JulioAlonso(Chirinos Medina)ChirinosMD

Cardiology • Philadelphia, PA

Adult Congenital Heart Disease

Associate Professor, Medicine, Perelman School of Medicine

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Office
3400 Civic Center Boulevard
South Tower, Rm. 11-138. Perelman Center for Advanced Medicine.
Philadelphia, PA 19104
Phone+1 215-573-6606

Fax+1 215-746-7415
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Summary

Dr. Julio Chirinos is a cardiologist in Philadelphia, PA and is affiliated with multiple hospitals in the area, including Hospital of the University of Pennsylvania and Hospital of the University of Pennsylvania. He received his medical degree from Other and has been in practice 18 years. He also speaks multiple languages, including Spanish. He specializes in adult congenital heart disease and is experienced in general cardiology.

Education & Training

University of Miami/Jackson Health SystemFellowship, Cardiovascular Disease, 2004 - 2007
University of Miami/Jackson Health SystemResidency, Internal Medicine, 2000 - 2004
OtherClass of 1999

Certifications & Licensure

PA State Medical License 2007 - 2024
FL State Medical License 2003 - 2008

Awards, Honors, & Recognition

Fellow American Heart Association
Fellow European Society of Cardiology

Clinical Trials

The Effects of Obesity and Obstructive Sleep Apnea on Inflammation and Heart Disease Start of enrollment: 2006 Sep 01
Completed
Not Applicable
Vasodilator Therapy for Heart Failure and Preserved Ejection Fraction Start of enrollment: 2012 Jan 01
Completed
Phase 2
Cardiac MRI for Severe Aortic Stenosis Start of enrollment: 2013 Jun 01
Completed
Effect of Inorganic Nitrates (Beetroot Juice) on Arterial Hemodynamics and Exercise Capacity Start of enrollment: 2013 Jan 01
Completed
Phase 2
Effect of Isosorbide Mononitrate on Hypertension to Improve Left Ventricular Hypertrophy, Fibrosis and Myocardial Function Start of enrollment: 2013 Aug 01
Withdrawn
Phase 2
Effect of KNO3 Compared to KCl on Oxygen UpTake in Heart Failure With Preserved Ejection Fraction (KNO3CK OUT HFPEF) Start of enrollment: 2016 Aug 01
Completed
Phase 2
Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS) Start of enrollment: 2018 May 01
Completed
Phase 2
Elimination or Prolongation of ACE Inhibitors and ARB in Coronavirus Disease 2019 Start of enrollment: 2020 Mar 31
Completed
Not Applicable
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Publications & Presentations

