KevinDanielAndujarMD

PubMed

• 22 citations
  Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
  Kevin Daniel Freeman-Cook, Robert Louis Hoffman, Nichol Miller, Jonathan Almaden, John Chionis, Qin Zhang, Koleen Eisele, Chaoting Liu, Cathy Zhang, Nanni Huser, Lisa ...> ;Cancer Cell. 2021 Oct 11
• 20 citations
  Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
  Kevin Daniel Freeman-Cook, Robert Louis Hoffman, Douglas Carl Behenna, Britton Boras, Jordan Carelli, Wade Diehl, Rose Ann Ferre, You-Ai He, Andrea Hui, Buwen Huang, N...> ;Journal of Medicinal Chemistry. 2021 Jun 10
• 58 citations
  Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A
  Casey L. Quinlan, Stephen E. Kaiser, Ben Bolaños, Nowlin Dawn Marie, Rita Grantner, Shannon Karlicek-Bryant, Jun Li Feng, Stephen Jenkinson, Kevin Daniel Freeman-Cook,...> ;Nature Chemical Biology. 2017 May 29
• 82 citations
  Lipophilic efficiency: the most important efficiency metric in medicinal chemistry.
  Kevin Daniel Freeman-Cook, Robert Louis Hoffman, Ted William Johnson> ;Future Medicinal Chemistry. 2013 Jan 30
• 36 citations
  Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists
  David W. Piotrowski, Kentaro Futatsugi, Joseph S. Warmus, Suvi T. M. Orr, Kevin Daniel Freeman-Cook, Allyn T. Londregan, Liuqing Wei, Sandra M. Jennings, Michael Herr,...> ;ACS Medicinal Chemistry Letters. 2013 Jan 10
• 35 citations
  Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.
  Kevin Daniel Freeman-Cook, Paul A. Amor, Scott Bader, Leanne M. Buzon, Steven B. Coffey, Jeffrey W. Corbett, Kenneth J. DiRico, Shawn D. Doran, Richard L. Elliott, Wil...> ;Journal of Medicinal Chemistry. 2012 Jan 11
• 4 citations
  Synthesis and biological evaluation of novel hygromycin A antibacterial agents.
  Michael Scott Visser, Kevin Daniel Freeman-Cook, Steven J. Brickner, Katherine E. Brighty, Phuong Le, Sarah K. Wade, Rhonda Monahan, Gary J. Martinelli, Kyle T. Blair,...> ;Bioorganic & Medicinal Chemistry Letters. 2010 Nov 15
• 47 citations
  Design of selective, ATP-competitive inhibitors of Akt.
  Kevin Daniel Freeman-Cook, Christopher Autry, Gary Borzillo, Deborah A. Gordon, Elsa G. Barbacci-Tobin, Vincent Bernardo, David Briere, Tracey Clark, Matthew Corbett, ...> ;Journal of Medicinal Chemistry. 2010 Jun 24
• 39 citations
  Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
  Jeffrey W. Corbett, Kevin Daniel Freeman-Cook, Richard L. Elliott, Felix Vajdos, Francis Rajamohan, Darcy Kohls, Eric S. Marr, Hailong Zhang, Liang Tong, Meihua Tu, Sh...> ;Bioorganic & Medicinal Chemistry Letters. 2010 Apr 1
• 17 citations
  Identification of an inhibitor of the MurC enzyme, which catalyzes an essential step in the peptidoglycan precursor synthesis pathway.
  Laura E. Zawadzke, Michael Norcia, Charlene R. Desbonnet, Hong Wang, Kevin Daniel Freeman-Cook, Thomas J. Dougherty> ;Assay and Drug Development Technologies. 2008 Mar 12
• 16 citations
  Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
  Kevin Daniel Freeman-Cook, Lawrence A. Reiter, Mark C. Noe, Amy S. Antipas, Dennis E. Danley, Kaushik Datta, James T. Downs, Shane A. Eisenbeis, James D. Eskra, David ...> ;Bioorganic & Medicinal Chemistry Letters. 2007 Dec 1
• 39 citations
  Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
  Lawrence A. Reiter, Kevin Daniel Freeman-Cook, Christopher S. Jones, Gary J. Martinelli, Amy S. Antipas, Martin A. Berliner, Kaushik Datta, James T. Downs, James D. Es...> ;Bioorganic & Medicinal Chemistry Letters. 2006 Nov 15
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