KrzysztofKirylukMD

PubMed

• Risk factors affecting polygenic score performance across diverse cohorts.
  Daniel Hui, Scott Dudek, Krzysztof Kiryluk, Theresa L Walunas, Iftikhar J Kullo, Wei-Qi Wei, Hemant K Tiwari, Josh F Peterson, Wendy K Chung, Brittney Davis, Atlas Kha...> ;Medrxiv. 2024 Apr 10
• Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain.
  Masashi Fujita, Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C White, Bernard Ng, Gilad Sahar Green, Orit Rozenblatt-Rosen, Devan Phillips, Liat Amir-Zilberstein, Hyo...> ;Nature Genetics. 2024 Apr 1
• Genetic testing in kidney transplantation helped develop a morbidity gene panel for evaluation of kidney transplant recipients.
  Becky M Ma, Naama Elefant, Martina Tedesco, Natalie Vena, Sarath K Murthy, Shiraz A Bheda, Sandy Yang, Nikita Tomar, Jun Y Zhang, Hila Milo Rasouly, Kelsie Bogyo, Syed...> ;Kidney International. 2024 Mar 21
• Combined Serologic and Genetic Risk Score and Prognostication of Phospholipase A2 receptor-Associated Membranous Nephropathy.
  Xiaofan Hu, Jing Xu, Wei Wang, Lili Liu, Yuanmeng Jing, Chenni Gao, Xialian Yu, Yi Li, Li Lin, Jun Tong, Qinjie Weng, Xiaoxia Pan, Wen Zhang, Hong Ren, Guisen Li, Krzy...> ;Clinical Journal of the American Society of Nephrology. 2024 Feb 29
• Return of polygenic risk scores in research: Stakeholders' views on the eMERGE-IV study.
  Maya Sabatello, Suzanne Bakken, Wendy K Chung, Elizabeth Cohn, Katherine D Crew, Krzysztof Kiryluk, Rita Kukafka, Chunhua Weng, Paul S Appelbaum> ;HGG Advances. 2024 Apr 11
• 1 citations
  Genetic versus self-reported African ancestry of the recipient and neighborhood predictors of kidney transplantation outcomes in 2 multiethnic urban cohorts.
  Zanoni, F., Neugut, Y., Liu, L., Zhang, J., Keating, B., Obayemi, J., Ratner, L., Cohen, D., Mohan, S., Gharavi, A., Kiryluk, K.> ;American Journal of Transplantation. 2024 Feb 6
• 4 citations
  Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations.
  Niall J Lennon, Leah C Kottyan, Christopher Kachulis, Noura S Abul-Husn, Josh Arias, Gillian Belbin, Jennifer E Below, Sonja I Berndt, Wendy K Chung, James J Cimino, E...> ;Nature Medicine. 2024 Feb 1
• The chromatin landscape of healthy and injured cell types in the human kidney.
  Gisch, D., Brennan, M., Lake, B., Basta, J., Keller, M., Melo Ferreira, R., Akilesh, S., Ghag, R., Lu, C., Cheng, Y., Collins, K., Parikh, S., Rovin, B., Robbins, L., ...> ;Nature Communications. 2024 Jan 10
• 1 citations
  Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy.
  Mariell Rivedal, Håvard Mikkelsen, Hans-Peter Marti, Lili Liu, Krzysztof Kiryluk, Thomas Knoop, Rune Bjørneklett, Yngvar Lunde Haaskjold, Jessica Furriol, Sabine Leh, ...> ;Kidney International. 2024 Apr 1
• Polygenic risk alters the penetrance of monogenic kidney disease.
  Khan, A., Shang, N., Weng, C., Hripcsak, G., Harris, P., Nestor, J., Gharavi, A., Kiryluk, K.> ;Nature Communications. 2023 Dec 14
• Mouse and human studies support DSTYK loss of function as a low-penetrance and variable expressivity risk factor for congenital urinary tract anomalies.
  Martino, J., Liu, Q., Vukojevic, K., Ke, J., Lim, T., Khan, A., Gupta, Y., Perez, A., Yan, Z., Milo Rasouly, H., Vena, N., Lippa, N., Giordano, J., Saraga, M., Saraga-...> ;Genetics in Medicine. 2023 Dec 1
• 3 citations
  Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease.
  Yask Gupta, David J Friedman, Michelle T McNulty, Atlas Khan, Brandon Lane, Chen Wang, Juntao Ke, Gina Jin, Benjamin Wooden, Andrea L Knob, Tze Y Lim, Gerald B Appel, ...> ;Nature Communications. 2023 Nov 30
• 3 citations
  Dimension-agnostic and granularity-based spatially variable gene identification using BSP.
  Juexin Wang, Jinpu Li, Skyler T Kramer, Li Su, Yuzhou Chang, Chunhui Xu, Michael T Eadon, Krzysztof Kiryluk, Qin Ma, Dong Xu> ;Nature Communications. 2023 Nov 14
