KarenMoultonMD

Cardiology • Aurora, CO

Associate Professor, Medicine, University of Colorado School of Medicine

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Office
12605 E 16th Ave
Research Complex 2
Aurora, CO 80045
Phone+1 303-724-5443
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Education & Training

Brigham and Women's HospitalFellowship, Cardiovascular Disease, 1994 - 1996
University of California (San Diego) Medical CenterResidency, Internal Medicine, 1986 - 1988
University of Washington School of MedicineClass of 1986

Certifications & Licensure

CA State Medical License 1988 - Present
CO State Medical License 2007 - 2025
MA State Medical License 1994 - 2008
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Publications & Presentations

PubMed

Smooth muscle-derived adventitial progenitor cells direct atherosclerotic plaque composition complexity in a Klf4-dependent manner.
Allison M Dubner, Sizhao Lu, Austin J Jolly, Keith A Strand, Marie F Mutryn, Tyler Hinthorn, Tysen Noble, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary Cm ...> ;JCI Insight. 2023 Nov 22
Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research-Brief Report.
Allison M Dubner, Sizhao Lu, Austin J Jolly, Tysen Noble, Tyler Hinthorn, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary C M Weiser-Evans> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Nov 1
Smooth muscle-derived adventitial progenitor cells promote key cell type transitions controlling plaque stability in atherosclerosis in a Klf4-dependent manner.
Allison M Dubner, Sizhao Lu, Austin J Jolly, Keith A Strand, Marie F Mutryn, Tyler Hinthorn, Tysen Noble, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary Cm ...> ;Biorxiv. 2023 Jul 19
4 citations
Redistribution of the chromatin remodeler Brg1 directs smooth muscle-derived adventitial progenitor-to-myofibroblast differentiation and vascular fibrosis.
Austin J Jolly, Sizhao Lu, Allison M Dubner, Keith A Strand, Marie F Mutryn, Aaron Pilotti-Riley, Etienne P Danis, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky,...> ;JCI Insight. 2023 May 8
6 citations
Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling.
Cierra J Walker, Dilara Batan, Carrie T Bishop, Daniel Ramirez, Brian A Aguado, Megan E Schroeder, Claudia Crocini, Jessica Schwisow, Karen Moulton, Laura Macdougall, ...> ;Bioengineering & Translational Medicine. 2022 Sep 1
17 citations
Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts.
Brian A Aguado, Cierra J Walker, Joseph C Grim, Megan E Schroeder, Dilara Batan, Brandon J Vogt, Andrea Gonzalez Rodriguez, Jessica A Schwisow, Karen S Moulton, Robert...> ;Circulation. 2022 Feb 15
9 citations
Matrix-Degrading Enzyme Expression and Aortic Fibrosis During Continuous-Flow Left Ventricular Mechanical Support
Amrut V. Ambardekar, Matthew S. Stratton, Evgenia Dobrinskikh, Kendall S. Hunter, BS Philip D. Tatman, Madeleine E. Lemieux, Joseph C. Cleveland, Rubin M. Tuder, Mary ...> ;Journal of the American College of Cardiology. 2021 Nov 2
14 citations
Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodeling.
Austin J Jolly, Sizhao Lu, Keith A. Strand, Allison M. Dubner, Marie F Mutryn, Raphael A. Nemenoff, Mark W. Majesky, Karen S. Moulton, Mary C.M. Weiser-Evans> ;Cardiovascular Research. 2021 May 14
29 citations
Smooth muscle–derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis
Sizhao Lu, Austin J Jolly, Keith A. Strand, Allison M. Dubner, Marie F Mutryn, Karen S. Moulton, Raphael A. Nemenoff, Mark W. Majesky, Mary C.M. Weiser-Evans> ;JCI Insight. 2020 Dec 3
8 citations
High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central R...
Keith A. Strand, Sizhao Lu, Marie F Mutryn, Linfeng Li, Qiong Zhou, Blake T. Enyart, Austin J Jolly, Allison M. Dubner, Karen S. Moulton, Raphael A. Nemenoff, Keith A....> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 Jun 25
