KevinMichaelWattMD

Pediatrics • Durham, NC

Pediatric Critical Care Medicine

Assistant Professor of Pediatrics, Duke University School of Medicine

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Office
2301 Erwin Rd
Durham, NC 27705
Phone+1 919-668-4000

Fax+1 919-620-4921
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Education & Training

Duke University HospitalFellowship, Pediatric Critical Care Medicine, 2009 - 2012
Duke University HospitalResidency, Pediatrics, 2006 - 2009
University of North Carolina at Chapel Hill School of MedicineClass of 2006

Certifications & Licensure

MT State Medical License 2022 - 2026
UT State Medical License 2019 - 2026
CO State Medical License 2022 - 2025
ID State Medical License 2022 - 2024
WY State Medical License 2022 - 2024
NC State Medical License 2006 - 2020
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Critical Care Medicine

Clinical Trials

Pharmacokinetics/Pharmacodynamics (PK/PD) of Fluconazole in Children on Extracorporeal Membrane Oxygenation (ECMO) Start of enrollment: 2010 Jul 01
Completed
Phase 1
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care Start of enrollment: 2011 Nov 01
Completed
Pharmacokinetics of Micafungin in Children on Extracorporeal Membrane Oxygenation Start of enrollment: 2013 Jan 01
Completed
Phase 1
Safety and Pharmacokinetics of Clindamycin in Pediatric Subjects With BMI ≥ 85th Percentile Start of enrollment: 2013 Jun 01
Completed
Phase 1
Pharmacokinetics of Multiple Dose Methadone in Children Treated for Opiate Withdrawal Start of enrollment: 2014 Jan 01
Completed
Pharmacokinetics of Dexmedetomidine in Children During Cardiopulmonary Bypass (CPB) Start of enrollment: 2014 Mar 01
Completed
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Publications & Presentations

