JoshuaAaronRegalMD, PhD, FRCPC(he/him)

PubMed

• Mining cancer genomes for change-of-metabolic-function mutations.
  Kevin J Tu, Bill H Diplas, Joshua A Regal, Matthew S Waitkus, Christopher J Pirozzi, Zachary J Reitman> ;Communications Biology. 2023 Nov 10
• Pooled genetic screens to identify vulnerabilities in TERT-promoter-mutant glioblastoma.
  Kevin J Tu, Connor E Stewart, Peter G Hendrickson, Joshua A Regal, So Young Kim, David M Ashley, Matthew S Waitkus, Zachary J Reitman> ;Oncogene. 2023 Oct 1
• Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population.
  Joshua A Regal, María E Guerra García, Vaibhav Jain, Vidyalakshmi Chandramohan, David M Ashley, Simon G Gregory, Eric M Thompson, Giselle Y López, Zachary J Reitman> ;Acta Neuropathologica Communications. 2023 Mar 25
• 3 citations
  The Effect ofLoss on Radiosensitivity of a Primary Mouse Model of-Deleted Brainstem Glioma.
  Connor E Stewart, María E Guerra-García, Lixia Luo, Nerissa T Williams, Yan Ma, Joshua A Regal, Debosir Ghosh, Patrick Sansone, Mark Oldham, Katherine Deland, Oren J B...> ;Cancers. 2022 Sep 17
• 3 citations
  Reversible mislocalization of a disease-associated MRE11 splice variant product.
  Andrea J. Hartlerode, Joshua A. Regal, David O. Ferguson> ;Scientific Reports. 2018 Jul 4
• 12 citations
  Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation
  Morgan Jones, Gail A. Osawa, Joshua A. Regal, Daniel N. Weinberg, James Taggart, Hande Kocak, Ann Friedman, David O. Ferguson, Catherine E. Keegan, Ivan Maillard> ;The Journal of Clinical Investigation. 2014 Jan 2
• 39 citations
  Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms
  Joshua A. Regal, Todd A. Festerling, Jeffrey Buis, David O. Ferguson> ;Human Molecular Genetics. 2013 Dec 20
• 160 citations
  A Spectrum of Severe Familial Liver Disorders Associate with Telomerase Mutations
  Rodrigo T. Calado, Joshua A. Regal, David E. Kleiner, David S. Schrump, Nathan R. Peterson, Veronica Pons, Stephen J. Chanock, Peter M. Lansdorp, Neal S. Young> ;Plos One. 2009 Nov 20
• 16 citations
  Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutations.
  Rodrigo T. Calado, Joshua A. Regal, Sachiko Kajigaya, Neal S. Young> ;European Journal of Clinical Investigation. 2009 Aug 11
• 264 citations
  Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.
  Rodrigo T. Calado, William T. Yewdell, Keisha L. Wilkerson, Joshua A. Regal, Sachiko Kajigaya, Constantine A. Stratakis, Neal S. Young> ;Blood. 2009 Sep 10
• 140 citations
  Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia
  Rodrigo T. Calado, Joshua A. Regal, Mark Hills, William T. Yewdell, Leandro F. Dalmazzo, Marco Antônio Zago, Peter M. Lansdorp, Donna E. Hogge, Stephen J. Chanock, Eli...> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Jan 27
• 76 citations
  Functional characterization of natural telomerase mutations found in patients with hematologic disorders.
  Zhong-Tao Xin, Adam D. Beauchamp, Rodrigo T. Calado, Jennifer W. Bradford, Joshua A. Regal, Aarthi Shenoy, Yuying Liang, Peter M. Lansdorp, Neal S. Young, Hinh Ly> ;Blood. 2007 Jan 15
• 90 citations
  Transient IκB Kinase Activity Mediates Temporal NF-κB Dynamics in Response to a Wide Range of Tumor Necrosis Factor-α Doses
  Raymond Cheong, Adriel Bergmann, Shannon L. Werner, Joshua Regal, Alexander Hoffmann, Andre Levchenko> ;The Journal of Biological Chemistry. 2006 Feb 3
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