• 2 citations
  Participant-guided development of bilingual genomic educational infographics for Electronic Medical Records and Genomics Phase IV study.
  Aimiel Casillan, Michelle E Florido, Jamie Galarza-Cornejo, Suzanne Bakken, John A Lynch, Wendy K Chung, Kathleen F Mittendorf, Eta S Berner, John J Connolly, Chunhua ...> ;Journal of the American Medical Informatics Association. 2024 Jan 18
• 1 citations
  Prospective, multi-site study of healthcare utilization after actionable monogenic findings from clinical sequencing.
  Jodell E Linder, Ran Tao, Wendy K Chung, Krzysztof Kiryluk, Cong Liu, Chunhua Weng, John J Connolly, Hakon Hakonarson, Margaret Harr, Kathleen A Leppig, Gail P Jarvik,...> ;American Journal of Human Genetics. 2023 Nov 2
• Pathologic-genomic correlation identified a novel variant in FN1 and established the diagnosis of recurrent fibronectin glomerulopathy in the kidney allograft.
  Ibrahim Batal, Samih H Nasr, Surendra Dasari, Astrid Weins, Natalie Vena, Michael B Stokes, Krzysztof Kiryluk, Gerald B Appel> ;American Journal of Transplantation. 2024 Mar 1
• Mendelian randomization for nephrologists.
  Ellen Dobrijevic, Anita van Zwieten, Krzysztof Kiryluk, Andrew J Grant, Germaine Wong, Armando Teixeira-Pinto> ;Kidney International. 2023 Dec 1
• 3 citations
  Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms.
  Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E Johnson, Wei-Qi Wei, Qiping Feng, Bahram Namjou, Krzysztof Kiryluk, Iftikhar J Kullo, Yuan Luo, Blair D Sulli...> ;Nature Communications. 2023 Sep 9
• 1 citations
  Anti-PLA2R Antibody Levels and Clinical Risk Factors for Treatment Nonresponse in Membranous Nephropathy.
  Sean J Barbour, Fernando C Fervenza, Dilshani Induruwage, Paul E Brenchley, Brad Rovin, Michelle A Hladunewich, Heather N Reich, Richard Lafayette, Nabeel Aslam, Geral...> ;Clinical Journal of the American Society of Nephrology. 2023 Oct 1
• 118 citations
  An atlas of healthy and injured cell states and niches in the human kidney.
  Blue B Lake, Rajasree Menon, Seth Winfree, Qiwen Hu, Ricardo Melo Ferreira, Kian Kalhor, Daria Barwinska, Edgar A Otto, Michael Ferkowicz, Dinh Diep, Nongluk Plongthon...> ;Nature. 2023 Jul 1
• A metadata framework for computational phenotypes.
  Matthew Spotnitz, Nripendra Acharya, James J Cimino, Shawn Murphy, Bahram Namjou, Nancy Crimmins, Theresa Walunas, Cong Liu, David Crosslin, Barbara Benoit, Elisabeth ...> ;JAMIA Open. 2023 Jul 1
• 18 citations
  Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy.
  Krzysztof Kiryluk, Elena Sanchez-Rodriguez, Xu-Jie Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasa, Jun Y Zhang, Olivia Balderes, Simone...> ;Nature Genetics. 2023 Jul 1
• Genome-wide Association Study for AKI.
  Pavan K Bhatraju, Ian B Stanaway, Melody R Palmer, Rajasree Menon, Jennifer A Schaub, Steven Menez, Anand Srivastava, F Perry Wilson, Krzysztof Kiryluk, Paul M Palevsk...> ;Kidney360. 2023 Jul 1
• Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations.
  Niall J Lennon, Leah C Kottyan, Christopher Kachulis, Noura Abul-Husn, Josh Arias, Gillian Belbin, Jennifer E Below, Sonja Berndt, Wendy Chung, James J Cimino, Ellen W...> ;Medrxiv. 2023 Jun 5
• 2 citations
  Global Incidence of IgA Nephropathy by Race and Ethnicity: A Systematic Review.
  Krzysztof Kiryluk, Daniel E Freedberg, Jai Radhakrishnan, Leslie Segall, Judith S Jacobson, Mohit Mathur, Sumit Mohan, Alfred I Neugut> ;Kidney360. 2023 Aug 1
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Lectures

• Kidney Failure Risk Prediction Equations in IgA Nephropathy: A Multicenter Risk Assessment Study in Chinese Patients 
  American Society of Nephrology Kidney Week 2019 - Washington, D.C. - 11/9/2019