KenjiM.CunnionMD

Pediatric Infectious Disease • Norfolk, VA

Associate Professor, Pediatrics, Eastern Virginia Medical School

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Office
601 Childrens Ln
Norfolk, VA 23507
Phone+1 757-668-7238

Fax+1 757-668-8275
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Education & Training

Duke University HospitalFellowship, Pediatric Infectious Diseases, 1996 - 2000
Virginia Commonwealth University Health SystemResidency, Pediatrics, 1993 - 1996
Duke University School of MedicineClass of 1993

Certifications & Licensure

VA State Medical License 1995 - 2024
NC State Medical License 1997 - 2003
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Infectious Diseases

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Fellow (FAAP) American Academy of Pediatrics

Publications & Presentations

PubMed

RLS-0071 Moderated Elevated Myeloperoxidase Level and Activity in an Asymptomatic Subject in Clinical Trial RLS-0071-101.
Jessica M Goss, Pamela Hair, Parvathi S Kumar, Ulrich Thienel, Kenji Cunnion, Alexander Ellis> ;The American Journal of Case Reports. 2023 May 26
The EPICC Family of Anti-Inflammatory Peptides: Next Generation Peptides, Additional Mechanisms of Action, andandEfficacy.
Neel K Krishna, Kenji M Cunnion, Grace A Parker> ;Frontiers in Immunology. 2022 Jan 1
2 citations
Peptide inhibition of acute lung injury in a novel two-hit rat model
Alana C. Sampson, Brittany P. Lassiter, Magdielis Gregory Rivera, Pamela S. Hair, Kaitlyn G. Jackson, Adrianne I. Enos, Turaj Vazifedan, Alice L. Werner, Marshall J. G...> ;Plos One. 2021 Oct 28
6 citations
Classical complement pathway inhibition reduces brain damage in a hypoxic ischemic encephalopathy animal model.
Parvathi S. Kumar, Pamela S. Hair, Kenji M. Cunnion, Neel K. Krishna, Thomas Bass> ;Plos One. 2021 Sep 30
2 citations
Peptide Inhibitor of Complement C1, RLS-0071, Reduces Zosteriform Spread of Herpes Simplex Virus Type 1 Skin Infection and Promotes Survival in Infected Mice.
Maimoona S Bhutta, Daniel G Sausen, Kirstin M Reed, Elisa S. Gallo, Pamela S. Hair, Brittany P. Lassiter, Neel K. Krishna, Kenji M. Cunnion, Ronen Borenstein> ;Viruses. 2021 Jul 22
Peptide inhibition of neutrophil-mediated injury after in vivo challenge with supernatant of Pseudomonas aeruginosa and immune-complexes.
Adrianne I. Enos, Parvathi Kumar, Brittany P. Lassiter, Alana C. Sampson, Pamela S. Hair, Neel K. Krishna, Kenji M. Cunnion> ;Plos One. 2021 Jul 9
5 citations
Delayed Hemolytic Transfusion Reaction in a Patient With Sickle Cell Disease and the Role of the Classical Complement Pathway: A Case Report.
Pamela S. Hair, Timothy Heck, Daniel T. Carr, Katherine D. Watson, Jessica Price, Neel K. Krishna, Kenji M. Cunnion, William Owen> ;Journal of Hematology. 2021 Feb 6
3 citations
Classical complement activation on human erythrocytes in subjects with systemic lupus erythematosus and a history of autoimmune hemolytic anemia.
Pamela S. Hair, Daniel W. Goldman, Jessica Li, Michelle Petri, Neel K. Krishna, Kenji M. Cunnion> ;Lupus. 2020 Jul 12
2 citations
A complement-mediated rat xenotransfusion model of platelet refractoriness.
Adrianne I. Enos, Pamela S. Hair, Neel K. Krishna, Kenji M. Cunnion> ;Molecular Immunology. 2020 Aug 1
1 citations
Incompatible erythrocyte transfusion with lipopolysaccharide induces acute lung injury in a novel rat model.
Magdielis Gregory Rivera, Alana C. Sampson, Pamela S. Hair, Haree K. Pallera, Kaitlyn G. Jackson, Adrianne I. Enos, Turaj Vazifedan, Alice L. Werner, Corinne L. Goldbe...> ;Plos One. 2020 Apr 20
6 citations
Inhibition of complement activation, myeloperoxidase, NET formation and oxidant activity by PIC1 peptide variants.
Pamela S. Hair, Adrianne I. Enos, Neel K. Krishna, Kenji M. Cunnion> ;Plos One. 2019 Dec 31
6 citations
Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1).
Kenji M. Cunnion, Lisa M. Feagin, Michael F. Chicella, Cortney L. Kaszowski, Pamela S. Hair, Jessica Price, William Owen> ;Case Reports in Hematology. 2019 Jan 30
2 citations
Trichophyton as a Rare Cause of Postoperative Wound Infection Resistant to Standard Empiric Antimicrobial Therapy.