23 citations
PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report.
Sizhao Lu, Keith A. Strand, Marie F Mutryn, Rebecca M. Tucker, Austin J Jolly, Seth B. Furgeson, Karen S. Moulton, Raphael A. Nemenoff, Mary C.M. Weiser-Evans> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 Feb 1
16 citations
Coronary Artery Remodeling and Fibrosis With Continuous-Flow Left Ventricular Assist Device Support
Amrut V. Ambardekar, Mary C.M. Weiser-Evans, Marcella Li, Suneet N. Purohit, Muhammad Aftab, T. Brett Reece, Karen S. Moulton> ;Circulation. Heart Failure. 2018 May 1
28 citations
PTEN deficiency promotes pathological vascular remodeling of human coronary arteries
Karen S. Moulton, Marcella Li, Keith A. Strand, Shawna Burgett, Penn McClatchey, Rebecca M. Tucker, Seth B. Furgeson, Sizhao Lu, Bruce E. Kirkpatrick, Joseph C. Clevel...> ;JCI Insight. 2018 Feb 22
48 citations
Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
Henrick Horita, Christina L. Wysoczynski, Lori A. Walker, Karen S. Moulton, Marcella Li, Allison C. Ostriker, Rebecca M. Tucker, Timothy A. McKinsey, Mair E. A. Church...> ;Nature Communications. 2016 Mar 4
55 citations
Attenuated Expression of Profilin-1 Confers Protection From Atherosclerosis in the LDL Receptor–Null Mouse
Giulio R. Romeo, Karen S. Moulton, Andrius Kazlauskas> ;Circulation Research. 2007 Aug 17
101 citations
Angiogenesis in atherosclerosis: gathering evidence beyond speculation.
Karen S. Moulton> ;Current Opinion in Lipidology. 2006 Oct 1
39 citations
Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis
Xiaokun Zeng, Joshua Chen, Yury I. Miller, Kashi Javaherian, Karen S. Moulton> ;Journal of Lipid Research. 2005 Sep 1
100 citations
Loss of Collagen XVIII Enhances Neovascularization and Vascular Permeability in Atherosclerosis
Karen S. Moulton, Bjorn R. Olsen, Silvia Sonn, Naomi Fukai, David Zurakowski, Xiaokun Zeng> ;Circulation. 2004 Sep 7
65 citations
E-selectin is required for the antiangiogenic activity of endostatin.
Ying Yu, Karen S. Moulton, Mohamed K. Khan, Sabrina Vineberg, Eileen Boye, Vannessa M. Davis, Peter E. O'Donnell, Joyce Bischoff, David S. Milstone> ;Proceedings of the National Academy of Sciences of the United States of America. 2004 May 25
97 citations
Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function
Alexander G. Marneros, Douglas R. Keene, Uwe Hansen, Naomi Fukai, Karen S. Moulton, Patrice Goletz, Gennadiy Moiseyev, Basil S. Pawlyk, Willi Halfter, Sucai Dong, Masa...> ;The EMBO Journal. 2004 Jan 14
49 citations
Adipose tissue growth and regression are regulated by angiopoietin-1.
Susan M. Dallabrida, David Zurakowski, Shu-Ching Shih, Lois E.H. Smith, Judah Folkman, Karen S. Moulton, Maria A Rupnick> ;Biochemical and Biophysical Research Communications. 2003 Nov 21
510 citations
Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis
Karen S. Moulton, Khashayar Vakili, David Zurakowski, Mohsin Soliman, Catherine Butterfield, Erik Sylvin, Kin-Ming Lo, Stephen D. Gillies, Kashi Javaherian, Judah Folkman> ;Proceedings of the National Academy of Sciences of the United States of America. 2003 Apr 15
112 citations
ArePlaque angiogenesis and atherosclerosis
Karen S. Moulton> ;Current Atherosclerosis Reports. 2001 May 1
31 citations
Angiogenesis in the huPBL-SCID model of human transplant rejection
Karen S. Moulton, Robert J. Melder, Vikas R. Dharnidharka, Janet Hardin-Young, Rakesh K. Jain, David M. Briscoe> ;Transplantation. 1999 Jun 27
553 citations
Angiogenesis Inhibitors Endostatin or TNP-470 Reduce Intimal Neovascularization and Plaque Growth in Apolipoprotein E–Deficient Mice
Karen S. Moulton, Eric A. Heller, Moritz A. Konerding, Evelyn Flynn, Wulf Palinski, Judah Folkman> ;Circulation. 1999 Apr 6
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