JulieDeaneSabaMD

PubMed

• AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis.
  Babak Oskouian, Joanna Y Lee, Shahab Asgharzadeh, Ranjha Khan, Meng Zhang, Julia R Weisbrod, Youn-Jeong Choi, Latika Puri, Ana E Aguilar, Piming Zhao, Julie D Saba> ;Oncogene. 2024 Apr 1
• 1 citations
  AAV-SPL 2.0, a Modified Adeno-Associated Virus Gene Therapy Agent for the Treatment of Sphingosine Phosphate Lyase Insufficiency Syndrome.
  Ranjha Khan, Babak Oskouian, Joanna Y Lee, Jeffrey B Hodgin, Yingbao Yang, Gizachew Tassew, Julie D Saba> ;International Journal of Molecular Sciences. 2023 Oct 25
• 5 citations
  Sphingosine phosphate lyase insufficiency syndrome: a systematic review.
  Zahra Pournasiri, Abbas Madani, Fatemeh Nazarpack, John A Sayer, Zahra Chavoshzadeh, Fatemeh Nili, Paulina Tran, Julie D Saba, Mahnaz Jamee> ;World Journal of Pediatrics. 2023 May 1
• 4 citations
  Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile
  Anna Katharina Spohner, Katja Jakobi, Sandra Trautmann, Dominique Thomas, Fabian Schumacher, Burkhard Kleuser, Dieter Lütjohann, Khadija El-Hindi, Sabine Grösch, Josef...> ;International Journal of Molecular Sciences. 2021 Sep 30
• 4 citations
  Genotype/Phenotype Interactions and First Steps Toward Targeted Therapy for Sphingosine Phosphate Lyase Insufficiency Syndrome.
  Julie D. Saba, Nancy Keller, Jen-Yeu Wang, Felicia Tang, Avi Slavin, Yizhuo Shen> ;Cell Biochemistry and Biophysics. 2021 Jun 16
• 15 citations
  Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome
  Piming Zhao, Gizachew B. Tassew, Joanna Y. Lee, Babak Oskouian, Denise P. Muñoz, Jeffrey B. Hodgin, Gordon L. Watson, Felicia Tang, Jen-Yeu Wang, Jinghui Luo, Yingbao ...> ;JCI Insight. 2021 Apr 22
• 15 citations
  MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome.
  K W Martin, Nicole Weaver, Khalid Alhasan, Evren Gumus, Bonnie Sullivan, Martin Zenker, Friedhelm Hildebrandt, Julie D. Saba> ;AJNR. American Journal of Neuroradiology. 2020 Aug 27
• 18 citations
  Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation.
  Piming Zhao, Isaac Desheng Liu, Jeffrey B. Hodgin, Peter I. Benke, Jeremy Selva, Federico Torta, Markus R. Wenk, James A. Endrizzi, Olivia West, Weixing Ou, Emily Tang...> ;Journal of Inherited Metabolic Disease. 2020 May 4
• Correction to: Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway.
  Piming Zhao, Ana E. Aguilar, Joanna Y. Lee, Lucy A. Paul, Jung H. Suh, Latika Puri, Meng Zhang, Jennifer A. Beckstead, Andrzej Witkowski, Robert O. Ryan, Julie D. Saba> ;Investigational New Drugs. 2019 Dec 1
• 51 citations
  Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease.
  Julie D. Saba> ;Journal of Lipid Research. 2019 Mar 1
• 35 citations
  Sphingosine phosphate lyase insufficiency syndrome (SPLIS): A novel inborn error of sphingolipid metabolism
  Youn-Jeong Choi, Julie D. Saba> ;Advances in Biological Regulation. 2019 Jan 1
• 28 citations
  Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study
  Jung H. Suh, Emilie Degagné, Elizabeth E. Gleghorn, Mala Setty, Alexis Rodriguez, K.T. Park, Sofia G. Verstraete, Melvin B. Heyman, Ashish S. Patel, Melissa Irek, Ginn...> ;Inflammatory Bowel Diseases. 2018 May 18
• 13 citations
  Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway.
  Piming Zhao, Ana E. Aguilar, Joanna Y. Lee, Lucy A. Paul, Jung H. Suh, Latika Puri, Meng Zhang, Jennifer A. Beckstead, Andrzej Witkowski, Robert O. Ryan, Julie D. Saba> ;Investigational New Drugs. 2018 Jan 16
• 21 citations
  S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling.
  Ashok Kumar, Jesus Zamora-Pineda, Emilie Degagné, Julie D. Saba> ;Mediators of Inflammation. 2017 Dec 3
• 25 citations
  Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity
  Claudine Hahn, Karolina Tyka, Julie D. Saba, Sigurd Lenzen, Ewa Gurgul-Convey> ;The Journal of Biological Chemistry. 2017 Dec 8
• 5 citations
  An LC/MS/MS method for quantitation of chemopreventive sphingadienes in food products and biological samples
  Jung H. Suh, A.M. Makarova, J.M. Gomez, Lucy A. Paul, Julie D. Saba> ;Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2017 Sep 1
• 2 citations
  Obinutuzumab-induced serum sickness following salvage therapy for chronic lymphocytic leukemia.
  Julie D. Saba, Aaron C Logan> ;Clinical Case Reports. 2017 Apr 24
• 128 citations
  Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency
  Svjetlana Lovric, Sara Gonçalves, Heon Yung Gee, Babak Oskouian, Honnappa Srinivas, Won-Il Choi, Shirlee Shril, Shazia Ashraf, Weizhen Tan, Jia Rao, Merlin Airik, Davi...> ;The Journal of Clinical Investigation. 2017 Mar 1
• 77 citations
  SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production
  Daniel N. Mitroi, Indulekha Karunakaran, Markus H. Gräler, Julie D. Saba, Dan Ehninger, Maria Dolores Ledesma, Gerhild van Echten-Deckert> ;Autophagy. 2017 Feb 28
• 3 citations
  The low down on sphingosine-1-phosphate lyase as a regulator of thymic egress.
  Julie D. Saba> ;Journal of Immunological Sciences. 2017 Dec 6
• 38 citations
  Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism.
  Daniel N. Mitroi, André U. Deutschmann, Maren Raucamp, Indulekha Karunakaran, Konstantine Glebov, Michael Hans, Jochen Walter, Julie D. Saba, Markus H. Gräler, Dan Ehn...> ;Scientific Reports. 2016 Nov 24
• 40 citations
  Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress
  Jesus Zamora-Pineda, Ashok Kumar, Jung H. Suh, Meng Zhang, Julie D. Saba> ;The Journal of Experimental Medicine. 2016 Nov 14
• 6 citations
  A facile stable-isotope dilution method for determination of sphingosine phosphate lyase activity.
  Jung H. Suh, Abeer Eltanawy, Apoorva Rangan, Julie D. Saba> ;Chemistry and Physics of Lipids. 2016 Jan 1
• 14 citations
  Regulation of Immune Cell Migration by Sphingosine-1-Phosphate.
  Ashok Kumar, Julie D. Saba> ;Cellular and Molecular Biology. 2015 Dec 31
• 36 citations
  Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
  Jung H. Suh, Julie D. Saba> ;Translational Cancer Research. 2015 Oct 1
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