PubMed

Use of Electronic Health Records to Identify Exposure-Response Relationships in Critically Ill Children: An Example of Midazolam and Delirium.
Kanecia O Zimmerman, Tracy G Spears, Marjan Cobbaert, Felix Boakye-Agyeman, Huali Wu, Michael Cohen-Wolkowiez, Kevin M Watt, Daniel K Benjamin Jr, Mara L Becker, Chani...> ;Journal of Pediatric Intensive Care. 2022 Dec 1
4 citations
Remdesivir and GS-441524 Extraction by Ex Vivo Extracorporeal Life Support Circuits.
Carina E Imburgia, Joseph E. Rower, Danielle J Green, Autumn M Mcknite, Walter E Kelley, Christopher A. Reilly, Kevin M. Watt> ;ASAIO Journal. 2021 Nov 17
9 citations
Optimal Dosing of Meropenem in a Small Cohort of Critically Ill Children Receiving Continuous Renal Replacement Therapy.
Wei Wei Tan, Kevin M. Watt, Felix Boakye-Agyeman, Michael Cohen-Wolkowiez, Yee Hui Mok, Chee Fu Yung, Yoke Hwee Chan> ;Journal of Clinical Pharmacology. 2021 Jun 1
9 citations
The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities.
Christina D. Chambers, Jerry A. Krishnan, Lorene Alba, Jessica D. Albano, Allison S. Bryant, Melanie Carver, Lee S. Cohen, Elena Gorodetsky, Sonia Hernandez-Diaz, Marg...> ;The Journal of Allergy and Clinical Immunology. 2021 Jun 1
3 citations
Amiodarone Extraction by the Extracorporeal Membrane Oxygenation Circuit.
C Griffin McDaniel, C Cole Honeycutt, Kevin M. Watt> ;The Journal of Extra-Corporeal Technology. 2021 Mar 1
8 citations
Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically Based Pharmacokinetic Modeling
Venkata K. Yellepeddi, Kaustubh Parashar, Spencer M. Dean, Kevin M. Watt, Jonathan E. Constance, Olga J. Baker> ;Clinical and Translational Science. 2021 Mar 1
7 citations
Population pharmacokinetics of olanzapine in children.
Anil R. Maharaj, Huali Wu, Kanecia O. Zimmerman, Julie Autmizguine, Rohit Kalra, Amira Al-Uzri, Catherine M.T. Sherwin, Stuart L. Goldstein, Kevin M. Watt, Jinson Erin...> ;British Journal of Clinical Pharmacology. 2021 Feb 1
7 citations
First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Phar...
Linda J. Van Eldik, Lumy Sawaki, Karen Bowen, Daniel T. Laskowitz, Robert J. Noveck, Byron Hauser, Lynn Jordan, Tracy Spears, Huali Wu, Kevin M. Watt, Shruti M. Raja, ...> ;Clinical Pharmacology in Drug Development. 2021 Feb 1
3 citations
Sedative and Analgesic Pharmacokinetics During Pediatric ECMO.
Kanecia O. Zimmerman, Samantha H Dallefeld, Christoph P. Hornik, Kevin M. Watt> ;The Journal of Pediatric Pharmacology and Therapeutics. 2020 Nov 1
3 citations
How to Rapidly Determine First-in-Children Dosing for COVID-19 Therapeutics.
Kevin M. Watt> ;JAMA Pediatrics. 2020 Oct 1
13 citations
Pharmacokinetics Alterations in Critically Ill Pediatric Patients on Extracorporeal Membrane Oxygenation: A Systematic Review.
Natalia Sutiman, Janine Cynthia Koh, Kevin M. Watt, Christoph P. Hornik, Beverly Murphy, Yoke Hwee Chan, Jan Hau Lee> ;Frontiers in Pediatrics. 2020 Jun 26
9 citations
Dexmedetomidine extraction by the extracorporeal membrane oxygenation circuit: results from an in vitro study:
Samantha H Dallefeld, Jennifer Sherwin, Kanecia O. Zimmerman, Kevin M. Watt> ;Perfusion. 2020 Apr 1
6 citations
Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis
Anil R. Maharaj, Huali Wu, Kanecia O. Zimmerman, David Speicher, Janice E. Sullivan, Kevin M. Watt, Amira Al-Uzri, Elizabeth H Payne, Jinson Erinjeri, Susan Lin, Barri...> ;Journal of Clinical Pharmacology. 2019 Dec 8
8 citations
Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass.
Kanecia O Zimmerman, Huali Wu, Matthew Laughon, Rachel G Greenberg, Richard Walczak, Scott R Schulman, P Brian Smith, Christoph P Hornik, Michael Cohen-Wolkowiez, Kevi...> ;Anesthesia and Analgesia. 2019 Dec 1
14 citations
Drug Dose Selection in Pediatric Obesity: Available Information for the Most Commonly Prescribed Drugs to Children.
Kathryn E. Kyler, Jonathan B. Wagner, Chelsea Hosey-Cojocari, Kevin M. Watt, Valentina Shakhnovich> ;Paediatric Drugs. 2019 Oct 1
8 citations
Risk of development of treated retinopathy of prematurity in very low birth weight infants.
Samantha Gonski, Susan R. Hupp, C. Michael Cotten, Reese H. Clark, Matthew M. Laughon, Kevin M. Watt, Christoph P. Hornik, Karan R. Kumar, P. Brian Smith, Rachel G. Gr...> ;Journal of Perinatology. 2019 Sep 6
4 citations
Population Pharmacokinetics of Milrinone in Infants, Children, and Adolescents.
Christoph P. Hornik, Ram Yogev, Peter M. Mourani, Kevin M. Watt, Janice E. Sullivan, Andrew M. Atz, David Speicher, Amira Al-Uzri, Michelle Adu-Darko, Elizabeth H Payn...> ;Journal of Clinical Pharmacology. 2019 Jul 17
7 citations
Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants
Jacqueline G Gerhart, Kevin M. Watt, Andrea N. Edginton, Kelly C. Wade, Sara Salerno, Daniel K. Benjamin, P. Brian Smith, Christoph P. Hornik, Michael Cohen-Wolkowiez,...> ;CPT. 2019 Jul 1
4 citations
Pharmacokinetics of ticarcillin-clavulanate in premature infants.
Kevin M. Watt, Christoph P. Hornik, Stephen J. Balevic, Gratias Mundakel, C. Michael Cotten, Barrie Harper, Daniel K. Benjamin, Ravinder Anand, Matthew M. Laughon, P. ...> ;British Journal of Clinical Pharmacology. 2019 May 1
24 citations
Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO.
Kevin M. Watt, Michael Cohen-Wolkowiez, Jeffrey S. Barrett, Michael Sevestre, Ping Zhao, Kim L. R. Brouwer, Andrea N. Edginton> ;CPT. 2018 Oct 1
4 citations
Clinical pharmacology considerations for children supported with ventricular assist devices.
Jennifer Sherwin, Elizabeth J. Thompson, Kevin D. Hill, Kevin M. Watt, Andrew J. Lodge, Daniel Gonzalez, Christoph P. Hornik> ;Cardiology in the Young. 2018 Jul 11
2 citations
Effect of renal function on antihypertensive drug safety and efficacy in children
Kevin M. Watt, Debbie Avant, Jennifer Sherwin, Daniel K. Benjamin, Christoph P. Hornik, Jennifer S. Li, P. Brian Smith> ;Pediatric Nephrology. 2018 Jan 1
9 citations
Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid
Sara Salerno, Andrea N. Edginton, Michael Cohen-Wolkowiez, Christoph P. Hornik, Kevin M. Watt, Brian D. Jamieson, Daniel Gonzalez> ;CPT. 2017 Dec 1
25 citations
Antifungal Extraction by the Extracorporeal Membrane Oxygenation Circuit.
Kevin M. Watt, Michael Cohen-Wolkowiez, Duane C. Williams, Desiree Bonadonna, Ira M. Cheifetz, Dhiren R. Thakker, Daniel K. Benjamin, Kim L. R. Brouwer> ;The Journal of Extra-Corporeal Technology. 2017 Sep 1
28 citations
Dalbavancin Pharmacokinetics and Safety in Children 3 Months to 11 Years of Age.
Daniel Gonzalez, John S. Bradley, Jeffrey L. Blumer, Ram Yogev, Kevin M. Watt, Laura P. James, Debra L. Palazzi, Varsha Bhatt-Mehta, Janice E. Sullivan, Li Zhang, Jenn...> ;The Pediatric Infectious Disease Journal. 2017 Jul 1
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