Madin-Darby canine kidney cells  
  Chacon-Heszele MF, Zuo X, Hellman NE, McKenna S, Choi SY, Huang L, Tobias JW, Park KM, Lipschutz JH, American Journal of Physiology, Renal Physiology, 1/1/2014
• Expression of Drosophila Forkhead Transcription Factors During Kidney Development  
  Baek JI, Choi SY, Chacon-Heszele MF, Zuo X, Lipschutz JH, Biochemical and Biophysical Research Communications, 1/1/2014
• The Exocyst and Regulatory GTPases in Urinary Exosomes  
  Chacon-Heszele MF, Zuo X, Baek JI, Choi SY, Ward CJ, Lipschutz JH, Physiological Reports, 1/1/2014
• Reduction of oxidative stress during recovery accelerates normalization of primary cilia length that is altered after ischemic injury in murine kidneys  
  Kim JI, Kim J, Jang HS, Noh MR, Lipschutz JH, Park KM, American Journal of Physiology, Renal Physiology, 1/1/2013
• Cdc42 Knockdown/Knockout Results in Ciliary Abnormalities and Cystic Kidneys  
  Choi SY, Chacon-Heszele MF, Huang L, McKenna S, Wilson FP, Zuo X, Lipschutz JH, Journal of the American Society of Nephrology, 1/1/2013
• Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury  
  Jang HS, Han SJ, Kim JI, Lee S, Lipschutz JH, Park KM, Biochimica et Biophysica Acta-Molecular Basis of Disease, 1/1/2013
• Exocyst Sec10 is Involved in Basolateral Protein Translation and Translocation in the Endoplasmic Reticulum  
  Choi SY, Fogelgren B, Zuo X, Huang L, McKenna S, Lingappa VR, Lipschutz JH, Nephron Experimental Nephrology, 1/1/2012
• The Exocyst Protein Sec10 Interacts with Polycystin-2 and Knockdown Causes PKD-Phenotypes  
  Fogelgren B, Lin SY, Zuo X, Jaffe K, Park KM, Reichert RJ, Bell PD, Burdine RD, Lipschutz JH, PLoS Genetics, 1/1/2011
• The Small GTPase Cdc42 is Essential for Primary Ciliogenesis In Renal Tubular Epithelial Cells  
  Zuo X, Fogelgren B, Lipschutz JH, Journal of Biological Chemistry, 1/1/2011
• Adeno-Associated Virus (AAV)-Mediated Gene Transfer to Renal Tubule Cells via a Retrograde Ureteral Approach  
  Chung DC, Fogelgren B, Park KM, Heidenberg J, Zuo X, Huang L, Bennett J, Lipschutz JH, Nephron Extra, 1/1/2011
• High Rate of Fistula Placement in a Cohort of Dialysis Patients in a Single Payer System  
  Blosser C, Ayehu G, Wu S, LoMagro RM, Mallone E, Brunelli SM, Itkin M, Golden M, McCombs P, Lipschutz JH, Hemodialysis International, 1/1/2010
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Lectures

• The Role of Arl13b and the Exocyst in Ciliogenesis and Exosome Signaling (Invited Talk) 
  Lucca, Italy - 8/4/2014
• Small GTPases in Primary Ciliogenesis (Invited Speaker for Extended Talk) 
  Atlanta, GA - 11/7/2013
• The Role of Cdc42 and the Exocyst in Polycystic Kidney Disease (Invited Lecture) 
  Ulsan National Institute of Science Technology, Ulsan, South Korea - 8/24/2013
• The Role of Cdc42 and the Exocyst in Ciliogenesis, Cystogenesis, and Polycystic Kidney Disease (Invited Lecture) 
  Daegu, South Korea - 8/22/2013
• The Exocyst and Cdc42 are Necessary for Ciliogenesis (Invited Talk) 
  Niagra Falls, NY - 6/27/2013
• The Role of Cdc42 and the Exocyst in Ciliogenesis and Cystogenesis (Invited Lecture) 
  Dallas, TX - 11/15/2012
• The Role of the Exocyst in Ciliogenesis and Renal Cystogenesis (Invited Lecture) 
  San Diego, CA - 5/9/2012
• The Role of the Exocyst in Ciliogenesis (Invited Talk) 
  Saxtons River, VT - 7/27/2011
• The Exocyst and Polycystic Kidney Disease (Invited Lecture) 
  San Francisco, CA - 3/30/2011
• Update on Polycystic Kidney Disease, Ciliogenesis, and the Exocyst (Invited Lecture) 
  3/30/2011
• Role of the Exocyst in Ciliogenesis (Invited Lecture) 
  3/2/2011
• Update on Polycystic Kidney Disease and Ciliogenesis (Invited Lecture) 
  2/22/2011
• Role of the Exocyst and Ciliary Exosomes in Urocrine Signaling (Invited Lecture) 
  1/20/2011
• The Exocyst and How to Build a Primary Cilium (Invited Talk) 
  Saxtons River, VT - 7/7/2010
• The Exocyst in Ciliogenesis and Cystogenesis (Invited Lecture) 
  4/12/2010
• Cystic Kidney Disease, Ciliogenesis, and the Exocyst (Invited Lecture) 
  4/9/2009
• Military Medicine: After Action Review 
  1/20/2009
• Polycystic Kidney Disease and the Exocyst (Invited Lecture) 
  San Francisco, CA - 12/17/2008
• Polycystic Kidney Disease Free Communications Session, “The Exocyst is Necessary for Primary Ciliogenesis and Cystogenesis and Interacts with Par3” (Invited Talk) 
  11/6/2008
• Branching Out-Renal Tubulogenesis and the MAPK Pathway (Invited Lecture) 
  Boston, MA - 4/16/2008
• Renal Branching Morphogenesis (Invited Lecture) 
  Indianapolis, IN - 6/22/2007
• Nephrogenesis (Invited Lecture) 
  San Francisco, CA - 6/14/2006
• Renal Branching Morphogenesis and the MAPK Pathway (Invited Lecture) 
  Baltimore, MD - 6/1/2006
• Tubulogenesis and the MAPK Pathway (Invited Lecture) 
  Jerusalem, Israel - 12/29/2005
• Tubulogenesis and Renal Development (Invited Lecture) 
  Haifa, Israel - 12/21/2005
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