PubMed

Urinary Proteomics and Outcomes in Heart Failure With Preserved Ejection Fraction.
Corinne Carland, Lei Zhao, Oday Salman, Jordana B Cohen, Payman Zamani, Qing Xiao, Ashok Dongre, Zhaoqing Wang, Christina Ebert, Danielle Greenawalt, Vanessa van Empel...> ;Journal of the American Heart Association. 2024 Apr 19
LDL-c Lowering, Ischemic Stroke, and Small Vessel Disease Brain Imaging Biomarkers: A Mendelian Randomization Study.
Marie-Joe Dib, Loukas Zagkos, Devendra Meena, Stephen Burgess, Dipender Gill, Julio A Chirinos> ;Stroke. 2024 Apr 4
Multi-Ethnic Study of Atherosclerosis Early Heart Failure Study: Rationale, Design, and Baseline Characteristics.
Lauren Beussink-Nelson, Benjamin H Freed, Julio A Chirinos, Peter H Brubaker, Dalane W Kitzman, Joseph Yeboah, Sylvia E Rosas, Mo Hu, João A C Lima, Jay Pandit, Alain ...> ;Circulation. Heart Failure. 2024 Mar 1
Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction.
Joe David Azzo, Marie-Joe Dib, Loukas Zagkos, Lei Zhao, Zhaoqing Wang, Ching-Pin Chang, Christina Ebert, Oday Salman, Sushrima Gan, Payman Zamani, Jordana B Cohen, Van...> ;Circulation. Heart Failure. 2024 Feb 1
1 citations
2024 Recommendations for Validation of Noninvasive Arterial Pulse Wave Velocity Measurement Devices.
Bart Spronck, Dimitrios Terentes-Printzios, Alberto P Avolio, Pierre Boutouyrie, Andrea Guala, Ana Jerončić, Stéphane Laurent, Eduardo C D Barbosa, Johannes Baulmann, ...> ;Hypertension. 2024 Jan 1
A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis.
Julia C Hotek, Theodore J Detwiler, Julio A Chirinos, Christopher P Regan> ;Journal of Pharmacological and Toxicological Methods. 2023 Nov 4
Proteomic Correlates of the Urinary Protein/Creatinine Ratio in Heart Failure With Preserved Ejection Fraction.
Sushrima Gan, Lei Zhao, Oday Salman, Zhaoqing Wang, Christina Ebert, Joe David Azzo, Marie Joe Dib, Payman Zamani, Jordana B Cohen, Karl Kammerhoff, Peter Schafer, Die...> ;The American Journal of Cardiology. 2023 Nov 1
Multi-ancestry epigenome-wide analyses identify methylated sites associated with aortic augmentation index in TOPMed MESA.
Xiaowei Hu, Jeongok G Logan, Younghoon Kwon, Joao A C Lima, David R Jacobs, Daniel Duprez, Lyndia Brumback, Kent D Taylor, Peter Durda, W Craig Johnson, Elaine Cornell...> ;Scientific Reports. 2023 Oct 17
Left Ventricular Mass, Sex and Body Size: Rectifying the Methods.
Julio A Chirinos> ;Hypertension. 2023 Oct 1
Relation of forward and backward traveling pressure waves with subclinical carotid artery wall remodeling and central pulse pressure.
Matthew K Armstrong, Virginia R Nuckols, Colin J Gimblet, Seth W Holwerda, Lyndsey E DuBose, Rachel E Luehrs, Abbi D Lane, Julio A Chirinos, Michelle W Voss, Gary L Pi...> ;Journal of Applied Physiology. 2023 Oct 1
Effect of acute handgrip and aerobic exercise on wasted pressure effort and arterial wave reflections in healthy aging.
Joseph M Stock, Ninette Shenouda, Nicholas V Chouramanis, Jordan C Patik, Christopher R Martens, William B Farquhar, Julio A Chirinos, David G Edwards> ;American Journal of Physiology. Heart and Circulatory Physiology. 2023 Oct 1
1 citations
Development and characterization of canine-specific computational models to predict pulsatile arterial hemodynamics and ventricular-arterial coupling.
Julia C Hotek, Julio A Chirinos, Theodore J Detwiler, Hillary K Regan, Christopher P Regan> ;Physiological Reports. 2023 Jun 1
2 citations
Exercise responses and mental health symptoms in COVID-19 survivors with dyspnoea.
Kathryn M Milne, Juthaporn Cowan, Michele R Schaeffer, Nha Voduc, Vicente Corrales-Medina, Kim L Lavoie, Julio A Chirinos, Joseph H Puyat, Sara J Abdallah, Jordan A Gu...> ;ERJ Open Research. 2023 May 1
Exercise Training in Heart Failure With Preserved Ejection Fraction: Is the Peripheral Vasculature Involved?
Julio A Chirinos> ;JACC. Heart Failure. 2023 Apr 1