Sheema Gaffar, John K. Birknes, Kenji M. Cunnion> ;Case Reports in Pediatrics. 2018 Dec 20
33 citations
Inhibition of Immune Complex Complement Activation and Neutrophil Extracellular Trap Formation by Peptide Inhibitor of Complement C1.
Pamela S. Hair, Adrianne I. Enos, Neel K. Krishna, Kenji M. Cunnion> ;Frontiers in Immunology. 2018 Mar 26
4 citations
Peptide Inhibitor of Complement C1 (PIC1) demonstrates antioxidant activity via single electron transport (SET) and hydrogen atom transfer (HAT).
Magdielis Gregory Rivera, Pamela S. Hair, Kenji M. Cunnion, Neel K. Krishna> ;Plos One. 2018 Mar 2
7 citations
Peptide Inhibitor of Complement C1 Inhibits the Peroxidase Activity of Hemoglobin and Myoglobin
Pamela S. Hair, Kenji M. Cunnion, Neel K. Krishna> ;International Journal of Peptides. 2017 Sep 10
20 citations
Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity.
Pamela S. Hair, Laura A. Sass, Turaj Vazifedan, Tushar A. Shah, Neel K. Krishna, Kenji M. Cunnion> ;Plos One. 2017 Mar 9
15 citations
Inhibition of Myeloperoxidase Activity in Cystic Fibrosis Sputum by Peptide Inhibitor of Complement C1 (PIC1).
Pamela S. Hair, Laura A. Sass, Neel K. Krishna, Kenji M. Cunnion> ;Plos One. 2017 Jan 30
13 citations
Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds.
Kenji M. Cunnion, Neel K. Krishna, Haree K. Pallera, Angela Pineros-Fernandez, Magdielis Gregory Rivera, Pamela S. Hair, Brittany P. Lassiter, Ryan W. Huyck, Mary Ann ...> ;Plos One. 2017 Jan 20
14 citations
Discriminating the hemolytic risk of blood type A plasmas using the complement hemolysis using human erythrocytes (CHUHE) assay.
Kenji M. Cunnion, Pamela S. Hair, Neel K. Krishna, Megan A. Sass, Clinton W. Enos, Pamela Whitley, Lanne Y. Maes, Corinne L. Goldberg> ;Transfusion. 2017 Mar 1
15 citations
Peptide inhibitor of complement C1 modulates acute intravascular hemolysis of mismatched red blood cells in rats
Parvathi S. Kumar, Haree K. Pallera, Pamela S. Hair, Magdielis Gregory Rivera, Tushar A. Shah, Alice L. Werner, Frank A. Lattanzio, Kenji M. Cunnion, Neel K. Krishna> ;Transfusion. 2016 Jun 10
11 citations
Effects of Well-Controlled HIV Infection on Complement Activation and Function.
Alexandria E.-B. Rossheim, Tina D. Cunningham, Pamela S. Hair, Tushar A. Shah, Kenji M. Cunnion, Stephanie B. Troy> ;Journal of Acquired Immune Deficiency Syndromes. 2016 Sep 1
20 citations
Eosinophil Quantitated Urine Kinetic: A novel assay for assessment of eosinophilic esophagitis
Kenji M. Cunnion, Lauren K. Willis, Heather B. Minto, Tanya C. Burch, Alice L. Werner, Tushar A. Shah, Neel K. Krishna, Julius O. Nyalwidhe, Kelly M. Maples> ;Annals of Allergy, Asthma & Immunology. 2016 May 1
12 citations
Discriminating complement-mediated acute transfusion reaction for type O+ red blood cells transfused into a B+ recipient with the complement hemolysis using human eryt...
Kenji M. Cunnion, Pamela S. Hair, Neel K. Krishna, Pamela Whitley, Corinne L. Goldberg, Emmanuel A. Fadeyi, Lanne Y. Maes> ;Transfusion. 2016 Mar 20
8 citations
A 1-Year-Old With Mycobacterium tuberculosis Endocarditis With Mass Spectrometry Analysis of Cardiac Vegetation Composition
Laura A. Sass, Keegan J. Ziemba, Elizabeth A. Heiser, Clifford T. Mauriello, Alice L. Werner, Maria A. Aguiar, Julius O. Nyalwidhe, Kenji M. Cunnion> ;Journal of the Pediatric Infectious Diseases Society. 2016 Mar 1
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Press Mentions

ReAlta Life Sciences Announces Dosing of First Patient in Phase 2 Trial of RLS-0071 for Acute Exacerbations of Chronic Obstructive Pulmonary DiseaseFebruary 22nd, 2024
ReAlta Life Sciences, Inc. Doses First Patient in Phase 1b Inhaled-LPS Challenge Clinical Trial to Support Development of RLS-0071 in Severe AsthmaJune 4th, 2022
Trial of RLS-0071 for Acute COPD Exacerbations Doses 1st PatientMarch 5th, 2024

Grant Support

Staphylococcus Aureus Binds Factor H To Moderate Complement Host DefenseNational Institute Of Allergy And Infectious Diseases2009–2010
Complement And The Clearance Of Staphylococcus AureusNational Institute Of Allergy And Infectious Diseases2002–2006
Complement And The Clearance Of Staphylococcus AureusNational Institute Of Allergy And Infectious Diseases2002