2 citations
Novel Measures of Arterial Hemodynamics and Wave Reflections Associated With Clinical Outcomes in Patients With Heart Failure.
Rebecca S Steinberg, Eisha Udeshi, Neal Dickert, Arshed Quyyumi, Julio A Chirinos, Alanna A Morris> ;Journal of the American Heart Association. 2023 Mar 21
10 citations
Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury.
Guo, Z., Valenzuela Ripoll, C., Picataggi, A., Rawnsley, D., Ozcan, M., Chirinos, J., Chendamarai, E., Girardi, A., Riehl, T., Evie, H., Diab, A., Kovacs, A., Hyrc, K....> ;JACC. Basic to Translational Science. 2023 Mar 1
3 citations
Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study.
Avner Ehrlich, Konstantinos Ioannidis, Makram Nasar, Ismaeel Abu Alkian, Yuval Daskal, Nofar Atari, Limor Kliker, Nir Rainy, Matan Hofree, Sigal Shafran Tikva, Inbal H...> ;Elife. 2023 Jan 27
Troponin elevation in the community: can you sleep on it?
Ali Javaheri, Julio A Chirinos> ;Sleep. 2023 Apr 12
1 citations
Relationship Between Ascending Thoracic Aortic Diameter and Blood Pressure: A Mendelian Randomization Study.
Michael G Levin, Catherine Tcheandjieu, James R Priest, Dipender Gill, Stephen Burgess, Scott M Damrauer, Julio A Chirinos, John DePaolo> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Feb 1
9 citations
A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019.
Julio A Chirinos, Patricio Lopez-Jaramillo, Evangelos J Giamarellos-Bourboulis, Gonzalo H Dávila-Del-Carpio, Abdul Rahman Bizri, Jaime F Andrade-Villanueva, Oday Salma...> ;Nature Metabolism. 2022 Dec 1
2 citations
The Role of Multimodality Imaging in the Evaluation of Heart Failure with Preserved Ejection Fraction.
Mahesh K Vidula, Paco E Bravo, Julio A Chirinos> ;Cardiology Clinics. 2022 Nov 1
8 citations
Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure.
Julio A Chirinos, Lei Zhao, Alexander L Reese-Petersen, Jordana B Cohen, Federica Genovese, A Mark Richards, Robert N Doughty, Javier Díez, Arantxa González, Ramón Que...> ;NEJM Evidence. 2022 Oct 1
3 citations
Aortic pressure-only wave separation analysis in adolescents: accuracy and associations with left ventricular mass index.
Matthew K Armstrong, Julio A Chirinos, Gaston K Kapuku, Gary L Pierce> ;Journal of Human Hypertension. 2023 Dec 1
23 citations
Renin-Angiotensin System Inhibitors in Patients With COVID-19: A Meta-Analysis of Randomized Controlled Trials Led by the International Society of Hypertension.
Sonali R Gnanenthiran, Claudio Borghi, Dylan Burger, Bruno Caramelli, Fadi Charchar, Julio A Chirinos, Jordana B Cohen, Antoine Cremer, Gian Luca Di Tanna, Alexandre D...> ;Journal of the American Heart Association. 2022 Sep 6
5 citations
Proteomic Analysis of Effects of Spironolactone in Heart Failure With Preserved Ejection Fraction.
Ali Javaheri, Ahmed Diab, Lei Zhao, Chenao Qian, Jordana B Cohen, Payman Zamani, Anupam Kumar, Zhaoqing Wang, Christina Ebert, Joseph Maranville, Erika Kvikstad, Micha...> ;Circulation. Heart Failure. 2022 Sep 1
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Journal Articles

Original Research Right Atrial Phasic Function in Heart Failure with Preserved and Reduced Ejection Fraction
Julio A Chirinos, Snigdha Jain, Swetha Gaddam, Jonathan Lee, ScienceDirect
Poor Glycemic Control Is Associated with Increased Extracellular Volume Fraction in Diabetes
Khuzaima Javaid, Swetha Gaddam, Julio A Chirinos, Diabetes Care
Pulsatile Arterial Haemodynamics in Heart Failure
Julio (Chirinos Medina) Chirinos, MD, European Heart Journal

Press Mentions

Promising Cholesterol Drug Against COVID-19 Fails in Human Trials; Doesn't Reduce Severe Symptoms or DeathNovember 8th, 2022
Researchers Suggests Better Prognostic Biomarkers for Heart Failure PatientSeptember 18th, 2022
Penn Medicine Study Finds Improved Biomarker for Heart FailureSeptember 16th, 2022
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